Evaluation of prognostic significance of hematological profiles after the intensive phase treatment in pulmonary tuberculosis patients from Romania

We evaluated in this cohort study the predictive ability of 23 peripheral blood parameters and ratios for treatment outcomes after the 2-month intensive phase in patients with PTB. In 63 patients out of 90 that turned culture negative, a significant decrease in white blood cell count, neutrophils, monocyte, hemoglobin, platelet, plateletcrit, erythrocyte sedimentation rate, MLR, NLR, PLR and SII values after anti-TB therapy compared to pretreatment was observed (p <0.001). Logistic regression analysis generated a model of predictors consisting of nine covariates. Spearman’s correlation analysis revealed significant positive correlations between NLR with NEU (r = 0.79, p<0.01), SII with NEU (r = 0.846, p<0.01), PLT with SII (r = 0.831, p<0.01), PLT with PCT (r = 0.71, p<0.01) and MPV with P-LCR (r = 0,897, p<0.01) in 63 patients out of 90 that turned culture negative after 2 months of treatment. ROC curve analysis indicated that all areas under the curve (AUC) revealed no statistically significant results, except lymphocyte for culture conversion. In summary, here we observed a set of hematological parameters that declined significantly as the disease was treated in patients that turned culture negative. Despite some limitations, our findings are useful for further studies aiming to identify hematological profiles that could predict the treatment outcome.

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Length and Weight (LW) Related Variations on Haematological Parameters of Hetropneustes Fossilis (Bloch.)

10.21203/rs.3.rs-996037/v1 ◽

2021 ◽

Author(s):

Induja Mishra ◽

Namita Joshi ◽

Pashupati Nath ◽

B. D. Joshi

Keyword(s):

Significant Positive Correlation ◽

Hematological Parameters ◽

Blood Parameters ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Mean Cell Volume ◽

Positive Correlation ◽

Erythrocyte Sedimentation ◽

Positive Correlations ◽

Living Creature

Abstract The paper mainly described the haematological values of a fresh water catfish Hetropneustes fossilis (Bloch.) in relation to its length and weight which are the prime basic factor of the differences in blood parameters of any living creature including fishes. The hematological parameters showed significant differences with increase in length and weight of the fishes. Differential leucocytes count did not showed any significant differences except macrophages and differential erythrocytes count showed significant differences only in macrocytes. All three groups (Length and weight) of fishes showed significant positive correlations for total erythrocytes count, hemoglobin, mean corpuscular hemoglobin and erythrocyte sedimentation rate while negative correlation was noted for mean corpuscular hemoglobin; mean cell volume. Among differential leukocytes count only neutrophil showed positive correlation, while other parameters did not show any significant correlation. In differential erythrocyte count only microcytes showed significant positive correlation.

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Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh

PLoS ONE ◽

10.1371/journal.pone.0255379 ◽

2021 ◽

Vol 16 (7) ◽

pp. e0255379

Author(s):

Md. Ashrafur Rahman ◽

Yeasna Shanjana ◽

Md. Ismail Tushar ◽

Tarif Mahmud ◽

Ghazi Muhammad Sayedur Rahman ◽

...

Keyword(s):

