Rate of Venous Thromboembolism in Patients With Metastatic Bone Disease Requiring Orthopaedic Surgery: A Systematic Review

OrthoMedia ◽  
2022 ◽  
2021 ◽  
pp. 839-848
Author(s):  
Mohamed Yakoub ◽  
John Healey

Metastatic spread of cancer to bone is frequent and causes pain, disability, and functional limitation. Non-surgical treatments such as chemotherapy and hormone therapy are effective in early disease. Administration of bisphosphonates or osteoprotegerin inhibitors prevent new ‘bone events’, thereby avoiding pain, radiation, and surgery. Radiotherapy arrests disease and relieves pain in many cases. Surgery is needed when the bone is weak or fractured. It effectively relieves pain and preserves function by bypassing the deficient bone with site-specific reconstructive surgery. Surgery should be selected based on projections of patient survival. New tools to make these projections are now available (https://www.pathfx.org/). New targeted drug therapies appear to be changing metastatic bone disease into a more chronic condition. This will alter the management of local disease in many histological subtypes of metastatic cancers.


2011 ◽  
Vol 98 (10) ◽  
pp. 1356-1364 ◽  
Author(s):  
B. Kanchanabat ◽  
W. Stapanavatr ◽  
S. Meknavin ◽  
C. Soorapanth ◽  
C. Sumanasrethakul ◽  
...  

2021 ◽  
Vol 64 (6) ◽  
pp. E550-E560
Author(s):  
Annalise Abbott ◽  
Joseph K. Kendal ◽  
Christopher Hewison ◽  
Shannon Puloski ◽  
Michael Monument

2019 ◽  
Vol 48 (8) ◽  
pp. 1161-1169 ◽  
Author(s):  
Nicolò Gennaro ◽  
Luca Maria Sconfienza ◽  
Federico Ambrogi ◽  
Sara Boveri ◽  
Ezio Lanza

2012 ◽  
Vol 20 (11) ◽  
pp. 2985-2998 ◽  
Author(s):  
Maria A. Lopez-Olivo ◽  
Nimit A. Shah ◽  
Greg Pratt ◽  
Jan M. Risser ◽  
Elaine Symanski ◽  
...  

1996 ◽  
Vol 76 (06) ◽  
pp. 0887-0892 ◽  
Author(s):  
Serena Ricotta ◽  
Alfonso lorio ◽  
Pasquale Parise ◽  
Giuseppe G Nenci ◽  
Giancarlo Agnelli

SummaryA high incidence of post-discharge venous thromboembolism in orthopaedic surgery patients has been recently reported drawing further attention to the unresolved issue of the optimal duration of the pharmacological prophylaxis. We performed an overview analysis in order to evaluate the incidence of late occurring clinically overt venous thromboembolism in major orthopaedic surgery patients discharged from the hospital with a negative venography and without further pharmacological prophylaxis. We selected the studies published from January 1974 to December 1995 on the prophylaxis of venous thromboembolism after major orthopaedic surgery fulfilling the following criteria: 1) adoption of pharmacological prophylaxis, 2) performing of a bilateral venography before discharge, 3) interruption of pharmacological prophylaxis at discharge in patients with negative venography, and 4) post-discharge follow-up of the patients for at least four weeks. Out of 31 identified studies, 13 fulfilled the overview criteria. The total number of evaluated patients was 4120. An adequate venography was obtained in 3469 patients (84.1%). In the 2361 patients with negative venography (68.1%), 30 episodes of symptomatic venous thromboembolism after hospital discharge were reported with a resulting cumulative incidence of 1.27% (95% C.I. 0.82-1.72) and a weighted mean incidence of 1.52% (95% C.I. 1.05-1.95). Six cases of pulmonary embolism were reported. Our overview showed a low incidence of clinically overt venous thromboembolism at follow-up in major orthopaedic surgery patients discharged with negative venography. Extending pharmacological prophylaxis in these patients does not appear to be justified. Venous thrombi leading to hospital re-admission are likely to be present but asymptomatic at the time of discharge. Future research should be directed toward improving the accuracy of non invasive diagnostic methods in order to replace venography in the screening of asymptomatic post-operative deep vein thrombosis.


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