scholarly journals Comparisons of survival outcomes of T2 intracholecystic papillary neoplasm of the gallbladder according to the surgical extent: Simple cholecystectomy vs. extended cholecystectomy

2021 ◽  
Vol 25 (1) ◽  
pp. S169-S169
Author(s):  
Jae Seung KANG ◽  
Yoo Jin CHOI ◽  
Hee Ju SOHN ◽  
Jung Min LEE ◽  
Youngmin HAN ◽  
...  
Keyword(s):  
Survival Outcomes ◽  
Simple Cholecystectomy ◽  
Extended Cholecystectomy ◽  
Papillary Neoplasm ◽  
Surgical Extent

scholarly journals Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (15) ◽  
pp. 3317
Author(s):  
Hyun Kang ◽  
Yoo Shin Choi ◽  
Suk-Won Suh ◽  
Geunjoo Choi ◽  
Jae Hyuk Do ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Large Scale ◽  
Treatment Guidelines ◽  
Prognostic Significance ◽  
Tumor Location ◽  
Cochrane Library ◽  
Poor Prognostic Factor ◽  
Simple Cholecystectomy ◽  
Survival Difference ◽  
Extended Cholecystectomy

(1) Background: The AJCC Cancer Staging Manual, Eighth Edition, subdivided T2 GBC into T2a and T2b. However, there still exist a lack of evidence on the prognostic significance of tumor location. The aim of the present study was to examine the existing evidence to determine the prognostic significance of tumor location of T2 gallbladder cancer (GBC) and to evaluate the optimal surgical extent according to tumor location. (2) Methods: We searched for relevant literature published in the electronic databases PubMed, MEDLINE, Web of Science, Cochrane Library, and Embase before September 2020 using search terms related to gallbladder, cancer, and stage. Data were weighted and pooled using random-effects modeling. (3) Results: Seven studies were deemed eligible for inclusion, representing a cohort of 1789 cases of resected T2 GBC. The overall survival for T2b tumor was significantly worse than that for T2a tumor (HR, 2.141; 95% confidence interval (CI), 1.140 to 4.023; I2 = 71.4%; Pchi2 = 0.007). The rate of lymph node metastasis was lower in the T2a group (26.6%) than in the T2b group (36.6%) (OR, 2.164; 95% CI, 1.309 to 3.575). There was no evidence of a survival difference between the patients who underwent extended cholecystectomy and simple cholecystectomy in T2a GBC (OR, 0.802; 95% CI, 0.618 to 1.042) and T2b GBC (OR, 0.820; 95% CI, 0.620 to 1.083). (4) Conclusions: Hepatic side tumor was a significant poor prognostic factor in T2 GBC. Extended cholecystectomy and simple cholecystectomy showed comparable survival outcomes in T2 GBC, and additional large-scale prospective studies are warranted to establish evidence-based treatment guidelines for T2 GBC.

Early Gallbladder Carcinoma: A Single-Center Experience

2006 ◽  
Vol 92 (6) ◽  
pp. 487-490 ◽  
Author(s):  
Vincenzo Cangemi ◽  
Enrico Fiori ◽  
Cristina Picchi ◽  
Alessandro De Cesare ◽  
Roberto Cangemi ◽  
...  
Keyword(s):  
Gallbladder Carcinoma ◽  
Tnm Classification ◽  
Muscularis Propria ◽  
Surgical Approaches ◽  
Term Survival ◽  
Simple Cholecystectomy ◽  
Single Center Experience ◽  
Appropriate Treatment ◽  
Extended Cholecystectomy

Aims and background Controversy continues regarding the best surgical treatment for early gallbladder carcinoma defined as a tumor confined to the mucosa (pT1a) or to the muscularis propria (pT1 b) according to the TNM classification. This study evaluates the effectiveness of different surgical approaches in patients with early gallbladder carcinoma in terms of long-term survival. Materials and methods From 1980 to 2001, 175 patients with gallbladder carcinoma were admitted to our department. Fifteen of them underwent resections for early gallbladder carcinoma: 4 patients for pT1a tumors and 11 patients for pT1b tumors. All patients with pT1a tumors and 8 patients with pT1b tumors underwent simple cholecystectomy. The remaining 3 patients with pT1 b tumors underwent extended cholecystectomy. Results The 5-10 year cumulative survival rate was 100% for patients with pT1a tumors, 37.5% for patients with pT1b tumors who underwent simple cholecystectomy, and 100% for patients with pT1b tumors who underwent extended cholecystectomy. Conclusions Simple cholecystectomy is the appropriate treatment for patients with pT1a tumors, whereas patients with pT1b tumors require an extended cholecystectomy.

