scholarly journals Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259861
Author(s):  
Caoimhe Fenton ◽  
Declan M. McLoughlin
Keyword(s):  
Predictive Value ◽  
Rating Scales ◽  
Rating Scale ◽  
Secondary Analysis ◽  
Predictive Ability ◽  
Early Improvement ◽  
Receiver Operating Characteristic Curves ◽  
Predictors Of Response ◽  
Therapeutic Outcomes ◽  
Hamilton Rating Scale

Objectives We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT. Methods This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three ‘full’ versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items. Results The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission. Conclusions Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.

Rating Scales as Predictors of Response to Tricyclic Antidepressants

1976 ◽  
Vol 10 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Graham D. Burrows ◽  
George Foenander ◽  
Brian Davies ◽  
Bruce A. Scoggins
Keyword(s):  
Tricyclic Antidepressants ◽  
Rating Scales ◽  
Rating Scale ◽  
Depressive Illness ◽  
Predictors Of Response ◽  
Significant Difference ◽  
Scale Scores ◽  
Nortriptyline Hydrochloride ◽  
Hamilton Rating Scale ◽  
Predict Treatment Response

Fifty-three patients suffering from depressive illness were classified as ‘responders’ or ‘non-responders’ on the basis of an “amelioration score” of the Hamilton Rating Scale for depression after six weeks treatment with nortriptyline hydrochloride at 150 mgs. daily. A multivariate analysis of variance was performed on the four psychological rating scale scores used, to determine whether rating scales could predict treatment response to tricyclic antidepressants. There was a significant difference between the two groups after adjustment for age. Subjects were then classified as ‘non-responders’ and ‘responders’ on the basis of their discriminant scores. The prediction of response to tricyclic antidepressants was found to be at 75% probability.

Depression in Inpatients: Bipolar vs Unipolar

2003 ◽  
Vol 92 (3) ◽  
pp. 1031-1039 ◽  
Author(s):  
Stella Dorz ◽  
Giuseppe Borgherini ◽  
Donatella Conforti ◽  
Caterina Scarso ◽  
Guido Magni
Keyword(s):  
Social Support ◽  
Major Depression ◽  
Social Adjustment ◽  
Rating Scales ◽  
Rating Scale ◽  
Social Impairment ◽  
Symptom Checklist ◽  
Bipolar Patients ◽  
Hamilton Rating Scale ◽  
Social Adjustment Scale

162 depressed inpatients were divided into three diagnostic groups to compare patterns of sociodemographic characteristics, psychopathology, and psychosocial: 35 had a single episode of major depression, 96 had recurrent major depression, and 31 had a bipolar disorder. Psychopathology and psychosocial functioning were measured by clinician-rated scales, Montgomery-Asberg Depression Rating Scale, Hamilton Rating Scale for Depression, Clinical Global Impression, and self-rating scales, Symptom Checklist-90, Social Support Questionnaire, Social Adjustment Scale. The three groups were comparable on sociodemographic variables, with the exception of education. Univariate analyses showed a similar social impairment as measured by Social Support Questionnaire, Social Adjustment Scale, and no significant differences were recorded for the psychopathology when the total test scores (Montgomery-Asberg Depression Rating Scale, Hamilton Rating Scale for Depression, Clinical Global Index, Symptom Checklist-90) were evaluated. Some differences emerged for single items in the Montgomery-Asberg Depression Rating Scale and Symptom Checklist-90. These findings suggest a substantial similarity among the three groups. Results are discussed in terms of the clinical similarities between unipolar and bipolar patients during a depressive episode as well as the limitations of cross-sectional study implies.

scholarly journals Detection of Depression in Acute Schizophrenia: Sensitivity and Specificity of 2 Standard Observer Rating Scales

2006 ◽  
Vol 51 (6) ◽  
pp. 387-392 ◽  
Author(s):  
Matthias J Müller ◽  
Kay-Maria Müller ◽  
Andreas Fellgiebel
Keyword(s):  
Sensitivity And Specificity ◽  
Rating Scales ◽  
Rating Scale ◽  
Severe Depression ◽  
Receiver Operating Characteristic Curves ◽  
Acute Schizophrenia ◽  
Standard Observer ◽  
Severity Of Depression ◽  
Sum Scores ◽  
Detection Of Depression

Objective: To compare the psychometric properties of the Calgary Depression Rating Scale (CDRS) and the Hamilton Depression Rating Scale (HDRS) for severity assessment of depression in acute schizophrenia. Method: During clinical routine treatment, we investigated 119 inpatients with acute schizophrenia, using the CDRS, the HDRS, and a global 4-point Depression Severity Scale (DEP-SEV). We compared CDRS and HDRS sum scores regarding their diagnostic accuracy, with global severity of depression as the criterion. We estimated sensitivity and specificity on the basis of receiver operating characteristic curves. Results: According to global clinical ratings (DEP-SEV), 31% of patients had no depression, 19% had mild, 31% had moderate, and 19% had severe depression. Sensitivity was significantly higher ( P < 0.05) for the CDRS than for the HDRS to assess mild (0.94 vs 0.76, cut-off 3 vs 10 points) or severe depression (1.00 vs 0.78, cut-off 11 vs 22 points); specificity was comparably high (≥ 0.88) for both scales. Conclusion: Despite the fact that both scales were effective in separating mild, moderate, and severe depression, significant advantages emerged for the CDRS to detect mild or severe depression in schizophrenia.

