scholarly journals MATHEMATICAL MODEL FOR THE INVESTIGATION OF HYPOXIC STATES IN THE HEART MUSCLE AT VIRAL DAMAGE

2021 ◽  
Vol 14 (4) ◽  
pp. 38-52
Author(s):  
N. I. Aralova ◽  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Viral Infection ◽  
Blood Vessels ◽  
Respiratory System ◽  
Mass Exchange ◽  
Partial Occlusion ◽  
Pharmacological Substance ◽  
Respiratory Gases ◽  
Hypoxic State

The main complications of organism damaged by SARS-CoV-2 virus are various cardiovascular system lesions. As a result, the secondary tissue hypoxia is developed and it is relevant to search the means for hypoxic state alleviation. Mathematical modeling of this process, followed by the imitation of hypoxic states development, and subsequent correction of hypoxia at this model may be one of the directions for investigations. Aim. The purpose of this study was to construct mathematical models of functional respiratory and blood circulatory systems to simulate the partial occlusion of blood vessels during viral infection lesions and pharmacological correction of resulting hypoxic state. Methods. Methods of mathematical modeling and dynamic programming were used. Transport and mass exchange of respiratory gases in organism, partial occlusion of blood vessels and influence of antihypoxant were described by the systems of ordinary nonlinear differential equations. Results. Mathematical model of functional respiratory system was developed to simulate pharmacological correction of hypoxic states caused by the complications in courses of viral infection lesions. The model was based on the theory of functional systems by P. K. Anokhin and the assumption about the main function of respiratory system. The interactions and interrelations of individual functional systems in organism were assumed. Constituent parts of our model were the models of transport and mass exchange of respiratory gases in organism, selforganization of respiratory and blood circulatory systems, partial occlusion of blood vessels and the transport of pharmacological substance. Conclusions. The series of computational experiments for averaged person organism demonstrated the possibility of tissue hypoxia compensation using pharmacological substance with vasodilating effect, and in the case of individual data array, it may be useful for the development of strategy and tactics for individual patient medical treatment.

MATHEMATICAL MODEL FOR SELECTING RESPIRATORY MODES FOR ARTIFICIAL VENTILATION OF THE LUNGS

2021 ◽  
Vol 3 ◽  
pp. 130-140
Author(s):  
Natalia Aralova ◽  
Keyword(s):  
Mathematical Model ◽  
Respiratory System ◽  
Artificial Ventilation ◽  
Exchange Process ◽  
Lung Ventilation ◽  
Viral Disease ◽  
Proposed Model ◽  
Ventilation Modes ◽  
Respiratory Gases ◽  
Ventilation Of The Lungs

COVID-19 mainly affects the lower respiratory tract, and in 20 % of people infected with the SARS-CoV-2 virus, it penetrates deep into the lungs. At the same time, the patient's condition quickly becomes critical, and the most severe patients must be urgently placed in the intensive care unit and connected to artificial lung ventilation (IVL) devices. Artificial ventilation is necessary when the lungs can no longer breathe in enough oxygen and breathe out the carbon dioxide that has been collected in them. In this case, ventilators take over the functions of the respiratory system. The methods of carrying out artificial ventilation of the lungs require not only experimental, but also theoretical justification. For the study, it is proposed to apply a mathematical model of the functional respiratory system, in which the breathing process is represented as a controlled dynamic system and which allows predicting the gas exchange process in the lung structures in the dynamics of the respiratory cycle under various disturbing influences. To expand the area of applicability, the process features characteristic of the conditions under consideration are taken into account. It is proposed to supplement the model with equations that take into account the elasticity and resistance of pulmonary structures. Since the possibility of obtaining quantitative and qualitative characteristics of the process of mass transfer of gases with various types of artificial ventilation of the lungs is essential, equations are proposed to describe different types of pulmonary respiration. Implementation of the proposed model will allow obtaining results on the study of the process of dynamics of respiratory gases during artificial ventilation of the lungs, contributing to the solution of practical problems on the optimization of the parameters of technical devices for artificial ventilation. The subsequent combination of the proposed model with the model of the development of a viral disease can, in the presence of an array of individual data, be of significant assistance in choosing mechanical ventilation modes in a complicated course of a viral disease.

