scholarly journals Abdominal tuberculosis misdiagnosed as acute surgical abdomen and carcinomatosis

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 355
Author(s):  
Edinson Dante Meregildo-Rodriguez ◽  
Rosita Claudia Tafur-Ramirez ◽  
Walter Giovanny Espino-Saavedra ◽  
Sonia Fiorella Angulo-Prentice
Keyword(s):  
Young Patients ◽  
Public Health Problem ◽  
Abdominal Tuberculosis ◽  
Definitive Diagnosis ◽  
The Other ◽  
Response To Treatment ◽  
Major Public Health Problem ◽  
Rt Pcr ◽  
Neoplastic Lesions ◽  
Low Prevalence

Tuberculosis is a major public health problem worldwide. Tuberculosis can be confused with other diseases and its diagnosis is frequently delayed, especially in areas of low prevalence. We report two cases of young patients who presented preoperatively as acute abdomen due to acute appendicitis. During the intra-operatory these cases were misdiagnosed as “carcinomatosis”, and in the postoperative period these cases were complicated with septic shock. In both cases, histopathology showed caseating granulomas which suggested tuberculous peritonitis and enteritis. Subsequently, RT-PCR in peritoneal fluid confirmed Mycobacterium tuberculosis. In one case the clinical response to treatment was excellent, and the other case was fatal. The aim of this report is to bring attention to the spectrum of tuberculosis, and to serve as a reminder of tuberculosis as the great imitator that can masquerade as cancer. Most tuberculous patients erroneously diagnosed as cancer have extensive “neoplastic” lesions that would suggest an advanced-stage malignancy. Assuming a case as an advanced cancer would reduce the chance of performing more exhaustive studies to get a definitive diagnosis and clinicians would be tempted to offer only palliative treatments.

scholarly journals Abdominal tuberculosis misdiagnosed as acute surgical abdomen and carcinomatosis

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 355
Author(s):  
Edinson Dante Meregildo-Rodriguez ◽  
Rosita Claudia Tafur-Ramirez ◽  
Walter Giovanny Espino-Saavedra ◽  
Sonia Fiorella Angulo-Prentice
Keyword(s):  
Young Patients ◽  
Public Health Problem ◽  
Abdominal Tuberculosis ◽  
Definitive Diagnosis ◽  
The Other ◽  
Response To Treatment ◽  
Major Public Health Problem ◽  
Rt Pcr ◽  
Neoplastic Lesions ◽  
Low Prevalence

Tuberculosis is a major public health problem worldwide. Tuberculosis can be confused with other diseases and its diagnosis is frequently delayed, especially in areas of low prevalence. Abdominal tuberculosis includes involvement of the gastrointestinal tract, peritoneum, lymph nodes, and/or solid organs; and accounts for 5% of all cases of tuberculosis. We report two cases of young patients who presented preoperatively as acute abdomen due to acute appendicitis. During surgery, these cases were misdiagnosed as “carcinomatosis”, and in the postoperative period these cases were complicated with septic shock. In both cases, histopathology showed caseating granulomas which suggested tuberculous peritonitis and enteritis. Subsequently, RT-PCR in peritoneal fluid confirmed Mycobacterium tuberculosis. In one case the clinical response to treatment was excellent, and the other case was fatal. The aim of this report is to bring attention to the spectrum of tuberculosis, and to serve as a reminder of tuberculosis as the great imitator that can masquerade as cancer. Most tuberculous patients erroneously diagnosed as cancer have extensive “neoplastic” lesions that would suggest an advanced-stage malignancy. Assuming a case as an advanced cancer would reduce the chance of performing more exhaustive studies to get a definitive diagnosis and clinicians would be tempted to offer only palliative treatments.

scholarly journals Pulmonary alterations in cocaine users

2004 ◽  
Vol 122 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Mário Terra Filho ◽  
Chen Chin Yen ◽  
Ubiratan de Paula Santos ◽  
Daniel Romero Muñoz
Keyword(s):  
Interstitial Fibrosis ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Lung Abscess ◽  
Pulmonary Complications ◽  
Major Public Health Problem ◽  
Pulmonary Infarction ◽  
Cocaine Use ◽  
Cocaine Users

