scholarly journals Shared Neural Representations of Cognitive Conflict and Negative Affect in the Medial Frontal Cortex

2020 ◽  
Vol 40 (45) ◽  
pp. 8715-8725 ◽  
Author(s):  
Luc Vermeylen ◽  
David Wisniewski ◽  
Carlos González-García ◽  
Vincent Hoofs ◽  
Wim Notebaert ◽  
...  
Keyword(s):  
Negative Affect ◽  
Frontal Cortex ◽  
Cognitive Conflict ◽  
Medial Frontal Cortex ◽  
Neural Representations

scholarly journals Shared neural representations of cognitive conflict and negative affect in the medial frontal cortex

2019 ◽  
Author(s):  
Luc Vermeylen ◽  
David Wisniewski ◽  
Carlos González-García ◽  
Vincent Hoofs ◽  
Wim Notebaert ◽  
...  
Keyword(s):  
Negative Affect ◽  
Frontal Cortex ◽  
Supplementary Motor Area ◽  
Cognitive Conflict ◽  
Medial Frontal Cortex ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Neural Representations ◽  
Fmri Study ◽  
Multivariate Pattern

AbstractInfluential theories of medial frontal cortex (MFC) function suggest that the MFC registers cognitive conflict as an aversive signal, but no study directly tested this idea. Instead, recent studies suggested that non-overlapping regions in the MFC process conflict and affect. In this pre-registered human fMRI study, we used multivariate pattern analyses to identify which regions respond similarly to conflict and aversive signals. The results reveal that, of all conflict- and value-related regions, the ventral pre-supplementary motor area (or dorsal anterior cingulate cortex) showed a shared neural pattern response to different conflict and affect tasks. These findings challenge recent conclusions that conflict and affect are processed independently, and provide support for integrative views of MFC function.

scholarly journals Enhanced population coding for rewarded choices in the medial frontal cortex of the mouse

2018 ◽  
Author(s):  
Michael J. Siniscalchi ◽  
Hongli Wang ◽  
Alex C. Kwan
Keyword(s):  
Frontal Cortex ◽  
Population Coding ◽  
Medial Frontal Cortex ◽  
Instrumental Behavior ◽  
Neural Representations ◽  
Neural Ensemble ◽  
Motor Region ◽  
Ensemble Activity ◽  
Insight Into ◽  
Selection Of

AbstractInstrumental behavior is characterized by the selection of actions based on the degree to which they lead to a desired outcome. However, we lack a detailed understanding of how rewarded actions are reinforced and preferentially implemented. In rodents, the medial frontal cortex is hypothesized to play an important role in this process, based in part on its capacity to encode chosen actions and their outcomes. We therefore asked how neural representations of choice and outcome might interact to facilitate instrumental behavior. To investigate this question, we imaged neural ensemble activity in layer 2/3 of the secondary motor region (M2) while mice engaged in a two-choice auditory discrimination task with probabilistic outcomes. Correct choices could result in one of three reward amounts (single-, double-, or omitted-reward), which allowed us to measure neural and behavioral effects of reward magnitude, as well as its categorical presence or absence. Single-unit and population decoding analyses revealed a consistent influence of outcome on choice signals in M2. Specifically, rewarded choices were more robustly encoded relative to unrewarded choices, with little dependence on the exact magnitude of reinforcement. Our results provide insight into the integration of past choices and outcomes in the rodent brain during instrumental behavior.

scholarly journals The geometry of domain-general performance monitoring representations in the human medial frontal cortex

2021 ◽  
Author(s):  
Zhongzheng Fu ◽  
Danielle Beam ◽  
Jeffrey M. Chung ◽  
Chrystal M. Reed ◽  
Adam N. Mamelak ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Performance Monitoring ◽  
Cognitive Conflict ◽  
Medial Frontal Cortex ◽  
Neural Population ◽  
Single Neurons ◽  
Task Specialization ◽  
Ex Post ◽  
Open Question ◽  
And Control

