scholarly journals Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland

2021 ◽  
Vol 11 (9) ◽  
pp. 43-48
Author(s):  
Konrad Kania ◽  
Maria Kalicka ◽  
Tomasz Korzec ◽  
Przemyslaw Raczkiewicz ◽  
Monika Kuc
Keyword(s):  
Clinical Course ◽  
Skin Lesions ◽  
Cowpox Virus ◽  
Cat Scratch Disease ◽  
Domestic Cats ◽  
Wild Rodents ◽  
Skin Changes ◽  
Natural Reservoir ◽  
Microbiological Examination ◽  
Facial Area

Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir. Infections in humans are commonly reported from contact with sick domestic cats, rarely directly from rats. Cow pox in humans is a rare zoonotic disease, the diagnosis of which is problematic due to its rarity and thus the lack of clinical experience.Case report:Presented with a summary of the available clinical data on a 15-year-old boy who became infected with cowpox by a domestic cat.The patient developed cutaneous macular changes in the facial area. Within 3 weeks of the onset of symptoms, the lesions progressed through the papular, vesicular and pustular stages before forming a hard black eschars (2 cm in diameter) with erythema and edema and regional lifadenopathy. Differential diagnosis consisting of cat scratch disease, anthrax and brucellosis excluded microbiological examination. The lesions left scars after 8 weeks of continuous topical antiseptic treatment.Conclusions:The clinical course may be complicated, and the improvement takes 4 to 8 weeks. Infection which entered through the skin changes was the cause of antibiotic therapy. Cowpox should be suspected in patients with poorly healing skin lesions accompanied by a painful black eschars with erythema and local lymphadenopathy.

scholarly journals Cowpox: reservoir hosts and geographic range

1999 ◽  
Vol 122 (3) ◽  
pp. 455-460 ◽  
Author(s):  
J. CHANTREY ◽  
H. MEYER ◽  
D. BAXBY ◽  
M. BEGON ◽  
K. J. BOWN ◽  
...  
Keyword(s):  
Great Britain ◽  
Direct Evidence ◽  
Geographic Range ◽  
Cowpox Virus ◽  
Domestic Cats ◽  
Wild Rodents ◽  
Seasonal Incidence ◽  
Wood Mice ◽  
Bank Voles ◽  
Reservoir Hosts

It is generally accepted that the reservoir hosts of cowpox virus are wild rodents, although direct evidence for this is lacking for much of the virus's geographic range. Here, through a combination of serology and PCR, we demonstrate conclusively that the main hosts in Great Britain are bank voles, wood mice and short-tailed field voles. However, we also suggest that wood mice may not be able to maintain infection alone, explaining the absence of cowpox from Ireland where voles are generally not found. Infection in wild rodents varies seasonally, and this variation probably underlies the marked seasonal incidence of infection in accidental hosts such as humans and domestic cats.

scholarly journals HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE

1963 ◽  
Vol 118 (4) ◽  
pp. 635-648 ◽  
Author(s):  
Peter Stastny ◽  
Vernie A. Stembridge ◽  
Morris Ziff
Keyword(s):  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Skin Lesions ◽  
Cutaneous Lesions ◽  
Adult Rats ◽  
Hydropic Degeneration ◽  
Skin Changes ◽  
Adult Rat ◽  
The One

The cutaneous lesions of adult rats with homologous disease are described, and evidence is presented to indicate that they have an immunologic basis. The skin changes included erythema, purpura, edema, and a variety of inflammatory lesions. In the more active lesions, dermal infiltration, hydropic degeneration, acanthosis, and atrophy of the epidermis with hyperkeratosis and follicular plugging were present. In some cases, ulceration and sloughing were also observed. More chronic lesions were characterized by atrophy of the epidermis and collagenization of the dermis with disappearance of the skin appendages. Rejection of autografts was observed simultaneously with acceptance of homografts. The histologic appearance of autografts undergoing rejection was similar to that of the spontaneous skin lesions, suggesting that the latter, too, had an immunologic basis. In favor of this, also, was the specificity of the dermatitis for the skin of the host, with sparing of neighboring homograft tissue. There was a histologic similarity between the spontaneous skin lesions of homologous disease and those of lupus erythematosus on the one hand, and scleroderma on the other, thus supporting the possibility that the cutaneous lesions of these connective tissue diseases of man may also have an immunologic basis. It was concluded that the adult rat with homologous disease may furnish a model for human autoimmune disease.

scholarly journals Effect of Genetic and Laboratory Findings on Clinical Course of Antisynthetase Syndrome in a Hungarian Cohort

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Katalin Szabó ◽  
Levente Bodoki ◽  
Melinda Nagy-Vincze ◽  
Anett Vincze ◽  
Erika Zilahi ◽  
...  
Keyword(s):  
Prognostic Markers ◽  
Clinical Course ◽  
Disease Onset ◽  
Skin Lesions ◽  
Clinical Database ◽  
Laboratory Findings ◽  
Disease Phenotypes ◽  
Genetic Features ◽  
Hla Dqa1

