scholarly journals Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Aspirin Modulation of IgE-Dependent Mast Cell Activation: Role of Aspirin-Induced Exacerbation of Immediate Allergy

2009 ◽  
Vol 110 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Yoshihiro Suzuki ◽  
Chisei Ra
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Skin Inflammation ◽  
Mast Cell Activation ◽  
Allergic Skin

scholarly journals Anti-Inflammatory Effects of Cold Thermal Therapy on Allergic Skin Inflammation Induced by Trimellitic Anhydride in BALB/c Mice

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Chun Hua Piao ◽  
Minjoo Kim ◽  
Thi Tho Bui ◽  
Eunjin Hyeon ◽  
Yanjing Fan ◽  
...  
Keyword(s):  
Mast Cell ◽  
Vascular Permeability ◽  
Cell Activation ◽  
Skin Inflammation ◽  
Thermal Therapy ◽  
Mast Cell Activation ◽  
Trimellitic Anhydride ◽  
Th2 Cytokine ◽  
Thermal Therapies ◽  
Allergic Skin

Cold and hot thermal therapies are widely used as a traditional therapy in many cultures and are often prescribed in the treatment of various musculoskeletal and neurological conditions which present themselves to primary care physicians. However, there are no reports that investigated either the effects of cold and hot thermal therapies on the skin inflammation of trimellitic anhydride- (TMA-) induced dermatitis-like contact hypersensitivity (CHS) mouse model, or the mechanism of thermal therapy on allergic skin inflammation. Therefore, in this study, to reveal the anti-inflammatory effect of thermal therapy and its mechanism on TMA-induced CHS, we analyzed ear-swelling response (ear edema), vascular permeability, serum IgE levels, histological examination, and histamine and Th2 cytokine levels. Cold thermal therapy reduced the ear-swelling response, the vascular permeability, the serum IgE levels, and the infiltration of eosinophils and mast cells as well as the mast cell degranulation. To determine the mechanism by which cold thermal therapy inhibits allergic skin inflammation, detailed studies were carried out revealing that cold thermal therapy suppressed IL-4 and IL-5 secretion and mast cell activation. These results indicated that cold thermal therapy cures skin inflammation of TMA-induced CHS by decreasing Th2 cytokine release, especially IL-4 and IL-5, and mast cell activation. These data suggest that new insight into the mechanism of robust therapeutic effects of cold thermal therapy against allergic dermatitis, and cold thermal therapy may prove to be a useful therapeutic modality on allergic inflammatory diseases as traditional use as well as Th2- or mast cell-mediated allergic responses.

Lactococcus lactisKR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation

2018 ◽  
Vol 126 (1) ◽  
pp. 230-241 ◽  
Author(s):  
M. Jin ◽  
S. Lee ◽  
Y.-A. Choi ◽  
H.-J. Jang ◽  
S.W. Lee ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Activation ◽  
Skin Inflammation ◽  
Mast Cell Activation ◽  
Dust Mite ◽  
Atopic Skin

Nitric oxide positively regulates Ag (I)-induced Ca2+ influx and mast cell activation: role of a nitric oxide synthase-independent pathway

2009 ◽  
Vol 86 (6) ◽  
pp. 1365-1375 ◽  
Author(s):  
Toshio Inoue ◽  
Yoshihiro Suzuki ◽  
Tetsuro Yoshimaru ◽  
Chisei Ra
Keyword(s):  
Nitric Oxide ◽  
Mast Cell ◽  
Nitric Oxide Synthase ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Oxide Synthase

Critical role of IgE-dependent mast cell activation in a murine model of allergic conjunctivitis

2009 ◽  
Vol 124 (4) ◽  
pp. 827-833.e2 ◽  
Author(s):  
Ken Fukuda ◽  
Masaharu Ohbayashi ◽  
Kei Morohoshi ◽  
Lane Zhang ◽  
Fu-Tong Liu ◽  
...  
Keyword(s):  
Mast Cell ◽  
Murine Model ◽  
Allergic Conjunctivitis ◽  
Cell Activation ◽  
Critical Role ◽  
Mast Cell Activation

Mast Cell Activation and the Role of Eicosanoids

2009 ◽  
pp. 91-99
Author(s):  
E. Nigel Wardle
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation

scholarly journals Differential use of BTK and PLC in FcεRI- and KIT-mediated mast cell activation: A marginal role of BTK upon KIT activation

2020 ◽  
Vol 1867 (4) ◽  
pp. 118622
Author(s):  
Anne Simonowski ◽  
Thomas Wilhelm ◽  
Pardes Habib ◽  
Carolin N. Zorn ◽  
Michael Huber
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation

TRPV4 is a key driver for mast cell activation in LL37mediated skin inflammation

2017 ◽  
Vol 86 (2) ◽  
pp. e69
Author(s):  
Anna Di_Nardo ◽  
Nicholas Mascarenhas ◽  
Zhenping Wang
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Skin Inflammation ◽  
Mast Cell Activation ◽  
Key Driver

scholarly journals The autocrine role of tryptase in pressure overload-induced mast cell activation, chymase release and cardiac fibrosis

2016 ◽  
Vol 10 ◽  
pp. 16-23 ◽  
Author(s):  
Jianping Li ◽  
Shaiban Jubair ◽  
Scott P. Levick ◽  
Joseph S. Janicki
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Cardiac Fibrosis ◽  
Pressure Overload ◽  
Mast Cell Activation

A new chemical tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation

2008 ◽  
Vol 76 (7) ◽  
pp. 912-921 ◽  
Author(s):  
Montserrat Buceta ◽  
Eduardo Domínguez ◽  
Marián Castro ◽  
José Brea ◽  
David Álvarez ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Adenosine A2b
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