Liraglutide combined with intense lifestyle modification in the management of obesity in adolescents

Abstract Objectives Childhood obesity is a public health concern worldwide, with rates continuing to rise, despite preventive measures. Lifestyle modification remains the mainstay in the treatment of patients with excessive weight, but unfortunately, this is not always successful. Options for medical management of obesity in the paediatric population are limited. Methods Seven adolescents (all girls, mean age 14.9 years) with a body mass index (BMI) above 98th percentile and serious complications secondary to obesity were offered an intense weight management programme. The participants were reviewed by a multidisciplinary team every two weeks for advice and support, and treated with daily subcutaneous injections of liraglutide (dose range 1.2–3.0 mg). Scores for anxiety and depression were evaluated using the Revised Child Anxiety and Depression Scale. Results The results showed a significant weight loss over the three months with an average reduction of 5.4 kg (4.2%; 95% CI 1.93–8.78; p=0.0087). The mean drop in BMI was 2.1 kg/m2, which is statistically significant (95% CI 0.973–3.199; p=0.0037). Resolution of complications (raised intracranial pressure and steatohepatitis) was noted following weight loss. Anxiety and depressive symptoms improved over the three-month intervention course, especially features of separation anxiety disorder. Liraglutide was well tolerated by all patients. Conclusions Liraglutide medication, alongside a dedicated multidisciplinary team guided lifestyle therapy, is effective and safe in the treatment for excessive weight in adolescents, leading to the reversal of the complications related to obesity and improvement in the psychological symptoms.

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The Revised Child Anxiety and Depression Scale: A Psychometric Investigation with Australian Youth

Behaviour Change ◽

10.1375/bech.19.2.90 ◽

2002 ◽

Vol 19 (2) ◽

pp. 90-101 ◽

Cited By ~ 57

Author(s):

Raelene L. de Ross ◽

Eleonora Gullone ◽

Bruce F. Chorpita

Keyword(s):

Anxiety Disorder ◽

Convergent Validity ◽

Child Anxiety ◽

Depression Scale ◽

Separation Anxiety Disorder ◽

Self Report ◽

Anxiety And Depression ◽

Normative Study ◽

Major Depressive ◽

Compulsive Disorder

AbstractThe Revised Child Anxiety and Depression Scale (RCADS) is a 47-item self-report measure intended to assess children's symptoms corresponding to selected DSM-IV anxiety and major depressive disorders. The scale comprises six subscales (e.g., Separation Anxiety Disorder; Social Phobia; Obsessive Compulsive Disorder; Panic Disorder; Generalised Anxiety Disorder; and Major Depressive Disorder). To date, only one normative study of youth has been published with results providing strong initial support for the reliability and validity of this new measure (Chorpita, Yim, Moffitt, Umemoto, & Francis, 2000). The present investigation provides additional psychometric data derived from an Australian sample comprising 405 youth aged 8 to 18 years. In general, the data were found to be consistent with those reported in the initial normative study. Internal consistency for the overall scale and its subscales was found to be adequate. Good convergent validity was demonstrated through moderate to strong correlations between the subscales of the RCADS with scores on the Revised Children's Manifest Anxiety Scale (RCMAS) and the Children's Depression Inventory (CDI). Confirmatory factor analysis suggested reasonable fit for the six-factor model by Chorpita et al. (2000). Notwithstanding the need for additional validation, it is concluded that the RCADS is a promising instrument for use in both clinical and research settings.

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Confirmatory factor analysis and psychometric properties of the Revised Child Anxiety and Depression Scale−30 (RCADS-30) in clinical and non-clinical samples

Revista de Psicopatología y Psicología Clínica ◽

10.5944/rppc.vol.22.num.3.2017.19332 ◽

2017 ◽

Vol 22 (3) ◽

pp. 183 ◽

Cited By ~ 4

Author(s):

Jose Antonio Piqueras ◽

David Pineda ◽

María Martin-Vivar ◽

Bonifacio Sandín

Keyword(s):

