Psychological distress among healthcare providers during COVID-19 in Asia: Systematic review and meta-analysis

Introduction COVID-19 pandemic is having a devastating effect on the mental health and wellbeing of healthcare providers (HCPs) globally. This review is aimed at determining the prevalence of depression, anxiety, stress, fear, burnout and resilience and its associated factors among HCPs in Asia during the COVID-19 pandemic. Material and methods We performed literature search using 4 databases from Medline, Cinahl, PubMed and Scopus from inception up to March 15, 2021 and selected relevant cross-sectional studies. Publication bias was assessed using funnel plot. Random effects model was used to estimate the pooled prevalence while risk factors were reported in odds ratio (OR) with 95% CI. Results We included 148 studies with 159,194 HCPs and the pooled prevalence for depression was 37.5% (95%CI: 33.8–41.3), anxiety 39.7(95%CI: 34.3–45.1), stress 36.4% (95%CI: 23.2–49.7), fear 71.3% (95%CI: 54.6–88.0), burnout 68.3% (95%CI: 54.0–82.5), and low resilience was 16.1% (95%CI: 12.8–19.4), respectively. The heterogeneity was high (I2>99.4%). Meta-analysis reported that both females (OR = 1.48; 95% CI = 1.30–1.68) and nurses (OR = 1.21; 95%CI = 1.02–1.45) were at increased risk of having depression and anxiety [(Female: OR = 1.66; 95% CI = 1.49–1.85), (Nurse: OR = 1.36; 95%CI = 1.16–1.58)]. Females were at increased risk of getting stress (OR = 1.59; 95%CI = 1.28–1.97). Conclusion In conclusion, one third of HCPs suffered from depression, anxiety and stress and more than two third of HCPs suffered from fear and burnout during the COVID-19 pandemic in Asia.

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Prevalence of Depression among Healthcare Workers during the COVID-19 Outbreak: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10153406 ◽

2021 ◽

Vol 10 (15) ◽

pp. 3406

Author(s):

Beatriz Olaya ◽

María Pérez-Moreno ◽

Juan Bueno-Notivol ◽

Patricia Gracia-García ◽

Isabel Lasheras ◽

...

Keyword(s):

Systematic Review ◽

Healthcare Workers ◽

Mental Health Problems ◽

Meta Analysis ◽

Medical Doctors ◽

Cross Sectional ◽

Random Effects Models ◽

Pooled Prevalence ◽

Prevalence Of Depression ◽

Common Mental Health Problems

Background: There is evidence of a high psychological toll from the COVID-19 pandemic in healthcare workers. This paper was aimed at conducting a systematic review and meta-analysis of studies reporting levels of depression among healthcare workers during the COVID-19 and estimating the pooled prevalence of depression. Methods: We searched for cross-sectional studies listed on PubMed from 1 December 2019 to 15 September 2020 that reported prevalence of depression in healthcare workers, nurses, medical doctors, and COVID-19 frontline professionals. The pooled proportions of depression were calculated with random effects models. Results: We identified 57 studies from seventeen countries. The pooled prevalence of depression in healthcare workers was 24% (95% CI: 20%−28%), 25% for nurses (95% CI: 18%−33%), 24% for medical doctors (95% CI: 16%−31%), and 43% for frontline professionals (95% CI: 28%−59%). Conclusions: The proportion of depression in nurses and medical doctors during the COVID-19 pandemic was similar to that found in the general population as previously reported in other meta-analyses conducted with smaller numbers of studies. Importantly, almost half of the frontline healthcare workers showed increased levels of depression. There is need for a comprehensive, international response to prevent and treat common mental health problems in healthcare workers.

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Prevalence of depression, anxiety and stress in china during COVID-19 pandemic: A systematic review with meta-analysis

The International Journal of Psychiatry in Medicine ◽

10.1177/0091217420978005 ◽

2020 ◽

pp. 009121742097800

Author(s):

Syeda Beenish Bareeqa ◽

Syed Ijlal Ahmed ◽

Syeda Sana Samar ◽

Waqas Yasin ◽

Sani Zehra ◽

...