The aim of this study was to determine the clinical, serological, and genetic features of anti-Jo-1 positive antisynthetase patients followed by a Hungarian single centre to identify prognostic markers, which can predict disease phenotypes and disease progression. It was a retrospective study using clinical database of 49 anti-Jo-1 positive patients. 100% of patients exhibited myositis, 73% interstitial lung disease, 88% arthritis, 65% Raynaud’s phenomenon, 43% fever, 33% mechanic’s hand, and 12% dysphagia. We could detect significant correlation between anti-Jo-1 titer and the CK and CRP levels at disease onset and during disease course. HLA DRB1⁎03 positivity was present in 68.96% of patients, where the CK level at diagnosis was significantly lower compared to the HLA DRB1⁎03 negative patients. HLA DQA1⁎0501-DQB1⁎0201 haplotype was found in 58.62% of patients, but no significant correlation was found regarding any clinical or laboratory features. Higher CRP, ESR level, RF positivity, and the presence of fever or vasculitic skin lesions at the time of diagnosis indicated a higher steroid demand and the administration of higher number of immunosuppressants during the follow-up within anti-Jo-1 positive patients. The organ involvement of the disease was not different in HLA-DRB1⁎0301 positive or negative patients who were positive to the anti-Jo-1 antibody; however, initial CK level was lower in HLA-DRB1⁎0301 positive patients. Distinct laboratory and clinical parameters at diagnosis could be considered as prognostic markers.

scholarly journals Handling of Scabies in Domestic Cat at Q-one Petklinik Surabaya

2021 ◽  
Vol 2 (2) ◽  
pp. 50
Author(s):  
Bagus Uda Palgunadi ◽  
Katarina Kole Grace Wangge ◽  
Lailia Dwi Kusuma Wardhani
Keyword(s):  
Physical Condition ◽  
Microscopic Examination ◽  
Direct Contact ◽  
Supportive Therapy ◽  
Sarcoptes Scabiei ◽  
The Body ◽  
Domestic Cat ◽  
Domestic Cats ◽  
Scabies Mite ◽  
Facial Area

Background: Scabies is a skin disease caused by Sarcoptes scabiei. Scabies is transmitted through direct contact with animals affected by scabies or contact with the source of scabies mite in area of cat lives. Purpose: This study aims to determine the management of scabies at Q-One PetKlinik Surabaya. Method: Handling domestic cats affected by S.scabiei began with an interview with the  owner and examinated with the physical condition of cats, and observed the body that was infected with S.scabiei. Scrabbing on scabs was conducted in the cat’s body which was located in the facial area, and followed by microscopic examination to observe the S.scabiei mite. Results: During April 2021, there were 13 domestic cats affected by scabies. Treatment for scabies was by administrated drugs containing 5% Permethrin. Cats were also given supportive therapy by grooming with antiectoparasite shampoo after two weeks from being given drugs. Conclusion: Handling cases of scabies in domestic cats at Q-One PetKlinik Surabaya is performed by cleaning the scab, applying an ointment containing 5% permethrin, and giving anti-histamine and anti-parasitic as well as providing supportive therapy in the form of grooming using shampoo containing anti-ectoparasites.

Medyczne i humanistyczne zagadnienia związane z psychodermatologią w praktyce lekarza rodzinnego, ginekologa i seksuologa

2020 ◽  
Vol 23 (3) ◽  
Author(s):  
Grażyna Jarząbek-Bielecka ◽  
Katarzyna Plagens-Rotman ◽  
Małgorzata Mizgier ◽  
Piotr Merks ◽  
Magdalena Czarnecka-Operacz ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Family Doctor ◽  
Holistic Approach ◽  
Self Esteem ◽  
Skin Lesions ◽  
The Body ◽  
Skin Changes ◽  
Developmental Age ◽  
Pain And Suffering ◽  
Similar Search

A family doctor, as well as a sexologist, gynecologist, in his medical practice encounters problems related to skin diseases significantly affecting the sense of femininity or masculinity. An example of such an issue, especially in gynecology of developmental age, is the problem of skin changes associated with androgenization syndromes. Typical dermatological diseases are sometimes associated with enormous pain, not only physical, but also mental, resulting from the fact that skin disease processes significantly disfigure the body, lower self-esteem and significantly affect the sexual sphere. Selected aspects related to the holistic approach to the issue of pain and suffering, also related to skin lesions, are presented. This issue, like all medical fields, is a source of philosophical reflection. It is inseparable from psychodermatology. The experience of the SARS-CoV-2 coronavirus pandemic, taking into account skin lesions, also prompts a similar search.

