Understanding and managing pain in the arthritic synovial joint: an update

2022 ◽  
Vol 27 (1) ◽  
pp. 1-5
Author(s):  
John Innes

Osteoarthritis is a very common cause of chronic pain in dogs and cats. Great progress has been made in the last 2–3 decades in unravelling the molecular mediators of joint pain. Now we are starting to see the benefits of this research in terms of new targets to block joint pain and new medicines reaching our pharmacy shelves. This review summarises the progress that has been made in understanding why and how arthritic joints cause pain. This will help readers understand novel medicines and provide insight into the others that might follow in the future.

1935 ◽  
Vol 39 (291) ◽  
pp. 191-212 ◽  
Author(s):  
Louis Breguet

It is a great honour for me to address the members of the oldest learned society devoted to aeronautics, the Royal Aeronautical Society, which was founded in 1866—six years before the Société Francaise de Navigation Aérienne of France was founded for the same purpose.The choice of a subject nowadays is a difficult matter; great progress has been made in aeronautical science—numerous research workers all over the world are endeavouring to solve the outstanding problems—and the reason I decided to take for my lecture the subject of the maximum speeds of commercial aeroplanes was that it appears to me to be a matter of the utmost importance for the future of commercial aeronautics and for linking up the different peoples of the globe.


2010 ◽  
Vol 19 (12) ◽  
pp. 2314-2325
Author(s):  
Ken'ichi Imai

A great progress has been made in strangeness nuclear physics in the past decade. Examples are; 1) The "hyperfine" structure of hypernuclei were measured with the Hyperball, and ΛN spin dependent interactions in p -shell hypernuclei were determined. 2) The "complete measurements" of the weak decay of hypernuclei were made and the np ratio puzzle in the non-mesonic decay was solved. 3) The discovery of a clean event of "Lambpha" and determination of its binding energy concluded that the Λ-Λ interaction is weak attractive. However, we still have important questions to be answered in this field, especially in relation with QCD and nuclear physics. For the future strangeness nuclear physics, we have and will have facilities such as JLab, SPring-8, Daphne, J-PARC, FAIR. We discuss experimental challenges in the strangeness nuclear physics and related fields in the next decade.


2020 ◽  
Vol 5 (1) ◽  
pp. 13
Author(s):  
Arman Syah Putra

The problem raised in this research is the implementation of ERP (Electronic Road Price) which will be applied in several street corners of the capital of Jakarta, many pros and cons that will occur in its application, ranging from its licensing to its application in the field, socialization to users the road in the capital is very important to do because it will directly intersect with motorized motorists in the capital of Jakarta, in its application also must be considered using what tools are best placed in every corner of the capital to help smooth the system to be applied, in this research the author will provide suggestions and frameworks so that the implementation of the ERP system (Electronic Road Price) can be carried out right away, with the suggestions that have been made are expected to influence the policies that will be made in terms of ERP (Electronic Road Price) in the future.


CounterText ◽  
2016 ◽  
Vol 2 (2) ◽  
pp. 217-235
Author(s):  
Gordon Calleja

This paper gives an insight into the design process of a game adaptation of Joy Division's Love Will Tear Us Apart (1980). It outlines the challenges faced in attempting to reconcile the diverging qualities of lyrical poetry and digital games. In so doing, the paper examines the design decisions made in every segment of the game with a particular focus on the tension between the core concerns of the lyrical work being adapted and established tenets of game design.


Author(s):  
Zoran Vrucinic

The future of medicine belongs to immunology and alergology. I tried to not be too wide in description, but on the other hand to mention the most important concepts of alergology to make access to these diseases more understandable, logical and more useful for our patients, that without complex pathophysiology and mechanism of immune reaction,we gain some basic insight into immunological principles. The name allergy to medicine was introduced by Pirquet in 1906, and is of Greek origin (allos-other + ergon-act; different reaction), essentially representing the reaction of an organism to a substance that has already been in contact with it, and manifested as a specific response thatmanifests as either a heightened reaction, a hypersensitivity, or as a reduced reaction immunity. Synonyms for hypersensitivity are: altered reactivity, reaction, hypersensitivity. The word sensitization comes from the Latin (sensibilitas, atis, f.), which means sensibility,sensitivity, and has retained that meaning in medical vocabulary, while in immunology and allergology this term implies the creation of hypersensitivity to an antigen. Antigen comes from the Greek words, anti-anti + genos-genus, the opposite, anti-substance substance that causes the body to produce antibodies.


Author(s):  
Thomas N. Sherratt ◽  
David M. Wilkinson

Why do we age? Why cooperate? Why do so many species engage in sex? Why do the tropics have so many species? When did humans start to affect world climate? This book provides an introduction to a range of fundamental questions that have taxed evolutionary biologists and ecologists for decades. Some of the phenomena discussed are, on first reflection, simply puzzling to understand from an evolutionary perspective, whilst others have direct implications for the future of the planet. All of the questions posed have at least a partial solution, all have seen exciting breakthroughs in recent years, yet many of the explanations continue to be hotly debated. Big Questions in Ecology and Evolution is a curiosity-driven book, written in an accessible way so as to appeal to a broad audience. It is very deliberately not a formal text book, but something designed to transmit the excitement and breadth of the field by discussing a number of major questions in ecology and evolution and how they have been answered. This is a book aimed at informing and inspiring anybody with an interest in ecology and evolution. It reveals to the reader the immense scope of the field, its fundamental importance, and the exciting breakthroughs that have been made in recent years.


2019 ◽  
Vol 20 (10) ◽  
pp. 1141-1154 ◽  
Author(s):  
Melanie Beeckman ◽  
Sean Hughes ◽  
Ama Kissi ◽  
Laura E. Simons ◽  
Liesbet Goubert

2020 ◽  
pp. bmjmilitary-2020-001455 ◽  
Author(s):  
Jonathan Blair Thomas Herron ◽  
K M Heil ◽  
D Reid

In 2015, the UK government published the National Strategic Defence and Security Review (SDSR) 2015, which laid out their vision for the future roles and structure of the UK Armed Forces. SDSR 2015 envisaged making broader use of the Armed Forces to support missions other than warfighting. One element of this would be to increase the scale and scope of defence engagement (DE) activities that the UK conducts overseas. DE activities traditionally involve the use of personnel and assets to help prevent conflict, build stability and gain influence with partner nations as part of a short-term training teams. This paper aimed to give an overview of the Specialist Infantry Group and its role in UK DE. It will explore the reasons why the SDSR 2015 recommended their formation as well as an insight into future tasks.


Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2978
Author(s):  
Chia-Jung Li ◽  
Yen-Dun Tony Tzeng ◽  
Yi-Han Chiu ◽  
Hung-Yu Lin ◽  
Ming-Feng Hou ◽  
...  

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.


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