scholarly journals Effect of Diesel Exhaust Particles on House Dust Mite–Induced Airway Eosinophilic Inflammation and Remodeling in Mice

2010 ◽  
Vol 112 (2) ◽  
pp. 192-202 ◽  
Author(s):  
Go Takahashi ◽  
Hiroyuki Tanaka ◽  
Keiko Wakahara ◽  
Reishi Nasu ◽  
Mikiko Hashimoto ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Eosinophilic Inflammation ◽  
Dust Mite ◽  
Exhaust Particles

scholarly journals Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hahn Jin Jung ◽  
Young-Kyung Ko ◽  
Woo Sub Shim ◽  
Hyun Jik Kim ◽  
Dong-Young Kim ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Allergic Symptom ◽  
Eosinophil Infiltration ◽  
Dust Mite ◽  
Symptom Scores ◽  
Exhaust Particles

AbstractDiesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear. Therefore, this study aimed to investigate the effect of DEP exposure on AR using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP. Allergic symptom scores, serum total and HDM-specific immunoglobulins (Igs), eosinophil infiltration in the nasal mucosa, cytological profiles in bronchoalveolar lavage fluid (BALF), and cytokine levels in the nasal mucosa and spleen cell culture were analyzed. Mice co-exposed to HDM and DEP showed increased allergic symptom scores compared with mice exposed to HDM alone. Reduced total IgE and HDM-specific IgE and IgG1 levels, decreased eosinophil infiltration in the nasal mucosa, and increased proportion of neutrophils in BALF were found in mice co-exposed to HDM and DEP. Interleukin (IL)-17A level was found to be increased in the nasal mucosa of the co-exposure group compared with that in the HDM-exposed group. The levels of IL-4, IL-13, interferon-γ, IL-25, IL-33, and TSLP expression showed no difference between the groups with and without DEP treatment. Increased expression of IL-17A in the nasal mucosa may contribute to DEP-mediated exacerbation of AR in HDM-sensitized murine AR model.

scholarly journals Diesel Exhaust Particles Induce Cysteine Oxidation and S-Glutathionylation in House Dust Mite Induced Murine Asthma

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e60632 ◽  
Author(s):  
Gerald B. Lee ◽  
Eric B. Brandt ◽  
Chang Xiao ◽  
Aaron M. Gibson ◽  
Timothy D. Le Cras ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Cysteine Oxidation ◽  
Dust Mite ◽  
Exhaust Particles

Enhancement of antigen-induced eosinophilic inflammation in the airways of mast-cell deficient mice by diesel exhaust particles

Toxicology ◽  
2002 ◽  
Vol 180 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Takamichi Ichinose ◽  
Hirohisa Takano ◽  
Yuichi Miyabara ◽  
Kaori Sadakaneo ◽  
Masaru Sagai ◽  
...  
Keyword(s):  
Mast Cell ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Eosinophilic Inflammation ◽  
Exhaust Particles ◽  
Deficient Mice

scholarly journals Diesel exhaust and house dust mite allergen lead to common changes in the airway methylome and hydroxymethylome

2018 ◽  
Vol 4 (3) ◽  
Author(s):  
Xue Zhang ◽  
Xiaoting Chen ◽  
Matthew T Weirauch ◽  
Xiang Zhang ◽  
J D Burleson ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Mite Allergen ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Dust Mite Allergen

Differences in airway-inflammation development by house dust mite and diesel exhaust inhalation among mouse strains

2003 ◽  
Vol 187 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Takamichi Ichinose ◽  
Hirohisa Takano ◽  
Kaori Sadakane ◽  
Rie Yanagisawa ◽  
Hiroaki Kawazato ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Diesel Exhaust ◽  
Mouse Strains ◽  
Dust Mite

Lipopolysaccharide amplifies eosinophilic inflammation after segmental challenge with house dust mite in asthmatics

Allergy ◽  
2014 ◽  
Vol 70 (3) ◽  
pp. 257-264 ◽  
Author(s):  
M. Berger ◽  
J. D. de Boer ◽  
P. Bresser ◽  
T. van der Poll ◽  
R. Lutter ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Eosinophilic Inflammation ◽  
Dust Mite
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