Perspectives into the possible effects of the B.1.1.7 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on spermatogenesis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Andrea M. T. Kallumadyil ◽  
Tess McClenahan ◽  
Samantha De Filippis ◽  
Ananya Vungarala ◽  
Nihal Satyadev ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Type Ii ◽  
Long Term Effects ◽  
Serum Samples ◽  
Infected Male ◽  
Angiotensin Converting Enzyme 2 ◽  
Renal Tubular Cells ◽  
Type Ii Pneumocytes ◽  
Renal Tubular

Abstract B.1.1.7 is a recently discovered variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated with increased transmissibility. Recent findings indicate that this variant has a propensity to infect adolescents and children at higher rates than adults. The virus gains entry into various body cells utilizing angiotensin-converting enzyme 2 (ACE-2) and basigin (CD147) as receptors. The virus mainly affects type II pneumocytes of lungs, endothelial cells, enterocytes, and renal tubular cells. It is reported to affect testes, causing testicular pain, and producing histopathological changes, as observed in some autopsies. The B.1.1.7 variant can also affect various cells in the testes. This raises a major concern regarding the long-term effects of the viral infection on spermatogenesis and highlights the pressing need for a robust database of serum samples from infected male children.

Type-II Endoleaks Following Endovascular AAA Repair:Preoperative Predictors and Long-term Effects

2001 ◽  
Vol 8 (5) ◽  
pp. 503-510 ◽  
Author(s):  
Frank R. Arko ◽  
Geoffrey D. Rubin ◽  
Bonnie L. Johnson ◽  
Bradley B. Hill ◽  
Thomas J. Fogarty ◽  
...  
Keyword(s):  
Type Ii ◽  
Long Term Effects

Long-term effects of dopamine-depleting brain lesions on spontaneous activity of type II striatal neurons: Relation to behavioral recovery

1986 ◽  
Vol 398 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Eric S. Nisenbaum ◽  
Edward M. Stricker ◽  
Michael J. Zigmond ◽  
Theodore W. Berger
Keyword(s):  
Spontaneous Activity ◽  
Brain Lesions ◽  
Type Ii ◽  
Striatal Neurons ◽  
Long Term Effects ◽  
Behavioral Recovery

Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series

2001 ◽  
Vol 16 (3) ◽  
pp. 186-190 ◽  
Author(s):  
K.N. Roy Chengappa ◽  
J. Levine ◽  
D. Rathore ◽  
H. Parepally ◽  
R. Atzert
Keyword(s):  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Case Series ◽  
Mood Stabilizer ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Long Term Effects ◽  
Antiepileptic Agent ◽  
Dsm Iv

SummaryTopiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.

Long-Term Effects of Bariatric Surgery on Type II Diabetes, Hypertension and Hyperlipidemia: A Meta-Analysis and Meta-Regression Study with 5-Year Follow-Up

2014 ◽  
Vol 25 (3) ◽  
pp. 397-405 ◽  
Author(s):  
Cristian Ricci ◽  
Maddalena Gaeta ◽  
Emanuele Rausa ◽  
Emanuele Asti ◽  
Francesco Bandera ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Type Ii Diabetes ◽  
Meta Analysis ◽  
Type Ii ◽  
Long Term Effects ◽  
Meta Regression

scholarly journals Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes in Female Rats

Metabolites ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 263 ◽  
Author(s):  
Yingli Yu ◽  
Pengli Wang ◽  
Ruili Yu ◽  
Jiaxi Lu ◽  
Miaomiao Jiang ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Female Rats ◽  
Proton Nuclear Magnetic Resonance ◽  
Long Term Effects ◽  
Serum Samples ◽  
Drug Induced ◽  
Clinical Safety ◽  
Tissue Samples ◽  
Unsaturated Lipids