Keyword(s):

Mental Health ◽

Meta Analysis ◽

Early Period ◽

Depression And Anxiety ◽

Health Issues ◽

Eligibility Criteria ◽

Pooled Prevalence ◽

Care Workers ◽

Prevalence Of Depression ◽

Novel Coronavirus

Background The novel coronavirus disease which is believed to have initially originated in Wuhan city of China at the end of 2019 was declared as pandemic by March 2020 by WHO. This pandemic significantly impacted the mental health of communities around the globe. This project draws data from available research to quantify COVID-19 mental health issues and its prevalence in China during the early period of the COVID-19 crisis. It is believed that this pooling of data will give fair estimate of the effects of the COVID-19 pandemic on mental health. Methods We conducted this study in accordance with PRISMA guidelines 2009. The protocol for this review is registered and published in PROSPERO (CRD42020182893). The databases used were Pubmed, Medline, Google scholar and Scopus. The studies were extracted according to pre-defined eligibility criteria and risk of bias assessment was conducted. The Meta-analysis was done using OpenMeta [analyst]. Results Total of 62382 participants in nineteen studies fulfilled the eligibility criteria. Stress was the most prevalent (48.1%) mental health consequence of Covid-19 pandemic, followed by depression (26.9%) and anxiety (21.8%). After performing subgroup analysis, prevalence of depression and anxiety in both females and frontline health care workers were high as compared to the prevalence in general Chinese population. Conclusion The prevalence of depression and anxiety is moderately high whereas pooled prevalence of stress was found to be very high in Chinese people during this Covid-19 crisis.

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Meta-Analysis of Prevalence of Depression in Dental Students during COVID-19 Pandemic

Medicina ◽

10.3390/medicina57111278 ◽

2021 ◽

Vol 57 (11) ◽

pp. 1278

Author(s):

Javier Santabárbara ◽

Naiara Ozamiz-Etxebarria ◽

Nahia Idoiaga ◽

Beatriz Olaya ◽

Juan Bueno-Novitol

Keyword(s):

Mental Health ◽

College Students ◽

Response Rate ◽

Negative Impact ◽

Meta Analysis ◽

Dental Students ◽

Random Effects Models ◽

Health And Wellbeing ◽

Pooled Prevalence ◽

Prevalence Of Depression

Background and Objectives: The COVID-19 pandemic has a negative impact on the mental health of the population in general, and in college students in particular. Dental students have seen their teaching altered and their clinical practice reduced. This study was aimed at conducting a systematic review and meta-analysis of studies reporting levels of depression among dental students during the COVID-19 and estimating the pooled prevalence of depression. Materials and Methods: Medline via PubMed and other databases were searched for studies on the prevalence of depression in dental undergraduates, published from 1 December 2019 to 1 September 2021. The pooled proportions of depression were calculated with random effects models. Results: We identified 13 studies from 9 countries. The pooled prevalence of depression in dental students was 37% (95% CI: 26–49%) with no variation due to gender, response rate or methodological quality. We only found a significantly higher prevalence of depression in studies from Asia compared to Europe and America. Conclusions: Our results suggest that dental students are suffering from higher levels of depression compared with the general population or other college students during the COVID-19 pandemic, with differences across regions. Measures to improve mental health and wellbeing of dental students during the pandemic are needed.

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Prevalence of depression among school going adolescents in India: a systematic review and meta-analysis of cross-sectional studies

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20210248 ◽

2021 ◽

Vol 8 (2) ◽

pp. 833

Author(s):

Prashanthi Kamath ◽

Sushma Marita Dsouza ◽

Subhransu Mahapatra ◽

Sruthi Jayakumar

Keyword(s):

Mental Health ◽

High School ◽

Systematic Review ◽

Meta Analysis ◽

Random Effect ◽

Cochrane Library ◽

Cross Sectional ◽

School Based ◽

Pooled Prevalence ◽

Prevalence Of Depression

The objective of this systematic review was to estimate the pooled prevalence of depression among schoolgoing adolescents in India by using Beck’s Depression Inventory (BDI 1 or BDI 2). A systematic literature search was conducted in PubMed, Ovid MEDLINE, Ovid EMBASE, CINAHL, Cochrane Library, PsycINFO and Google Scholar to identify cross-sectional school-based studies published during 1990-2020. Studies with pre-identified mental illness were excluded. Heterogeneity between studies were examined and estimates were pooled using a random-effects model. Subgroup and sensitivity analysis were performed. Publication bias was evaluated using funnel plot and Egger’s test. We included 13 studies in the meta-analysis. The random effect meta-analysis revealed that the pooled prevalence of depression among school going adolescents was 53% (95% CI: 41% - 65%). By gender, the prevalence was 50% (95 % CI: 38%–62%) in males and 57% (95% CI: 46% - 69%) in females. The subgroup analysis revealed that the pooled prevalence increased with the education levels (High school: 42%; High school and pre-university: 55%; and Pre-university: 67%). In this review we found that more than half of the school going adolescents in India suffered from depression that ranged from mild to severe. These results draw attention to re-look at the mental health policy and newer public health approaches to address depression. Further, strengthening school-based mental health services, along with the community and center-based care is crucial to prevent and effective management of depression among adolescents.

