AUREOMYCIN IN THE TREATMENT OF EXPERIMENTAL AND CLINICAL INFECTIONS WITH H. INFLUENZAE, TYPE B

PEDIATRICS ◽  
1950 ◽  
Vol 5 (2) ◽  
pp. 267-275
Author(s):  
CAROLINE A. CHANDLER ◽  
HORACE L. HODES
Keyword(s):  
Body Weight ◽  
Clinical Improvement ◽  
Complete Recovery ◽  
Spinal Fluid ◽  
Response To Treatment ◽  
Type B ◽  
Adequate Treatment ◽  
Residual Damage ◽  
Toxic Reactions

Aureomycin, in doses of 20 mg./kg. body weight, was as effective in the treatment of mice infected with H. influenzae, type B, as streptomycin and dihydrostreptomycin, and more effective than polymyxin or Q-19. Two infants with H. influenzae, type B, meningitis were treated successfully with aureomycin and sulfadiazine. Spinal fluid cultures became negative and marked clinical improvement occurred within 48 hours. Both patients went on to complete recovery. Three children were treated with aureomycin alone. Although their response to treatment was not so rapid as that of the infants treated with aureomycin and sulfadiazine, rccovery was assured within four to seven days and subsequently there were no evidences of residual damage. No serious toxic reactions to aureomycin were apparent. A sixth patient, desperately ill on admission, succumbed within 36 hours in spite of adequate treatment with combined aureomycin and sulfadiazine.

scholarly journals Heterotopic ossification in the post cruciate ligament of the knee: a case report and literature review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Cun Li ◽  
Zonggui Huang ◽  
K. C. Anil ◽  
Chendeng Lao ◽  
Qianghua Wu ◽  
...  
Keyword(s):  
Literature Review ◽  
Heterotopic Ossification ◽  
Knee Pain ◽  
Cruciate Ligament ◽  
Complete Recovery ◽  
X Rays ◽  
Related Factors ◽  
Knee Motion ◽  
Adequate Treatment ◽  
The Difference

Abstract Background Heterotopic ossification (HO) is noted most frequently in periarticular muscles and has not yet been reported in the cruciate ligaments of the knee. We present a rare case of symptomatic ossification of the posterior cruciate ligament (PCL). Case presentation A 59-year-old woman had a 2-year history of knee pain that was getting worse during knee motion and had restricted knee motion for 1 year. X-rays could not show the lesion clearly. Multi-planar computed tomography demonstrated ossification within the PCL with mild osteoarthritic changes and excluded any other intra-articular pathology. The patient underwent arthroscopic debridement and then experienced immediate relief of pain and complete recovery of range of motion. Conclusion This is the first report of HO in the PCL as a possible cause of knee pain and restricted knee motion. On the basis of literature review, this case elaborates the difference between HO and calcification in the ligaments, the related factors inducing HO and the undefined pathogenesis, and favorable prognosis after adequate treatment.

Superior Orbital Fissure Syndrome due to Sinusitis: Report of Two Cases

2005 ◽  
Vol 19 (4) ◽  
pp. 417-420 ◽  
Author(s):  
Fabio de Rezende Pinna ◽  
Daniel L. Dutra ◽  
Maura C. Neves ◽  
Fabrizio Ricci Romano ◽  
Richard L. Voegels ◽  
...  
Keyword(s):  
Early Recognition ◽  
Complete Recovery ◽  
Ocular Motility ◽  
Intravenous Antibiotic ◽  
Superior Orbital Fissure ◽  
Adequate Treatment ◽  
Superior Orbital Fissure Syndrome ◽  
Brain Involvement ◽  
The Brain ◽  
Anatomic Region