Hematological Parameters ◽

Treatment Protocol ◽

Blood Parameters ◽

Rt Pcr ◽

C Reactive Protein ◽

Reactive Protein ◽

Hematological Abnormalities ◽

Positive Correlations ◽

Patients Experience ◽

D Dimer

Background The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual associations between specific blood parameters and COVID-19 are not well understood. Here we aimed to assess the correlations between hematological parameters and the severity of COVID-19. Methods We included COVID-19 patients who were admitted to Evercare Hospital Ltd, Dhaka, Bangladesh, between November 10, 2020, to April 12, 2021, with a confirmed case of RT-PCR test. We recorded demographic information, clinical data, and routine hematological examination results of all COVID-19 patients. We performed statistical analyses and interpretation of data to compare severe COVID-19 patients (SCP) and non-severe COVID-19 patients (NSCP). Results The age and BMI of the admitted COVID-19 patients were 48.79±8.53 years and 25.82±3.75 kg/m2. This study included a total of 306 hospitalized COVID-19 patients. Among them, NSCP and SCP were 198 and 108, respectively. And we recorded 12 deaths from SCP. We observed the alterations of several hematological parameters between SCP and NSCP. Among them, we noticed the increased levels of C-reactive protein (CRP), d-dimer, and ferritin showed good indicative value to evaluate the severity of COVID-19. Also, there were positive correlations among these parameters. Moreover, we found correlations between the outcomes of COVID-19 patients with patient’s demographics and comorbid diseases. Conclusion Based on our results, CRP, d-dimer, and ferritin levels at admission to hospitals represent simple assessment factors for COVID-19 severity and the treatment decisions at the hospital setup. These blood parameters could serve as indicators for the prognosis and severity of COVID-19. Therefore, our study findings might help to develop a treatment protocol for COVID-19 patients at the hospital setup.

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Change in body weight and treatment outcome in sputum positive pulmonary tuberculosis patients treated under directly observed treatment short-course

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20182172 ◽

2018 ◽

Vol 5 (6) ◽

pp. 2431

Author(s):

Malangori A. Parande ◽

Pradip S. Borle ◽

Vinay S. Tapare ◽

Sudhakar W. More ◽

Susmita S. Bhattacharya

Keyword(s):

Body Weight ◽

Treatment Outcome ◽

Weight Gain ◽

Pulmonary Tuberculosis ◽

Prognostic Significance ◽

Intensive Phase ◽

Tuberculosis Patients ◽

Tb Treatment ◽

End Of Treatment ◽

Significant Difference

Background: Patients with tuberculosis often suffer from severe weight loss and is used as useful marker to predict TB treatment outcome. Hence a study was planned with an objective to determine the change of patient’s body weight over time throughout treatment and to determine whether there was any association with treatment outcome.Methods: This was a retrospective cohort study, planned to be conducted among all smear positive pulmonary tuberculosis patients registered in a Tuberculosis Unit of Pune corporation, during the period of January to December 2015. Body weights of patients were recorded from TB treatment cards at the time of diagnosis, after 2 months of intensive phase of treatment and at the end of treatment. Total 344 cases were enrolled. Chi-Square test and Fisher’s exact test and repeated measure ANOVA test was used for analysis.Results: A bad outcome was more likely among the category II cases as compared to category I, among non-adherent to treatment cases in continuation phase and higher sputum grading at the time of diagnosis i. e. in 3+ sputum smear grading. The weights of the patients at the time of diagnosis, at end of intensive phase and at end of treatment showed statistical significant difference (p<0.0001). The weight gain, more so at end of treatment was significantly associated with good outcome.Conclusions: Weight gain has prognostic significance in patients with tuberculosis and should be considered as a surrogate marker to monitor response to TB treatment especially in developing countries where extensive laboratory tests are not feasible.

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Stromal Cell-Derived Factor 1α (SDF-1α) in Invasive Breast Cancer: Associations with Vasculo-Angiogenic Factors and Prognostic Significance

Cancers ◽

10.3390/cancers13081952 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1952

Author(s):

Elżbieta Zarychta ◽

Barbara Ruszkowska-Ciastek ◽

Kornel Bielawski ◽

Piotr Rhone

Keyword(s):

