Respiratory Syncytial Virus Prophylaxis in Down Syndrome: A Prospective Cohort Study

PEDIATRICS ◽  
2014 ◽  
Vol 133 (6) ◽  
pp. 1031-1037 ◽  
Author(s):  
H. Yi ◽  
K. L. Lanctot ◽  
L. Bont ◽  
B. L. P. Bloemers ◽  
M. Weijerman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Syncytial Virus

scholarly journals Respiratory Syncytial Virus Prophylaxis In Down Syndrome: A Prospective Cohort Study

2014 ◽  
Vol 17 (3) ◽  
pp. A171
Author(s):  
H. Yi ◽  
K.L. Lanctot ◽  
L. Bont ◽  
B. Bloemers ◽  
M. van Furth ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Syncytial Virus

scholarly journals Burden of Influenza and Respiratory Syncytial Virus Infection in Pregnant Women and Infants Under 6 Months in Mongolia: A Prospective Cohort Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148421 ◽  
Author(s):  
Liling Chaw ◽  
Taro Kamigaki ◽  
Alexanderyn Burmaa ◽  
Chuluunbatiin Urtnasan ◽  
Ishiin Od ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Pregnant Women ◽  
Prospective Cohort Study ◽  
Respiratory Syncytial Virus Infection ◽  
Prospective Cohort ◽  
Syncytial Virus

scholarly journals Underlying cardiopulmonary conditions as a risk factor for influenza and respiratory syncytial virus infection among community-dwelling adults aged ≥65 years in Thailand: Findings from a two-year prospective cohort study

2021 ◽  
Author(s):  
Prabda Praphasiri ◽  
Manash Shrestha ◽  
Jayanton Patumanond ◽  
Sutthichai Nakphook ◽  
Sutthinan Chawalchitiporn ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Respiratory Illness ◽  
Community Dwelling ◽  
Chronic Obstructive ◽  
Increased Risk ◽  
Syncytial Virus

Background: Adults with cardiopulmonary conditions are at increased risk for complications from influenza and respiratory syncytial virus (RSV) infection, but few data are available from middle-income countries. Methods: Using data from a prospective cohort study of influenza vaccine effectiveness among community-dwelling Thai adults aged ≥65 years, we estimated and compared the incidence of influenza and RSV in those with and without cardiopulmonary conditions. During May 2015-May 2017, older adults in a rural province in Thailand were followed weekly with year-round surveillance for acute respiratory illness (ARI), defined broadly as new onset or worsening of cough with or without fever, and hospitalized ARI. When ill, nasal self-swabs and/or nasopharyngeal swabs were collected for reverse-transcription polymerase chain reaction testing. We used Poisson regression to calculate incidence rate ratios (IRR), adjusting for age, sex, past healthcare-seeking behavior, weekly influenza activity, and influenza vaccination. Results: Overall, 3,220 adults with a median age of 71 years (IQR 68-76) were enrolled; 1,324 (41.1%) were male; and 313 (9.7%) had ≥1 underlying cardio-pulmonary condition, most commonly chronic obstructive pulmonary disease (131; 41.2%) or asthma (73; 23.3%). Compared to those without, participants with cardiopulmonary conditions had higher incidences of ARI, influenza, and RSV (Adjusted IRR: 1.83, 95% CI 1.63-2.05; 1.84, 95% CI 1.05-3.23; 2.02, 95% CI 1.10-3.72, respectively). Conclusion: Our findings show that older adults in rural Thailand with cardiopulmonary conditions have increased rates of ARI, influenza, and RSV infections, and support efforts to ensure this population has access to influenza vaccines and other respiratory illness prevention measures.

Asthma and Immunoglobulin E Antibodies After Respiratory Syncytial Virus Bronchiolitis: A Prospective Cohort Study With Matched Controls

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 500-505 ◽  
Author(s):  
N. Sigurs ◽  
R. Bjarnason ◽  
F. Sigurbergsson ◽  
B. Kjellman ◽  
B. Björkstén
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Prospective Cohort ◽  
Egg White ◽  
Control Group ◽  
Igg Antibodies ◽  
Ige Antibodies ◽  
Syncytial Virus

