scholarly journals Agreement between heart rate at first ventilatory threshold on treadmill and at 6-min walk test in coronary artery disease patients on β-blockers treatment

2021 ◽  
Vol 17 (5) ◽  
pp. 362-368
Author(s):  
Leonardo Calegari ◽  
Igor Moreira ◽  
Andrei Falkowski ◽  
José Basileu Caon Reolão ◽  
Marlus Karsten ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Ventilatory Threshold ◽  
Walk Test ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Β Blockers ◽  
Artery Disease ◽  
Stable Cad ◽  
Acceptable Agreement

The purpose of this study was to verify the accuracy of the agreement between heart rate at the first ventilatory threshold (HRVT1) and heart rate at the end of the 6-min walk test (HR6MWT) in coronary artery disease (CAD) patients on β-blockers treatment. This was a cross-sectional study with stable CAD patients, which performed a cardiopulmonary exercise test (CPET) on a treadmill and a 6-min walk test (6MWT) on nonconsecutive days. The accuracy of agreement between HRVT1 and HR6MWT was evaluated by Bland–Altman analysis and Lin’s concordance correlation coefficient (rc), mean absolute percentage error (MAPE), and standard error of estimate (SEE). Seventeen stable CAD patients on β-blockers treatment (male, 64.7%; age, 61± 10 years) were included in data analysis. The Bland–Altman analysis revealed a negative bias of -0.41 ± 6.4 bpm (95% limits of agreements, -13 to 12.2 bpm) between HRVT1 and HR6MWT. There was acceptable agreement between HRVT1 and HR6MWT (rc = 0.84; 95% confidence interval, 0.63 to 0.93; study power analysis= 0.79). The MAPE of the HR6MWT was 5.1% and SEE was 6.6 bpm. The ratio HRVT1/HRpeak and HR6MWT/HRpeak from CPET were not significantly different (81%± 5% vs. 81%± 6%, P= 0.85); respectively. There was a high correlation between HRVT1 and HR6MWT (r= 0.85, P< 0.0001). Finally, the results of the present study demonstrate that there was an acceptable agreement between HRVT1 and HR6MWT in CAD patients on β-blockers treatment and suggest that HR6MWT may be useful to prescribe and control aerobic exercise intensity in cardiac rehabilitation programs.

scholarly journals Heart rate deflection point as a non-invasive method to determine the anaerobic threshold in trained elderly women in the aquatic environment

2020 ◽  
Vol 19 (6) ◽  
pp. 468
Author(s):  
Luana Siqueira Andrade ◽  
Mariana Silva Häfele ◽  
Gustavo Zaccaria Schaun ◽  
Samara Nickel Rodrigues ◽  
Mariana Borba Gomes ◽  
...  
Keyword(s):  
Heart Rate ◽  
Anaerobic Threshold ◽  
Perceived Exertion ◽  
Elderly Women ◽  
Ventilatory Threshold ◽  
Altman Analysis ◽  
Incremental Test ◽  
Bland Altman Analysis ◽  
Water Based ◽  
Invasive Method

Introduction: The anaerobic threshold (AT) determination is important for individualizing the aerobic training prescription. Objective: To compare and verify the agreement between oxygen uptake (VO2), heart rate (HR), and rate of perceived exertion (RPE) at the AT determined by the ventilatory threshold (VT) and heart rate deflection point (HRDP) methods during an aquatic incremental test in trained older women. Methods: Nine elderly women (64.3 ± 4.4 years) engaged in a water-based training program in the last three months performed a maximum incremental test using the water-based stationary running exercise. The test started at a 70 bpm cadence for 2 min, followed by 15 bpm increments every 2 min until exhaustion. VO2, HR and RPE were measured throughout the test and the AT was identified for each method (i.e., VT and HRDP) by three experienced physiologists. Paired t-test and Bland-Altman analysis were used for data analysis (α=0.05). Results: There was no difference between the VT and HRDP methods (p>0.05) and the Bland-Altman analysis showed acceptable agreement between them for all investigated outcomes (VO2: 22.9 ± 5.1 vs. 23.5 ± 4.7 ml.kg-1.min-1, IC95%: -3-+4 ml.kg-1.min-1; HR: 147 ± 11 vs. 147 ± 11 bpm, IC95%: -9-+8 bpm; RPE: 16 ± 1 vs. 16 ± 1, IC95%: -2-+3). Conclusion: Based on these findings, both HR and RPE determined by the HRDP can be used as valid parameters and practical tools for field prescription of intensity during water-based exercises in elderly trained women.Keywords: exercise, aging, exercise test, hydrotherapy, oxygen consumption. 

