scholarly journals A 71-year-old woman with abdominal pain and acute renal failure

2007 ◽  
Vol 177 (5) ◽  
pp. 454-455 ◽  
Author(s):  
A. Schattner ◽  
J. Kopolovic ◽  
E. Melzer ◽  
J. Rapoport
2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S9-S10
Author(s):  
Anne M Butler ◽  
Michael Durkin ◽  
Matthew R Keller ◽  
Yinjiao Ma ◽  
William Powderly ◽  
...  

Abstract Background Urinary tract infection (UTI) is one of the most common indications for outpatient antibiotic prescriptions in otherwise healthy women, yet the comparative safety of antibiotics for empirical therapy is not well established. We compared the risk of adverse drug events by antibiotic treatment regimen among premenopausal women with uncomplicated UTI. Methods Using the IBM MarketScan Commercial Database (2006–2015), we identified healthy, non-pregnant women aged 18–44 who were diagnosed with UTI and prescribed a same-day antibiotic with activity against common uropathogens. Patients were followed for outcomes with varying follow-up periods: 3 days (anaphylaxis), 14 days (acute renal failure, skin rash, urticaria/hives, nausea/vomiting, abdominal pain), 30 days (vaginitis/vulvovaginal candidiasis, non-C. difficile diarrhea) and 90 days (C. difficile diarrhea, pneumonia, tendinopathy, retinal detachment). We estimated propensity score-weighted hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models. Results Of 1,140,602 eligible women, the distribution of antibiotic receipt was fluoroquinolones (44%), trimethoprim-sulfamethoxazole (TMP/SMX) (28%), nitrofurantoin (24%), narrow-spectrum β-Lactam / β-Lactamase inhibitor combinations (“β-Lactams”) (3%), broad-spectrum β-Lactams (1%) and amoxicillin/ampicillin (1%). Of two first-line agents, we observed higher risk of outcomes among TMP/SMX vs. nitrofurantoin initiators: acute renal failure (HR 2.46, 95% CI 1.46–4.14), skin rash (HR 2.43, 95% CI 2.13–2.77), urticaria (HR 1.35, 95% CI 1.18–1.56), nausea/vomiting (HR 1.19, 95% CI 1.10–1.29) and abdominal pain (HR 1.14, 95% CI 1.09–1.19). Compared to nitrofurantoin, non-first-line agents (fluoroquinolones, broad-, and/or narrow-spectrum β-Lactams) were associated with higher risk of acute renal failure, skin rash, nausea/vomiting, abdominal pain, vaginitis/vulvovaginal candidiasis, diarrhea (C. difficile & non-C. difficile), pneumonia and tendinopathy. Conclusion The risk of adverse drug events differs widely by antibiotic agent, with substantial differences in first-line agents. Understanding antibiotic safety is critical to prevent suboptimal antibiotic prescribing and reduce adverse events. Disclosures Margaret A. Olsen, PhD, MPH, Merck (Grant/Research Support)Pfizer (Consultant, Grant/Research Support)


2019 ◽  
Vol 15 (2) ◽  
pp. 299-302
Author(s):  
Giorgio Colombo ◽  
Ludovico Furlan ◽  
Francesco Mucci ◽  
Stefania Zannoni ◽  
Maria Carmela Andrisani ◽  
...  

2014 ◽  
Vol 14 (2) ◽  
pp. 195-197
Author(s):  
FM Mofakharul Islam ◽  
AK Saha ◽  
MA Mannan ◽  
TU Hassan ◽  
M Rahman ◽  
...  

A 19 yrs old male was admitted with upper abdominal pain and vomiting following ingestion of a fluid he thought to be beer. After repeated inquiry it was found that the clear fluid was “Fog Juice’’, used to produce artificial “Fog” or Smoke on the stage. After 36 hours of ingestion the patient developed severe respiratory distress & itching. Investigation reports confirmed Acute Renal Failure & Hyperkalaemia. He was sent to Nephrology Unit for dialysis, but the poor victim expired there about 48 hours after ingestion.DOI: http://dx.doi.org/10.3329/jom.v14i2.19687 J Medicine 2013, 14(2): 195-197


2007 ◽  
Vol 9 (1) ◽  
Author(s):  
Faisal Shaikh ◽  
Marina Serper

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