CONTEXT: Brazilian researchers have recently recognized a marked increase in the number of people using abusable drugs and the consequences of this habit. It has become a major public health problem in a potentially productive segment of the general population. In the last few years, several medical articles have given special emphasis to pulmonary complications related to cocaine use. This review is based on this information and experience acquired with groups of cocaine users. OBJECTIVE: To present to physicians the pulmonary aspects of cocaine use and warn about the various effects this drug has on the respiratory system, stressing those related to long-term use. DESIGN: Narrative review. METHOD: Pulmonary complications are described. These may include infections (Staphylococcus aureus, pulmonary tuberculosis, acquired immunodeficiency syndrome/aids, etc.), aspiration pneumonia, lung abscess, empyema, septic embolism, non-cardiogenic pulmonary edema, barotrauma, pulmonary granulomatosis, bronchiolitis obliterans and organizing pneumonia, pneumonitis and interstitial fibrosis, pneumonitis hypersensitivity, lung infiltrates and eosinophilia in individuals with bronchial hyperreactivity, diffuse alveolar hemorrhage, vasculitis, pulmonary infarction, pulmonary hypertension and alterations in gas exchange. It is concluded that physicians should give special attention to the various pulmonary and clinical manifestations related to cocaine use, particularly in young patients.

Prevalence of porA pseudogene deletion among Neisseria gonorrhoeae isolates referred to the UK’s Gonococcal Resistance to Antimicrobials Surveillance Program

Sexual Health ◽  
2017 ◽  
Vol 14 (4) ◽  
pp. 392 ◽  
Author(s):  
Martina Toby ◽  
Pamela Saunders ◽  
Michelle Cole ◽  
Vlad Grigorjev ◽  
Sarah Alexander ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
False Negative ◽  
Public Health Problem ◽  
Surveillance Program ◽  
Major Public Health Problem ◽  
Negative Results ◽  
False Negative Results ◽  
Confirmatory Tests ◽  
Polymerase Chain ◽  
Low Prevalence

porA pseudogene-negative Neisseria gonorrhoeae isolates produce false-negative results when examined by polymerase chain reaction (PCR) with porA pseudogene targets. In the present study, 533 representative gonococcal isolates received in 2011 via the Gonococcal Resistance to Antimicrobials Surveillance Program were examined to determine the prevalence of porA-negative isolates. Less than 0.4% (2/533) of isolates were found to be reproducibly negative with the porA real-time PCR but were confirmed as N. gonorrhoeae with molecular, biochemical and immunological confirmatory tests. Sequencing revealed both isolates contained the Neisseria meningitidis porA gene. Low prevalence indicates that although these isolates do not present a major public health problem, microbiologists should remain vigilant.

Molecular Detection of Hepatitis C Virus amongst Patients in Five Selected Hospitals in Niger State, Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 60-69
Author(s):  
M U Iduh ◽  
F A Kuta ◽  
M E Abalaka ◽  
K O Shitu
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Direct Sequencing ◽  
Rna Extraction ◽  
Public Health Problem ◽  
Developed Countries ◽  
Response To Treatment ◽  
Hcv Rna ◽  
Major Public Health Problem ◽  
Polymerase Chain

Hepatitis C Virus (HCV) is a major public health problem in developing and developed countries worldwide. It is responsible for liver diseases and hepatocellular carcinoma in chronically-infected patients. This study therefore aimed to identify the strain of HCV among HCV seropositive subjects in Niger State. A total of 44 HCV seropositive blood samples which consisted of 27 males and 17 females were analyzed (after Viral RNA extraction) for the presence of HCV-RNA by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Nine (20.5%) of the samples were positive for HCV RNA. HCV-RNA positive samples were genotyped by direct sequencing at 5’UTR region genomes; sequences were aligned on MEGA 6.0 and confirmed by phylogenetic analysis. HCV genotype 1b was the only one distributed among the participants. The findings are relevant as predictors for using antiviral therapy in this population because the response to treatment varies according to the genotype.

scholarly journals Dengue Fever: In-Hospital Management of Critically ill Adult Patients