Umbilical Cord Oxygen Content and Neonatal Morbidity at Term

2017 ◽  
Vol 35 (04) ◽  
pp. 331-335 ◽  
Author(s):  
Lorene Temming ◽  
Molly Stout ◽  
George Macones ◽  
Alison Cahill ◽  
Methodius Tuuli ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Secondary Analysis ◽  
Area Under The Curve ◽  
Predictive Ability ◽  
Neonatal Morbidity ◽  
Meconium Aspiration Syndrome ◽  
Receiver Operating Characteristic Curves ◽  
The Relationship ◽  
Primary Composite Outcome ◽  
Ischemic Encephalopathy

Objective The objective of this study was to investigate the relationship between umbilical cord partial pressure of oxygen (pO2) at delivery and neonatal morbidity. Study Design This is a secondary analysis of a prospective cohort study of term deliveries with universal cord gas collection between 2010 and 2014. The primary composite outcome of neonatal morbidity included neonatal death, meconium aspiration syndrome, intubation, mechanical ventilation, hypoxic-ischemic encephalopathy, and hypothermia treatment. Umbilical artery (UA), vein (UV), UV minus UA (Δ) pO2, and hypoxemia (pO2 ≤ fifth percentile) were compared between patients with and without neonatal morbidity. Areas under the receiver-operating characteristic curves were used to assess the predictive ability of pO2. Results Of 7,789 patients with paired umbilical cord pO2, 106 (1.4%) had the composite neonatal morbidity. UA pO2 was significantly lower in patients with neonatal morbidity compared with those without (median [interquartile range]: 16 (12, 21) vs. 19 (15, 24) mm Hg, p < 0.001). There was no difference in median UV pO2 or ΔpO2 between the groups. UA and UV hypoxemia were significantly more common in patients with neonatal morbidity. UA pO2 had limited predictive ability for neonatal morbidity (area under the curve: 0.61, 95% confidence interval: 0.6–0.7). Conclusion Although UA pO2 is significantly lower in patients with neonatal morbidity, it is a poor predictor of neonatal morbidity at term.

scholarly journals Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania

2004 ◽  
Vol 185 (6) ◽  
pp. 472-478 ◽  
Author(s):  
Robert W. Baker ◽  
Eileen Brown ◽  
Hagop S. Akiskal ◽  
Joseph R. Calabrese ◽  
Terence A. Ketter ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Rating Scale ◽  
Secondary Analysis ◽  
Young Mania ◽  
Double Blind ◽  
Randomised Study ◽  
Score Improvement ◽  
Open Treatment ◽  
Hamilton Rating Scale

BackgroundFew controlled studies examine the treatment of depressive features in mania.AimsTo evaluate the efficacy of olanzapine, in combination with lithium or valproate, for treating depressive symptoms associated with mania.MethodSecondary analysis of a 6-week, double-blind, randomised study of olanzapine (5–20 mg/day) or placebo combined with ongoing valproate or lithium open treatment for 344 patients in mixed or manic episodes. This analysis focused on a dysphoric subgroup with baseline Hamilton Rating Scale for Depression (HRSD) total scores of 20 or over contrasted with non-dysphoric patients.ResultsIn the dysphoric subgroup (n=85) mean HRSD total score improvement was significantly greater in olanzapine co-therapy patients than in those receiving placebo plus lithium or valproate (P<0.001). Substantial contributors to this superiority included the HRSD Maier sub-scale (P=0.013) and the suicide item (P=0.001). Total Young Mania Rating Scale improvement was also superior with olanzapine co-therapy.ConclusionsIn patients with acute dysphoric mania, addition of olanzapine to ongoing lithium or valproate monotherapy significantly improved depressive symptom, mania and suicidality ratings.