Breast Cancer ◽

Invasive Breast Cancer ◽

Stromal Cell ◽

Prognostic Significance ◽

Disease Free Survival ◽

Breast Cancer Patients ◽

Roc Curve Analysis ◽

Stromal Cell Derived Factor ◽

A Prospective Study

(1) Background: Tumour angiogenesis is critical for the progression of neoplasms. A prospective study was designed to examine the utility of stromal cell-derived factor 1α (SDF-1α) and selected vasculo-angiogenic parameters for estimating the probability of disease relapse in 84 primary, operable invasive breast cancer (IBrC) patients (40 (48%) with stage IA and 44 (52%) with stage IIA and IIB). (2) Methods: We explored the prognostic value of the plasma levels of SDF-1α, vascular endothelial growth factor A (VEGF-A), the soluble forms of VEGF receptors type 1 and 2, and the number of circulating endothelial progenitor cells (circulating EPCs) in breast cancer patients. The median follow-up duration was 58 months, with complete follow-up for the first event. (3) Results: According to ROC curve analysis, the optimal cut-off point for SDF-1α (for discriminating between patients at high and low risk of relapse) was 42 pg/mL, providing 57% sensitivity and 75% specificity. Kaplan–Meier curves for disease-free survival (DFS) showed that concentrations of SDF-1α lower than 42 pg/dL together with a VEGFR1 lower than 29.86 pg/mL were significantly associated with shorter DFS in IBrC patients (p = 0.0381). Patients with both SDF-1α lower than 42 pg/dL and a number of circulating EPCs lower than 9.68 cells/µL had significantly shorter DFS (p = 0.0138). (4) Conclusions: Our results imply the clinical usefulness of SDF-1α, sVEGFR1 and the number of circulating EPCs as prognostic markers for breast cancer in clinical settings.

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Effect of Acetic Acid and Sodium Bicarbonate Supplemented to Drinking Water on Water Quality, Growth Performance, Organ Weights, Cecal Traits and Hematological Parameters of Young Broilers

Animals ◽

10.3390/ani11071865 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1865

Author(s):

Yordan Martínez ◽

Cristopher Isaac Almendares ◽

Cristhian José Hernández ◽

Mavir Carolina Avellaneda ◽

Ana Melissa Urquía ◽

...

Keyword(s):

Water Quality ◽

Drinking Water ◽

Acetic Acid ◽

Sodium Bicarbonate ◽

Growth Performance ◽

Hematological Parameters ◽

Relative Weight ◽

Biological Response ◽

Blood Parameters ◽

Organ Weights

To evaluate the effect of acetic acid and sodium bicarbonate supplemented to drinking water on water quality, growth performance, relative organ weights, cecal traits and hematological parameters of broilers, a total of 456 one-day-old Cobb MV × Cobb 500 FF mixed broilers were randomly placed in three experimental treatments, with four replicates per treatment and 38 birds per replicate, for 10 days. The treatments consisted of the use of acetic acid (0.4%; T1) as acidifier, an apparently neutral pH (T2) and sodium bicarbonate (1%; T3) as alkalizer of the drinking water. T3 showed the highest values (p < 0.05) for total dissolved solids, electrical conductivity, salinity and pH. T1 and T2 showed the same productive response (p > 0.05); however, T3 decreased (p < 0.05) body weight, feed intake and the relative weight of the pancreas and immune organs and increased (p < 0.05) water intake, mortality and relative weight of the heart and liver. Likewise, T3 increased (p < 0.05) the cecal pH, although without changes for the cecal lactic cecal bacteria count and blood parameters (p > 0.05). The acid pH of the drinking water had no effect on the biological response of broilers compared to T2; however, the T3 provoked high mortality, ascites, low productivity and abnormal growth of some organs.

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Preterm newborn adaptive responses to daily nursing, during NICU stay, associate with the neurodevelopment, two years later

American Journal of Perinatology ◽

10.1055/a-1649-2077 ◽

2021 ◽

Author(s):

Stefano Bembich ◽

Francesco Maria Risso ◽

Nicoleta Stan ◽

Domitilla Lamba ◽

Carolina Banova ◽

...

Keyword(s):