Objective. To study the occurrence of bronchial obstructive symptoms and immunoglobulin (Ig) E antibodies after respiratory syncytial virus (RSV) bronchiolitis in infancy. Previous studies of this subject have mostly been retrospective or without controls, or the controls have not been followed prospectively. Design. This was a prospective cohort study with matched controls. Participants. Forty-seven infants had experienced RSV bronchiolitis severe enough to cause hospitalization at a mean age of 3½ months. For each child with RSV infection, two controls were acquired from the local Child Health Center and matched for date of birth, sex, and residence. Only one control was obtained for one RSV child, and the control group thus contained 93 children. Methods. All the children underwent two follow-up examinations, the first one at a mean age of 1 year and the second at a mean age of 3 years. At the first follow-up, a skin-prick test against egg white was performed, and serum IgG antibodies against RSV were measured. At the second follow-up, serum IgE antibodies were measured using screening tests for common food and inhalant antibodies, and skin-prick tests against egg white, cat, birch, and mite allergen were performed. Hereditary and environmental factors (passive smoking, indoor furred animals) and duration of breast-feeding were recorded. Results. At the first follow-up, 89% in the RSV group and 27% in the control group had IgG antibodies against RSV (P < .001). At the second follow-up, asthma, defined as three episodes of bronchial obstruction verified by a physician, was found in 11 of 47 children (23%) in the RSV group and in 1 of 93 children (1%) in the control group (P < .001). A positive test for IgE antibodies was noted in 14 of 44 (32%) RSV children and in 8 of 92 (9%) children in the control group (P = .002). An analysis of risk factors for the development of asthma and IgE antibodies on the whole group of 140 children showed that RSV bronchiolitis was the most important risk factor, and a family history of atopy or asthma further increased the risk. Conclusions. Respiratory syncytial virus bronchiolitis during the first year of life apparently is an important risk factor for the development of asthma and sensitization to common allergens during the subsequent 2 years, particularly in children with heredity for atopy/asthma.

ASTHMA AND IMMUNOGLOBULIN E (IgE) ANTIBODIES AFTER RESPIRATORY SYNCYTIAL VIRUS (RSV) BRONCHIOLITIS: A PROSPECTIVE COHORT STUDY WITH MATCHED CONTROLS

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 329-329
Author(s):  
James E. Gern
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Family History ◽  
Prospective Cohort ◽  
Immunoglobulin E ◽  
Specific Ige ◽  
Ige Antibodies ◽  
History Of ◽  
Syncytial Virus

RSV bronchiolitis was the most important risk factor for the development of asthma and allergen-specific IgE, although a family history of atopy or asthma further increased the risk.

scholarly journals Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study

2018 ◽  
Vol 212 (5) ◽  
pp. 295-300 ◽  
Author(s):  
Sally-Ann Cooper ◽  
Elita Smiley ◽  
Linda Allan ◽  
Jillian Morrison
Keyword(s):  
Down Syndrome ◽  
Cohort Study ◽  
General Population ◽  
Intellectual Disabilities ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Unipolar Depression ◽  
First Episode ◽  
Problem Behaviours ◽  
Adults With Intellectual Disabilities

BackgroundIncidence and determinants of affective disorders among adults with intellectual disabilities are unknown.AimsTo investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports.MethodProspective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years.ResultsThere was 70% cohort retention (n = 651). Despite high mood stabiliser use (22.4%), 2-year incident mania at 1.1% is higher than the general population; 0.3% for first episode (standardised incident ratio (SIR) = 41.5, or 52.7 excluding Down syndrome). For any bipolar episode the SIR was 2.0 (or 2.5 excluding Down syndrome). Depression incidence at 7.2% is similar to the general population (SIR = 1.2), suggesting more enduring/undertreatment given the higher prevalence. Problem behaviours (odds ratio (OR) = 2.3) and life events (OR = 1.3) predict incident unipolar depression.ConclusionsDepression needs improved treatment. Mania has received remarkably little attention in this population, despite high prevalence and incidence (similar to schizophrenia), and given the importance of clinician awareness for accurate differential diagnosis from attention-deficit hyperactivity disorder and problem behaviours.Declaration of interestNone.

Do foot posture, deformity, and footwear fit influence physical activity levels in children with Down syndrome? A prospective cohort study

2016 ◽  
Vol 42 (4) ◽  
pp. 332-338 ◽  
Author(s):  
Nora Shields ◽  
Polly Lim ◽  
Dennis Wollersheim ◽  
Nikolaos Nikolopoulos ◽  
Joanna Barrett ◽  
...  
Keyword(s):  
Physical Activity ◽  
Down Syndrome ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Activity Levels ◽  
Children With Down Syndrome ◽  
Physical Activity Levels ◽  
Foot Posture ◽  
Footwear Fit

Down Syndrome: A Novel Risk Factor for Respiratory Syncytial Virus Bronchiolitis A Prospective Birth-Cohort Study

PEDIATRICS ◽  
2007 ◽  
Vol 120 (4) ◽  
pp. e1076-e1081 ◽  
Author(s):  
B. L.P. Bloemers ◽  
A. M. van Furth ◽  
M. E. Weijerman ◽  
R. J.B.J. Gemke ◽  
C. J.M. Broers ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Risk Factor ◽  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Respiratory Syncytial Virus Bronchiolitis ◽  
Syncytial Virus ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study
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