scholarly journals Survival Benefits of Simple Versus Extended Cholecystectomy and Lymphadenectomy for Patients With T2 Gallbladder Cancer: A Propensity-Matched Population-Based Study (2010 to 2015)

2021 ◽  
Vol 11 ◽  
Author(s):  
Wei Zhang ◽  
Zhangkan Huang ◽  
Wen-er Wang ◽  
Xu Che
Keyword(s):  
Overall Survival ◽  
Propensity Score ◽  
Gallbladder Cancer ◽  
Propensity Score Matching ◽  
Survival Benefit ◽  
Confounding Factors ◽  
Simple Cholecystectomy ◽  
Regional Lymphadenectomy ◽  
Extended Cholecystectomy ◽  
Significant Survival

ObjectiveThis article aims to evaluate the survival benefits of simple cholecystectomy, extended cholecystectomy, as well as scope regional lymphadenectomy for T2 gallbladder cancer (GBC) patients.MethodsWe identified eligible patients from the Surveillance, Epidemiology, and End Results database. The confounding factors were controlled via propensity score matching. The log-rank test was utilized to compare overall survival. The multivariate Cox regression was then used to determine risk factors.ResultsOverall, data from 1,009 patients were obtained. The median overall survival (OS) of 915 patients that underwent simple cholecystectomy was 15 months; the median OS of 94 patients that underwent extended cholecystectomy was 17 months. There were no significant differences before and after propensity score matching (p = 0.542 and p = 0.258). The patients who received regional lymphadenectomy did show significant survival benefit, compared to those who did not receive regional lymphadenectomy. Furthermore, this benefit is observed in the N0 stage, but not observed in the N1 stage. In addition, the OS of patients who received lymphadenectomy for four or more regions was significantly better than those who received one to three regions lymphadenectomy. Age, the scope of regional lymphadenectomy, N stage, and tumor size were identified as prognostic factors.ConclusionsExtended cholecystectomy was not observed to significantly improve postoperative prognosis of patients with T2 GBC. However, there was a significant survival benefit shown for those with regional lymphadenectomy, particularly for patients with negative lymph nodes. Future studies on the control of potential confounding factors and longer follow-ups are still needed.

Intracystic Papillary Neoplasm of Gall Bladder: A Case Report

2019 ◽  
Vol 3 (1) ◽  
pp. 64-66
Author(s):  
Dipendra Kumar Mallik ◽  
Suman Khanal ◽  
Sunil Dhakal ◽  
Roshan Mishra ◽  
Ishan Dhungana ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Tumor Cells ◽  
Metastatic Carcinoma ◽  
Prior History ◽  
R0 Resection ◽  
Bladder Mucosa ◽  
Extended Cholecystectomy ◽  
History Of ◽  
Papillary Neoplasm ◽  
Papillary Growth

Intracystic papillary neoplasm of gallbladder (ICPNG) is defined as macroscopic papillary growth in the gallbladder. We report a case of ICPNG with epigastric metastasis. A 70-year-old woman was referred to our hospital with epigastric mass, with prior history of laproscopic cholecystectomy 15 months before. Post op histopathology report revealed Intracystic papillary neoplasm (premalignant lesion). Microscopic findings state tumor cells arranged in complex papillary pattern with fibrovascular core arising from gall bladder mucosa. Few of the Rokitansky Aschoff sinuses (RAS) also involved by these tumor cells. Adjacent gall bladder mucosa shows pyloric metaplasia. On FNAC of epigastric mass it showed Metastatic carcinoma favoring Adenocarcinoma. In present case, ICPNG was seen with few of Rokitansky Aschoff sinuses. It is necessary to determine appropriate proper surgical approach likely extended cholecystectomy, or pancreaticoduodenectomy to get R0 resection.

scholarly journals A Case of Intracystic Papillary Neoplasm With an Associated Invasive Adenocarcinoma

2017 ◽  
Vol 102 (5-6) ◽  
pp. 267-271 ◽  
Author(s):  
Takayuki Shimizu ◽  
Keiichi Kubota ◽  
Takayuki Shiraki ◽  
Yuhki Sakuraoka ◽  
Takatsugu Matsumoto ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Serosal Invasion ◽  
Invasive Adenocarcinoma ◽  
Abdominal Ultrasonography ◽  
D2 Lymph Node Dissection ◽  
Positron Emission ◽  
Extended Cholecystectomy ◽  
Papillary Neoplasm