Application of the method of mathematical modeling for forecasting channel deformations at the underwater crossing of the main pipeline

2020 ◽  
Vol 10 (6) ◽  
pp. 599-609
Author(s):  
Valery А. Gruzdev ◽  
◽  
Georgy V. Mosolov ◽  
Ekaterina A. Sabayda ◽  
◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Roughness Coefficient ◽  
Computational Domain ◽  
Channel Deformations ◽  
Geological Surveys ◽  
Kuban River ◽  
The Stability ◽  
Protective Structures

In order to determine the possibility of using the method of mathematical modeling for making long-term forecasts of channel deformations of trunk line underwater crossing (TLUC) through water obstacles, a methodology for performing and analyzing the results of mathematical modeling of channel deformations in the TLUC zone across the Kuban River is considered. Within the framework of the work, the following tasks were solved: 1) the format and composition of the initial data necessary for mathematical modeling were determined; 2) the procedure for assigning the boundaries of the computational domain of the model was considered, the computational domain was broken down into the computational grid, the zoning of the computational domain was performed by the value of the roughness coefficient; 3) the analysis of the results of modeling the water flow was carried out without taking the bottom deformations into account, as well as modeling the bottom deformations, the specifics of the verification and calibration calculations were determined to build a reliable mathematical model; 4) considered the possibility of using the method of mathematical modeling to check the stability of the bottom in the area of TLUC in the presence of man-made dumping or protective structure. It has been established that modeling the flow hydraulics and structure of currents, making short-term forecasts of local high-altitude reshaping of the bottom, determining the tendencies of erosion and accumulation of sediments upstream and downstream of protective structures are applicable for predicting channel deformations in the zone of the TLUC. In all these cases, it is mandatory to have materials from engineering-hydro-meteorological and engineering-geological surveys in an amount sufficient to compile a reliable mathematical model.

On the displacements of the contours of the optic-electronic space images. Mathematical modeling of displacement

2017 ◽  
Vol 992 (4) ◽  
pp. 32-38 ◽  
Author(s):  
E.G. Voronin
Keyword(s):  
Mathematical Modeling ◽  
Remote Sensing ◽  
Mathematical Model ◽  
Point Of View ◽  
Design Features ◽  
Space Images ◽  
Electronic Imaging ◽  
Measuring Accuracy ◽  
Physical Laws

The article opens a cycle of three consecutive publications dedicated to the phenomenon of the displacement of the same points in overlapping scans obtained adjacent CCD matrices with opto-electronic imagery. This phenomenon was noticed by other authors, but the proposed explanation for the origin of displacements and the resulting estimates are insufficient, and developed their solutions seem controversial from the point of view of recovery of the measuring accuracy of opticalelectronic space images, determined by the physical laws of their formation. In the first article the mathematical modeling of the expected displacements based on the design features of a scanning opto-electronic imaging equipment. It is shown that actual bias cannot be forecast, because they include additional terms, which may be gross, systematic and random values. The proposed algorithm for computing the most probable values of the additional displacement and ways to address some of the systematic components of these displacements in a mathematical model of optical-electronic remote sensing.

scholarly journals Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection

Viruses ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 547
Author(s):  
Veronika Bernhauerová ◽  
Veronica V. Rezelj ◽  
Marco Vignuzzi
Keyword(s):  
Mathematical Model ◽  
Viral Infection ◽  
Host Cell ◽  
Decay Time ◽  
Zika Virus ◽  
Infectious Virus ◽  
Numerical Characterization ◽  
The Mathematical Model

Mathematical models of in vitro viral kinetics help us understand and quantify the main determinants underlying the virus–host cell interactions. We aimed to provide a numerical characterization of the Zika virus (ZIKV) in vitro infection kinetics, an arthropod-borne emerging virus that has gained public recognition due to its association with microcephaly in newborns. The mathematical model of in vitro viral infection typically assumes that degradation of extracellular infectious virus proceeds in an exponential manner, that is, each viral particle has the same probability of losing infectivity at any given time. We incubated ZIKV stock in the cell culture media and sampled with high frequency for quantification over the course of 96 h. The data showed a delay in the virus degradation in the first 24 h followed by a decline, which could not be captured by the model with exponentially distributed decay time of infectious virus. Thus, we proposed a model, in which inactivation of infectious ZIKV is gamma distributed and fit the model to the temporal measurements of infectious virus remaining in the media. The model was able to reproduce the data well and yielded the decay time of infectious ZIKV to be 40 h. We studied the in vitro ZIKV infection kinetics by conducting cell infection at two distinct multiplicity of infection and measuring viral loads over time. We fit the mathematical model of in vitro viral infection with gamma distributed degradation time of infectious virus to the viral growth data and identified the timespans and rates involved within the ZIKV-host cell interplay. Our mathematical analysis combined with the data provides a well-described example of non-exponential viral decay dynamics and presents numerical characterization of in vitro infection with ZIKV.

scholarly journals A Mathematical Model of the Controlled Plant of the Réspiratory System

1971 ◽  
Vol 11 (10) ◽  
pp. 810-834 ◽  
Author(s):  
T.J. Trueb ◽  
N.S. Cherniack ◽  
A.F. D'Souza ◽  
A.P. Fishman
Keyword(s):  
Mathematical Model ◽  
Respiratory System