Skin Signs

2015 ◽  
Author(s):  
Aziz Shaibani
Keyword(s):  
Inflammatory Diseases ◽  
Neuromuscular Diseases ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Congenital Disorders ◽  
Amyopathic Dermatomyositis ◽  
Dark Skin ◽  
Skin Changes ◽  
Neurocutaneous Syndromes ◽  
Skin Signs

Many neuromuscular diseases are expressed by skin manifestations such as dermatomyositis. Skin changes of dermatomyositis are of many types and can be subtle in dark skin. Skin rash may be the only finding in dermatomyositis (amyopathic dermatomyositis). Many systemic inflammatory diseases are associated with skin lesions and neuromuscular involvement such as vasculitis, SLE, and scleroderma. Steroids may lead to acne-like skin lesions that should be differentiated from the rash of the underlying disease. Since the skin and nervous system are both ectodermal in origin, many hereditary and congenital disorders affect both (neurocutaneous syndromes). This chapter provides examples of skin signs that are associated with neuromuscular diseases.

scholarly journals Variations of Dermatological Findings in New-Borns of a Community Hospital in Nepal

2018 ◽  
Vol 37 (3) ◽  
pp. 261-266
Author(s):  
Asim Shrestha ◽  
Smriti Shrestha
Keyword(s):  
Community Hospital ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Term Pregnancy ◽  
Cross Sectional ◽  
Skin Changes ◽  
Caesarean Section Delivery ◽  
Mongolian Spot

Introduction: Skin manifestations are common in neonates. The prevalence of skin changes and their association with neonatal and maternal factors are not adequately documented in Nepal. It is important to differentiate common benign skin lesions from infrequent skin changes that cause morbidity, requiring medical management. The objectives of this study were to determine the pattern of skin lesions in new-borns and their association with maternal and neonatal variables.Material and Methods: This was a prospective, cross-sectional study conducted in obstetric unit of the hospital from December 2016 to May 2017. Outborn babies and babies shifted to NICU were excluded.Results: A total of 935 new-borns were examined. The commonest skin lesions were Mongolian spot (66.7%), Erythema toxicum (46.6%), Milia (44.4%), Epstein pearls (26.4%) and Salmon patch (11.9%). Mothers aged 35 years or older (63.6%) had statistically significant association with Erythema toxicum (p=0.01). Erythema toxicum was more in primiparity, term pregnancy and caesarean section delivery. Milia was associated with male babies. Salmon patch was seen more in term pregnancy. Congenital melanocytic nevus, haemangioma and port-wine stain were noted in three, two and one new-borns respectively, which alter morbidity and hence are important to diagnose in time.Conclusion: We found that 93.8% of neonates had at one or more skin lesions. The majority of skin lesions were benign and transient. Erythema toxicum was seen commonly in mothers aged 35 and more. Salmon patch was seen more in term pregnancy.  

scholarly journals Metastatic plasma cell leukemia to the skin: a case report with review of the literature

2021 ◽  
Author(s):  
Elena Pezzolo ◽  
Deborah Saraggi ◽  
Luigi Naldi
Keyword(s):  
Plasma Cell ◽  
Plasma Cells ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Skin Lesions ◽  
Plasma Cell Leukemia ◽  
Cell Leukemia ◽  
Leukemia Cutis ◽  
Aggressive Clinical Course ◽  
New Skin

Plasma cell leukemia (PCL) is a rare variant of leukemia with an aggressive clinical course and a poor prognosis. The cutaneous involvement in PCL is very rare either at clinical presentation of leukemia, namely “leukemia cutis”, or in the metastatic PCL to the skin. We present a case of eruptive multiple cutaneous nodules in a 56-year-old man with metastatic PCL. Histologically, a diffuse dermal and subcutaneous infiltration of ovoid cells with amphophilic cytoplasm and eccentrically located nucleus consistent with plasmacytoid morphology was observed. Neoplastic cells showed strong immunoexpression for CD138 and CD38 consistent with plasma cells phenotype, and loss of expression of CD56. Kappa light chain restriction similar to the phenotype of his PCL was demonstrated. We suggest that the evaluation of new skin lesions in leukemic patients should include a histopathologic examination to establish the diagnosis as soon as possible and a correct management of the disease.

scholarly journals Relationship between xerosis and pruritus in patients with chronic kidney disease

2017 ◽  
Vol 71 (0) ◽  
pp. 0-0
Author(s):  
Katarzyna Kiliś-Pstrusińska ◽  
Elżbieta Wojtowicz-Prus ◽  
Jacek Szepietowski
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Treatment Options ◽  
Skin Lesions ◽  
Chronic Kidney Diseases ◽  
Skin Changes ◽  
Uremic Pruritus ◽  
Common Skin

Xerosis and pruritus are the most common skin disorders in patients with chronic kidney diseases (CKD). The prevalence and intensity of those skin changes are higher in patients undergoing dialysis, independent of its type, compared to patients treated conservatively. However, they can occur even in the early stages of CKD and be very bothersome for the sufferers. The problem of dry skin in CKD patients, its characteristics, reasons and relationship between xerosis and pruritus have been described. The current views on the pathogenesis of chronic kidney disease-associated pruritus (CKD-P), formerly known as uremic pruritus, have been discussed. This article summarizes the available treatment options for CKD-P, including both topical and systemic therapies. The authors direct attention to the need for skin lesions treatment in order to prevent their progression and to improve the quality of patients’ life.

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