scholarly journals PRIMARY PREVENTION OF DEMENTIA: THE FUTURE OF POPULATION-BASED MULTIDOMAIN LIFESTYLE INTERVENTIONS

2017 ◽  
pp. 1-3
Author(s):  
Y. Lee
Keyword(s):  
Risk Factors ◽  
Physical Inactivity ◽  
Health Impact ◽  
Population Based ◽  
Preventive Strategies ◽  
Dementia Prevalence ◽  
Dementia Prevention ◽  
Low Education ◽  
Disease Modifying ◽  
Potential Public Health

Dementia affects 46.8 million of the world’s population, and is projected to increase to 131.5 million by 2050 (1). Increasingly, with no available disease-modifying drug or cure for the disease, preventive strategies are being pursued to curb the worldwide epidemic. Accumulating evidence supports the importance of dementia prevention, with seven risk factors (diabetes mellitus, midlife obesity, midlife hypertension, physical inactivity, depression, smoking, and low education) estimated to contribute to 9.6 million cases, equivalent to a third of Alzheimer’s disease worldwide (2). The potential public health impact of prevention is huge as a 20% reduction per decade from 2010 in the prevalence of these risk factors would translate to a 16.3% (1.5 million) reduction in dementia prevalence by 2050.

scholarly journals A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2025
Author(s):  
Tomasz Sawicki ◽  
Monika Ruszkowska ◽  
Anna Danielewicz ◽  
Ewa Niedźwiedzka ◽  
Tomasz Arłukowicz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Physical Inactivity ◽  
Ecological Factors ◽  
Population Based ◽  
Review Article ◽  
Therapeutic Interventions ◽  
Factors Associated ◽  
Hereditary Factors ◽  
Disease Stages

This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity, smoking and alcohol consumption can also be addressed through therapeutic interventions. We also made efforts to systematize available literature and data on epidemiology, diagnosis, type and nature of symptoms and disease stages. Further study of colorectal cancer and progress made globally is crucial to inform future strategies in controlling the disease’s burden through population-based preventative initiatives.

scholarly journals Cluster analysis of risk factors for chronic non-communicable diseases in elderly Brazilians: population-based cross-sectional studies in a rural town

2021 ◽  
Vol 10 (17) ◽  
pp. e18101724202
Author(s):  
Saulo Vasconcelos Rocha ◽  
Sabrina Correia de Oliveira ◽  
Hector Luiz Rodrigues Munaro ◽  
Camila Fabiana Rossi Squarcini ◽  
Bruna Maria Palotino Ferreira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Physical Inactivity ◽  
Economic Status ◽  
The Elderly ◽  
Tobacco Consumption ◽  
Population Based ◽  
Communicable Diseases ◽  
Cross Sectional ◽  
Non Communicable Diseases ◽  
Sociodemographic Variables

Negative health behaviors incorporated into lifestyle are considered the main risk factors for chronic non-communicable diseases (NCDs) in adults and the elderly. However, the relationship between the aggregation of these factors and the sociodemographic conditions of the elderly needs to be better elucidated. The aim of this study was to analyze the simultaneity of the five risk factors for NCDs in the elderly with low economic status living in a rural city in Brazil, and their association with sociodemographic variables. Cross-sectional study was conducted with elderly people from Family Health Units of the city of Ibicui-Bahia, Brazil, where 310 elderly were enrolled. Rates of physical inactivity in leisure (PIL), alcohol consumption, sedentary behavior, overweight/obesity and tobacco consumption were collected through a questionnaire in an individual interview. The average age among participants was 71.62 (± 8.16) years. The group presenting the five behaviors had high scores in both sexes (men O/E = 242.5; women O/E = 161.7). Among men and women, the highest scores found through clustering of simultaneous NCD risk factors were for the consumption of alcohol with smoking, and physical inactivity with smoking. When analyzing the association between groups and sociodemographic characteristics, men were more physically inactive than women (OR = 0.96, CI = 0.92-0.98) and concomitantly had unhealthy habits (smoking). In conclusion, the elderly are exposed to health risk factors for concurrent CNCDs and the accumulation of these risk factors was not associated with sociodemographic variables, it is suggested that further studies be carried out with the prevalent variables as well as to analyze why the elderly population presents these levels.