Flexibly adapting behavior to achieve a desired goal depends on the ability to monitor one's own performance. A key open question is how performance monitoring can be both highly flexible to support multiple tasks and specialized to support specific tasks. We characterized performance monitoring representations by recording single neurons in the human medial frontal cortex (MFC). Subjects performed two tasks that involve three types of cognitive conflict. Neural population representations of conflict, error and control demand generalized across tasks and time while at the same time also encoding task specialization. This arose from a combination of single neurons whose responses were task-invariant and non-linearly mixed. Neurons encoding conflict ex-post served to iteratively update internal estimates of control demand as predicted by a Bayesian model. These findings reveal how the MFC representation of evaluative signals are both abstract and specific, suggesting a mechanism for computing and maintaining control demand estimates across trials and tasks.

scholarly journals Enhanced Population Coding for Rewarded Choices in the Medial Frontal Cortex of the Mouse

2019 ◽  
Vol 29 (10) ◽  
pp. 4090-4106 ◽  
Author(s):  
Michael J Siniscalchi ◽  
Hongli Wang ◽  
Alex C Kwan
Keyword(s):  
Frontal Cortex ◽  
Population Coding ◽  
Medial Frontal Cortex ◽  
Instrumental Behavior ◽  
Neural Representations ◽  
Neural Ensemble ◽  
Motor Region ◽  
Ensemble Activity ◽  
Insight Into ◽  
Selection Of

Abstract Instrumental behavior is characterized by the selection of actions based on the degree to which they lead to a desired outcome. However, we lack a detailed understanding of how rewarded actions are reinforced and preferentially implemented. In rodents, the medial frontal cortex is hypothesized to play an important role in this process, based in part on its capacity to encode chosen actions and their outcomes. We therefore asked how neural representations of choice and outcome might interact to facilitate instrumental behavior. To investigate this question, we imaged neural ensemble activity in layer 2/3 of the secondary motor region (M2) while mice engaged in a two-choice auditory discrimination task with probabilistic outcomes. Correct choices could result in one of three reward amounts (single, double or omitted reward), which allowed us to measure neural and behavioral effects of reward magnitude, as well as its categorical presence or absence. Single-unit and population decoding analyses revealed a consistent influence of outcome on choice signals in M2. Specifically, rewarded choices were more robustly encoded relative to unrewarded choices, with little dependence on the exact magnitude of reinforcement. Our results provide insight into the integration of past choices and outcomes in the rodent brain during instrumental behavior.

Stay or Go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice

Cell Calcium ◽  
2021 ◽  
pp. 102388
Author(s):  
Alex L. Keyes ◽  
Young-cho Kim ◽  
Peter J. Bosch ◽  
Yuriy M. Usachev ◽  
Georgina M. Aldridge
Keyword(s):  
Frontal Cortex ◽  
Neuronal Activity ◽  
Medial Frontal Cortex ◽  
Preference Task

scholarly journals Internally Generated Preactivation of Single Neurons in Human Medial Frontal Cortex Predicts Volition

Neuron ◽  
2011 ◽  
Vol 69 (3) ◽  
pp. 548-562 ◽  
Author(s):  
Itzhak Fried ◽  
Roy Mukamel ◽  
Gabriel Kreiman
Keyword(s):  
Frontal Cortex ◽  
Medial Frontal Cortex ◽  
Single Neurons

scholarly journals Human subthalamic nucleus–medial frontal cortex theta phase coherence is involved in conflict and error related cortical monitoring

NeuroImage ◽  
2016 ◽  
Vol 137 ◽  
pp. 178-187 ◽  
Author(s):  
Baltazar Zavala ◽  
Huiling Tan ◽  
Keyoumars Ashkan ◽  
Thomas Foltynie ◽  
Patricia Limousin ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Subthalamic Nucleus ◽  
Phase Coherence ◽  
Medial Frontal Cortex ◽  
Theta Phase

Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats

2005 ◽  
Vol 1039 (1-2) ◽  
pp. 90-96 ◽  
Author(s):  
Mostofa Jamal ◽  
Kiyoshi Ameno ◽  
Weihuan Wang ◽  
Mitsuru Kumihashi ◽  
Setsuko Ameno ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Acetylcholine Release ◽  
Medial Frontal Cortex ◽  
Freely Moving Rats ◽  
Freely Moving ◽  
Acetaldehyde Metabolism
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