Background The potential morbidity and mortality of sphenoid sinus infectious processes are related to their proximity to vital structures within the orbit, such as the cavernous sinus and the brain. Involvement of the posterior orbit can result in superior orbital fissure syndrome, a rare entity affecting structures that cross this anatomic region. Early recognition of this syndrome is mandatory. Delays in adequate treatment may compromise the patient's prognosis. Methods We present two cases of incomplete superior orbital fissure syndrome due to infectious processes of the posterior ethmoid and sphenoid sinuses. Conclusions In our experience, endoscopic decompression of the lamina papyracea shows complete recovery of extrinsic ocular motility in these patients and should be combined with intravenous antibiotic therapy.

scholarly journals Possible factors for ankle fractures

2010 ◽  
Vol 67 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Dejan Tabakovic ◽  
Radovan Manojlovic ◽  
Marko Kadija ◽  
Mihailo Ille ◽  
Goran Turkovic ◽  
...  
Keyword(s):  
Body Weight ◽  
Significant Risk ◽  
Ankle Fractures ◽  
Type B ◽  
Physical Exercises ◽  
Appropriate Treatment ◽  
Fracture Body ◽  
Type C ◽  
Fracture Types

Background/Aim. Classification of ankle fractures is commonly used for selecting an appropriate treatment and prognosing an outcome of definite management. One of the most used classifications is the Danis-Weber classification. To the best of our knowledge, in the available literature, there are no parameters affecting specific types of ankle fractures according to the Danis-Weber classification. The aim of this study was to analyze the correlation of the following parameters: age, body weight, body mass index (BMI), height, osteoporosis, osteopenia and physical exercises with specific types of ankle fractures using the Danis-Weber classification. Methods. A total of 85 patients grouped by the Danis-Weber classification fracture types were analyzed and the significance of certain parameters for specific types of ankle fractures was established. Results. The proportion of females was significantly higher (p < 0.001) with a significantly higher age (59.9 years, SD ? 14.2) in relation to males (45.1 years, SD ? 12.8) (p < 0.0001). Type A fracture was most frequent in the younger patients (34.2 years, SD ? 8.6), and those with increased physical exercises (p = 0.020). In type B fracture, the risk factor was osteoporosis (p = 0.0180), while in type C fracture, body weight (p = 0.017) and osteoporosis (p = 0.004) were significant parameters. Conclusion. Statistical analysis using the Danis-Weber classification reveals that there are certain parameters suggesting significant risk factors for specific types of ankle fractures.

scholarly journals Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project

2021 ◽  
Vol 28 ◽  
pp. 107327482110384
Author(s):  
Mohammad A. J. Abdulla ◽  
Prem Chandra ◽  
Susanna El Akiki ◽  
Mahmood B. Aldapt ◽  
Sundus Sardar ◽  
...  
Keyword(s):  
Body Weight ◽  
Survival Curve ◽  
Statistical Significance ◽  
Response Assessment ◽  
Test Methods ◽  
Response To Treatment ◽  
Molecular Response ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Transcript Type

Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. Methodology We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients’ management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan–Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. Results/conclusion In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance.

scholarly journals CYSTOSTOMY DUE TO URETHRAL OBSTRUCTION IN A CAT: CLINICAL CASE

2021 ◽  
Vol 245 (1) ◽  
pp. 215-218
Author(s):  
N.V. Shamsutdinova ◽  
◽  
Keyword(s):  
Veterinary Medicine ◽  
Clinical Case ◽  
Complete Recovery ◽  
Treatment Method ◽  
Anatomical Structure ◽  
Urethral Obstruction ◽  
Common Reason ◽  
Adequate Treatment ◽  
Urgent Task

Violation of the process of urination in cats is a fairly common reason for owners to contact veterinary clinics. The development of an adequate treatment method for urethral obstruction, based on the pathogenesis of the disease and taking into account the anatomical structure of the cat's urinary sys-tem, remains an urgent task of modern veterinary medicine. Cystotomy with suturing of the catheter and subsequent detoxification therapy can achieve complete recovery, as the cause of blockage of the urethra is eliminated.

