scholarly journals Use of the Metastatic Lymph Node Ratio to Evaluate the Prognosis of Esophageal Cancer Patients with Node Metastasis Following Radical Esophagectomy

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73446 ◽  
Author(s):  
Zhenyu He ◽  
Sangang Wu ◽  
Qun Li ◽  
Qin Lin ◽  
Junjie Xu
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Radical Esophagectomy ◽  
Node Metastasis ◽  
Metastatic Lymph ◽  
Node Ratio

Prognostic impact of postoperative radiation in patients with radical esophagectomy and pathologic lymph nodes positive esophageal cancer.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 101-101
Author(s):  
Yaping Xu ◽  
Xiaojiang Sun ◽  
Yuanda Zheng
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Stage Iii ◽  
Postoperative Radiation ◽  
Radical Esophagectomy ◽  
Metastatic Lymph ◽  
Node Ratio

101 Background: Though postoperative radiation for esophageal cancer is offered in selected cases, there is conflicting evidence as to whether it improves overall survival (OS). We performed a retrospective investigation to analyze the prognosis impact of adjuvant radiation in a large cohort of patients. Methods: From 2002 to 2008, 545 patients underwent radical esophagectomy (R0) with or without postoperative radiation were eligible for retrospectively analysis. Patients were grouped to surgery only (n=346) and surgery plus postoperative radiation therapy (PORT) (n=199). Radiation dose was 50 Gy in 25 fractions. Kaplan-Meier and Cox regression analysis were used to compare OS. Results: The use of PORT was associated with significantly improved OS ( p =0.006). The median OS was 31 months in the group receiving PORT and 21 months in the group undergoing surgery alone. The addition of PORT improved OS at 3 years from 38.3 to 45.8% compared with surgery alone. For American Joint Committee on Cancer (AJCC) stage III esophageal cancer (T1-2N2M0, T3N1-2M0, T4N1-3M0), there was significant improvement on OS ( p < 0.001) in PORT group, for not only metastatic lymph-node ratio <0.25 ( p = 0.047), but also metastatic lymph-node ratio >0.25 ( p = 0.013). However, for stages IIB disease (T1-2N1M0) there was no significant differences. Conclusions: This large population-based analysis supports the use of PORT for pathologic lymph nodes positive stage III esophageal cancer. Our results suggest that a subset of such patients may benefit from aggressive local therapy.

Prognostic Significance of the Metastatic Lymph Node Ratio in Gastric Cancer Patients

2009 ◽  
Vol 33 (11) ◽  
pp. 2378-2382 ◽  
Author(s):  
Naoto Fukuda ◽  
Yasuyuki Sugiyama ◽  
Akira Midorikawa ◽  
Hiroyuki Mushiake
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Gastric Cancer Patients

Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?

2013 ◽  
Vol 108 (4) ◽  
pp. 256-263 ◽  
Author(s):  
Suhail I. Sayed ◽  
Shilpi Sharma ◽  
Pawan Rane ◽  
Sagar Vaishampayan ◽  
Sanjay Talole ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Oral Cavity Cancer ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph ◽  
Node Ratio
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