scholarly journals The Risk Factors of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis Study

2017 ◽  
Vol 5 (4) ◽  
pp. 253-263 ◽  
Author(s):  
Faezeh Kiani ◽  
Marzieh Saei Ghare Naz ◽  
Fatemeh Sayehmiri ◽  
Kourosh Sayehmiri ◽  
Hakimeh Zali
2020 ◽  
Vol 11 (6) ◽  
pp. 599-616 ◽  
Author(s):  
Maleesa M. Pathirana ◽  
Zohra S. Lassi ◽  
Claire T. Roberts ◽  
Prabha H. Andraweera

AbstractGestational diabetes mellitus (GDM) is a pregnancy complication that affects one in seven pregnancies. Emerging evidence demonstrates that children born of pregnancies complicated by GDM may be at increased risk of cardiovascular disease (CVD) in adulthood. Therefore, the aim of this study was to determine cardiovascular risk factors in offspring exposed to GDM in utero. PubMed, CINAHL, SCOPUS, and EMBASE databases were searched. Information was extracted on established CVD risk factors including blood pressure, lipids, blood glucose, fasting insulin, body mass index (BMI), and endothelial/microvascular function. The review protocol is registered in PROSPERO (CRD42018094983). Prospective and retrospective studies comparing offspring exposed to GDM compared to controls (non-GDM pregnancies) were considered. We included studies that defined GDM based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) definition, or prior definitions. The PRISMA guidelines were followed in conducting this systematic review. Methodological quality was assessed using the Newcastle–Ottawa Quality Assessment Scale. Study selection, data extraction, and quality assessment were done by two independent reviewers. The data were pooled using a random-effects model. Of 59 eligible studies, 24 were included in the meta-analysis. Offspring exposed to GDM had higher systolic blood pressure (mean difference (MD): 1.75 mmHg, 95% CI 0.57–2.94; eight studies, 7264 participants), BMI z-score (MD 0.11, 95% CI 0.02–0.20; nine studies, 8759 participants), and glucose (standard MD 0.43, 95% CI 0.08–0.77; 11 studies, 6423 participants) than control participants. In conclusion, offspring exposed to GDM have elevated systolic blood pressure, BMI, and glucose. Those exposed to GDM in utero may benefit from early childhood blood pressure measurements.


2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Kai Wei Lee ◽  
Siew Mooi Ching ◽  
Vasudevan Ramachandran ◽  
Anne Yee ◽  
Fan Kee Hoo ◽  
...  

2020 ◽  
Vol 11 (3) ◽  
pp. 244-245
Author(s):  
Maleesa M. Pathirana ◽  
Zohra S. Lassi ◽  
Claire T. Roberts ◽  
Prabha H. Andraweera

AbstractThis commentary is an author response to Lu and Wang, regarding the manuscript entitled ‘Cardiovascular risk factors in offspring exposed to gestational diabetes mellitus in utero: Systematic review and meta-analysis’. We address their concern regarding duplication of studies in the meta-analysis and the quality of included studies.


2021 ◽  
Vol 50 (8) ◽  
pp. 2367-2377
Author(s):  
Lieng Teng Cheong ◽  
Ken Yong Foo ◽  
Mun Lum Ka ◽  
Yung Toh Shen ◽  
Xuan Hii Chan ◽  
...  

Gestational diabetes mellitus (GDM) is glucose intolerance first diagnosed during pregnancy. In Malaysia, the prevalence, risk factors, and maternal/foetal outcomes vary somewhat among the local studies. In this systematic review of Malaysian studies, we synthesise relevant data from 13 journal articles (including 10,285 women with gestational diabetes). A meta-analysis of twelve datasets showed a prevalence of 21.5% (95% CI 17.3 to 25.9%, random effect model). Clinical factors in the mother found to increase her risk of GDM were consistent with international data. A meta-analysis of complications showed statistically significant increase for macrosomia (OR 3.08, 95% CI 1.77 to 5.36) but not for pre-eclampsia (OR 1.44, 95% CI 0.52 to 4.00) and caesarean delivery (OR 1.31, 95% CI 0.98 to 1.75). The high prevalence of gestational diabetes mellitus and documented adverse consequences support the need for universal screening of this condition in all pregnant women in Malaysia.


2019 ◽  
Author(s):  
Jose Alberto Martínez-Hortelano ◽  
Ivan Cavero Redondo ◽  
Celia Alvarez ◽  
Ana Díez-Fernández ◽  
Montserrat Hernández-Luengo ◽  
...  

2021 ◽  
Vol 38 ◽  
pp. 101016
Author(s):  
Gayathri Delanerolle ◽  
Peter Phiri ◽  
Yutian Zeng ◽  
Kathleen Marston ◽  
Nicola Tempest ◽  
...  

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