Mathematical modeling of fluid movement inside the eyeball during intravitreal injection

2021 ◽  
pp. 106-109
Author(s):  
D.V. Lipatov ◽  
◽  
S.A. Skladchikov ◽  
N.P. Savenkova ◽  
V.V. Novoderezkin ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Residence Time ◽  
Complex Structure ◽  
Posterior Vitreous Detachment ◽  
Vitreous Body ◽  
Complete Removal ◽  
Intravitreal Injections ◽  
The World

Background. The avalanche-like growth of intravitreal injections in the world has significantly increased interest in the hemodynamics of the processes that occur in the eye when a drug is injected into the vitreous cavity. Every year, the number of intravitreally used drugs and promising areas in which they can be used is growing. This also applies to the creation of new combined medicines and the development of drugs with a long-term therapeutic effect. Aims. Create mathematical model of eyeball to evaluate the movement of the drug substance in it; to estimate the time of the drug's presence in the eye cavity before its complete removal, to characterize the ways of its removal from the eye cavity; to assess the significance of posterior vitreous detachment during the time when the drug is present in the eye cavity; to evaluate the effect on the hydrodynamics of the depth of drug administration. Results. When the drug is administered closer to the center of the eyeball, its residence time increases in comparison with the parietal administration. With a complete posterior detachment of the vitreous body, the time of finding the drug in the eye is prolonged compared to its absence. The obtained results of mathematical modeling of the movement of the drug administered intravitreally cannot be mechanically transferred to the human eye, due to the more complex structure of the latter. Key words: intravitreal injections, vitreous body, mathematic computing.

MATHEMATICAL MODELING OF CONCRETE STRUCTURE CORROSION IN BIOLOGICALLY AGGRESSIVE ENVIRONMENTS

2021 ◽  
Vol 3 (102) ◽  
pp. 55-67
Author(s):  
VARVARA E. RUMYANTSEVA ◽  
SVETLANA A. LOGINOVA ◽  
NATALIA E. KARTSEVA
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Mass Transfer ◽  
Parabolic Type ◽  
Cement Concrete ◽  
Mass Conductivity ◽  
Kinetics And Dynamics ◽  
Biological Corrosion ◽  
First Time ◽  
Fourth Kind

In the aquatic environment, biocorrosion is an important factor affecting the reliability and durability of concrete structures. The destruction of cement concretes during biological corrosion is determined by the processes of mass transfer. The article presents the development of a calculated mathematical model of liquid corrosion in cement concrete, taking into account the biogenic factor. For the first time, a model of mass transfer in an unbounded two-layer plate is considered in the form of differential equations of parabolic type in partial derivatives with boundary conditions of the second kind at the interface between concrete and liquid and of the fourth kind at the interface between concrete and biofilm. The results of a numerical experiment are presented to study the influence of the coefficients of mass conductivity and mass transfer on the kinetics and dynamics of the process.

Methods of Mathematical Modeling of the Leaching Process of Cobalt-Containing Solutions

2021 ◽  
Vol 316 ◽  
pp. 661-666
Author(s):  
Nataliya V. Mokrova
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Chemical Kinetics ◽  
Group Method ◽  
Data Handling ◽  
Multistage Processes ◽  
Leaching Process ◽  
Proposed Model ◽  
Simulation Results ◽  
The Mathematical Model

Current cobalt processing practices are described. This article discusses the advantages of the group argument accounting method for mathematical modeling of the leaching process of cobalt solutions. Identification of the mathematical model of the cascade of reactors of cobalt-producing is presented. Group method of data handling is allowing: to eliminate the need to calculate quantities of chemical kinetics; to get the opportunity to take into account the results of mixed experiments; to exclude the influence of random interference on the simulation results. The proposed model confirms the capabilities of the group method of data handling for describing multistage processes.

A prey–predator model and control of a nematodes pest using control in banana: Mathematical modeling and qualitative analysis

2021 ◽  
pp. 2150089
Author(s):  
Sudhakar Yadav ◽  
Vivek Kumar
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Local Stability ◽  
Detection Method ◽  
Initial Release ◽  
Pest Detection ◽  
Predator Model ◽  
And Control ◽  
The Mathematical Model ◽  
Theoretical Results

This study develops a mathematical model for describing the dynamics of the banana-nematodes and its pest detection method to help banana farmers. Two criteria: the mathematical model and the type of nematodes pest control system are discussed. The sensitivity analysis, local stability, global stability, and the dynamic behavior of the mathematical model are performed. Further, we also develop and discuss the optimal control mathematical model. This mathematical model represents various modes of management, including the initial release of infected predators as well as the destroying of nematodes. The theoretical results are shown and verified by numerical simulations.

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