Influence of Drinking Water Quality on the Current of Acute Radiation Disease in Mice

Purpose: Assessing the role of various factors in the formation of radioresistance is an important branch of radiobiology. The quality of drinking water, as it turned out, can significantly affect radioresistance. Against the background of studying the antiradiation properties of various types of water, differing in mineral and isotopic composition, the problem of the influence of tap water on the course of radiation injury remained underestimated. This circumstance determined the purpose of the work: to evaluate the modifying effect of tap water on the course of acute radiation sickness after X-ray irradiation of mice at an average lethal dose. Material and methods: Female ICR (CD-1) mice were irradiated with an average lethal dose once – 6.5 Gy of X-ray irradiation. After irradiation, half of the mice received tap water as drinking water, and the other half received artificially mineralized drinking water. Results: Keeping animals on tap water significantly reduced the survival rate of mice both with a single dose (log-rank test p=0.02, χ2=5.38) compared with animals receiving artificially mineralized distilled water. In addition, in the group of mice that received tap water, an increase in the rate of death of mice and a lower preservation of the group mass of animals during the development of acute radiation injury was noted. Conclusion: Tap water, used as drinking water, increases the damaging effect of radiation when X-rays are irradiated in mice.

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Bone marrow response to acute radiation injury in RFM/U mice after whole- and partial-body exposure to X-rays

The International Journal of Applied Radiation and Isotopes ◽

10.1016/0020-708x(68)90057-4 ◽

1968 ◽

Vol 19 (9) ◽

pp. 695-702 ◽

Cited By ~ 3

Author(s):

J.S. Wellington ◽

R.M. Elashoff ◽

F.C. Ludwig

Keyword(s):

Bone Marrow ◽

Radiation Injury ◽

Acute Radiation ◽

X Rays ◽

Acute Radiation Injury ◽

Partial Body

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Radioprotective Efficiency of Fullerenol in Irradiated Mice

Materials Science Forum ◽

10.4028/www.scientific.net/msf.494.549 ◽

2005 ◽

Vol 494 ◽

pp. 549-554 ◽

Cited By ~ 22

Author(s):

S. Trajković ◽

S. Dobrić ◽

A. Djordjević ◽

V. Dragojević-Simić ◽

Z. Milovanović

Keyword(s):

Radiation Injury ◽

Lethal Dose ◽

Mass Gain ◽

Whole Body ◽

X Rays ◽

Male Adult ◽

X Ray ◽

The Mean ◽

Higher Doses

In vitro studies have demonstrated that fullerenol, a polyhydroxylated derivative of fullerene (C60(OH)n n = 12-26), has a high antioxidative potential. Since any radiation injury is mainly a consequence of the action of free radical species, the aim of this study was to examine radioprotective efficiency of fullerenol in whole-body irradiated mice. The experiment was performed on male, adult, white mice, whole-body irradiated with Xrays doses of 6 to 8 Gy (X-ray energy of 8 MV). Fullerenol C60(OH)24 was given in doses of 10 and 100 mg/kg i.p. 30 minutes before irradiation. The experimental groups consisted of 25-30 animals each. The survival rate and body mass gain of irradiated animals were monitored for 30 days after irradiation. The mean lethal times (LT50) of irradiated mice and mean lethal dose of X-rays were calculated and compared. The results showed that fullerenol C60(OH)24, in a dose of 100 mg/kg i.p., prolonged LT50 of irradiated mice. This effect was especially pronounced in mice irradiated with 7 and 8 Gy of X-rays. It seems that radioprotective efficiency of fullerenol C60(OH)24 is more marked in mice irradiated by higher doses of X-rays.

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HemaMax™, a Recombinant Human Interleukin-12, Is a Potent Mitigator of Acute Radiation Injury in Mice and Non-Human Primates

PLoS ONE ◽

10.1371/journal.pone.0030434 ◽

2012 ◽

Vol 7 (2) ◽

pp. e30434 ◽

Cited By ~ 36

Author(s):

Lena A. Basile ◽

Dolph Ellefson ◽

Zoya Gluzman-Poltorak ◽

Katiana Junes-Gill ◽

Vernon Mar ◽

...

