scholarly journals Development of determination methods of quetiapine fumarate for forensic-pharmaceutical purposes

2021 ◽  
pp. 4-12
Author(s):  
Olena Bevz ◽  
Igor Sych ◽  
Angelina Shaposhnyk ◽  
Irina Sych ◽  
Olga Kryvanych ◽  
...  
Keyword(s):  
Uv Light ◽  
Generic Drugs ◽  
High Sensitivity ◽  
Ammonia Solution ◽  
Mass Detection ◽  
Quetiapine Fumarate ◽  
Forensic Examination ◽  
Mass Spectrometric Detector ◽  
Thermo Fisher Scientific ◽  
Dragendorff Reagent

Quetiapine fumarate (an antipsychotic) is part of numerous generic drugs that are in fairly wide demand among the population, therefore, more and more data appear on the counterfeiting and smuggling of funds, as well as non-medical use, which are life-threatening for the population and explain the high prevalence of the active ingredient as object of forensic examination. The aim. To develop an algorithm for conducting a forensic pharmaceutical examination and propose a method for determining quetiapine fumarate for forensic pharmaceutical purposes. Materials and methods. All studies were performed using reagents that meet the EP, USP and USPU requirements, Class A glassware and qualified devices. Identification by IR spectroscopy was performed in the range from 500 to 4000 cm-1 on the device “Nicolet 380 FT-IR Spectrometer by Thermo Fisher Scientific” using a prefix “Smart Perfomer” with a ZnSe crystal. The UV absorption spectra of the solutions were recorded using a Specord 205 spectrophotometer from Analytik Jena AG (Germany). TLC was performed on Merck chromatographic plates (silica gel 60G F254, Germany). The following systems were used as mobile phases: hexane – acetone – 25 % ammonia solution (60: 40: 2); methanol – 25 % ammonia solution (100: 1.5), hexane – acetone – 25 % ammonia solution (50: 45: 5). Detection was performed under UV light (254 nm), followed by spraying with Dragendorff reagent. Analysis by gas chromatography with mass detection was performed using a GC gas chromatograph with a mass spectrometric detector GCMS-QP2020. Data were analyzed using the program: GCMSsolution, LabSolutions Insight (Shimadzu Corporation, Tokyo, Japan). Results. An algorithm for conducting a forensic pharmaceutical examination in accordance with the current legislation of Ukraine has been developed, methods for determining quetiapine for forensic pharmaceutical purposes have been proposed. Conclusions. The developed methods for determining quetiapine meet the requirements of the current legislation of Ukraine and the Ministry of Justice of Ukraine. The obtained data prove the high sensitivity and reproducibility of the methods and prove the possibility of their introduction into the practice of forensic examination

scholarly journals Persistent luminescence nanoparticles for cancer theranostics application

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Nian Liu ◽  
Xiao Chen ◽  
Xia Sun ◽  
Xiaolian Sun ◽  
Junpeng Shi
Keyword(s):  
Uv Light ◽  
Combined Therapy ◽  
Tumor Therapy ◽  
High Sensitivity ◽  
Persistent Luminescence ◽  
Therapeutic Drugs ◽  
High Penetration ◽  
Recent Developments ◽  
Cancer Theranostics

AbstractPersistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLNPs are also widely used in persistent luminescence (PersL) imaging-guided tumor therapy. In this review, we first summarize the recent developments in the synthesis and surface functionalization of PLNPs, as well as their toxicity studies. We then discuss the in vivo PersL imaging and multimodal imaging from different excitation sources. Furthermore, we highlight PLNPs-based cancer theranostics applications, such as fluorescence-guided surgery, photothermal therapy, photodynamic therapy, drug/gene delivery and combined therapy. Finally, future prospects and challenges of PLNPs in the research of translational medicine are also discussed.

scholarly journals High Sensitivity of NO Gas Sensors Based on Novel Ag-Doped ZnO Nanoflowers Enhanced with a UV Light-Emitting Diode

ACS Omega ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 13798-13807 ◽  
Author(s):  
You-Ting Tsai ◽  
Shoou-Jinn Chang ◽  
Liang-Wen Ji ◽  
Yu-Jen Hsiao ◽  
I-Tseng Tang ◽  
...  
Keyword(s):  
Gas Sensors ◽  
Uv Light ◽  
Light Emitting Diode ◽  
High Sensitivity ◽  
Light Emitting ◽  
Doped Zno

A High Performance UV Photodetector from Thin Film Diamond

1995 ◽  
Vol 416 ◽  
Author(s):  
Robert D. Mckeag ◽  
Michael D. Whitfield ◽  
Simon Sm Chan ◽  
Lisa Ys Pang ◽  
Richard B. Jackman
Keyword(s):  
Thin Film ◽  
Visible Light ◽  
Quantum Efficiency ◽  
Dark Current ◽  
External Quantum Efficiency ◽  
High Performance ◽  
Uv Light ◽  
High Sensitivity ◽  
Uv Photodetector ◽  
Deep Uv

ABSTRACTThin film diamond has been used to fabricate a photodetector which displays high sensitivity to deep UV light, with an external quantum efficiency of greater than one, a dark current of less than 0.1nA and which is near ‘blind’ to visible light.