scholarly journals Stroke incidence and association with risk factors in women: a 32-year follow-up of the Prospective Population Study of Women in Gothenburg

BMJ Open ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. e005173 ◽  
Author(s):  
Ann Blomstrand ◽  
Christian Blomstrand ◽  
Nashmil Ariai ◽  
Calle Bengtsson ◽  
Cecilia Björkelund
Keyword(s):  
Risk Factors ◽  
Population Study ◽  
Physical Inactivity ◽  
Stroke Risk ◽  
Diastolic Pressure ◽  
Incidence Rates ◽  
Stroke Incidence ◽  
Increased Risk ◽  
Low Education ◽  
High Bmi

ObjectiveTo study stroke incidence among women over 32 years of age with a focus on subdividing by stroke type, to consolidate end points and associations with risk factors.DesignProspective population study initiated in 1968–1969 with follow-ups in 1974, 1980, 1992 and 2001.SettingGothenburg, Sweden.ParticipantsA sample of 1462 women from five age strata examined in 1968–1969, representative of women in the general population.Main outcome measuresMain types of first-ever stroke and fatal stroke during 1968–2001 identified and validated. Stroke incidence rates in different age strata. Association with baseline smoking, body mass index (BMI), waist–hip ratio, hypertension, serum lipids, physical inactivity, perceived mental stress and education. Associations with atrial fibrillation (AF), diabetes, baseline hypertension and myocardial infarction (MI). Blood pressure (BP) levels 1–3, corresponding to modern guidelines, in relation to stroke risk.Results184 (12.6%) cases of first-ever stroke, 33 (18%) of them fatal. Validation reduced unspecified stroke diagnoses from 37% to 11%. Age-standardised incidence rate per 100 000 person-years was 448. A multivariate model showed a significant association between ischaemic stroke and high BMI: HR 1.07 (95% CI 1.02 to 1.12), smoking 1.78 (1.23 to 2.57) and low education 1.17 (1.01 to 1.35). Significant association was seen between haemorrhagic stroke and, besides age, physical inactivity 2.18 (1.04 to 4.58) and for total stroke also hypertension 1.45 (1.02 to 2.08). Survival analysis showed a significantly increased risk of stroke in participants with diabetes (p<0.001), AF (p<0.001) and hypertension (p=0.001), but not MI. Stroke risk increased with increasing BP levels but was already seen for diastolic pressure grade 1 and particularly when combined with systolic BP grade 1; 1.62 (1.17 to 2.25).ConclusionsHypertension, smoking, AF, diabetes and high BMI were associated with increased stroke risk. Low education was associated with stroke. Validation of National Patient Registry diagnoses to increase specified diagnoses improved data quality.

scholarly journals Prevalence and determinants of the metabolic syndrome among Tunisian adults: results of the Transition and Health Impact in North Africa (TAHINA) project

2012 ◽  
Vol 16 (4) ◽  
pp. 582-590 ◽  
Author(s):  
Hanen Belfki ◽  
Samir Ben Ali ◽  
Hajer Aounallah-Skhiri ◽  
Pierre Traissac ◽  
Souha Bougatef ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
North Africa ◽  
Health Impact ◽  
Population Based ◽  
Cross Sectional Study ◽  
Intervention Programme ◽  
Cvd Risk ◽  
Cross Sectional ◽  
The Metabolic Syndrome