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Prevalence, incidence and comparative meta-analysis of all-cause and specific-cause cardiovascular disease in patients with serious mental illness

European Psychiatry ◽

10.1016/j.eurpsy.2017.02.238 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S319-S320

Author(s):

M. Solmi ◽

N. Veronese ◽

B. Beatrice ◽

R. Stella ◽

S. Paolo ◽

...

Keyword(s):

Cardiovascular Disease ◽

Mental Illness ◽

Total Population ◽

Meta Analysis ◽

Cross Sectional ◽

Pooled Prevalence ◽

Increased Risk ◽

Competing Interest ◽

Ischemic Attack

Patients with severe mental illness (SMI) have been described at higher risk of cardiovascular disease (CVD). The aim of this systematic review and meta-analysis was to quantify prevalence, incidence, cross-sectional association and longitudinal increased risk of coronary heart disease (CHD), stroke, transient ischemic attack and cerebrovascular disease (CBVD), heart failure (HF), peripheral vascular disease (PVD), death due to CVD, and any CVD in patients with SMI. We included 92 studies, with a total population of 3,371,461 patients (BD = 241,226, MDD = 476,102, SCZ = 1,721,586, SMI = 932,547) and 113,925,577 controls. Pooled prevalence of any CVD in SMI was 9.9% (95% CI = 7.4–13.3) (33 studies, 360,144 patients). Compared to controls, after adjusting for a median of 7 confounders, SMI was associated with higher risk of CVD in cross-sectional studies, OR:1.53 (95% CI = 1.27–1.83) (11 studies), with CHD OR: 1.51 (95% CI = 1.47–1.55) (5 studies), with CBVD OR: 1.42 (95% CI = 1.21–1.66) (6 studies), and tended to be associated with HF OR: 1.28 (95% CI = 0.99–1.65) (4 studies). Cumulative incidence was 3.6 CVD events in a median follow-up period of 8.4 years (range: 1.76–30). After considering a median of 6 confounders, SMI was associated with higher longitudinal risk of CVD in longitudinal studies HR: 1.78 (95% CI = 1.6, 1.98) (31 studies), of CHD: HR: 1.54 (95% CI 1.30–1.82) (18 studies), of CBVD HR: 1.64 (95% CI 1.26–2.14) (11 studies), of HF HR:2.10 (95% CI 1.64–2.70) (2 studies), of PVD, unadjusted RR: 3.11 (95% CI 2.46–3.91) (3 studies), of death due to CVD, HR 1.85 (95% CI 1.53–2.24) (16 studies). In this meta-analysis, the association between SMI and CVD has been quantified in a world representative sample; we suggest prevention of CVD should be warranted as standard care in SMI.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Prevalence of Depression among Epileptic Patients and its Association with Drug Therapy: A Systematic Review and Meta-Analysis

10.1101/387571 ◽

2018 ◽

Author(s):

Getenet Dessie ◽

Henok Mulugeta ◽

Cheru Tessema Leshargie ◽

Fasil Wagnew ◽

Sahai Burrowes

Keyword(s):

Systematic Review ◽

Random Effects ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Random Effects Model ◽

