Iron Status and Infant Feeding Practices in an Urban Ambulatory Center

PEDIATRICS ◽  
1983 ◽  
Vol 72 (1) ◽  
pp. 33-36
Author(s):  
P. David Sadowitz ◽  
Frank A. Oski
Keyword(s):  
Iron Deficiency ◽  
Infant Feeding ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Feeding Practices ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Infant Feeding Practices ◽  
Cow's Milk ◽  
Iron Deficient

The relationship of infant feeding practices to iron status was examined in a group of 280 infants, 9 to 12 months of age, attending a "well-baby" clinic. Of this group, 7.6% were found to be iron depleted, 19.7% were iron deficient without anemia, and 8.2% were iron deficient with anemia. The incidence of iron-deficiency anemia was significantly greater in the black infants than the white infants (14.3% v 2.7%). The introduction of whole cow's milk into the diet had occurred prior to 6 months of age in 29.2% of the infants, and 62.1% of these infants had laboratory evidence of nutritional iron inadequacy, as contrasted with only 21.8% of those with iron deficiencies fed cow's milk after 6 months of age. Of the 21 infants with iron-deficiency anemia, 19 (90.5%) had been fed whole cow's milk prior to 6 months of age. Iron deficiency remains a nutritional problem for infants in an urban setting and is largely a result of the early introduction of whole cow's milk into the diet.

scholarly journals Association of Infant Feeding Practices with Iron Status and Hematologic Parametersin Thai Infants at 6 Months of Age

2021 ◽  
Author(s):  
Chayatat Ruangkit ◽  
Nawapat Prachakittikul ◽  
Nutthida Hemprachitchai ◽  
Oraporn Dumrongwongsiri ◽  
Sasivimon Soonsawad
Keyword(s):  
Logistic Regression ◽  
Iron Deficiency ◽  
Infant Feeding ◽  
Iron Supplementation ◽  
Complete Blood Count ◽  
Reference Group ◽  
Iron Status ◽  
Feeding Practices ◽  
Deficiency Anemia ◽  
Infant Feeding Practices

Abstract Background: An infant's iron intake in the first 6 months of life comes solely from milk intake. However, infants' feeding practices vary, and their association with infants' iron status and hematologic parameters has not been well studied. We aimed to evaluate how different infant feeding practices associate with iron status and hematologic parameters among 6-month-old Thai infants. Methods: In a retrospective chart review, we identified 403 infants who attended a well-baby clinic and received laboratory screening for anemia (complete blood count and serum ferritin) at 6-month visits. Infants were categorized into four groups according to feeding practices. Hematologic parameters and incidence of anemia (hemoglobin [Hb]<11 g/dL), iron deficiency (ID; ferritin<12 ng/mL), and iron deficiency anemia (IDA; Hb<11 g/dL and ferritin<12 ng/mL) were compared between groups. Univariate and multiple logistic regression models were used to identify IDA associated factors among 6-month-old infants. Results: In total, 105 infants were breastfed (BF), 78 were breastfed with iron supplementation (BI), 109 infants were mixed-fed (breast milk and formula) with or without iron supplementation starting at age 4 months (MF), and 111 infants were formula-fed (FF). The BF group had the highest incidence of anemia, ID, and IDA. Anemia was found in 38.1% of BF infants compared with 21.8% of BI, 19.3% of MF, and 16.2% of FF infants (p<0.001). ID was found in 28.6% of BF infants compared with 3.8% of BI, 3.7% of MF, and 0.9% of FF infants (p<0.001). IDA was found in 17.1% of BF infants compared with 2.6% of BI, 0.9% of MF, and 0.9% of FF infants (p<0.001). In multivariate logistic regression, higher weight gain during 0–6 months slightly increased the risk of IDA and higher birth weight slightly decreased this risk. BI, MF, and FF infants had 90.4%, 97.5%, and 96.9% decreased risk of IDA, respectively, with BF infants as a reference group. Conclusion: The incidence of anemia, ID, and IDA at age 6 months was higher in BF than FF or partially BF infants. However, iron supplements in BF infants starting at 4 months significantly reduced their ID and IDA incidence.