AbstractObjectiveTo determine the prevalence of metabolic syndrome (MetS) and its components and to evaluate the relationship between this diagnosis and cardiovascular risk factors, demographic and socio-economic variables.DesignA cross-sectional study using a questionnaire including information on sociodemographic and CVD risk factors. Blood pressure, anthropometric indices, fasting glucose and lipid profile were measured. MetS was defined according to the criteria of the National Cholesterol Education Program, Adult Treatment Panel III.SettingThe whole Tunisian territory; Transition and Health Impact in North Africa (TAHINA) project.SubjectsA total of 4654 individuals (1840 men and 2814 women), aged 35 to 74 years, who participated in the Tunisian national survey.ResultsThe overall prevalence of MetS was 30·0 %, higher in women (36·1 %) than in men (20·6 %; P < 0·001). In both genders MetS prevalence increased significantly with age (P < 0·001), but this increase was more important in women. Multiple regression analyses showed that the odds for MetS increased significantly with urban area for both men and women (P < 0·05 and P < 0·001, respectively). The multivariate models showed also that the odds for MetS increased significantly with increasing level of education and in those with a family history of CVD for men (both P < 0·05) and after the menopausal transition for women (P < 0·05).ConclusionsThe study highlights the MetS problem in a middle-income developing country. There is an urgent need for a comprehensive, integrated, population-based intervention programme to ameliorate the growing problem of MetS in Tunisians.

scholarly journals The Effect of Sex and Wealth on Population Attributable Risk Factors for Dementia in South Africa

2021 ◽  
Vol 12 ◽  
Author(s):  
Kirsten Bobrow ◽  
Tina Hoang ◽  
Deborah E. Barnes ◽  
Raquel C. Gardner ◽  
Isabel E. Allen ◽  
...  
Keyword(s):  
Risk Factors ◽  
South Africa ◽  
Risk Factor ◽  
Social Determinants Of Health ◽  
Social Isolation ◽  
Social Determinants ◽  
Physical Inactivity ◽  
Modifiable Risk Factors ◽  
Dementia Risk ◽  
Low Education

Background and Aims: South Africa is a middle-income country with high levels of income inequality and a rapidly aging population and increasing dementia prevalence. Little is known about which risk factors for dementia are important and how they differ by social determinants of health as well as key demographic characteristics such as sex and wealth. We sought to calculate the population attributable risks (PARs) for established potentially modifiable risk factors for dementia among these different groups.Methods: We obtained risk factor prevalence from population-based surveys for established dementia risk factors (diabetes, midlife hypertension, midlife obesity, physical inactivity, depression, smoking, low educational attainment, social isolation). We used relative risk estimates reported in previous meta-analyses and estimated PARs using Levin's formula and accounting for communality. We tested for one-way and two-way interactions by sex and wealth using Pearson's χ2. In stratified analyses, we performed tests for trend using logistic regression.Results: The prevalence of established risk factors for dementia ranged from 5% for depression to 64% for low education. After accounting for communality, the risk factors contributing the greatest PAR were low education (weighted PAR 12%, 95% CI 7% to 18%), physical inactivity (9, 5–14%), and midlife hypertension (6, 5–14%). Together, 45% of dementia cases may be attributable to modifiable risk factors (95% CI 25–59%). We found significant interactions (p &lt; 0.005) between sex, wealth, or both (sex * wealth) and each risk factor except social isolation and physical activity. Low education was inversely associated with wealth in both male and female. The PAR for midlife hypertension, obesity, and diabetes was associated with increasing wealth, and was higher in female. In contrast, the PAR for smoking was higher in male (8% vs. 2%) and was associated with increasing wealth among female only. We found that either a strategy of large reductions in selected risk factors with the highest PAR (midlife hypertension, smoking, physical inactivity) or small reductions across all risk factors could potentially reduce dementia cases by as many as 250,000 by 2050.Discussions: The potential impact on dementia risk by decreasing exposure to established dementia risk factors is large and differs by sex and social determinants of health like wealth. Risk factor PAR should inform national and local health policy dementia initiatives in South Africa including which risk factors to target in the whole population and which to target in high-risk groups for maximum public health benefit.

scholarly journals Socioeconomic Impact on the Prevalence of Cardiovascular Risk Factors in Wallonia, Belgium: A Population-Based Study

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Sylvie Streel ◽  
Anne-Françoise Donneau ◽  
Axelle Hoge ◽  
Sven Majerus ◽  
Philippe Kolh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Abdominal Obesity ◽  
Physical Inactivity ◽  
Adult Population ◽  
Risk Groups ◽  
Population Based ◽  
Current Smoking ◽  
Specific Risk