2021 ◽  
Vol 2 (2) ◽  
pp. 5
Author(s):  
Kiran Fatima ◽  
Aamir Shahzad
Keyword(s):  
Public Health ◽  
Critically Ill ◽  
Public Health Problem ◽  
Adult Patients ◽  
Response To Treatment ◽  
Major Public Health Problem ◽  
Close Monitoring ◽  
Careful Attention ◽  
Mortality And Morbidity ◽  
Significant Mortality

Dengue is rapidly becoming a major public health problem with significant mortality and morbidity. Management especially in first two days needs careful attention. We present a review of current literature on the management critically ill adult patients of dengue in hospital settings. Early diagnosis and close monitoring of response to treatment are necessary to prevent worse outcomes.

scholarly journals Molecular Detection of Hepatitis C Virus amongst Patients in Five Selected Hospitals in Niger State, Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 60-69
Author(s):  
M U Iduh ◽  
F A Kuta ◽  
M E Abalaka ◽  
K O Shitu
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Direct Sequencing ◽  
Rna Extraction ◽  
Public Health Problem ◽  
Developed Countries ◽  
Response To Treatment ◽  
Hcv Rna ◽  
Major Public Health Problem ◽  
Polymerase Chain

Hepatitis C Virus (HCV) is a major public health problem in developing and developed countries worldwide. It is responsible for liver diseases and hepatocellular carcinoma in chronically-infected patients. This study therefore aimed to identify the strain of HCV among HCV seropositive subjects in Niger State. A total of 44 HCV seropositive blood samples which consisted of 27 males and 17 females were analyzed (after Viral RNA extraction) for the presence of HCV-RNA by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Nine (20.5%) of the samples were positive for HCV RNA. HCV-RNA positive samples were genotyped by direct sequencing at 5’UTR region genomes; sequences were aligned on MEGA 6.0 and confirmed by phylogenetic analysis. HCV genotype 1b was the only one distributed among the participants. The findings are relevant as predictors for using antiviral therapy in this population because the response to treatment varies according to the genotype.

scholarly journals The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Wei Su ◽  
Wen Xie ◽  
Qingkun Shang ◽  
Bing Su
Keyword(s):  
Noncoding Rna ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Rt Pcr ◽  
Average Life Expectancy ◽  
Vegf Mrna ◽  
Normal Cartilage ◽  
Effective Strategies ◽  
Inhibition Of Angiogenesis ◽  
Bone And Cartilage Development

Osteoarthritis (OA) is becoming a major public health problem in China, especially considering the increase in average life expectancy of the population. Thus, enhanced understanding of the molecular changes associated with OA is urgently needed to develop more effective strategies for the diagnosis and treatment of this debilitating disease. LncRNAs play an important role in the processes of bone and cartilage development. Maternally expressed gene 3 (MEG3) is a maternally expressed lncRNA and may function as a tumor suppressor by inhibiting angiogenesis. OA is closely associated with angiogenesis and the inhibition of angiogenesis presents a novel therapeutic approach to reduce inflammation and pain in OA. In this study, we detected the mRNA expression of MEG3 and VEGF in articular cartilage samples from 20 OA patients and 10 healthy volunteers by real-time RT-PCR. VEGF protein is detected by ELISA in cartilage samples. The results show that human MEG3 is significantly downregulated in OA patients compared to normal cartilage samples. However, higher levels of VEGF mRNA and protein are found in OA compared to the control. Moreover, MEG3 levels are inversely associated with VEGF levels, suggesting that MEG3 may be involved in OA development through the regulation of angiogenesis.

scholarly journals Trend Analysis of Malaria Occurrence in Wolaita Zone, Southern Ethiopia: Retrospective Cross-Sectional Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Deresse Legesse ◽  
Yusuf Haji ◽  
Solomon Abreha
Keyword(s):  
Public Health Problem ◽  
Cross Sectional Study ◽  
Health Centers ◽  
The Other ◽  
Southern Ethiopia ◽  
Major Public Health Problem ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Record Review

