scholarly journals Urinary Osteocalcin as a Marker of Bone Metabolism

2005 ◽  
Vol 51 (3) ◽  
pp. 618-628 ◽  
Author(s):  
Kaisa K Ivaska ◽  
Sanna-Maria Käkönen ◽  
Paul Gerdhem ◽  
Karl J Obrant ◽  
Kim Pettersson ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Elderly Women ◽  
Circadian Variation ◽  
Serum Markers ◽  
Seasonal Effects ◽  
Molecular Forms ◽  
Turnover Rates ◽  
Turnover Markers

Abstract Background: Osteocalcin (OC) is produced by osteoblasts during bone formation, and circulating OC has been used in clinical investigations as a marker of bone metabolism. OC is excreted into urine by glomerular filtration and can be found in urine as midmolecule fragments. Methods: We developed and evaluated three immunoassays (U-MidOC, U-LongOC, and U-TotalOC) for the detection of various molecular forms of urine OC (U-OC). We evaluated the association of U-OC with other markers of bone turnover and with bone mass in 1044 elderly women and studied seasonal and circadian variation of U-OC. Results: U-OC correlated with other bone turnover markers [Spearman correlation (r), 0.30–0.57; P <0.0001], demonstrating the association between U-OC and skeletal metabolism. There was also a significant association between bone metabolism assessed by U-OC quartiles and bone mass assessed by total body bone mineral content (P <0.0001). The seasonal effects appeared to be rather small, but we observed a significant circadian rhythm similar to the one reported for serum OC with high values in the morning and low values in the afternoon. Conclusions: The three immunoassays had unique specificities toward different naturally occurring U-OC fragments. U-OC concentrations measured with any of these assays correlated with bone turnover rates assessed by conventional serum markers of bone metabolism. The measurement of OC in urine samples could be used as an index of bone turnover in monitoring bone metabolism.

Bone Mineral Density and Biochemical Markers of Bone Metabolism in Women Engaging in Recreational Horseback Riding

2016 ◽  
Vol 13 (5) ◽  
pp. 520-524 ◽  
Author(s):  
Agnieszka Kaczmarek ◽  
Alicja Nowak ◽  
Piotr Leszczynski
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Horseback Riding ◽  
Mineral Density ◽  
Turnover Markers

Background:An increased occurrence of lifestyle-related diseases such as osteoporosis indicates the necessity for taking preventive action, including regularly engaging in physical activity. The aim of the study was to assess the areal bone mineral density (aBMD) and bone turnover markers levels in young adult women engaging in recreational horseback riding and to determine the relationship between training characteristics and bone metabolism indices.Methods:The study involved 43 women: 23 equestrians and 20 age- and body mass index–matched controls. The hip and spine aBMD and serum levels of the bone turnover markers: osteocalcin and collagen type I cross-linked C-telopeptide were measured.Results:No significant differences were found in somatic features, concentrations of bone turnover markers, or bone mass variables. Correlation analysis of the equestrian participants showed significant relationship between body mass and BMDL1–L4 (P < .05) as well as between BMI and BMDL1–L4 (P ≤ .01) and z-score L1–L4 (P < .05).Conclusions:The study showed no differences in bone mass and levels of bone metabolic indices between groups of women practicing horseback riding at the recreational level and subjects who do not participate in frequent systematic physical activity. No relationship between training characteristics and bone turnover markers were found.

The changes in bone turnover markers of female systemic lupus erythematousus patients without glucocorticoid

Lupus ◽  
2021 ◽  
Vol 30 (6) ◽  
pp. 965-971
Author(s):  
Wang Tianle ◽  
Zhang Yingying ◽  
Hong Baojian ◽  
Gu Juanfang ◽  
Wang Hongzhi ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Amino Terminal ◽  
Normal People ◽  
Turnover Markers

