Custom 3D-Printed Hemipelvis Reconstruction After Internal Hemipelvectomy and Failed Revision Arthroplasty: Ilium Fixation Achieves Excellent Mid Term Survival

Aims Total hip arthroplasty (THA) patients undergoing or having a prior lumbar spine fusion (LSF) have an increased risk of mechanical complications. The aim of this registry-based, retrospective comparative cohort study is to assess the longer term survival of THA in patients who have undergone a LSF during a 17-year period (2000 to 2017). Methods A registry-based population study was conducted on 679 patients who underwent both THA and LSF surgeries. Patients were identified from the regional arthroplasty data base and cross linked to patients with LSF from the regional hospital discharge database between 2000 and 2017. Demographic data, diagnosis leading to primary THA, primary implant survival, perioperative complications, number and causes of failure, and patients requiring revision arthroplasty were collated and compared. For comparison, data from 67,919 primary THAs performed during the same time time period were also retrieved and analyzed. Results Patients undergoing THA and LSF showed homogeneous demographic data compared to those undergoing THA alone, but a significantly lower eight-year THA implant survival (96.7 vs 96.0, p = 0.024) was observed. Moreover, THA plus LSF patients showed increased incidence of mechanical complications in the first two years after THA surgery compared to THA alone patients. Conclusion This registry-based population study shows that approximately 679 (1%) THA patients were subjected to LSF. Patients undergoing THA and LSF have an increased risk of mechanical complications with their THA and a slightly increased risk of revision arthroplasty. Cite this article: Bone Joint J 2021;103-B(3):486–491.

Download Full-text

Long-Term Maintenance and Meiotic Entry of Early Germ Cells in Murine Testicular Organoids Functionalized by 3D Printed Scaffolds and Air-Medium Interface Cultivation

Frontiers in Physiology ◽

10.3389/fphys.2021.757565 ◽

2021 ◽

Vol 12 ◽

Author(s):

Guillaume Richer ◽

Robin M. Hobbs ◽

Katherine L. Loveland ◽

Ellen Goossens ◽

Yoni Baert

Keyword(s):

Germ Cells ◽

Mouse Strains ◽

Term Survival ◽

Tissue Degeneration ◽

Testicular Cells ◽

Medium Interface ◽

3D Printed ◽

Cell Functionality ◽

Air Medium

Short-term germ cell survival and central tissue degeneration limit organoid cultures. Here, testicular organoids (TOs) were generated from two different mouse strains in 3D printed one-layer scaffolds (1LS) at the air-medium interface displaying tubule-like structures and Leydig cell functionality supporting long-term survival and differentiation of germ cells to the meiotic phase. Chimeric TOs, consisting of a mixture of primary testicular cells and EGFP+ germline stem (GS) cells, were cultured in two-layer scaffolds (2LSs) for better entrapment. They showed an improved spheroidal morphology consisting of one intact tubule-like structure and surrounding interstitium, representing the functional unit of a testis. However, GS cells did not survive long-term culture. Consequently, further optimization of the culture medium is required to enhance the maintenance and differentiation of germ cells. The opportunities TOs offer to manipulate somatic and germ cells are essential for the study of male infertility and the search for potential therapies.

Download Full-text

Long-term Survival Analysis of Total Ankle Arthroplasty and Patient Risk Factor for Failure

Foot & Ankle Orthopaedics ◽

10.1177/2473011420s00297 ◽

2020 ◽

Vol 5 (4) ◽

pp. 2473011420S0029

Author(s):

Sung-Jae Kim ◽

Hwa-Jun Kang ◽

Ki Chun Kim

Keyword(s):