Background. Monitoring the epidemiology of cardiovascular risk factors (CRFs) and their determinants is important to develop appropriate recommendations to prevent cardiovascular diseases in specific risk groups. The NESCaV study was designed to collect standardized data to estimate the prevalence of CRFs in relation to socioeconomic parameters among the general adult population in the province of Liège, Wallonia, Belgium.Methods. A representative stratified random sample of 1017 subjects, aged 20–69 years, participated in the NESCaV study (2010–2012). A self-administered questionnaire, a clinical examination, and laboratory tests were performed on participants. CRFs included hypertension, dyslipidemia, global obesity, abdominal obesity, diabetes, current smoking, and physical inactivity. Covariates were education and subjective and objective socioeconomic levels. Data were analyzed by weighted logistic regression.Results. The prevalence of hypertension, abdominal obesity, global obesity, current smoking, and physical inactivity was higher in subjects with low education and who considered themselves “financially in need.” Living below poverty threshold also increased the risk of global and abdominal obesity, current smoking, and physical inactivity.Conclusion. The study shows that socioeconomic factors impact the prevalence of CRFs in the adult population of Wallonia. Current public health policies should be adjusted to reduce health inequalities in specific risk groups.

scholarly journals Risk factors for chronic non-communicable diseases and the CARMEN Initiative: a population-based study in the South of Brazil

2008 ◽  
Vol 24 (12) ◽  
pp. 2767-2774 ◽  
Author(s):  
Marcelo Fernandes Capilheira ◽  
Iná S. Santos ◽  
Mario Renato Azevedo Jr. ◽  
Felipe Fossati Reichert
Keyword(s):  
Risk Factors ◽  
Physical Inactivity ◽  
Population Based ◽  
Communicable Diseases ◽  
Excess Weight ◽  
The South ◽  
Population Based Study ◽  
Non Communicable Diseases ◽  
South Of Brazil ◽  
Health Organization

The CARMEN Initiative is a strategy of the Pan American Health Organization and the World Health Organization that proposes population-based interventions to reduce risk factors for chronic non-communicable diseases (CNCD) by approaching them simultaneously. The present study aims to provide a baseline for further interventions by the CARMEN Initiative based on a cross-sectional population-based study of 3,100 adults (>20 years old) in Pelotas, a city in the South of Brazil. Prevalence of smoking, physical inactivity, diabetes mellitus, hypertension, and excess weight were studied and presented separately and aggregated in various combinations. The most frequent risk factor was physical inactivity (73.2%), followed by excess weight (48.1%). Women were less active and thinner than men. More than half of the sample showed two or three risk factors (53.4%). The combination of physical inactivity and excess weight was observed in 34.7% of the sample, while 10.8% presented physical inactivity, excess weight, and hypertension concurrently. The accumulation of risk factors for CNCD is frequent in the study population and the identification of the most common combinations is essential for planning future interventions.

Exercise and dementia prevention

2020 ◽  
Vol 20 (3) ◽  
pp. 234-240 ◽  
Author(s):  
Jane Alty ◽  
Maree Farrow ◽  
Katherine Lawler
Keyword(s):  
Risk Factors ◽  
Physical Inactivity ◽  
Lifestyle Changes ◽  
Current Evidence ◽  
Prevention Strategies ◽  
Neuroprotective Drugs ◽  
Age Related ◽  
Dementia Risk ◽  
Dementia Prevention ◽  
Age Related Cognitive Decline

Ageing, genetic, medical and lifestyle factors contribute to the risk of Alzheimer’s disease and other dementias. Around a third of dementia cases are attributable to modifiable risk factors such as physical inactivity, smoking and hypertension. With the rising prevalence and lack of neuroprotective drugs, there is renewed focus on dementia prevention strategies across the lifespan. Neurologists encounter many people with risk factors for dementia and are frequently asked whether lifestyle changes may help. Exercise has emerged as a key intervention for influencing cognition positively, including reducing the risk of age-related cognitive decline and dementia. This article focuses on the current evidence for physical inactivity as a modifiable dementia risk factor and aims to support neurologists when discussing risk reduction.

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