scholarly journals RESISTANCE TO ANTIBIOTICS AND THEIR UTILIZATION BY MICROORGANISMS

2021 ◽  
Vol 14 (3) ◽  
pp. 22-29
Author(s):  
N.B. Golub ◽  

With the development of antibiotics application, their spread in the natural environment increases dramatically. The presence of antibiotics in the environment changes microorganism and other living beings ratio and composition, which causes a negative impact on biochemical processes that take place in the environment. The spread of antibiotic resistance genes in environmental microorganisms is a growing problem of environmental safety and human health. Aim. The objective of the work was to analyze the adaptation mechanisms of microorganisms to the influence of antibiotics and methods for antibiotics utilization. Results. The mechanisms of microorganisms’ adaptation to antibiotics are shown. The conditions for utilization of different antibiotics classes by microorganisms are provided. Conclusions. Methods of antibiotics destruction depend on its structure and physicochemical properties. Physico-chemical methods are used for local waste purification and are not suitable for antibiotics disposal in the natural environment. The decomposition products can also have a negative effect on the microorganisms’ cells. Depending on the class of antibiotics, their biodegradation occurs by different types of microorganisms. It has been shown that sulfonamides and amphinecoles are easily destroyed by many heterotrophic bacteria; biodegradation of aminoglycosides occurs by a strain of Pseudomonas spp.; tetracyclines - mushrooms; β-lactams - through the microorganisms’ association including: Burkholderiales, Pseudomonadales, Enterobacteriales, Actinomycetales, Rhizobiales, Sphingobacteriales. A consortium of destructors must be created to dispose of a specific classes of antibiotics.

2015 ◽  
Vol 5 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Тихонова ◽  
Elena Tikhonova ◽  
Демиденкова ◽  
Lyubov Demidenkova ◽  
Хазова ◽  
...  

The modern concept of gardening involves the use of large amounts of inert materials, different designs, and modern forms. Widespread urbanization of territories entails almost complete exclusion of green spaces, landscapes mediocrity and aggressive environments. All this has a negative effect not only on the environment but also has a negative impact on human. Reduced Stress resistance reduces and the working population decreases, the percentage of various diseases increases. In this paper we consider the question of proposing how to tie urbanized area with the surrounding environment. Along with urbanized areas a suburban town, so-called "second home" play a major role in people´s lives. Accomplishment of such areas should include elements that allow a person to relax as much as possible by working days. Since the cottage villages are composed of model homes, it suggests the monotony plan of surrounding territory. The best decoration of such areas is the use of tree and shrub vegetation, as well as decorative flower crops. Flower decoration of adjoining areas refreshes dull monotony of typical households. Given the impact of current trends in landscape design, we note the following aspects of the areas design. Rectilinear forms of trees and bushes are disappearing as the most fashionable style decision is a landscape of the site. Manor house in the Russian style looks particularly attractive, as historically Russian style was associated with the natural environment. Cottage village is ideally located surrounded by forest on the banks of a natural lake. The objective of our work was to unify the territory of cottage settlement with the surrounding ecosystem. For small areas "small" gardens are ideal decision. We also offer to create more comfortable living environment to emphasize the conditional zoning with green hedges. The paper presents a range of plants that will accentuate central Russian landscape and create coherent whole perception of the village and the environment.


2020 ◽  
Vol 18 (9) ◽  
pp. 1787-1798
Author(s):  
S.N. Ayusheeva

Subject. This article assesses the effectiveness of the existing system of environmental management based on the user-pays principle in terms of reducing the negative impact on the environment. Objectives. The article aims to conduct a comparative analysis of the anthropogenic impact on natural environment components and deficiency payments for pollution in the model areas of the Russian Federation. Methods. For the study, I used the methods of computational, comparative, systems, and structural analyses. Results. Based on the ecological rating of the Russian Federation subjects, the article defines model areas, assesses the degree of anthropogenic impact on the basis of pollution relative rates, and describes the particularities of environmental investment in the selected areas. Conclusions. The system of payments for pollution does not affect the economic behavior of economic entities.


2020 ◽  
Vol 25 (4) ◽  
pp. 287-294
Author(s):  
S. I. Kutukova ◽  
N. P. Beliak ◽  
G. A. Raskin ◽  
M. S. Mukhina ◽  
Yu. V. Ivaskova ◽  
...  