Intracystic papillary neoplasm (ICPN) is a preinvasive neoplasm of the gallbladder. Preoperative discrimination between ICPN and gallbladder cancer (GC) is difficult. The standard surgical strategy for ICPN has not yet been established. Herein, we report a case of ICPN with an associated invasive adenocarcinoma. A gallbladder tumor was detected by abdominal ultrasonography in an asymptomatic 69-year-old man, and he was referred to our hospital. Although computed tomography (CT), endoscopic ultrasonography, and magnetic resonance imaging findings in the present case were similar to those for GC, positron emission tomography-CT revealed that fluorodeoxyglucose (FDG) did not accumulate within the tumor. These imaging features suggested that patient was suspected to have GC with serosal invasion, and he underwent extended cholecystectomy and D2 lymph node dissection. He did not develop any postoperative complications, and he was discharged on postoperative day 7. There was no evidence of recurrence for 20 months after surgery. Histopathologic examination confirmed ICPN with an associated invasive adenocarcinoma. Because a previous study reported that almost half of ICPNs more than 1.0 cm in size often developed invasive cancer as our case, ICPNs more than 1.0 cm should be suspected of developing invasive carcinoma regardless of positive or negative accumulation of FDG.

Su1490 CHARACTERIZATION OF PANCREATIC INTRADUCTAL PAPILLARY NEOPLASM-DERIVED CANCER, MUCINOUS CYSTIC NEOPLASM-DERIVED CANCER, AND ADENOCARCINOMA: NATIONAL SURVIVAL OUTCOMES DATA

2020 ◽  
Vol 158 (6) ◽  
pp. S-600-S-601
Author(s):  
Daryl Ramai ◽  
Mohamed Barakat ◽  
Amaninder J. Dhaliwal ◽  
Mohamed M. Abdelfatah
Keyword(s):  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Survival Outcomes ◽  
Intraductal Papillary Neoplasm ◽  
National Survival ◽  
Papillary Neoplasm

Is more surgery better for patients with gallbladder cancer? A survival analysis of extended versus simple cholecystectomy.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15615-e15615
Author(s):  
Christos Fountzilas ◽  
Marcela Mazo- Canola ◽  
Brian Hernandez ◽  
Michelle Janania Martinez ◽  
Ruchi Hamal ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Retrospective Analysis ◽  
Small Sample Size ◽  
Small Sample ◽  
Single Institution ◽  
Free Survival ◽  
Entire Cohort ◽  
Simple Cholecystectomy ◽  
Kaplan Meier ◽  
Extended Cholecystectomy

e15615 Background: Gallbladder cancer (GBC) is a rare cancer; the minority of patients have resectable tumor at diagnosis. Based on retrospective, single-institution data, extended cholecystectomy (EXT) has been recommended over simple cholecystectomy (CHOL) in >T1 tumors; however, effect of EXT on survival is unclear. Thus, we evaluated the survival of patients with resectable GBC at our institution. Methods: Retrospective analysis from 1/1/2005 to 1/1/2016 for patients with GBC. Patients with advanced or metastatic disease were excluded. The Recurrence-free survival (RFS) and overall survival (OS) were calculated using the Kaplan-Meier method. Results: 68 patients with GBC; 26 (38%) with early disease. Twelve patients had EXT. Patient/tumor characteristics are shown in Table. Median RFS was 22 months (95% CI: 9-not reached) and OS was 25 months (95% CI: 15-not reached) for the entire cohort. Median RFS was increased in CHOL (30 months) relative to EXT (9 months); p=0.73. OS appeared similar between the two groups (25 vs. 23 months for CHOL and EXT group, respectively). Conclusions: EXT appears to improve RFS with no effect on OS in patients with early GBC. Due to the limitations of small sample size and retrospective analysis, multi-institutional collaborations are necessary to better identify optimal management. [Table: see text]

Skull Base and Intracranial Invasion Patterns and Survival Outcomes of Non-Melanoma Skin Cancers

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Yusuf Dundar ◽  
Richard Cannon ◽  
Marcus Monroe ◽  
Luke Buckman ◽  
Jason Hunt
Keyword(s):  
Skull Base ◽  
Survival Outcomes ◽  
Skin Cancers ◽  
Invasion Patterns ◽  
Melanoma Skin

Improved survival outcomes for orthotopic liver transplant (OLT): 12 years experience at Irish transplant

Endoscopy ◽  
2005 ◽  
Vol 37 (05) ◽  
Author(s):  
A Qasim ◽  
B Zaman ◽  
B Blake ◽  
T Tajuddin ◽  
J Geoghegan ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Orthotopic Liver Transplant ◽  
Survival Outcomes
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