Pooled Prevalence ◽

Prevalence Of Depression ◽

Epileptic Patients ◽

Sub Saharan ◽

Patients With Epilepsy

AbstractBackgroundDespite the high prevalence of epilepsy in sub-Saharan Africa and the established relationship between depression and epilepsy, the extent of comorbid epilepsy and depression in the region is still poorly understood. This systematic review and meta-analysis aims to address this gap in the literature by determining the pooled prevalence of depression among epileptic patients in sub-Saharan Africa.MethodsA systematic desk review and electronic web-based search of PubMed, Google Scholar, EMBASE, PsycINFO and the World Health Organization’s Hinari portal (which includes the SCOPUS, African Index Medicus, and African Journals Online databases) identified peer-reviewed research studies and doctoral dissertations on the prevalence of depression among patients with epilepsy using pre-defined quality and inclusion criteria. Relevant data were extracted and descriptive summaries of the studies presented in tabular form. The I2 test was used to assess heterogeneity across studies. A random effects model was used to estimate the pooled prevalence of comorbidity at a 95% confidence interval (CI). Funnel plot asymmetry and Egger’s tests were used to check for publication bias. The final effect size was determined by applying a trim and fill analysis in a random-effects model.ResultsOur search identified 167 studies, of which 16 articles were eligible for inclusion the final analysis. The pooled estimate of prevalence of depression among patients with epilepsy was 32.71 (95% CI: 25.50 - 39.91). Regional sub-group analysis found that the pooled prevalence in East Africa was 34.52 (95% CI: 23.53 - 45.51) and 29.69 (95% CI: 22.7 - 36.68) in Southern and West Africa. The odds of depression among epileptic patients receiving polytherapy were 2.65 higher than in those receiving monotherapy (95% CI: 1.49 - 4.71, I2=79.1%, p < 0.05).ConclusionOur findings indicate high comorbidity in sub-Saharan Africa and suggests that it may be more prevalent there than elsewhere. Comorbidity is statistically associated with polytherapy. Given the high levels of epilepsy in the region, more attention should be paid to incorporating depression screening and treatment into existing epilepsy programs and to revising treatment guidelines on comorbid depression to reduce polytherapy.

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Depression and Anxiety in Pregnancy during COVID-19: A Rapid Review and Meta-Analysis

10.31234/osf.io/n8b7x ◽

2021 ◽

Author(s):

Lianne Tomfohr-Madsen ◽

Gerald Giesbrecht ◽

Catherine Lebel ◽

Nicole Racine ◽

Sheri Madigan

Keyword(s):

Pregnant Women ◽

Meta Analysis ◽

Systematic Search ◽

Rapid Review ◽

Depression And Anxiety ◽

Inclusion Criteria ◽

Pooled Prevalence ◽

Prevalence Of Depression ◽

Meta Analyses ◽

In Pregnancy

Objective: The present study rapidly reviewed and meta-analyzed the worldwide prevalence of depression and anxiety among pregnant women during the COVID-19 pandemic. Methods: A systematic search of the literature and meta-analyses were conducted. Results: Fifteen studies with 11,091 participants met inclusion criteria. Depression was assessed in 11 studies, with a pooled prevalence of .265 or 26.5% and anxiety in 12 studies, with a pooled prevalence of .335 or 33.5%. Conclusions: Rates of depression and anxiety during pregnancy are elevated during the pandemic. There is an urgent need to ensure screening and treatment for depression and anxiety during pregnancy.

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Estimating Heterogeneity and Pooled Prevalence of Classical Swine Fever in Pigs in India: A Meta-analysis

Indian Journal of Animal Research ◽

10.18805/ijar.b-4374 ◽

2021 ◽

Author(s):

P. Prema ◽

Y.C. Bangar ◽

Vijay Bahadur Sharma ◽

Sanjay Kumar ◽

Dinesh Kumar ◽

...

Keyword(s):

Random Effects ◽

Rna Virus ◽

Meta Analysis ◽

Classical Swine Fever ◽

Economic Losses ◽

Forest Plot ◽

High Morbidity ◽

Random Effects Model ◽

Funnel Plot ◽

Pooled Prevalence

Background: Classical swine fever (CSF) is caused by small enveloped RNA virus that belongs to the Flaviviridae family and causes high morbidity and mortality events for pig farming. In India, it is highly prevalent but with varied distribution in various geographical areas resulting in substantial economic losses to farmers. The discrepancy in prevalence estimates across studies needs to be evaluated in order to strengthen the prevention and control strategies of CSF in pigs. The aim of the present study was to provide the pooled estimate of the prevalence of classical swine fever (CSF) in India and to examine the consistency of those estimates between published studies.Methods: The data regarding prevalence of CSF in 7045 pigs were compiled from 22 published studies using comprehensive literature search for period from 1998 to 2018. The pooled prevalence of CSF was obtained under random effects model and heterogeneity between studies was determined using I² Index. Representation of meta-analysis was done using forest plot and followed by funnel plot, Baujat plot and radial plot.Result: The result of Meta-analysis revealed that pooled estimate of prevalence of CSF under random effects model was 45% (95% confidence interval: 35, 55%) in India. The heterogeneity statistic (Q) was found to be significant (p less than 0.001) with I² = 98% which indicated that prevalence of CSF was inconsistent between the studies. Likewise, results of funnel plot and Radial plot indicated heterogeneity between studies. Most influential studies for overall heterogeneity were identified using Baujat and radical plots.