Objectives SLE is a chronic autoimmune disease, which can affect the level of bone metabolism and increase the risk of osteoporosis and fracture. The purpose of this research is to study the effect of SLE on bone turnover markers without the influence of glucocorticoids. Methods A total of 865 female subjects were recruited from Zhejiang Provincial People’s Hospital and the First Hospital of Jiaxing, including 391 SLE patients without the influence of glucocorticoids and 474 non-SLE people. We detected Bone turnover markers including amino-terminal propeptide of type 1 procollagen (P1NP), C-terminal turnover of β - I collagen (β-CTX), N-terminal midfragment of osteocalcin (NMID) and 25(OH)D, and analyzed the difference in Bone turnover markers between the SLE group and the control group, as well as the influence of age and season on bone metabolism in female SLE patients. Results In the SLE group, the average age was 43.93±13.95 years old. In the control group, the average age was 44.84±11.42 years old. There was no difference between the two groups (t = 1.03, P = 0.30). P1NP, NMID and 25(OH)D in the SLE group were significantly lower than those in the control group (Z = 8.44, p < 0.001; Z = 14.41, p < 0.001; Z = 2.19, p = 0.029), and β-CTX in the SLE group was significantly higher than that in the control group (Z = 2.61, p = 0.009). In addition, the levers of β-CTX, NMID, P1NP and 25(OH)D in older SLE female patients were statistically significantly higher than those in younger (ρ = 0.104, p = 0.041; ρ = 0.223, p < 0.001; ρ = 0.105, p = 0.038; ρ = 0.289, p < 0.001). Moreover, β-CTX reached a high value in summer and PINP reached a low value in winter. Conclusion The bone formation markers of female SLE patients without glucocorticoid were lower than those of normal people and the bone resorption marker was higher than that of normal people. The 25 (OH) D of female SLE patients without glucocorticoid was lower than that of normal people. The risk of osteoporosis and fracture may be higher in elderly women with SLE. The bone resorption level of female SLE patients is high in summer and the bone formation level is low in winter.

scholarly journals Diurnal Rhythms of Bone Turnover Markers in Three Ethnic Groups

2016 ◽  
Vol 101 (8) ◽  
pp. 3222-3230 ◽  
Author(s):  
Jean Redmond ◽  
Anthony J. Fulford ◽  
Landing Jarjou ◽  
Bo Zhou ◽  
Ann Prentice ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Ethnic Groups ◽  
Bone Turnover Markers ◽  
Type I Collagen ◽  
Diurnal Rhythms ◽  
Type I ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Turnover Markers

Context: Ethnic groups differ in fragility fracture risk and bone metabolism. Differences in diurnal rhythms (DRs) of bone turnover and PTH may play a role. Objective: We investigated the DRs of plasma bone turnover markers (BTMs), PTH, and 1,25(OH)2D in three groups with pronounced differences in bone metabolism and plasma PTH. Participants: Healthy Gambian, Chinese, and white British adults (ages 60–75 years; 30 per country). Interventions: Observational study with sample collection every 4 hours for 24 hours. Main Outcomes: Levels of plasma C-terminal telopeptide of type I collagen, procollagen type-1 N-propeptide, N-mid osteocalcin, bone alkaline phosphatase, PTH, and 1,25-dihydroxyvitamin D were measured. DRs were analyzed with random-effects Fourier regression and cross-correlation and regression analyses to assess associations between DRs and fasting and 24-hour means of BTMs and PTH. Results: Concentrations of BTMs, PTH, and 1,25-dihydroxyvitamin D were higher in Gambians compared to other groups (P &lt; .05). The DRs were significant for all variables and groups (P &lt; .03) and were unimodal, with a nocturnal peak and a daytime nadir for BTMs, whereas PTH had two peaks. The DRs of BTMs and PTH were significantly cross-correlated for all groups (P &lt; .05). There was a significant positive association between C-terminal telopeptide of type I collagen and PTH in the British and Gambian groups (P = .03), but not the Chinese group. Conclusions: Despite ethnic differences in plasma BTMs and PTH, DRs were similar. This indicates that alteration of rhythmicity and loss of coupling of bone resorption and formation associated with an elevated PTH in other studies may not uniformly occur across different populations and needs to be considered in the interpretation of PTH as a risk factor of increased bone loss.

Bone Metabolism, Bone Mineral Content, and Density in Elite Late Teen Female Sprinters

2021 ◽  
Author(s):  
Yuka Tsukahara ◽  
Suguru Torii ◽  
Fumihiro Yamasawa ◽  
Jun Iwamoto ◽  
Takanobu Otsuka ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Mineral Content ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Content ◽  
Whole Body ◽  
Tartrate Resistant Acid Phosphatase ◽  
Intensive Training ◽  
Turnover Markers

AbstractWith intensive training, bone injuries are a major concern for athletes. To assess bone condition, we often measure bone turnover markers, bone mineral content and density; however, in junior athletes, it is not easy to distinguish changes caused by bone injuries from those caused by growth, because the metabolism is increased in both cases. Moreover, although some studies have examined female endurance athletes, knowledge regarding changes in static and dynamic bone conditions in late teen athletes is limited. In this study, we measured the bone mineral content and density, as well as bone turnover markers, in 40 elite female sprinters in their late teens. Whole body mode dual-energy X-ray absorptiometry was performed to measure bone mineral content and density. Blood samples were collected to determine bone resorption and formation markers at the end of track season in 2016 and during the same period of the following year. Body weight and bone mineral content significantly increased, and tartrate-resistant acid phosphatase type 5b, bone-type alkaline phosphatase, and osteocalcin significantly decreased after a year. Furthermore, the rate of change in bone mineral content was higher in younger athletes, indicating that bone growth approaches completion in the late teen years and that bone metabolism accordingly decreases.