scholarly journals A COMPARATIVE RANDOMIZED CLINICAL TRIAL OF NAVAYAS LOUHA SYRUP AND NISHA LOUHA SYRUP IN THE MANAGEMENT OF IRON DEFICIENCY ANEMIA IN INDIAN CHILDREN WITH SPECIAL REFERENCE TO PANDU ROGA

2020 ◽  
Vol 11 (6) ◽  
pp. 16-21
Author(s):  
Bharti Tiwari ◽  
Amar Singh Tiwari ◽  
Satish Chand Gupta
Keyword(s):  
Clinical Trial ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Clinical Efficacy ◽  
World Health ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Indian Children ◽  
Cow's Milk ◽  
Iron Deficient

Iron deficiency is the most usual dietary deficiency worldwide, approximately 25% of the world’s population suffering from iron deficiency anemia according to the World Health Organization. A Neonate has total body iron of 250 mg (80 mg/kg), obtained from maternal sources. In the first 6 months of life, during the period when the infant gets an iron-deficient milk diet, this amount decreases to 60 mg/kg. Infants fed with cow’s milk are at greater risk to develop iron deficiency anemia because calcium from cow’s milk is competing with iron for absorption. There are a large number of formulations (like Navayas Louha Syrup, Nisha Louha Syrup etc.) that are mentioned to prevent iron deficiency anemia in Indian children. Despite lack of scientific data regarding the clinical efficacy of Navayas Louha Syrup and Nisha Louha Syrup, an effort has been done to present the current scenario. 60 anemic patients of either sex age between 1-15 years were randomly selected from Kaumarabhritya O.P.D. and I.P.D. of Rani Dullaiya Post Graduate Ayurvedic College and Hospital, Bhopal (M.P), India. Overall, in the study Navayas Louha is 74.53% and Nisha Louha is 69.34% having clinical efficacy. The study was showed in clinical trial efficacy of Navayas Louha syrup is better than Nisha Louha syrup in the management of iron deficiency anemia in Indian children.

scholarly journals The Consequence of Excessive Consumption of Cow’s Milk: Protein-Losing Enteropathy with Anasarca in the Course of Iron Deficiency Anemia—Case Reports and a Literature Review

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 828
Author(s):  
Karolina Graczykowska ◽  
Joanna Kaczmarek ◽  
Dominika Wilczyńska ◽  
Ewa Łoś-Rycharska ◽  
Aneta Krogulska
Keyword(s):  
Iron Deficiency ◽  
Literature Review ◽  
Iron Deficiency Anemia ◽  
Case Reports ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Milk Consumption ◽  
Protein Losing Enteropathy ◽  
Cow's Milk ◽  
Excessive Consumption

Cow’s milk is a key component of a child’s diet. While the consumption of even trace amounts can result in allergy to its proteins and/or hypolactasia, excessive cow’s milk consumption can result in numerous health complications, including iron deficiency, due to the diet being improperly balanced. Although the incidence of iron deficiency has declined, it remains the most widespread nutritional deficiency globally and the most common cause of anemia. One rare consequence of anemia caused by iron deficiency is protein-losing enteropathy; however, the mechanisms of its development are unclear. The following manuscript, based on a literature review, presents two rare cases of children, a 16-month-old boy and a 2.5-year-old girl, who developed severe microcytic anemia, enteropathy with hypoalbuminemia, and anasarca as a result of excessive cow’s milk consumption. It highlights the possible relationship between excessive consumption of cow’s milk in children and severe iron deficiency anemia with accompanying hypoalbuminemia; it may also result in serious clinical conditions, even in children that do not demonstrate food hypersensitivity.

Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia

2020 ◽  
Vol 35 (9) ◽  
pp. 585-590
Author(s):  
Raquel Farias-Moeller ◽  
Sara Siddiqui ◽  
Megan Orr ◽  
Lileth Mondok
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Mean Corpuscular Volume ◽  
Milk Intake ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Corpuscular Volume ◽  
Cow's Milk ◽  
Cerebral Sinovenous Thrombosis ◽  
Sinovenous Thrombosis

Introduction: In young children, excessive cow’s milk intake causes iron-deficiency anemia, which is associated with hypercoagulable states. We present a case series of 4 toddlers with excessive milk intake iron-deficiency anemia and cerebral sinovenous thrombosis. Methods: Retrospective chart review of 4 patients was performed for patients with cerebral sinovenous thrombosis and iron-deficiency anemia secondary to excessive milk intake. Iron-deficiency anemia was defined as hemoglobin <11 mg/dL, mean corpuscular volume <70 fL, and serum ferritin <12 μg/L. Excessive milk intake was defined as consumption of >24 oz daily. Clinical, laboratory, and radiographic features were reviewed. Results: Age ranged from 12 to 24 months. Average hemoglobin, hematocrit, mean corpuscular volume, and ferritin levels were 6.1 g/dL, 22.7 g/dL, 52.7 fL, and 3.2 ng/mL, respectively. Daily milk consumption ranged from 40 to 60 oz. All patients presented with focal neurologic deficits, including seizures in 3. The location of cerebral sinovenous thrombosis varied, and 3 patients had venous infarcts, one of them hemorrhagic. All patients had a limited diet and were described as “picky eaters” by their parents, and only 1 had transitioned of a bottle. All patients were treated with anticoagulation, iron supplementation, and extensive dietary counseling to reduce cow’s milk intake. Conclusion: Iron-deficiency anemia due to excessive milk intake is an important and preventable etiology of pediatric cerebral sinovenous thrombosis. Focused anticipatory guidance is necessary for at-risk groups to prevent this neurologic emergency.

scholarly journals Effects of Iron Deficiency Anemia and Its Rapid Correction on the Serum Metabolomic Profile of Rhesus Infants

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1070-1070
Author(s):  
Brian Sandri ◽  
Gabriele Lubach ◽  
Eric Lock ◽  
Michael Georgieff ◽  
Pamela Kling ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Acid Production ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Iron Dextran ◽  
Metabolomic Profile ◽  
Intramuscular Injections ◽  
Iron Deficient ◽  
Rapid Correction

Abstract Objectives To determine whether rapid correction of iron deficiency using intramuscular iron dextran normalizes serum metabolomic changes in a nonhuman primate model of iron deficiency anemia (IDA). Methods Blood was collected from naturally iron-sufficient (IS; n = 10) and IDA (n = 12) male and female infant rhesus monkeys (Macaca mulatta) at 6 months of age. IDA infants were treated with intramuscular injections of iron dextran, 10 mg/weekly for 4–8 weeks. Iron status was reevaluated following treatment using hematological measurements and sera were metabolically profiled using HPLC/MS with isobaric standards for identification and quantification. Results Early-life iron deficiency anemia negatively affects many cellular metabolic processes, including energy production, electron transport, and oxidative degradation of toxins. Slow iron repletion with dietary supplementation restores iron deficient monkeys from a hematological perspective, but the serum metabolomic profile remains differed from monkeys that had been iron sufficient their entire life. Whether rapid iron restoration through intramuscular injections of iron dextran normalizes serum metabolomic profile is not known. A total of 654 metabolites were measured with differences in 53 metabolites identified between IS and IDA monkeys at 6 months (P 0.05). Pathway analyses provided evidence of altered liver function, hypometabolic state, differential essential fatty acid production, irregular inosine and guanosine metabolism, and atypical bile acid production in IDA infants. After treatment, iron-related hematological parameters had recovered, but the formerly IDA infants remained metabolically distinct from the IS infants, with 225 metabolites differentially expressed between the groups. Conclusions As with slow iron repletion, rapid iron repletion does not normalize the altered serum metabolomic profile in rhesus infants with IDA, suggesting the need for iron supplementation in the pre-anemic stage. Funding Sources National Institutes of Health.