scholarly journals Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia

2011 ◽  
Vol 65 (3-4) ◽  
pp. 94-101
Author(s):  
Inga Balode ◽  
Sanda Jēgere ◽  
Iveta Mintāle ◽  
Inga Narbute ◽  
Gustavs Latkovskis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Angiotensin Receptor Blockers ◽  
Stable Coronary Artery Disease ◽  
Pulse Palpation ◽  
Co Morbidity ◽  
Β Blockers ◽  
Artery Disease

Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia The aim of the study was to characterise coronary artery disease (CAD) outpatients in Latvia by risk factors (RF) including heart rate (HR), physical examination data, clinical data and treatment. Twelve practitioners had each examined and questioned 6 to 12 patients with established CAD (n = 120). The most frequent cardiovascular (CV) RF and co-morbidity were dyslipidemia (94.2%) and hypertension (78.3%), respectively. Prevalence of increased resting HR (≥70 bpm) was 35.9% and 33.6%, when measured by pulse palpation and electrocardiography, respectively. Regarding other RFs, prevalence of treated but insufficiently controlled blood pressure 140/90 mmHg, total cholesterol 1 > 5 mmol/l and triglycerides > 1.7 mmol/l was 25.8%, 30.1% and 33.3%, respectively. Aspirin, statins and angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers were used in 96.7%, 94.2% and 85.0% of cases, respectively. Beta blockers were used in 81.7% of cases. Average daily doses of most frequently used β blockers (metoprolol and bisoprolol) were 32% and 53% from target doses, respectively. In three cases β blockers were combined with ivabradin. Our results suggest that practitioners follow guidelines and consider CV prevention by treating CAD patients. Our data identified, however, unused potential for better control of increased HR by higher doses and combinations of HR-reducing agents.

scholarly journals Differential Effect of β-Blockers for Heart Rate Control in Coronary Artery Disease

2011 ◽  
Vol 34 (12) ◽  
pp. 748-754 ◽  
Author(s):  
Alberto Cordero ◽  
Vicente Bertomeu-González ◽  
Pilar Mazón ◽  
José Moreno-Arribas ◽  
Lorenzo Fácila ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Rate Control ◽  
Differential Effect ◽  
Heart Rate Control ◽  
Β Blockers ◽  
Artery Disease

scholarly journals Β-blockers: the lack of taskimplementation or the unwillingness of doctors in the russian federation to optimize the treatment?

2014 ◽  
Vol 11 (1) ◽  
pp. 56-63
Author(s):  
I V Fomin ◽  
D S Polyakov
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Russian Federation ◽  
Representative Sample ◽  
Clinical Manifestations ◽  
The Russian Federation ◽  
Β Blockers ◽  
Artery Disease ◽  
Almost All

The purpose of the study. The achievedheart rate of 50-60 beats per minute in patients after acute myocardial infarction, and up to50-70 beats per minute for patients with stable angina is considered effective. Assuming that in Russia low doses of β-blockers are often used, thequestion was raised: «How common tachycardia can bein patients with coronary heart disease (CHD) and chronic heart failure (CHF), and whether there are strategic approaches to achieving the targets in heart rate in these patients in real clinical practice and are β-blockers often used in patients for whom this group of drugs is the basic one?»Materials and Methods. Work carried out in the framework of the Russian epidemiological study of a representative sample of the European partof the Russian Federation. All patients with CHF and coronary artery disease were divided into two subgroups: heart rate reducers not receiving medicines and receiving at least one heart rate reducing drug (a β-blocker, calcium channel 1 and 3rd type (AK) blockers, glycosides).Results and discussion. In a representative sample of the program in healthy individuals (without clinical manifestations of coronary arterydisease) tachycardia was diagnosed in 7,1% of cases. Almost all respondents without CHD (87,3%) had normal heart rate from 61 to 80 beats per minute. Number of respondents without CHD with heart rate of 70 to 79 bpm. per min. (54,1%) turned out to be significantly less than that of patients with rhythm in any form of coronary artery disease (p

scholarly journals Quantitative myocardial perfusion response to adenosine and regadenoson in patients with suspected coronary artery disease

