Impact of educational preeclampsia prevention booklet on knowledge and adherence to low dose aspirin among pregnant women with high risk for preeclampsia

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Rella Indah Karunia ◽  
Anita Purnamayanti ◽  
Fransiscus O.H. Prasetyadi
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
P Value ◽  
Dose Aspirin ◽  
Validated Questionnaire ◽  
Low Dose Aspirin ◽  
Significant Difference ◽  
Before And After ◽  
The Impact

AbstractBackgroundPostpartum bleeding and pregnancy induced hypertension – including preeclampsia – remain to be a great cause of maternal mortality. The use of aspirin for preventing preeclampsia has been practiced recently by fetomaternal specialists in Indonesia. This study aimed to analyze the impact of education using an aspirin booklet provided by pharmacists on knowledge and adherence in taking aspirin among pregnant women with high risk for preeclampsia.MethodsThis was one group of pretest-posttest study. We enrolled all pregnant women with high risk for preeclampsia screened at 11+0–13+6 weeks’ gestation at Fetomaternal Clinic, Dr. Ramelan Naval Hospital, Surabaya. All subjects prescribed with low-dose aspirin (100 mg) for preeclampsia prevention received oral and written education using the aspirin booklet and had been followed up for 2 months. Knowledge about aspirin for preeclampsia prevention was measured by a validated questionnaire developed for this study. Adherence to aspirin was measured by pill count method.ResultsA total of 12 pregnant women with high risk for preeclampsia were included during the study period. This study showed a statistically significant difference on knowledge of preeclampsia prevention before and after receiving oral and written education using aspirin booklet (p-value = 0.020), as well as aspirin adherence (p-value = 0.011).ConclusionThe use of oral education and written aspirin booklet provided by pharmacists had impact on knowledge of preeclampsia prevention and adherence in taking aspirin among pregnant women with high risk for preeclampsia. We recommend to conduct randomized control study of adequate number of subjects.

scholarly journals 48: Effect of obesity on platelet inhibition in high-risk pregnant women treated with low dose aspirin

2019 ◽  
Vol 220 (1) ◽  
pp. S38-S39 ◽  
Author(s):  
Matthew M. Finneran ◽  
Veronica M. Gonzalez-Brown ◽  
Devin D. Smith ◽  
Mark B. Landon ◽  
Kara Rood
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
Platelet Inhibition ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals 175: Effect of body size on preeclampsia risk-reducing potential of low-dose aspirin among high-risk pregnant women

2020 ◽  
Vol 222 (1) ◽  
pp. S124-S125
Author(s):  
James Lasky ◽  
Roxane Handal-Orefice ◽  
Desmond Sutton ◽  
Sheila Nemeth ◽  
Alexander M. Friedman ◽  
...  
Keyword(s):  
Body Size ◽  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Risk Reducing ◽  
Reducing Potential

scholarly journals Effect of low dose aspirin on fetal outcome in women at risk for developing pregnancy induced hypertension

2020 ◽  
Vol 7 (4) ◽  
pp. 865
Author(s):  
Madhusmita Pradhan ◽  
Jyotiranjan Champatiray ◽  
Kishore V. S.
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Gestational Age ◽  
Low Dose ◽  
Pregnancy Induced Hypertension ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Induced Hypertension

Background: Though pregnancy induced hypertension is a worldwide problem, it is more prevalent in developing countries particularly south east Asian and African countries. It contributes to 20% of perinatal death and 40-50% of low birth weight babies in India. Fetal salvage is also an important consideration in providing quality care. Low dose aspirin given between 12 weeks to 28 weeks of gestational age in high-risk women at Developing Pregnancy Induced Hypertension (PIH) is anticipated to prevent the development of PIH and complications that arises especially those regarding maternal and fetal mortality due to PIH.Methods: This prospective randomized controlled trial was conducted in the dept of O and G, SCB MC and Hospital, Cuttack during November 2018 to October 2019. Pregnant women between the gestational age of 13 to 28 week were screened for risk factors and included in this study. Low dose aspirin of 60 mg daily till delivery was given to pregnant women who consented to be a part of study randomly with the other group taking placebo.Results: Incidence of IUGR babies in low dose aspirin treated mothers was as low as 1%. Incidence of LBW babies is lower in low dose aspirin treated mothers than with those who were not treated. Mean birth weight in cases was 2780 gm±352 gm vs control 2592 gm±483 gm. There is increased incidence of still birth in high risk group not treated with aspirin. No significant difference in reducing incidence premature deliveries between case and control.Conclusions: Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy and its complication like IUGR and low birth weight. Low dose aspirin reduces the incidence of PIH. Low dose aspirin can be considered a safe drug without any deleterious side effect for mother and the fetus. Benefits of prevention of PIH, justifies its administration in women at high risk.