Severe Iron-Deficiency Anemia Still an Issue in Toddlers

2014 ◽  
Vol 53 (14) ◽  
pp. 1352-1358 ◽  
Author(s):  
Gabrielle Paoletti ◽  
Debra L. Bogen ◽  
A. Kim Ritchey
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Motor Development ◽  
Retrospective Chart Review ◽  
Microcytic Anemia ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Milk Consumption ◽  
Cow's Milk ◽  
The Mean

Background and Objectives. Chronic, severe iron-deficiency anemia (IDA) in the first years of life increases the risk of irreversibly compromised cognitive, affective, and motor development. While IDA in infants has decreased because of dietary changes (iron-fortified formula and delaying cow’s milk), toddlers (13-36 months) are equally vulnerable to the adverse effects of IDA. We aimed to show that despite public health efforts, severe IDA remains a problem in toddlers and is associated with excess milk consumption. Methods. Retrospective chart review of children 6 to 36 months admitted to or evaluated by hematology at a children’s hospital from January 1, 2005 to December 31, 2010 with a severe microcytic anemia (hemoglobin [Hb] <9 g/dL and mean corpuscular volume (MCV) <75 fL). Results. We identified 68 infants and toddlers with severe IDA; most (84%) were 13 to 36 months old. The mean Hb and MCV were 6.0 g/dL (range = 2.2-8.9 g/dL) and 54.0 fL (range = 45.5-69.8 fL), respectively. Fatigue, poor appetite, and pica were the most common symptoms, found in 43%, 29%, and 22% of patients, respectively. Only 41% of parents reported pale skin while 77% of physicians recorded it on physical exam. Daily cow’s milk consumption surpassed 24 ounces for 47 of 48 children with reported intake; 11 consumed more than 64 ounces per day. Conclusions. Despite current screening recommendations, severe IDA continues to be a problem in toddlers and strongly correlates with excess cow’s milk consumption. This reiterates the importance of screening for IDA into routine toddler care.

scholarly journals Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Cross Sectional ◽  
Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

scholarly journals Cow's milk, infant formula and iron-deficiency anemia

2006 ◽  
Vol 82 (2) ◽  
pp. 161-164
Author(s):  
Mauro Batista de Morais ◽  
Dirce Maria Sigulem
Keyword(s):  
Iron Deficiency ◽  
Infant Formula ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Cow's Milk

Infant Feeding Practices and Their Possible Relationship to the Etiology of Diabetes Mellitus

PEDIATRICS ◽  
1994 ◽  
Vol 94 (5) ◽  
pp. 752-754
Author(s):  
Keyword(s):  
Diabetes Mellitus ◽  
Infant Feeding ◽  
Milk Protein ◽  
Feeding Practices ◽  
Cow’S Milk ◽  
Infant Feeding Practices ◽  
Diabetes Susceptibility ◽  
Cow's Milk ◽  
Destructive Process ◽  
Cow’S Milk Protein

1. Insulin-dependent diabetes mellitus develops within a group of individuals who carry specific diabetes susceptibility traits. Because all of the potential diabetes "susceptibility genes" are not known, currently it is not possible to identify all individuals at risk. It appears, however, that a small percentage of such individuals will ever develop clinical diabetes mellitus. 2. The autoimmune destructive process may be triggered by a number of environmental events. 3. Early exposure of infants to cow's milk protein may be an important factor in the initiation of the β cell destructive process in some individuals. It is not known whether the cow's milk protein in commercially available infant formulas is associated with this process. 4. The avoidance of cow's milk protein for the first several months of life may reduce the later development of IDDM or delay its onset in susceptible individuals. 5. Research directed toward further defining the possible relationship between infant feeding practices and the development of IDDM is needed.

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