Sex Steroids, Bone Mass and Bone Turnover Markers in Asian Indians

2014 ◽  
Vol 17 (3) ◽  
pp. 413
Author(s):  
M.P. Desai ◽  
K. Venkat ◽  
K. V. Bhanu Prakash ◽  
M. Khatkhatay
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Sex Steroids ◽  
Bone Turnover Markers ◽  
Asian Indians ◽  
Turnover Markers

Relationship Among VDR (BsmI and FokI), COLIA1, and CTR Polymorphisms with Bone Mass, Bone Turnover Markers, and Sex Hormones in Men

2002 ◽  
Vol 70 (6) ◽  
pp. 457-462 ◽  
Author(s):  
V. Braga ◽  
A. Sangalli ◽  
G. Malerba ◽  
M. Mottes ◽  
S. Mirandola ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Sex Hormones ◽  
Bone Turnover Markers ◽  
Turnover Markers

Low Bone Mass in Thalassemia: The Thalassemia Clinical Research Network (TCRN) Experience.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3613-3613
Author(s):  
Maria G. Vogiatzi ◽  
Joseph Lane ◽  
Martin Fleisher ◽  
Eric A. Macklin ◽  
Ellen B. Fung ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Bone Disease ◽  
Bone Turnover Markers ◽  
Research Network ◽  
Dietary Calcium Intake ◽  
Low Bone Mass ◽  
Mineral Density ◽  
T Score ◽  
Turnover Markers

Abstract Low bone mass is emerging as a frequent and debilitating morbidity in Thalassemia (thal). The TCRN conducted a cross-sectional observational study to determine the prevalence and factors contributing to bone disease among North American thal patients (pts). Spinal (L1-L4) Bone Mineral Density (BMD) Z- and T-score measurements by DXA (Hologic 4500 and Delphi models) were read centrally. Each subject’s weight, height, hematologic, endocrine and genetic parameters, iron chelation and transfusion regimens, dietary calcium intake, history of fractures and bone pain, self-reported physical activity and bone turnover markers were assessed. BMD was measured in 302 pts: 207 Thal Major (TM), 37 Thal Intermedia (TI), 35 Beta E, 7 Hemoglobin H disease (HbH), 2 homozygous alpha (α) and 14 HbH/Constant Spring (HbH/CS). Among all diagnostic groups, the prevalence of low bone mass (LBM; Z/T <-2), reduced bone mass (RBM; Z/T -2 to -1) and normal bone mass (NBM; Z/T >-1) was 52%, 27% and 21%, respectively. LBM prevalence was 55% in TM, 53% in TI, 51% in Beta E, 0% in HbH, 50% in α and 43% in HbH/CS. RBM prevalence was 26% in TM, 22% in TI, 31% in Beta E, 71% in HbH, 50% in α and 29% in HbH/CS. Pt groups aged: 6–11 yrs, 11–20 yrs, 20+ yrs had Z/T-scores mean±SD[n] were: −1.32±0.82[51], −1.73±1.08[77] and −2.43±1.14[174], respectively. Z/T-scores were significantly lower among older pts (p<.001) and significantly higher among heavier pts after controlling for Tanner stage. Mean age-adjusted Z/T-scores of thal diagnostic groups and their slopes vs. age did not differ significantly although the samples of some groups were small. Among TM and TI pts, those with genotype β°/β° tended to have lower age- and weight-adjusted Z/T-scores (mean [95% CI]: −2.25 [−2.65 to −1.86], n=39). Less than 1% had hypoparathyroidism, 4% vit D deficiency, 8.5% diabetes mellitus, 8.5% hypothyroidism and 11.5% growth hormone deficiency (GHD). Only GHD was significantly correlated with decreased Z/T-scores after controlling for age and diagnosis. Urinary N-telopeptide (NTx) is elevated across all three age groups (median[IQR] mM BCE/mM creatinine: 664[456–930], 302[90–624], 69[34–124]), respectively. Preliminary analysis of bone turnover markers in a subset of subjects (n=114) suggests that NTx, urinary or serum was a significant independent predictor of spine Z/T-scores controlled for age and age-adjusted weight. There was no relationship between Z/T-score and serum osteocalcin. This large and comprehensive study of thal bone disease has demonstrated that decreased bone mass occurs with high frequency, worsens with age, is affected by weight and GHD and is associated with elevated NTx, i.e. increased bone resorption. Future studies are needed to identify efficacious long-term therapies to improve thal bone disease.

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