scholarly journals Effect of low dose aspirin on maternal outcome in women at risk for developing pregnancy induced hypertension

2020 ◽  
Vol 9 (4) ◽  
pp. 1590
Author(s):  
Madhusmita Pradhan ◽  
Kishore S. V. ◽  
Jyotiranjan Champatiray
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
Multiple Pregnancy ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Induced Hypertension

Background: Pre-eclampsia is not totally a preventable disease. It is found more related to chains of social ills such as poor maternal nutrition, limited or no antenatal care and poor reproductive education. However, some specific “high-risk” factors leading to pregnancy induced hypertension (PIH) may be identified in individuals which include and not limited to young and elderly primigravida, multiple pregnancy, diabetes, Rh incompatibility, new paternity, pre-existing vascular or renal disease, family history of hypertension, pre-eclampsia and eclampsia, obesity, thrombophilia. Low dose aspirin given in 2nd trimester in these high-risk women is anticipated to prevent the development of PIH.Methods: This prospective randomized controlled trial was conducted in the department of obstetrics and gynecology, SCB MC and Hospital, Cuttack during November 2018 to October 2019. Pregnant women between the gestational age of 13th to 28th weeks were screened for risk factors and included in this study. Low dose aspirin of 60 mg daily till delivery was given to pregnant women who consented to be a part of study randomly with the other group having placebo.Results: Protienuric hypertension was high in control group who did not receive aspirin. Low dose aspirin significantly reduces PIH in high-risk group (3.48% in case versus 23.52% in control). Low dose aspirin was not associated with significant increase in placental bleeding. Low dose aspirin was generally safe for the fetus and new born infant with no evidence of an increased likelihood of bleeding.Conclusions: Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy. Low dose aspirin reduces the incidence of PIH. Low dose aspirin can be considered a safe drug without any deleterious side effect for mother and the fetus. Benefits of prevention of PIH, justifies its administration in women at high risk.

scholarly journals EDUKASI PRENATAL ATTACHMENT DAPAT MENINGKATKAN KELEKATAN IBU DAN JANIN PADA IBU HAMIL RISIKO TINGGI

2020 ◽  
Vol 8 (01) ◽  
pp. 34-51
Author(s):  
Mariani Mariani ◽  
Shinta Wahyusari ◽  
Nova Hikmawati
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Sampling Technique ◽  
First Trimester ◽  
Average Score ◽  
P Value ◽  
Prenatal Attachment ◽  
Significant Difference ◽  
Before And After ◽  
The Relationship

Introduction: The prevalence of high-risk pregnancies in Indonesia is still quite high. Mothers who suffer from illness and pregnancy complications can influence the outcome of the pregnancy, which risks the occurrence of maternal and fetal morbidity and mortality. The psychological effects of high-risk pregnancies are anxiety, stress, and the mother experiences a crisis that can affect the relationship between mother and fetus. These conditions can continue in the relationship between mother and baby after birth. Therefore there needs to be an effort to increase the attachment of the mother and fetus, one of which can be done by providing education. This study aims to determine the effect of prenatal attachment education on maternal and fetal attachment in high-risk pregnant women in Paiton Subdistrict, Probolinggo Regency. Method: The study was conducted in Paiton Subdistrict, Probolinggo Regency in Mei-Juni 2019. The research method used was quasy experiment using pre-post test design. The population in this study were all high risk pregnant women in Dringu Subdistrict, Probolinggo Regency. The sampling technique used in this study was purposive sampling by determining the sample in accordance with the inclusion criteria. The number of samples to be used was 20 respondents. Data collection techniques using a questionnaire. Data were analyzed using Wilcoxon using SPSS. Results and Analysis: The results obtained showed the average score of attachment of the mother and fetus before the intervention was 52.15 and after the intervention was 60.50. There was a significant difference in the attachment of the mother and fetus before and after the intervention with a p value of 0,000 (p <0,000). Discussion: Prenatal care education needs to be included in the prenatal classroom program and started being given to pregnant women since the first trimester.   Keywords: attachment, prenatal attachment, high risk pregnant women

scholarly journals Role of aspirin dose in reducing uterine artery resistance in 16-24 weeks pregnant women with abnormal uterine artery resistance