Anxiety Disorder ◽

Psychometric Properties ◽

Emotional Disorders ◽

Child Anxiety ◽

Depression Scale ◽

Separation Anxiety Disorder ◽

Self Report ◽

Anxiety And Depression ◽

Clinical Samples ◽

Compulsive Disorder

Abstract: The 30-item shortened version of the Revised Child Anxiety and Depression Scale (RCADS-30) is a self-report instrument to assess symptoms of anxiety and depressive disorders. This study examined the factor structure, reliability, and construct validity of the RCADS-30, based on a sample of children and adolescents in clinical and community settings. Results provide evidence for (a) the six factors of the scale (separation anxiety disorder, generalized anxiety disorder, panic disorder, social phobia, obsessive-compulsive disorder, and major depressive disorder), (b) reliability (alpha and omega), and (c) convergent and discriminant validity against self-report and clinical interview criteria. The RCADS-30 demonstrated sound psychometric properties and that it is a suitable instrument to assess depression and anxiety disorder symptoms. Based on established cut-off scores, the scale also showed adequate capacity to differentiate emotional disorders from other mental disorders or the absence of diagnosis.Resumen: Análisis factorial confirmatorio y propiedades psicométricas de la Revised Child Anxiety and Depression Scale (RCADS-30) en muestras clínicas y no clínicas. La versión abreviada de 30 ítems de la Revised Child Anxiety and Depression Scale (RCADS-30) es un instrumento de autoinforme para evaluar síntomas de los trastornos de ansiedad y depresivos. Este estudio examinó la estructura factorial, la fiabilidad y la validez de constructo de la RCADS-30 en una muestra de niños y adolescentes procedentes de muestras clínicas y comunitarias. Los resultados aportan evidencia sobre (a) los seis factores de la escala (trastorno de ansiedad de separación, trastorno de ansiedad generalizada, trastorno de pánico, fobia social, trastorno obsesivo-compulsivo, y trastorno depresivo mayor), (b) fiabilidad (alfa y omega), y (c) validez convergente y discriminante sobre autoinformes y entrevista clínica. La RCADS-30 demostró poseer buenas propiedades psicométricas y ser adecuada para evaluar los síntomas de los trastornos de ansiedad y depresivos. Sobre la base de puntos de corte establecidos, la escala mostró adecuada capacidad para diferenciar los trastornos emocionales de otros problemas mentales o la ausencia de diagnóstico.

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The French Version of the Revised Child Anxiety and Depression Scale (RCADS) in a Nonclinical Sample

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000158 ◽

2015 ◽

Vol 74 (3) ◽

pp. 119-127 ◽

Cited By ~ 10

Author(s):

Martine Bouvard ◽

Anne Denis ◽

Jean-Luc Roulin

Keyword(s):

Factor Analysis ◽

Anxiety Disorder ◽

Confirmatory Factor Analysis ◽

Generalized Anxiety Disorder ◽

Child Anxiety ◽

Depression Scale ◽

Anxiety And Depression ◽

Generalized Anxiety ◽

French Version ◽

Confirmatory Factor

This article investigates the psychometric properties of the Revised Child Anxiety and Depression Scale (RCADS). A group of 704 adolescents completed the questionnaires in their classrooms. This study examines potential confirmatory factor analysis factor models of the RCADS as well as the relationships between the RCADS and the Screen for Child Anxiety Related Emotional Disorders-Revised (SCARED-R). A subsample of 595 adolescents also completed an anxiety questionnaire (Fear Survey Schedule for Children-Revised, FSSC-R) and a depression questionnaire (Center for Epidemiological Studies Depression Scale, CES-D). Confirmatory factor analysis of the RCADS suggests that the 6-factor model reasonably fits the data. All subscales were positively intercorrelated, with rs varying between .48 (generalized anxiety disorder-major depression disorder) and .65 (generalized anxiety disorder-social phobia/obsessive-compulsive disorder). The RCADS total score and all the RCADS scales were found to have good internal consistency (> .70). The correlations between the RCADS subscales and their SCARED-R counterparts are generally substantial. Convergent validity was found with the FSSC-R and the CES-D. The study included normal adolescents aged 10 to 19. Therefore, the findings cannot be extended to children under 10, nor to a clinical population. Altogether, the French version of the RCADS showed reasonable psychometric properties.

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Revised Child Anxiety and Depression Scale

PsycTESTS Dataset ◽

10.1037/t03547-000 ◽

2000 ◽

Author(s):

Bruce F. Chorpita ◽

Letitia Yim ◽

Catherine Moffitt ◽

Lori A. Umemoto ◽

Sarah E. Francis

Keyword(s):

Child Anxiety ◽

Depression Scale ◽

Anxiety And Depression

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Cross-cultural measurement invariance of the Revised Child Anxiety and Depression Scale across 11 world-wide societies

Epidemiology and Psychiatric Sciences ◽

10.1017/s204579601600038x ◽

2016 ◽

Vol 26 (4) ◽

pp. 430-440 ◽

Cited By ~ 10

Author(s):

D. Stevanovic ◽

Z. Bagheri ◽

O. Atilola ◽

P. Vostanis ◽

D. Stupar ◽

...