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Depression and Its Help Seeking Behaviors: A Systematic Review and Meta-Analysis of Community Survey in Ethiopia

Depression Research and Treatment ◽

10.1155/2018/1592596 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 3

Author(s):

Berhanu Boru Bifftu ◽

Wubet Worku Takele ◽

Yonas Deressa Guracho ◽

Fekadu Ambaw Yehualashet

Keyword(s):

Publication Bias ◽

Help Seeking ◽

Assessment Tool ◽

Meta Analysis ◽

Mental Illnesses ◽

Significant Heterogeneity ◽

Cross Sectional ◽

Help Seeking Behaviors ◽

Pooled Prevalence ◽

Prevalence Of Depression

Background. Depression is one of the most common mental illnesses affecting around 322 million individual in the world. Although the prevalence of depression is high and its treatment is effective, little is known about its pooled prevalence and help seeking behaviors in the community settings of Ethiopia. Thus, this study aimed to determine the pooled prevalence of depression and its help seeking behaviors in Ethiopia. Methods. A systematic literature search in the databases of Pub-Med, Cochrane, and Google Scholar was performed. The quality of studies was assessed using the Newcastle-Ottawa quality assessment tool adapted for cross-sectional studies. Heterogeneity test and evidence of publication bias were assessed. Moreover, sensitivity test was also performed. Pooled prevalence of depression and its help seeking behavior were calculated using random effects model. Results. A total 13 studies for depression, 4 studies for help seeking intention, and 5 studies for help seeking behaviour were included in this review. The pooled prevalence of depression and help seeking intention and behaviour was found to be 20.5% (95% CI; 16.5% -24.4%), 42% (95% CI; 23%-60%), and 38% (95% CI; 23%-52%), respectively. There is no significant heterogeneity for depression (I2 = 0%, p =0.620), help seeking intention (I2 = 0%, p =0.996), and behaviour (I2 = 0%, p =0.896). There is no publication bias for depression egger’s test (p =0.689). Conclusion. More than one in every five individuals were experiencing depression. Less than one-third of individuals with depression seek help from modern treatment. Authors suggest community based mental health screening and treatment.

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Meta-analysis of the prevalence of depression among breast cancer survivors in Iran: an urgent need for community supportive care programs

Epidemiology and Health ◽

10.4178/epih.e2019030 ◽

2019 ◽

Vol 41 ◽

pp. e2019030 ◽

Cited By ~ 4

Author(s):

Hassan Ahmadi Gharaei ◽

Mostafa Dianatinasab ◽

Seyyed Mostafa Kouhestani ◽

Mohammad Fararouei ◽

Hossein Moameri ◽

...

Keyword(s):

Breast Cancer ◽

Supportive Care ◽

Breast Cancer Survivors ◽

Assessment Tool ◽

Meta Analysis ◽

Significant Heterogeneity ◽

Cross Sectional ◽

Pooled Prevalence ◽

Prevalence Of Depression ◽

Depression Assessment

OBJECTIVES: Depression, which is the most common comorbidity in breast cancer (BC) patients, has adverse effects on patients’ quality of life, disease progress, and survival.METHODS: The protocol of this study was registered in PROSPERO (registration No. CRD42019121494). We electronically searched published studies through January 2019 with the aim of finding articles that investigated the prevalence of depression among BC survivors. Web of Science, Scopus, PubMed/MEDLINE, Science Direct, and Google Scholar were searched to obtain relevant published studies. This review included 14 cross-sectional and 4 cohort studies published from 2000 to 2018. We used a random-effects model to conduct the meta-analysis and generated a summary estimate for the pooled prevalence with 95% confidence intervals (CIs). A subgroup analysis was also conducted based on the depression assessment tool used and the study design.RESULTS: The total sample size of the studies contained 2,799 women with BC, including 1,228 women who were diagnosed with depression. The pooled prevalence of depression among Iranian women with BC was 46.83% (95% CI, 33.77 to 59.88) with significant heterogeneity (I2 =98.5%; p<0.001). The prevalence of depression ranged from 14.00% (95% CI, 4.91 to 23.09) to 95.90% (95% CI, 91.97 to 99.83). The results of the subgroup analyses suggested that the depression assessment tool, year of publication, and study design were sources of heterogeneity.CONCLUSIONS: Our findings indicate a high prevalence of depression among BC patients, underscoring the urgent need for clinicians and health authorities to provide well-defined social and psychological supportive care programs for these patients.

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