Induced Membrane Technique: Effects of Antbiotic-impregnated Spacers on Healing of a Critical-size Femoral Defect in a Rat Model

OrthoMedia ◽  
2022 ◽  
2015 ◽  
Vol 33 (4) ◽  
pp. 488-495 ◽  
Author(s):  
Per Bosemark ◽  
Christina Perdikouri ◽  
Mea Pelkonen ◽  
Hanna Isaksson ◽  
Magnus Tägil

Author(s):  
Maximilian Leiblein ◽  
Andreas Winkenbach ◽  
Elias Koch ◽  
Alexander Schaible ◽  
Hubert Büchner ◽  
...  

Abstract Purpose The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. Compared to mature periosteum, the induced membrane differs significantly. However, both play a crucial role in bone regeneration. As part of a histological and radiological post-evaluation of an earlier project, we analyzed the influence of the granule size of the bone void filler Herafill® on development of periosteum regrowth in a critical size defect. Methods We compared three different sizes of Herafill® granules (Heraeus Medical GmbH, Wehrheim) in vivo in a rat femoral critical size defect (10 mm) treated with the induced membrane technique. After 8 weeks healing time, femurs were harvested and taken for histological and radiological analysis. Results A significantly increased regrowth of periosteum into the defect was found when small granules were used. Large granules showed significantly increased occurrence of bone capping. Small granules lead to significant increase in callus formation in the vicinity to the membrane. Conclusion The size of Herafill® granules has significant impact on the development of periosteal-like structures around the defect using Masquelet’s induced membrane technique. Small granules show significantly increased regrowth of periosteum and improved bone formation adjacent to the induced membrane.


2016 ◽  
Vol 6 (3) ◽  
pp. e65 ◽  
Author(s):  
Arnaud Felden ◽  
Jean-Charles Aurégan ◽  
Alina Badina ◽  
Christophe Glorion ◽  
Stéphanie Pannier

2020 ◽  
Vol 102 (14) ◽  
pp. 1269-1278
Author(s):  
Jae-Woo Cho ◽  
William T. Kent ◽  
Chang-Wug Oh ◽  
Beom-Soo Kim ◽  
Won-Tae Cho ◽  
...  

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mohammed soliman ◽  
Yousif Khira ◽  
.mohamed Elzoheiry ◽  
ahmad abdelwahab

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