Regression Analysis ◽

Survival Analysis ◽

Survival Rate ◽

Revision Arthroplasty ◽

Survival Duration ◽

Term Survival ◽

Patient Risk ◽

Long Term Survival ◽

Cox Regression Analysis

Category: Ankle; Ankle Arthritis Introduction/Purpose: The aim of current study is to perform long-term survival analysis for TAA of 5619 cases, and identify patient risk for failure of TAA. Methods: Total of 7516 cases of TAA were identified from national insurance claim data of South Korea during 2007 to 2018. After exclusion of bilateral cases and cases performed on 2018, total 5619 cases of primary TAA cases were included. TAA failure was defined as case with revision arthroplasty or case with TAA implant removal and arthrodesis after primary TAA. Patient age, hospital size, comorbidities were included for survival analysis. Kaplan-Meier survival analysis was performed during study period, and Multivariable Cox regression analysis were performed. Results: During study period, five-year survival rate was 95.4%, and 10-year survival rate was 91.1%, and mean survival duration was 9.6 years. Regression analysis revealed that younger age (< 65, adjusted hazard ration (AHR), 1.812; p< 0.001), chronic pulmonary disease (AHR, 1.476; p= 0.013), diabetes (AHR, 1.443; p= 0.014), alcohol consumption (AHR, 1.524; p= 0.032) showed significant high odds ratio for TAA failure. Conclusion: Current study was performed with largest cohort with TAA procedures in literature. 10-year survival rate was 91.4%, young age and some comorbidities revealed as significant predictor for TAA failure.

Download Full-text

Do custom 3D-printed revision acetabular implants provide enough value to justify the additional costs? The health-economic comparison of a new porous 3D-printed hip implant for revision arthroplasty of Paprosky type 3B acetabular defects and its closest alternative

Orthopaedics & Traumatology Surgery & Research ◽

10.1016/j.otsr.2020.03.012 ◽

2020 ◽

pp. 102600

Author(s):

Philip Tack ◽

Jan Victor ◽

Paul Gemmel ◽

Lieven Annemans

Keyword(s):

Health Economic ◽

Revision Arthroplasty ◽

Hip Implant ◽

Additional Costs ◽

3D Printed ◽

Acetabular Defects ◽

Economic Comparison

Download Full-text

Reconstruction of Total Bone Defects following Resection of Malignant Tumors of the Upper Extremity with 3D Printed Prostheses: Presentation of Two Patients with a Follow-Up of Three Years

Case Reports in Orthopedics ◽

10.1155/2020/8822466 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Thomas Ackmann ◽

Sebastian Klingebiel ◽

Georg Gosheger ◽

Anna Rachbauer ◽

Christoph Theil ◽

...

Keyword(s):

Upper Extremity ◽

Bone Tumors ◽

Malignant Tumors ◽

Local Treatment ◽

Tumor Resection ◽

Bone Defects ◽

Malignant Bone Tumors ◽

Term Survival ◽

First Case ◽

3D Printed

Wide tumor resection is the local treatment of choice for patients with primary malignant bone tumors and a prerequisite for long-term survival. We present two patients that underwent total bone resection in the upper limb because of primary malignant bone tumors. The defects were then reconstructed by a 3D printed prosthesis, a procedure that, to our knowledge, has not been reported for bone defects of the upper extremity so far. Complete resection of the affected bone was required in a five-year-old girl with a high-grade osteoblastic osteosarcoma of the humerus and a 53-year-old man with a dedifferentiated leiomyosarcoma of the radius, due to the tumor’s extent. Following neoadjuvant chemotherapy, resection of the entire affected humerus including the axillary nerve took place in the first case and the entire affected radius including parts of the radial nerve in the second case. Approximately three years after surgery, both patients are alive and pain-free. Despite a postoperative drop hand that affected the now 56-year-old man, he is able to carry out everyday activities such as brushing his teeth, writing, and eating. The now eight-year-old girl is also able to engage in normal activities with her left arm such as eating and carrying lightweight objects. Both patients are tumor-free to date.

Download Full-text

Caspases and apoptosis

Essays in Biochemistry ◽

10.1042/bse0380009 ◽

2002 ◽

Vol 38 ◽

pp. 9-19 ◽

Cited By ~ 121

Author(s):

Guy S Salvesen

Keyword(s):

Cysteine Proteases ◽

Signalling Pathways ◽

Term Survival ◽

Mature Adult ◽

Intracellular Signalling Pathways ◽

Adult Cell ◽

Caspase Family ◽

Cell Fragments ◽

Pro Inflammatory Cytokines

The ability of metazoan cells to undergo programmed cell death is vital to both the precise development and long-term survival of the mature adult. Cell deaths that result from engagement of this programme end in apoptosis, the ordered dismantling of the cell that results in its 'silent' demise, in which packaged cell fragments are removed by phagocytosis. This co-ordinated demise is mediated by members of a family of cysteine proteases known as caspases, whose activation follows characteristic apoptotic stimuli, and whose substrates include many proteins, the limited cleavage of which causes the characteristic morphology of apoptosis. In vertebrates, a subset of caspases has evolved to participate in the activation of pro-inflammatory cytokines, and thus members of the caspase family participate in one of two very distinct intracellular signalling pathways.

Download Full-text