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haiyan Song ◽  
Zhaoke Dong ◽  
Lili Li ◽  
Zengbin Lu ◽  
Chao Li ◽  
...  

Abstract Apolygus lucorum (Meyer-Dür) (Hemiptera: Miridae) tends to feed on young plant tissues. To explore the relationship between stylet probing behaviors of adult A. lucorum and conditions of cotton leaves, we conducted an experiment using electropenetrography (EPG). Behaviors were recorded on four cotton varieties, in relation to thickness and biochemical traits of differently-aged leaves. Cotton leaf age had a significant effect on the probing behavior of A. lucorum but cotton variety did not. One-day-old leaves of A. lucorum received the highest mean number of stylet probes (penetrations) per insect, and longest mean durations per insect of combined stylet probing or its components, cell rupture and ingestion behaviors. All of the leaf traits (thickness and biochemical substances) were similar among these four cotton varieties. Leaf thickness had a significantly negative effect on the same four variables above. Gossypol and tannin also had a negative impact on combined probing duration. Redundancy analysis showed that the four EPG variables were closely related to nutrient substances (amino acids, sugar, and water) while they had the opposite relationship with plant defense substances (gossypol and tannin). On cotton in the seedling stages, A. lucorum fed more readily on the youngest, thinnest leaves in our no-choice EPG experiments. Nutrients and chemical resistance substances determined the probing duration of A. lucorum. Our findings can contribute to better understanding of patterns of feeding and host consumption by A. lucorum, ultimately improving cotton resistance to A. lucorum.


Author(s):  
Frowin Fasold ◽  
Benjamin Noël ◽  
André Nicklas ◽  
Fabian Lukac ◽  
Stefanie Klatt

Throwing a ball is a primary skill in team-handball and can be directly influenced by the properties of different types of balls. Therefore, the use of different balls (i.e., methodic ball) recommended by the handball federations (e.g., IHF) and the education guidelines, are important in teaching throwing. Previous studies have shown that movement patterns and throwing velocity can be influenced by different ball types and sizes. However, the influence of these factors on throwing accuracy has not been investigated in detail yet. This study aims to replicate the findings of previous studies on increasing throwing velocity in children by comparing the use of a soft methodic ball with a size 0 handball. Furthermore, this study investigates the influence of these balls on throwing accuracy. In an experimental study, participants (10-years of age) threw a soft methodic ball and a size 0 ball at target areas in a handball goal. For all the throws, throwing velocity and accuracy were measured. Commensurate with previous research, throwing velocity was higher for the soft methodic ball compared to a size 0 ball. No difference was found in accuracy, although, it is worth mentioning that the participants were only experienced in throwing using the size 0 ball. Moreover, only one-third of the children favored throwing with a size 0 ball, which is what they are used to in training and competition. The results of our study, therefore, confirm that using soft methodic balls additionally, positively influences the throwing velocity and has no negative effect on the accuracy in throwing among young handball beginners.


2021 ◽  
pp. 1-21
Author(s):  
Davide Vittori

Abstract Scholars have long debated whether populism harms or improves the quality of democracy. This article contributes to this debate by focusing on the impact of populist parties in government. In particular, it inquires: (1) whether populists in government are more likely than non-populists to negatively affect the quality of democracies; (2) whether the role of populists in government matters; and (3) which type of populism is expected to negatively affect the quality of liberal-democratic regimes. The results find strong evidence that the role of populists in government affects several qualities of democracy. While robust, the findings related to (2) are less clear-cut than those pertaining to (1). Finally, regardless of their role in government, different types of populism have different impacts on the qualities of democracy. The results show that exclusionary populist parties in government tend to have more of a negative impact than other forms of populism.