Keyword(s):

Depressive Symptoms ◽

Ethnic Groups ◽

Measurement Invariance ◽

Factor Model ◽

Child Anxiety ◽

Depression Scale ◽

The Philippines ◽

Cross Cultural ◽

Health Study ◽

Anxiety And Depression

Background.In order to compare estimates by one assessment scale across various cultures/ethnic groups, an important aspect that needs to be demonstrated is that its construct across these groups is invariant when measured using a similar and simultaneous approach (i.e., demonstrated cross-cultural measurement invariance). One of the methods for evaluating measurement invariance is testing for differential item functioning (DIF), which assesses whether different groups respond differently to particular items. The aim of this study was to evaluate the cross-cultural measurement invariance of the Revised Child Anxiety and Depression Scale (RCADS) in societies with different socioeconomic, cultural, and religious backgrounds.Methods.The study was organised by the International Child Mental Health Study Group. Self-reported data were collected from adolescents residing in 11 countries: Brazil, Bulgaria, Croatia, Indonesia, Montenegro, Nigeria, Palestinian Territories, the Philippines, Portugal, Romania and Serbia. The multiple-indicators multiple-causes model was used to test the RCADS items for DIF across the countries.Results.Ten items exhibited DIF considering all cross-country comparisons. Only one or two items were flagged with DIF in the head-to-head comparisons, while there were three to five items flagged with DIF, when one country was compared with the others. Even with all cross-culturally non-invariant items removed from nine language versions tested, the original factor model representing six anxiety and depressive symptoms subscales was not significantly violated.Conclusions.There is clear evidence that relatively small number of the RCADS items is non-invariant, especially when comparing two different cultural/ethnic groups, which indicates on its sound cross-cultural validity and suitability for cross-cultural comparisons in adolescent anxiety and depressive symptoms.

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Revised Child Anxiety and Depression Scale--Brazilian Version

PsycTESTS Dataset ◽

10.1037/t80209-000 ◽

2019 ◽

Author(s):

Fabio Eduardo Fontana ◽

Michael Pereira da Silva ◽

Oldemar Mazzardo ◽

Seong-In Choi ◽

Priscila Lumi ◽

...

Keyword(s):

Child Anxiety ◽

Depression Scale ◽

Anxiety And Depression ◽

Brazilian Version

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Psychometric properties of the Revised Child Anxiety and Depression Scale in Greek Adolescents

Clinical Child Psychology and Psychiatry ◽

10.1177/13591045211056502 ◽

2021 ◽

pp. 135910452110565

Author(s):

Ioanna Giannopoulou ◽

Evdokia Pasalari ◽

Paraskevi Bali ◽

Dimitra Grammatikaki ◽

Panagiotis Ferentinos

Keyword(s):

Psychometric Properties ◽

Measurement Invariance ◽

Emotional Disorders ◽

Rating Scale ◽

Child Anxiety ◽

Depression Scale ◽

Anxiety And Depression ◽

Depression Symptoms ◽

Divergent Validity ◽

Convergent And Divergent Validity

The psychometric properties of the Revised Child Anxiety and Depression Scale (RCADS-47) are established cross-culturally but lacking for the Greek population. The present study examined RCADS internal consistency and validity (structural and concurrent) in Greek adolescents, and tested measurement invariance across sex and age groups. We recruited 619 secondary school students ( n = 321 females), aged 12–18 years ( n = 318, 12–14-year-olds). Besides RCADS, all students completed Strengths and Difficulties Questionnaire (SDQ), a subsample ( n = 300) completed Screen for Child Anxiety-Related Emotional Disorders (SCARED), whereas a non-overlapping subsample ( n = 219) completed Depression Self-Rating Scale (DSRS). Structural validity was examined with Confirmatory Factor Analysis and measurement invariance was assessed with Multiple Indicators Multiple Causes (MIMIC) modeling. Convergent and divergent validity were examined using Spearman correlations between RCADS subscales and DSRS, SCARED, and SDQ validators. The six-factor model fitted the data best, validating the originally proposed RCADS structure. Three items displayed differential item functioning for sex, another three for age group, and one item for both, albeit with trivial effect sizes ( d < 0.2). Cronbach’s alpha was .94. Convergent and divergent validity were also established. In conclusion, the RCADS is a valid and reliable instrument for assessing anxiety and depression symptoms in Greek adolescents.

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