2021 ◽  
Author(s):  
Tanja Kero ◽  
Antti Saraste ◽  
Bo Lagerqvist ◽  
Jens Sörensen ◽  
Essi Pikkarainen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Suspected Coronary Artery Disease ◽  
Altman Analysis ◽  
Limits Of Agreement ◽  
Bland Altman Analysis ◽  
Quantitative Myocardial Perfusion ◽  
Artery Disease ◽  
Pet Scans ◽  
Global Mean

Abstract Background The aim of the present study was to compare the quantitative flow responses of regadenoson against adenosine using cardiac 15O-water PET imaging in patients with suspected or known coronary artery disease (CAD). Methods Hyperemic myocardial blood flow (MBF) after adenosine and regadenoson was compared using correlation and Bland–Altman analysis in 21 patients who underwent rest and adenosine 15O-water PET scans followed by rest and regadenoson 15O-water PET scans. Results Global mean (± SD) MBF values at rest and stress were 0.92 ± 0.27 and 2.68 ± 0.80 mL·g·min for the adenosine study and 0.95 ± 0.29 and 2.76 ± 0.79 mL·g·min for the regadenoson study (P = 0.55 and P = 0.49). The correlations between global and regional adenosine- and regadenoson-based stress MBF were strong (r = 0.80 and r = 0.77). The biases were small for both global and regional MBF comparisons (0.08 and 0.09 mL·min·g), but the limits of agreement were wide for stress MBF. Conclusion The correlation between regadenoson- and adenosine-induced hyperemic MBF was strong but the agreement was only moderate indicating that established cut-off values for 150-water PET should be used cautiously if using regadenoson as vasodilator.

scholarly journals Heart rate and use of β-blockers in Mexican stable outpatients with coronary artery disease

2015 ◽  
Vol 85 (4) ◽  
pp. 270-277
Author(s):  
Marco Antonio Alcocer-Gamba ◽  
Carlos Martínez-Sánchez ◽  
Juan Verdejo-Paris ◽  
Roberto Ferrari ◽  
Kim Fox ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Β Blockers ◽  
Artery Disease

Osteoprotegerin and Osteopontin Serum Levels are Associated with Vascular Function and Inflammation in Coronary Artery Disease Patients

2020 ◽  
Vol 18 (5) ◽  
pp. 523-530 ◽  
Author(s):  
Konstantinos Maniatis ◽  
Gerasimos Siasos ◽  
Evangelos Oikonomou ◽  
Manolis Vavuranakis ◽  
Marina Zaromytidou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Vascular Function ◽  
Serum Levels ◽  
Atherosclerosis Progression ◽  
Control Subjects ◽  
Significant Difference ◽  
Artery Disease ◽  
Stable Cad

Background: Osteoprotegerin and osteopontin have recently emerged as key factors in both vascular remodelling and atherosclerosis progression. Interleukin-6 (IL-6) is an inflammatory cytokine with a key role in atherosclerosis. The relationship of osteoprotegerin, osteopontin, and IL-6 serum levels with endothelial function and arterial stiffness was evaluated in patients with coronary artery disease (CAD). Methods: We enrolled 219 patients with stable CAD and 112 control subjects. Osteoprotegerin, osteopontin and IL-6 serum levels were measured using an ELISA assay. Endothelial function was evaluated by flow-mediated dilation (FMD) in the brachial artery and carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness. Results: There was no significant difference between control subjects and CAD patients according to age and sex. Compared with control subjects, CAD patients had significantly impaired FMD (p<0.001) and increased PWV (p=0.009). CAD patients also had significantly higher levels of osteoprotegerin (p<0.001), osteopontin (p<0.001) and IL-6 (p=0.03), compared with control subjects. Moreover, IL-6 levels were correlated with osteoprotegerin (r=0.17, p=0.01) and osteopontin (r=0.30, p<0.001) levels. FMD was correlated with osteoprotegerin levels independent of possible confounders [b coefficient= - 0.79, 95% CI (-1.54, -0.05), p=0.04]. Conclusion: CAD patients have increased osteoprotegerin, osteopontin and IL-6 levels. Moreover, there is a consistent association between osteoprotegerin and osteopontin serum levels, vascular function and inflammation in CAD patients. These findings suggest another possible mechanism linking osteoprotegerin and osteopontin serum levels with CAD progression through arterial wall stiffening and inflammation.

Sign in / Sign up

Export Citation Format

Share Document