scholarly journals Development and Application of the Analytical Methods with Spectrometry for Bio-Related Compounds

1998 ◽  
Vol 118 (11) ◽  
pp. 483-492 ◽  
Author(s):  
Tomofumi SANTA
Author(s):  
xxx

AbstractA workshop on problems related to the analysis of nicotine and nicotine metabolites in body fluids at levels pertinent to the human situation was held in November 1974 in Stockholm. It was organized by C. Enzell, B. Holmstedt and A. Pilotti at the request of the Medical Advisory Board of the Swedish Tobacco Company. The goal of the workshop was to summarize the present state of art in the area outlined by the organizers and to discuss critically the advantages and limitations of the different analytical methods available today. EIeven experts in the field of metabolism, detection and biosynthesis of nicotine and related compounds were therefore invited to present papers on these topics and to participate in the discussions. AIl speakers invited were able to attend and the papers were arranged in the following groups:Each speaker had one hour and a half at his disposal which included the discussion which, due to the informal atmosphere and the smaII number of participants, was very lively and fruitful. The papers read at this workshop comprise a very valuable coverage of recent research in the fields of metabolism of nicotine and minor tobacco alkaloids, and of the various methods available for detection of these alkaloids. The abstracts are given below, while full papers, now edited by A. Pilotti, can be obtained on request from C. Enzell of the Swedish Tobacco Company


1967 ◽  
Vol 5 (6) ◽  
pp. 297-302 ◽  
Author(s):  
M. G. Horning ◽  
E. A. Boucher ◽  
A. M. Moss

Author(s):  
I. Reis ◽  
V. Krämer ◽  
A. Seiler ◽  
D. Topa ◽  
E. Keller

The title phase, first detected in the early 1980s but hitherto unpublished, has been resynthesized and structurally characterized. Unambiguous determination of the chemical composition was not possible by structure analysis alone, but required additional analytical methods. The complex structure shows a close similarity to the structures of two related compounds, one known by the formula Pb1.6In8Bi4S19and the other being the ternary compound Pb6In10S21. This is despite the fact that the three phases correspond to very different Pb:Bi ratios. A geometric mechanism is described by which the three structures can be transformed into each other, provided that the heavy atoms Pb and Bi are treated as equivalent.


2013 ◽  
Vol 15 (1) ◽  
pp. 1-12 ◽  

Emerging pollutants are increasingly detected in aqueous environmental samples, with pharmaceuticals and related compounds consisting a large category with many diverse groups, including parent compounds and their metabolites/transformation products. Significant research is performed on this subject worldwide, in order to obtain information regarding their occurrence, fate and health effects. In this effort, development and optimization of highly sensitive and accurate analytical methods for their determination in environmental samples is a necessity, but also a challenge. Advanced analytical methods for emerging pollutants include liquid chromatography (LC) or gas chromatography (GC) followed by tandem mass spectrometric (MS/MS) detection. These methods, combined with a variety of sample preparation procedures, provide the ability to analyze emerging pollutants in the environment in trace levels, and to identify and quantify their oxidation/degradation products. However, there are still many analytical aspects that need improvement and optimization for increasing the accuracy and sensitivity of the methods, in order to be able to fill the gaps of knowledge on the studied compounds.


1999 ◽  
Vol 34 (1) ◽  
pp. 3-36 ◽  
Author(s):  
Hing-Biu Lee

Abstract Analytical methods published in the last 20 years for the extraction, chromato-graphic separation, and quantification of alkylphenol ethoxylates (APEO) and related compounds in environmental samples are reviewed. Examples of various isolation and preconcentration techniques for water, effluent, sediment and sludge are presented. This includes procedures from the classical liquid-liquid and Soxhlet extraction to the up-to-date solid phase and supercritical fluid extraction. Chromatographic separation of APEO by normal and reversed phase liquid chromatography (LC) and capillary column gas chromatography (GC) is compared. A variety of quantification methods involving the common LC and GC detectors as well as various mass spectrometric techniques are also discussed.


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