scholarly journals Preimplantation-embryo-specific Cell-cycle Regulation is Attributable to a Low Expression of Retinoblastoma Protein Rather Than Its Phosphorylation

2011 ◽  
Vol 57 (4) ◽  
pp. 492-499 ◽  
Author(s):  
Asuka EGASHIRA ◽  
Kiyoshi KANO ◽  
Kunihiko NAITO
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Preimplantation Embryo ◽  
Retinoblastoma Protein ◽  
Specific Cell ◽  
Cycle Regulation ◽  
Low Expression

scholarly journals The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation

Oncogene ◽  
2000 ◽  
Vol 19 (32) ◽  
pp. 3598-3608 ◽  
Author(s):  
Laura Hertel ◽  
Sandra Rolle ◽  
Marco De Andrea ◽  
Barbara Azzimonti ◽  
Raffaella Osello ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Retinoblastoma Protein ◽  
Cycle Regulation

scholarly journals APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway

2016 ◽  
Vol 36 (5) ◽  
Author(s):  
Ajeena Ramanujan ◽  
Swati Tiwari
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Alternative Pathway ◽  
Retinoblastoma Protein ◽  
S Phase ◽  
Anaphase Promoting Complex ◽  
Anti Cancer ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
Cycle Regulation

The ubiquitin (Ub) ligase anaphase promoting complex/cyclosome (APC/C) and the tumour suppressor retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G1-phase of the cell cycle whereas pRB keeps a check on proliferation by inhibiting transition to the S-phase. APC/C and pRB interact with each other via the co-activator of APC/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB using a post-translational mechanism. Both pRB and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism. Both are also targeted by transforming viruses. We discuss recent advances in our understanding of the involvement of APC/C and pRB in cell cycle based decisions and how these insights will be useful for development of anti-cancer and anti-viral drugs.

scholarly journals Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 ◽  
Vol 8 (17) ◽  
pp. 2008-2021 ◽  
Author(s):  
E Y Lee ◽  
N Hu ◽  
S S Yuan ◽  
L A Cox ◽  
A Bradley ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Retinoblastoma Protein ◽  
Dual Roles ◽  
Neuron Differentiation ◽  
Cycle Regulation

scholarly journals An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Julia Bittmann ◽  
Rokas Grigaitis ◽  
Lorenzo Galanti ◽  
Silas Amarell ◽  
Florian Wilfling ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Regulation ◽  
Cell Cycle Control ◽  
S Phase ◽  
Specific Cell ◽  
Protein Functionality ◽  
M Phase ◽  
Cell Cycle Phases ◽  
Cycle Regulation

Cell cycle tags allow to restrict target protein expression to specific cell cycle phases. Here, we present an advanced toolbox of cell cycle tag constructs in budding yeast with defined and compatible peak expression that allow comparison of protein functionality at different cell cycle phases. We apply this technology to the question of how and when Mus81-Mms4 and Yen1 nucleases act on DNA replication or recombination structures. Restriction of Mus81-Mms4 to M phase but not S phase allows a wildtype response to various forms of replication perturbation and DNA damage in S phase, suggesting it acts as a post-replicative resolvase. Moreover, we use cell cycle tags to reinstall cell cycle control to a deregulated version of Yen1, showing that its premature activation interferes with the response to perturbed replication. Curbing resolvase activity and establishing a hierarchy of resolution mechanisms are therefore the principal reasons underlying resolvase cell cycle regulation.

The retinoblastoma protein and cell cycle regulation

1992 ◽  
Vol 8 (5) ◽  
pp. 180-185 ◽  
Author(s):  
P.A. Hamel ◽  
B.L. Gallie ◽  
R.A. Phillips
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Retinoblastoma Protein ◽  
Cycle Regulation
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