Background. Malaria is a major public health problem in Ethiopia. The trend of malaria occurrence remains unknown in the study area. This study is aimed at determining the last five years’ trend of malaria occurrence from 2008/09 to 2012/13 in Wolaita Zone, Southern Ethiopia. Methods. A health facility-based retrospective study was conducted in Wolaita Zone from March to August, 2014. Five years’ laboratory confirmed malaria record review was made from six health centers. Result. A total of 105,755 laboratory confirmed malaria cases were reported, with total slide positivity rate of 33.27% and mean annual occurrence of 21,151 cases. Malaria occurred with a fluctuating trend in the study area, with its peak occurring at the year 2011/12. Overall, no remarkable decline in the total laboratory confirmed malaria was observed in the last five years. P. falciparum was the predominantly reported species, accounting for 75,929 (71.80%) of cases. The highest slide positivity rate was observed in the age group of 5–14 years (40.5%) followed by 1–4 years (35.5%). Two malaria peak seasons occurred: one from September to December and the other from April to June. Conclusion. No remarkable decline in laboratory confirmed malaria in the last five years was observed.

scholarly journals Two sequential PCR amplifications for detection of Schistosoma mansoni in stool samples with low parasite load

2012 ◽  
Vol 54 (5) ◽  
pp. 245-248 ◽  
Author(s):  
Maria Cristina Carvalho do Espírito-Santo ◽  
Mónica Viviana Alvarado-Mora ◽  
Pedro Luiz Silva Pinto ◽  
Flair José Carrilho ◽  
João Renato Rebello Pinho ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
False Negative ◽  
Public Health Problem ◽  
Parasite Load ◽  
Detection Sensitivity ◽  
Major Public Health Problem ◽  
Guanidine Isothiocyanate ◽  
Negative Results ◽  
False Negative Results ◽  
Low Prevalence

Schistosomiasis constitutes a major public health problem, with an estimated 200 million individuals infected worldwide and 700 million people living in risk areas. In Brazil there are areas of high, medium and low endemicity. Studies have shown that in endemic areas with a low prevalence of Schistosoma infection the sensitivity of parasitological methods is clearly reduced. Consequently diagnosis is often impeded due to the presence of false-negative results. The aim of this study is to present the PCR reamplification (Re-PCR) protocol for the detection of Schistosoma mansoni in samples with low parasite load (with less than 100 eggs per gram (epg) of feces). Three methods were used for the lysis of the envelopes of the S. mansoni eggs and two techniques of DNA extraction were carried out. Extracted DNA was quantified, and the results suggested that the extraction technique, which mixed glass beads with a guanidine isothiocyanate/phenol/chloroform (GT) solution, produced good results. PCR reamplification was conducted and detection sensitivity was found to be five eggs per 500 mg of artificially marked feces. The results achieved using these methods suggest that they are potentially viable for the detection of Schistosoma infection with low parasite load.

scholarly journals Comparative Trials of 5% Permethrin Lotions Vs 1% Gamma Benzene Hexachloride Lotions in Treatment of Scabies

2018 ◽  
Vol 7 (2) ◽  
pp. 44-49
Author(s):  
Manish Pradhan ◽  
Dipa Rai ◽  
Sagar Paudel ◽  
Chandra Bhal Jha
Keyword(s):  
Public Health Problem ◽  
Cost Effective ◽  
Skin Condition ◽  
The Other ◽  
Major Public Health Problem ◽  
Group A ◽  
Benzene Hexachloride ◽  
Group B ◽  
Pruritic Skin ◽  
Comparative Trials

Background: Scabies is a contagious pruritic skin condition caused by the mite Sarcoptesscabiei var. hominis, and it is one of the major public health problem in developing country like ours. To determine and compare the efficacy of topical permethrin and topical gamma benzene hexachloride in treatment of scabies in population of Nepal. Methods: This was a prospective, randomized, comparative study conducted in 300 diagnosed cases of scabies treated with permethrin and gamma benzene hexachloride. Results: At the end of 2nd week, treatment was effective in 91.2% cases in permethrin (group A) and 64.6% in gamma benzene hexachloride (group B). After switch over of the non-improved patients to the other group drug, 6.7% were treated successfully with gamma benzene hexachloride and 80.9% were treated successfully with permethrin at the end of 4th week. No major side effects were observed in both groups. Gamma benzene hexachloride was found to be cost effective than permethrin. Conclusion: Permethrin was found to be more effective than gamma benzene hexachloride in treatment of scabies.

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