Methylphenidate May Treat Apathy Independent of Depression

2005 ◽  
Vol 39 (11) ◽  
pp. 1947-1949 ◽  
Author(s):  
Prasad R Padala ◽  
Frederick Petty ◽  
Subhash C Bhatia
Keyword(s):  
Major Depression ◽  
Treatment Regimen ◽  
Rating Scales ◽  
Rating Scale ◽  
Case Summary ◽  
Long Time ◽  
History Of ◽  
High Degree ◽  
Hamilton Rating Scale

OBJECTIVE To report a case of apathy treated with methylphenidate in which improvement in apathy was independent of improvement of depression. CASE SUMMARY A 47-year-old woman with a 20-year history of recurrent major depression was diagnosed as having significant apathy with lack of initiative and motivation. Over the course of a 4-week treatment regimen with methylphenidate, her apathy, as measured by the Apathy Evaluation Scale, improved, with her score decreasing from 57 to 31. During this period, her depression, as assessed by the 21-item Hamilton Rating Scale for Depression, remained unchanged. DISCUSSION Our report of improvement of apathy with methylphenidate is consistent with other reports in the literature, although previous studies have not specifically used the rating scales to assess apathy. Even though this patient had experienced apathy for a long time, it had not been detected due to lack of direct questioning. In this case, as noted, the improvement of apathy was independent of improvement in depression. CONCLUSIONS A high degree of suspicion and specific inquiry is required for identification of apathy. Once detected, methylphenidate may be beneficial in its treatment, a strategy that may work independently of augmentation of antidepressants.

Semi-structured Depression Scale Sensitive to Change with Treatment for Use in the Elderly

1994 ◽  
Vol 164 (4) ◽  
pp. 522-527 ◽  
Author(s):  
A. V. Ravindran ◽  
K. Welburn ◽  
J. R. M. Copeland
Keyword(s):  
Rating Scales ◽  
Rating Scale ◽  
Antidepressant Treatment ◽  
Depression Scale ◽  
The Elderly ◽  
Structured Interview ◽  
The Core ◽  
New Instrument ◽  
Before And After ◽  
Hamilton Rating Scale

The construction of a semi-structured interview depression scale that is sensitive to change for use in the elderly is described. Depression items from a well validated diagnostic instrument, the Geriatric Mental State Schedule (GMSS), were used as the core items in the development of the instrument. Improvement in depression in 80 elderly patients was independently assessed with two standard rating scales for depression, the Hamilton Rating Scale for Depression and the Beck Depression Inventory, and by an independent clinician's judgement before and after standard antidepressant treatment. Depression items that were sensitive to change were retained from the core items to form the new instrument. Results indicate that this scale is reliable and valid, shows better correlation with both the clinician's and the patient's judgement of improvement than the standard instruments, and is sparing of the rater's time.

Prediction of Successful Rehabilitation by Nurse Rating Scale

1979 ◽  
Vol 134 (4) ◽  
pp. 422-426 ◽  
Author(s):  
Alistair E. Philip
Keyword(s):  
Regression Analysis ◽  
Predictive Value ◽  
Rating Scales ◽  
Rating Scale ◽  
Behaviour Rating ◽  
Successful Rehabilitation

SummaryThe predictive value of the NOSIE, a ward behaviour rating scale, was investigated in a group of long-stay patients. After a follow-up period of 3 ½ years, it was found that all NOSIE scales differentiated continuing in-patients from those discharged. Regression analysis showed that age and florid psychoticism carried most predictive weight. These findings and the value of reliable rating scales for rehabilitation purposes are discussed.

Effects of desvenlafaxine versus placebo on MDD symptom clusters: A pooled analysis

2020 ◽  
Vol 34 (3) ◽  
pp. 280-292 ◽  
Author(s):  
Martin A Katzman ◽  
Xuemei Wang ◽  
Dalia B Wajsbrot ◽  
Matthieu Boucher
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Pooled Analysis ◽  
Symptom Clusters ◽  
Analysis Of Covariance ◽  
Major Depressive ◽  
Double Blind ◽  
Early Improvement ◽  
Hamilton Rating Scale

Background: Major depressive disorder is characterized by the presence of at least five of nine specific symptoms that contribute to clinically significant functional impairment. This analysis examined the effect of desvenlafaxine (50 or 100 mg) versus placebo on symptom cluster scores and the association between early improvement in symptom clusters and symptomatic or functional remission at week 8. Methods: Using data from nine double-blind, placebo-controlled studies of desvenlafaxine for the treatment of major depressive disorder ( N=4317), the effect of desvenlafaxine 50 or 100 mg versus placebo on scores for symptom clusters based on 17-item Hamilton Rating Scale for Depression items was assessed using analysis of covariance. Association between early improvement in symptom clusters (⩾20% improvement from baseline at week 2) and symptomatic and functional remission (17-item Hamilton Rating Scale for Depression total score ⩽7; Sheehan Disability Scale score <7) at week 8 was analyzed using logistic regression. Symptom clusters based on Montgomery–Åsberg Depression Rating Scale were also examined. Results: Desvenlafaxine 50 or 100 mg was associated with significant improvement from baseline compared to placebo for all symptom clusters ( p<0.001), except a sleep cluster for desvenlafaxine 100 mg. For all symptom clusters, early improvement was significantly associated with achievement of symptomatic and functional remission at week 8 for all treatment groups ( p⩽0.0254). Conclusion: Early improvement in symptom clusters significantly predicts symptomatic or functional remission at week 8 in patients with depression receiving desvenlafaxine (50 or 100 mg) or placebo. Importantly, patients without early improvement were less likely to remit.

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