Preterm Newborn ◽

Adaptive Responses ◽

Very Preterm ◽

Autonomic Motor ◽

Postmenstrual Age ◽

Preterm Babies ◽

Positive Correlations ◽

Spearman’S Correlation ◽

Preterm Newborns ◽

Bayley Scales

Objective: To evaluate if adaptive responses of very preterm newborns to NICU daily nursing, specifically bathing and weighing procedures, are associated with their neurodevelopment two years later. Study design: Twenty-six very preterm newborns, with a gestational age < 32 weeks, were enrolled. Infants' adaptive responses to daily nursing were evaluated, at 30-32-35 postmenstrual age (PMA) weeks, by an observational sheet. Neurodevelopment was assessed, at 24 months of corrected age, by the Bayley Scales of Infant and Toddler Development, third edition. Autonomic, motor, and self-regulatory responses to NICU nursing were analyzed, by Spearman's correlation coefficient and multivariate linear regression, with Bayley’s cognitive, language, and motor scales. Results: Significant (P < 0.05) positive correlations of self-regulatory and autonomic responses to nursing with all Bailey’s scales were found at 30- and 32-weeks PMA. At 35 weeks PMA, only self-regulatory responses had significant positive correlations with all Bailey’s scales. When adjusted for birth weight and sex, the significant associations were confirmed only at 30- and 32-weeks PMA. Conclusion: Very preterm newborn adaptive responses to NICU daily nursing reveal to be positively related to forthcoming neurodevelopment two years later, as early as the 30th week PMA. Helping preterm babies to adapt to daily NICU nursing may promote their future neurobeahaviour.

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RESVERATROL INCLUSION COMPLEX WITH β-CYCLODEXTRIN (RCD): CHARACTERIZATION AND EVALUATION OF TOXICITY IN WISTAR RATS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i1.15399 ◽

2016 ◽

Vol 9 (1) ◽

pp. 27 ◽

Cited By ~ 2

Author(s):

V. S. K. Nishihira ◽

N. J. Mezzomo ◽

M. D. Baldissera ◽

R. A. Vaucher ◽

C. G. Pinto ◽

...

Keyword(s):

Inclusion Complex ◽

Oral Administration ◽

Biochemical Parameters ◽

Wistar Rats ◽

Metabolic Diseases ◽

Hematological Parameters ◽

Density Lipoprotein ◽

Blood Parameters ◽

Control Group ◽

Scanning Calorimetry

Objective: The aim of this study was to characterise the resveratrol inclusion complex with β-cyclodextrin (RCD) and evaluate their toxicity in wistar rats.Methods: The RCD were prepared in ultra-turrax. For characterization of the RCD were used: Fourier transform infra-red Spectroscopy, Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC) and X-ray powder diffraction. The RCD and others 4 treatments were performed by the chronic oral administration in 35 rats during 60 ds. After the treatments they were euthanized and the serum blood were collected to analyzed some hemogram and biochemical parameters including aspartyl aminotransferase (AST); alanine aminotransferase (AST); phosphatase alkaline (ALP); total bilirubin (TB); direct bilirubin (DB); total protein (TP); total cholesterol (TC), triacylglycerol (TAG), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), calcium, iron and phosphate using fully automated biochemistry analyzer.Results: The characterization results indicated a successful formation of the RCD. All hematological parameters analysed were within the normal values in all the groups. Furthermore, the hemogram and biochemical parameters were significantly (P>0.05) similar to the control group.Conclusion: The daily oral administration during 60 d of RCD are not harmful on blood parameters of Wistar rats. Thus, RCD can be used safely for treatment of some metabolic diseases.

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Repatriation turnover revisited: A focus on South African multinational enterprises

South African Journal of Economic and Management Sciences ◽

10.4102/sajems.v21i1.1680 ◽

2018 ◽

Vol 21 (1) ◽

Author(s):

Christiaan J. Naude ◽

A. Johan Vogel

Keyword(s):

South African ◽

Quantitative Study ◽

Negative Correlation ◽

Multinational Enterprises ◽

Multinational Enterprise ◽

First Year ◽

Turnover Rates ◽

Expatriate Managers ◽

Positive Correlations ◽

Spearman’S Correlation

Background: The topic of repatriation turnover as a major source of concern for repatriates and their multinational enterprise has been covered extensively in the literature over the years, with the literature showing that between 15% and 38% of repatriated expatriates leave the employment of their multinational enterprise within the first year after repatriation. However, no such study has focused on the repatriation of South African expatriates. Aim: The primary aim of this study was to determine if there is a correlation between the repatriation practices of South African multinational enterprises and their repatriation turnover rates. The secondary aim of the study was to determine why repatriated employees leave the employment of South African multinational enterprises. Method: This quantitative study surveyed 41 expatriate managers of South African multinational enterprises, with the Mann-Whitney U test and Spearman’s correlation coefficient being used to test for correlations between the repatriation practices of South African multinational enterprises and their repatriation turnover rates. Results: The results revealed positive correlations between appointing a mentor to an expatriate to assist with the repatriation process, conducting an orientation programme prior to repatriation and supporting the expatriate with various initiatives during repatriation and lower repatriation turnover rates. Meanwhile a negative correlation was found between when a multinational enterprise starts with an orientation programme prior to repatriation and repatriation turnover rates. Conclusion: These findings provide valuable insights for South African multinational enterprises into practices they can employ to reduce their repatriation turnover rates.