Pre-clinical safety evaluation of traditional medicines is imperative because of the universality of drug-induced adverse reactions. Psoralen and isopsoralen are the major active molecules and quality-control components of a traditional herbal medicine which is popularly used in Asia, Fructus Psoraleae. The purpose of this study is to assess the long-term effects of psoralen and isopsoralen with low levels on the biochemical parameters and metabolic profiles of rats. Three doses (14, 28, and 56 mg/kg) of psoralen and one dose (28 mg/kg) of isopsoralen were administered to rats over 12 weeks. Blood and selected tissue samples were collected and analyzed for hematology, serum biochemistry, and histopathology. Metabolic changes in serum samples were detected via proton nuclear magnetic resonance (1H-NMR) spectroscopy. We found that psoralen significantly changed the visceral coefficients, blood biochemical parameters, and histopathology, and isopsoralen extra influenced the hematological index. Moreover, psoralen induced remarkable elevations of forvaline, isoleucine, isobutyrate, alanine, acetone, pyruvate, glutamine, citrate, unsaturated lipids, choline, creatine, phenylalanine, and 4-hydroxybenzoate, and significant reductions of ethanol and dimethyl sulfone. Isopsoralen only induced a few remarkable changes of metabolites. These results suggest that chronic exposure to low-level of psoralen causes a disturbance in alanine metabolism, glutamate metabolism, urea cycle, glucose-alanine cycle, ammonia recycling, glycine, and serine metabolism pathways. Psoralen and isopsoralen showed different toxicity characteristics to the rats.

scholarly journals Indirect effects of severe acute respiratory syndrome coronavirus 2 on the kidney in coronavirus disease patients

2020 ◽  
Vol 13 (3) ◽  
pp. 347-353 ◽  
Author(s):  
Aymeric Couturier ◽  
Sophie Ferlicot ◽  
Kévin Chevalier ◽  
Matthieu Guillet ◽  
Marie Essig ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Kidney Tissue ◽  
Kidney Injury ◽  
Renal Tubular Cells ◽  
Collapsing Glomerulopathy ◽  
Tubulointerstitial Lesions ◽  
Polymerase Chain ◽  
Renal Tubular ◽  
Novel Coronavirus ◽  
Kidney Lesions

Abstract Among patients hospitalized for novel coronavirus disease (COVID-19), between 10 and 14% develop an acute kidney injury and around half display marked proteinuria and haematuria. Post-mortem analyses of COVID-19 kidney tissue suggest that renal tubular cells and podocytes are affected. Here we report two cases of collapsing glomerulopathy and tubulointerstitial lesions in living COVID-19 patients. Despite our use of sensitive reverse transcription polymerase chain reaction techniques in this study, we failed to detect the virus in blood, urine and kidney tissues. Our observations suggest that these kidney lesions are probably not due to direct infection of the kidney by severe acute respiratory syndrome coronavirus 2.

Cardiotoxicity in rabbits after a low-level exposure to diazinon, propoxur, and chlorpyrifos

2014 ◽  
Vol 33 (12) ◽  
pp. 1241-1252 ◽  
Author(s):  
A Zafiropoulos ◽  
K Tsarouhas ◽  
C Tsitsimpikou ◽  
P Fragkiadaki ◽  
I Germanakis ◽  
...  
Keyword(s):  
Cardiac Tissue ◽  
Total Duration ◽  
Cardiac Complications ◽  
Long Term Effects ◽  
Serum Samples ◽  
Cardiac Tissues ◽  
Low Level ◽  
Experimental Scheme ◽  
Echocardiographic Evaluation

Lethal cardiac complications leading to death and various arrhythmias have been reported after organophosphate and/or carbamate poisonings. The present study focuses on the long-term effects of repeated low-level exposure to diazinon, propoxur, and chlorpyrifos (CPF) on cardiac function in rabbits. The yearly based experimental scheme of exposure consisted of two oral administration periods, lasting 3 months and 1 month each, interrupted by an 8-month washout period (total duration 12 months). At the end of the experimental scheme, the rabbits underwent an echocardiographic evaluation under sedation, after which they were killed and the tissue and serum samples were collected. A mild localized cardiotoxic effect was established by echocardiography for the three pesticides tested. Severe histological alterations were identified, especially in the diazinon-treated animals in agreement with increased persistence of this pesticide established in the cardiac tissue. In addition, all pesticides tested increased the oxidative stress and oxidative modifications in the genomic DNA content of the cardiac tissues, each one following a distinct mechanism.

scholarly journals Long-term effects of increased dietary polyunsaturated fat from walnuts on metabolic parameters in type II diabetes

2009 ◽  
Vol 63 (8) ◽  
pp. 1008-1015 ◽  
Author(s):  
L C Tapsell ◽  
M J Batterham ◽  
G Teuss ◽  
S-Y Tan ◽  
S Dalton ◽  
...  
Keyword(s):  
Type Ii Diabetes ◽  
Metabolic Parameters ◽  
Type Ii ◽  
Polyunsaturated Fat ◽  
Long Term Effects
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