Keyword(s):

Radiation Injury ◽

Acute Radiation ◽

Interleukin 12 ◽

Acute Radiation Injury

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Re-Examination of the Exacerbating Effect of Inflammasome Components during Radiation Injury

Radiation Research ◽

10.1667/rade-21-00142.1 ◽

2021 ◽

Author(s):

W. June Brickey ◽

Michael A. Thompson ◽

Zhecheng Sheng ◽

Zhiguo Li ◽

Kouros Owzar ◽

...

Keyword(s):

Cellular Response ◽

Radiation Injury ◽

Therapeutic Benefit ◽

Acute Radiation ◽

Cellular Damage ◽

Inflammatory Factors ◽

Experimental Conditions ◽

Acute Radiation Injury ◽

Radiation Induced

Radiation can be applied for therapeutic benefit against cancer or may result in devastating harm due to accidental or intentional release of nuclear energy. In all cases, radiation exposure causes molecular and cellular damage, resulting in the production of inflammatory factors and danger signals. Several classes of innate immune receptors sense the released damage associated molecules and activate cellular response pathways, including the induction of inflammasome signaling that impacts IL-1β/IL-18 maturation and cell death. A previous report indicated inflammasomes aggravate acute radiation syndrome. In contrast, here we find that inflammasome components do not exacerbate gamma-radiation-induced injury by examining heterozygous and gene-deletion littermate controls in addition to wild-type mice. Absence of some inflammasome genes, such as caspase-1/11 and Nlrp3, enhance susceptibility of treated mice to acute radiation injury, indicating importance of the inflammasome pathway in radioprotection. Surprisingly, we discover that the survival outcome may be sex-dependent as more inflammasome-deficient male mice are susceptible to radiation-induced injury. We discuss parameters that may influence the role of inflammasomes as radioprotective or radioexacerbating factors in recovery from radiation injury including the use of littermate controls, the sex of the animals, differences in microbiota within the colonies and other experimental conditions. Under the conditions tested, inflammasome components do not exacerbate radiation injury, but rather provide protective benefit.

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Early Biomarkers Associated with P53 Signaling for Acute Radiation Injury

Life ◽

10.3390/life12010099 ◽

2022 ◽

Vol 12 (1) ◽

pp. 99

Author(s):

Weihong Li ◽

Shixiang Zhou ◽

Meng Jia ◽

Xiaoxin Li ◽

Lin Li ◽

...

Keyword(s):

Ionizing Radiation ◽

Candidate Genes ◽

Radiation Injury ◽

Acute Radiation ◽

Dose Assessment ◽

Healthy Population ◽

P53 Signaling ◽

Acute Radiation Injury ◽

Effective Combination ◽

Accurate Dose

Accurate dose assessment within 1 day or even 12 h after exposure through current methods of dose estimation remains a challenge, in response to a large number of casualties caused by nuclear or radiation accidents. P53 signaling pathway plays an important role in DNA damage repair and cell apoptosis induced by ionizing radiation. The changes of radiation-induced P53 related genes in the early stage of ionizing radiation should compensate for the deficiency of lymphocyte decline and γ-H2AX analysis as novel biomarkers of radiation damage. Bioinformatic analysis was performed on previous data to find candidate genes from human peripheral blood irradiated in vitro. The expression levels of candidate genes were detected by RT-PCR. The expressions of screened DDB2, AEN, TRIAP1, and TRAF4 were stable in healthy population, but significantly up-regulated by radiation, with time specificity and dose dependence in 2–24 h after irradiation. They are early indicators for medical treatment in acute radiation injury. Their effective combination could achieve a more accurate dose assessment for large-scale wounded patients within 24 h post exposure. The effective combination of p53-related genes DDB2, AEN, TRIAP1, and TRAF4 is a novel biodosimetry for a large number of people exposed to acute nuclear accidents.

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