2019 ◽  
Vol 26 (3) ◽  
pp. 128
Author(s):  
Muhammad Arief Adibrata ◽  
Agus Sulistyono ◽  
Ernawati Ernawati
Keyword(s):  
Pregnant Women ◽  
Uterine Artery ◽  
Low Dose ◽  
Ultrasound Examination ◽  
Doppler Velocimetry ◽  
Dose Aspirin ◽  
Level Ii ◽  
Low Dose Aspirin ◽  
Before And After ◽  
Level I

Objectives: To compare the decrease of resistance index (RI) from uterine artery in pregnant woman receiving low dose aspirin therapy between 80 mg/day and 125 mg/day who had abnormal doppler velocimetry (DV) ultrasound examination at 16-24 weeks.Materials and Methods: An experimental study using double blind randomized clinical trial design. Subjects were from Mulyorejo and Kalijudan public health service in Surabaya, that included pregnant women with 16-24 weeks of pregnancy with abnormal uterine artery velocimetry ultrasound. The results of ultrasound Doppler examination were divided into four levels; normal (RI<0.58; (-) diastolic notching), level I (RI> 0.58; (-) diastolic notching), level II (RI<0.58; (+) disatolic notching) and level III (RI> 0.58; (+) diastolic notching). Uterine doppler ultrasound examination was performed at Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia, by fetomaternal consultants before and after the admin-istration of low-dose aspirin of 125 mg/day and 80 mg/day for four weeks.Results: Ninety subjects were obtained and randomized into 2 groups, with 45 subject in each group. Before treatment, in 125 mg/day group those with level I were 34 subjects and level III 11 subjects. In 80 mg/day group, level I 41 subjects, level II 2 subjects and level III 2 subjects. After 4 weeks of treatment, a second DV USG was performed in Aspirin 125 mg/day group. Normal were 40 subjects, level I 4 subjects, and level III 1 subject. In aspirin group 80 mg/day, normal 22 subjects, level I 19 subjects and level III 4 subjects. The analysis was performed with Wilcoxon test before and after treatment in both aspirin treatment group 125 mg/day and 80 mg/day with p value respectively, p=0.001 and p=0.005.Conclusion: Compared with aspirin of 80 mg/day, aspirin of 125 mg/day is more superior to decrease uterine arterial resistance in pregnant women with ultrasound uterine arterial doppler velocimetry at 16-24 weeks gestational age.

scholarly journals A Promising Effect of Pravastatin For Reducing Preeclamsia Incidence In High Risk Pregnant Women

2019 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Fariska Zata ◽  
Mohammad Nasir
Keyword(s):  
Cardiovascular Disease ◽  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
Early Prevention ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Definitive Therapy ◽  
History Of

Preeclamsia is still a threat in obstetrics because it is the leading cause of maternal death (15-20% in developing countries). Globally, preeclampsia causes 70,000-80,000 pregnant women to die and 500,000 babies die annually1, with increased morbidity such as prematurity and fetal growth disturbance2. The exact cause of preeclampsia is still not clearly known (also called "The disease of theory"), but recent studies shows that the imbalance of pro-angiogenic (VEGF, PlGF) and anti-angiogenic factors (sFlt-1, s-Eng) plays an important role in the pathogenesis preeclampsia. The presence of general maternal endothelial dysfunction induced by an imbalance of these factors is a major phenomenon in preeclampsia, which results in placental hypoxia / ischemia, resulting in vasoconstriction resulting in hypertension1. Termination of pregnancy is still as a definitive therapy for preeclamsia. Therefore, early prevention is necessary in the management of preeclampsia. In 2013, ACOG recommended the administration of low-dose aspirin and calcium 1 gram / day to patients in pregnant women with high risk of preeclamsia3. However, low-dose aspirin is less useful in preventing preeclampsia in patients with a history of previous chronic hypertension4 and not reduce the incidence of term preeclampsia (the incidence of preeclampsia at gestational age above 37 weeks)5,6. This weakness of low-dose aspirin has led to recent research focusing on the prevention of preeclampsia. The similarity between the pathogenesis mechanism of preeclampsia and cardiovascular disease makes pravastatin (a protective therapy in cardiovascular disease before) as a potential agent for preventing preeclampsia7. Therefore, the role of pravastatin for reducing preeclampsia incidence in high risk pregnant women will be discussed in this article.

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