2021 ◽  
Vol 19 (1) ◽  
pp. 462-470
Author(s):  
Marta Bożym ◽  
Beata Klojzy-Karczmarczyk

Abstract Environmental pollution by mercury is a local problem in Poland and concerns mainly industrial sites. Foundry waste are usually characterized by low mercury content compared to other heavy metals. Spent foundry sands with low content of Hg are the main component of foundry waste. However, Hg may be present in foundry dust, which may also be landfilled. Due to Hg toxicity, even a minimal content may have a negative impact on biota. This study focuses on assessing the mercury content of landfilled foundry waste (LFW), to assess its toxicity. Currently tested waste is recovered and reused as a road aggregate. The results were compared with the mercury content of local soils as the reference level. Waste samples were taken from foundry landfill. The mercury content, fractional composition, organic matter (OM) and total organic carbon content, pH and elementary composition of waste were analysed. It was found that the mercury content in LFW was very low, at the level of natural content in soils and did not pose a threat to the environment. The statistical analysis shows that mercury was not associated with OM of the waste, in contrast to soils, probably due to different types of OM in both materials.


Mathematics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1341
Author(s):  
Tinggui Chen ◽  
Lijuan Peng ◽  
Jianjun Yang ◽  
Guodong Cong

With highly developed social media, English learning Applications have become a new type of mobile learning resources, and online comments posted by users after using them have not only become an important source of intellectual competition for enterprises, but can also help understand customers’ requirements, thereby improving product functionalities and service quality, and solve the pain points of product iteration and innovation. Based on this, this paper crawled the online user comments of three typical APPs (BaiCiZhan, MoMoBeiDanCi and BuBeiDanCi), through emotion analysis and hotspot mining technology, to obtain user requirements and then the K-means clustering method was used to analyze user requirements. Finally, quantile regression is used to find out which user needs have an impact on the downloads of English vocabulary APPs. The results show that: (1) Positive comments have a more significant impact on users’ downloads behavior than negative online comments. (2) English vocabulary APPs with higher downloads, both the 5-star user ratings and the increase of emotional requirement have a negative effect on the increase in APP downloads, while the enterprise’s service requirement improvement has a positive effect on the increase of APP downloads. (3) Regarding English vocabulary APPs with average or high downloads, improving the adaptability and Appearance requirements have significant negative impact on downloads. (4) The functional requirements to improve products will have a significant positive impact on the increase in downloads of English vocabulary APPs.


1984 ◽  
Vol 62 (9) ◽  
pp. 1968-1970 ◽  
Author(s):  
William G. Roland ◽  
L. Michael Coon

Recovery of intertidal Porphyra beds following hand harvest was studied near the northwest tip of the Queen Charlotte Islands, B.C. Twenty-six percent of the standing crop of Porphyra perforata J. Ag. was removed in a large plot in June 1981; no negative effect on standing crop was apparent in May 1982 as compared with the adjacent control area. There was no negative impact on percent cover of Porphyra (mostly P. perforata) within 1 year after hand harvest of seven, approximately 1-m2 plots, as compared with respective controls. Annual fluctuation in cover, biomass, and relative mix of Porphyra species was large. Porphyra cover in a small plot harvested in early June 1981 increased to 86% of the June value by mid-July 1981, indicating substantial growth of the remaining thallus fragments and small, whole plants within one season. It was concluded that sustained yield of Porphyra beds can be assured if harvest is restricted to gathering by hand.


2015 ◽  
Vol 16 (3) ◽  
pp. 332-356 ◽  
Author(s):  
JOHN HÖGSTRÖM

AbstractIt has been argued that economic development and democracy create new opportunities and resources for women to access political power, which should increase gender equality in politics. However, empirical evidence from previous research that supports this argument is mixed. The contribution of this study is to expand the research on gender equality in politics through an in-depth examination of the effect of development and democracy on gender equality in cabinets. This has been completed through separate analyses that include most of the countries in the world across three levels of development (least-developed, developing, and developed) and across different types of political regimes (democracies, royal dictatorships, military dictatorships, and civilian dictatorships). The results demonstrate that economic development and democracy only affect gender equality in cabinets positively in a few environments. Accordingly, the context is important and there seem to be thresholds before development and democracy have any effect. Development has a positive effect in developed countries and in democracies, but it has a negative effect in dictatorships, and the negative effect is strongest in military dictatorships. The level of democracy has a positive effect mainly in dictatorships, and the strongest effect is in civilian dictatorships. The article demonstrates the importance of dividing samples into subsets to increase understanding of what affects women's representation in cabinets in different environments, and I ask scholars to subset samples and run separate analyses more often in comparative studies.


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