scholarly journals Differential virulence of camel Trypanosoma evansi isolates in mice

Parasitology ◽  
2018 ◽  
Vol 145 (9) ◽  
pp. 1235-1242 ◽  
Author(s):  
Christine M. Kamidi ◽  
Joanna Auma ◽  
Paul O. Mireji ◽  
Kariuki Ndungu ◽  
Rosemary Bateta ◽  
...  
Keyword(s):  
Body Weight ◽  
South America ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Post Infection ◽  
Trypanosoma Evansi ◽  
Type B ◽  
Mortality And Morbidity ◽  
Live Body Weight ◽  
High Virulence

AbstractThis study assessed the virulence of Trypanosoma evansi, the causative agent of camel trypanosomiasis (surra), affecting mainly camels among other hosts in Africa, Asia and South America, with high mortality and morbidity. Using Swiss white mice, we assessed virulence of 17 T. evansi isolates collected from surra endemic countries. We determined parasitaemia, live body weight, packed cell volume (PCV) and survivorship in mice, for a period of 60 days’ post infection. Based on survivorship, the 17 isolates were classified into three virulence categories; low (31–60 days), moderate (11–30 days) and high (0–10 days). Differences in survivorship, PCV and bodyweights between categories were significant and correlated (P < 0.05). Of the 10 Kenyan isolates, four were of low, five moderate and one (Type B) of high virulence. These findings suggest differential virulence between T. evansi isolates. In conclusion, these results show that the virulence of T. evansi may be region specific, the phenotype of the circulating parasite should be considered in the management of surra. There is also need to collect more isolates from other surra endemic regions to confirm this observation.

PENICILLIN THERAPY OF LATE CONGENITAL SYPHILIS

PEDIATRICS ◽  
1948 ◽  
Vol 1 (5) ◽  
pp. 601-616
Author(s):  
RALPH V. PLATOU ◽  
JOHN T. KOMETANI
Keyword(s):  
Body Weight ◽  
Congenital Syphilis ◽  
Single Agent ◽  
Previous Treatment ◽  
Spinal Fluid ◽  
Older Children ◽  
Total Dosage ◽  
Intramuscular Injections ◽  
Interstitial Keratitis ◽  
Penicillin Therapy

Though no valid comparisons can be made until more patients have been treated and followed for a longer time, it seems to us that penicillin used alone is at least as effective as any other single agent for the treatment of late congenital syphilis. To what extent treatment or time alone contribute to improvements cannot yet be stated. Most of the clinical and serologic indications of healing developed rather slowly; in only a few patients with the most superficial lesions were there objective signs of improvement during therapy. The treatment schedules we employed are similar to those previously recommended for infants. At present we advise a total dosage comprising at least 100,000 units commercial penicillin per kilogram body weight, divided into 100 equal intramuscular injections and given at two to three hour intervals around the clock for eight or more days. Therapeutic reactions, entirely febrile in nature, have all been transient and benign. There were no deaths. We believe that the simplicity, safety and convenience of these plans make them preferable to the more costly, hazardous, and time-consuming older methods; further-more, they effectively curtail the appallingly high delinquency rates formerly prevailing. Results were significantly better for children treated under six years of age than they were for older children, and also for those who had normal spinal fluid before treatment; they were suggestively but not significantly better among those for whom the larger dosage schedules were used. Outcome was significantly worse in those who had received previous treatment of any sort. There were just three relapse—two defined only serologically, and one by a questionable recurrence of interstitial keratitis. About a quarter of those with latent congenital syphilis have become seronegative. The poorest results ensued for patients with clinical neurosyphilis; two children from this group continued to exhibit definite deterioration. For interstitial keratitis, results were most gratifying in two patients treated within a month of onset. Seventy-two per cent of all patients with late congenital syphilis so far treated with penicillin and followed for more than two months are clinically well and have negative serologic reactions or progressively declining titers.