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Development and health status of Centropomus undecimalisparasitized by Rhabdosynochus rhabdosynochus (Monogenea) under different salinity and temperature conditions

Revista Brasileira de Parasitologia Veterinária ◽

10.1590/s1984-29612015062 ◽

2015 ◽

Vol 24 (3) ◽

pp. 350-356 ◽

Cited By ~ 1

Author(s):

Giovanni Lemos de Mello ◽

Gabriela Tomas Jerônimo ◽

Karen Roberta Tancredo ◽

Jéssica Brol ◽

Evelyn Jacques de Almeida ◽

...

Keyword(s):

Hematological Parameters ◽

Hemoglobin Concentration ◽

Economic Losses ◽

Mean Corpuscular Hemoglobin ◽

Experimental Conditions ◽

Different Temperatures ◽

The Mean ◽

Positive Correlations ◽

C 32 ◽

Wbc Count

This study evaluated the correlation of hematological parameters with the mean abundance of the monogenean helminth Rhabdosynochus rhabdosynochus in Centropomus undecimalis reared at different temperatures and salinities. The experimental conditions were: 28 °C/0 ppt (parts per thousand); 28 °C/15 ppt; 28 °C/32 ppt; 25 °C/0 ppt; 25 °C/15 ppt; and 25 °C/32 ppt. The prevalence was 100.0% in fish at 28 °C/15 ppt, 28 °C/32 ppt and 25 °C/15 ppt, which was significantly different (p < 0.05) from those at 25 °C/32 ppt. The red blood cell (RBC) count, hematocrit and total leukocyte (WBC) count were significantly higher in fish at 28 °C/15 ppt and 28 °C/32 ppt. The mean abundance of R. rhabdosynochus, hematocrit and RBC showed positive correlations (P < 0.05) with temperature (ρ= 0.3908; ρ= 0.4771 and ρ = 0.2812). Mean abundance showed negative correlations with hemoglobin (ρ= -0.3567) and mean corpuscular hemoglobin concentration (MCHC) (ρ = -0.2684). No correlation between abundance and salinity was detected among the experimental conditions (ρ = -0.0204). The low numbers of monogeneans recorded (min -1 and max -33) explain the few changes to fish health. This suggests that these experimental conditions may be recommended for development of rearing of C. undecimalis in Brazil, without any influence or economic losses from R. rhabdosynochus.

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PHYSIOLOGICAL STATE AND PRODUCTIVITY OF ANIMALS UNDER THERMAL STRESS

VESTNIK OF THE BASHKIR STATE AGRARIAN UNIVERSITY ◽

10.31563/1684-7628-2019-51-3-26-31 ◽

2019 ◽

Vol 51 (3) ◽

pp. 26-31

Author(s):

E.A. Azhmuldinov ◽

◽

Yu.N. Chernyshenko ◽

M.G. Titov ◽

◽

...

Keyword(s):

Hematological Parameters ◽

Physiological State ◽

Live Weight ◽

Blood Parameters ◽

Maximum Temperature ◽

Total Plasma ◽

Ambient Temperatures ◽

Study Results ◽

Total Plasma Protein ◽

Negative Effect

A study was conducted of the effect of heat stress on the clinical and physiological state of male rabbits at the age of 5 months with an average live weight of 1551 g. The maximum temperature the animals were exposed to during the experiment was +42 °C. The study results showed a decrease in feed intake and an increase in water consumption, which contributed to a decrease in live weight. Hematological parameters, including hemoglobin, erythrocytes, leukocytes, total plasma protein, globulins and cholesterol increased during the action of this stress factor. It was found that the effect of high ambient temperatures on rabbits negatively affected their physiological functions; the negative effect was reflected by the morphological and biochemical blood parameters.

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