Aortic emergencies

2021 ◽  
pp. 805-819
Author(s):  
Marc Schepens ◽  
Eric Graulus
Keyword(s):  
Type A ◽  
Acute Type ◽  
Type B ◽  
Endovascular Techniques ◽  
Adequate Treatment ◽  
Urgent Surgery ◽  
Acute Type A Dissection ◽  
Golden Standard ◽  
Life Threatening ◽  
Type A Dissection

Acute aortic dissection is without any doubt the most feared and life threatening aortic emergency. It is associated with a dreadful mortality rate and an immediate and accurate diagnosis without delay followed by adequate treatment is mandatory. It is important to make a distinction between acute type A, uncomplicated and complicated type B. Acute type A dissection generally requires urgent surgery, complicated type B dissections are treated with endovascular techniques; there is ongoing debate whether uncomplicated type B dissections should also be treated by endografts in its early phase. Surgical repair of acute type A dissection consists of the replacement of the intrapericardial ascending aorta with varying segments of the arch and/or aortic root. The endovascular techniques with stentgrafts deployed into the proximal descending aorta in type B dissections have revolutionized the surgical therapy and the patient�s immediate and medium-term survival. For chronic postdissection aneurysms open surgery still remains the golden standard. Acute traumatic aortic isthmus ruptures are similar life threatening conditions and account for one of the main causes of death at the time of traumatic accidents. In these situations also stentgrafts have changed the outcome of these severe and multiple traumatic patients.

scholarly journals Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016)

2019 ◽  
Vol 36 (1) ◽  
pp. 25-31
Author(s):  
Danielle Mendelsohn ◽  
John R. Lewis ◽  
Kristin Iglesias Scott ◽  
Dorothy C. Brown ◽  
Alexander M. Reiter
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Clinicopathological Features ◽  
Response To Therapy ◽  
Oral Disease ◽  
Response To Treatment ◽  
Inclusion Criteria ◽  
Lesion Location ◽  
Referral Practice

The objectives of this study were to retrospectively describe clinicopathological features of eosinophilic oral disease in dogs, to identify possible risk factors or predispositions to the condition, and to report overall treatment response. Canine medical records from a veterinary teaching hospital and private referral practice over a 17-year period were reviewed for a diagnosis of eosinophilic oral disease. Twenty-four dogs with 26 lesions met the inclusion criteria. Patient mean age and body weight were 6.8 (3.8) years and 13.4 kg, respectively. Fifteen breeds were represented including Cavalier King Charles spaniel (16.7%), Labrador retriever (12.5%), and West Highland white terrier (12.5%). Eosinophilic lesions were found in the palate (65.4%), tongue (26.9%), and other oral locations (7.7%). Median follow-up time was 5 months. Analysis revealed statistically significant associations between lesion location and body weight (palatal and tongue lesions were more likely in smaller dogs, whereas lesions in the other category [lip or mucosa] were more likely in larger dogs). There was a correlation in lesion location and resolution (all dogs with palatal lesions became asymptomatic at their last recheck), and resolution and the use of antibiotics plus prednisone (greater likelihood of resolution without the use of this combination). Seventy percent of asymptomatic dogs resolved without medication or with allergen therapy alone, suggesting that asymptomatic dogs may respond well to conservative management. No associations were found between lesion location and breed, signalment and response to therapy, lesion resolution and the use of glucocorticoids, or significance of peripheral eosinophilia.

Excess body weight as a predictor of response to treatment with antidepressants in patients with depressive disorder

2020 ◽  
Vol 267 ◽  
pp. 153-170 ◽  
Author(s):  
Svetlana Puzhko ◽  
Sarah A.E. Aboushawareb ◽  
Irina Kudrina ◽  
Tibor Schuster ◽  
Tracie A. Barnett ◽  
...  
Keyword(s):  
Body Weight ◽  
Depressive Disorder ◽  
Response To Treatment ◽  
Excess Body Weight
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