Electromechanical model of a resonating nano-cantilever-based sensor for high-resolution and high-sensitivity mass detection

2001 ◽  
Vol 12 (2) ◽  
pp. 100-104 ◽  
Author(s):  
G Abadal ◽  
Z J Davis ◽  
B Helbo ◽  
X Borrisé ◽  
R Ruiz ◽  
...  
Keyword(s):  
High Resolution ◽  
High Sensitivity ◽  
Mass Detection ◽  
Electromechanical Model

A Lab-on-a-Chip Device Using a Dielectrophoresis-Aligned Carbon Nanotube Sensor Array

2011 ◽  
Author(s):  
Pengfei Li ◽  
Nan Lei ◽  
Jie Xu ◽  
Wei Xue
Keyword(s):  
Carbon Nanotube ◽  
Sensor Array ◽  
Uv Light ◽  
Lab On A Chip ◽  
High Sensitivity ◽  
Metal Electrodes ◽  
Flow Sensors ◽  
Single Walled Carbon Nanotube ◽  
Ph Values

Here we report the design, fabrication, and characterization of a lab-on-a-chip device using a nanotube-based sensor array. The microfluidic components are composed of an ultraviolet (UV) light-defined, cross-linked SU-8 microchannel and a polydimethylsiloxane (PDMS) top cover. The hybrid microfluidic structure provides a fully sealed microchannel, well-aligned features, and precisely positioned nanosensors. Well-organized single-walled carbon nanotube (SWNT) thin films are deposited and aligned across the electrodes on a silicon substrate with dielectrophoresis. The assembly of SWNTs is carried out in a sealed microchannel. The SWNT devices are configured as two-terminal resistor-type sensors with the metal electrodes as the probing pads and the dielectrophoretically captured SWNTs as the sensing elements. The SWNT devices are used as integrated flow sensors to monitor the flow rate in the microchannel. In addition, when exposed to aqueous solutions with various pH values, these sensors change their resistance accordingly and demonstrate high sensitivity towards pH solutions.

scholarly journals Photo Alignment Materials with High Sensitivity to Near UV Light.

1998 ◽  
Vol 11 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Yutaka Makita ◽  
Toru Natsui ◽  
Shin-ichi Kimura ◽  
Shoichi Nakata ◽  
Masayuki Kimura ◽  
...  
Keyword(s):  
Uv Light ◽  
High Sensitivity ◽  
Photo Alignment

scholarly journals Heterochromatin protein 1 is recruited to various types of DNA damage

2009 ◽  
Vol 185 (4) ◽  
pp. 577-586 ◽  
Author(s):  
Martijn S. Luijsterburg ◽  
Christoffel Dinant ◽  
Hannes Lans ◽  
Jan Stap ◽  
Elzbieta Wiernasz ◽  
...  
Keyword(s):  
Dna Damage ◽  
Uv Light ◽  
High Sensitivity ◽  
Heterochromatin Protein 1 ◽  
Heterochromatin Protein ◽  
Strand Breaks ◽  
Essential Components ◽  
Associated Proteins ◽  
Chromo Shadow Domain ◽  
Hp1 Proteins

Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-α, HP1-β, and HP1-γ are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow domain of HP1 and is independent of H3K9 trimethylation and proteins that detect UV damage and DSBs. Loss of HP1 results in high sensitivity to UV light and ionizing radiation in the nematode Caenorhabditis elegans, indicating that HP1 proteins are essential components of DNA damage response (DDR) systems. Analysis of single and double HP1 mutants in nematodes suggests that HP1 homologues have both unique and overlapping functions in the DDR. Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage.

Prototype of Frame-Type Cantilever for Biosensor and Femtogram Detection

2010 ◽  
Vol 459 ◽  
pp. 134-139 ◽  
Author(s):  
Hayato Sone ◽  
Shoichi Ichikawa ◽  
Yuji Matsubara ◽  
Mitsumasa Suzuki ◽  
Haruki Okano ◽  
...  
Keyword(s):  
Gold Film ◽  
Fem Simulation ◽  
High Sensitivity ◽  
Film Deposition ◽  
Frequency Change ◽  
Mass Detection ◽  
Atomic Force ◽  
Highly Sensitive ◽  
Resonance Frequencies ◽  
Conventional Type

The possibility of realizing femtogram mass detection using a frame-type microcantilever has been studied in bioscience. To realize highly sensitive mass detection by reducing the viscose resistance in liquids, we designed frame-type cantilevers using finite element modeling (FEM). We fabricated prototypes of mesh-type, hole-type and conventional-type cantilevers using a semiconductor process. The properties of the cantilevers were measured by a conventional atomic force microscope (AFM) system. The measured resonance frequencies of the cantilevers were almost consistent with the calculated results of the FEM simulation in air. The resonance frequency and quality (Q) factor of the mesh-type cantilever were larger than those of the conventional-type cantilever in water. We measured the frequency change due to gold film deposition on the mesh-type cantilever. Then, we estimated the mass sensitivity of the cantilever at about 16.6 fg/Hz. This value is more than 10 times smaller than that of the conventional-type cantilever. These results indicate that the mesh-type cantilever has the advantage of reducing the viscous resistance and achieving high sensitivity in liquids.

scholarly journals Chromatographic Methods for the Determination of Aminexil, Pyridoxine, and Niacinamide in a Novel Cosmetic Hair Preparation

2020 ◽  
Vol 103 (4) ◽  
pp. 1167-1172
Author(s):  
Mamdouh R Rezk ◽  
Hebatallah M Essam ◽  
Enas A Amer ◽  
Dina M S Youssif
Keyword(s):  
High Performance ◽  
High Sensitivity ◽  
Ammonia Solution ◽  
Hplc Method ◽  
The Novel ◽  
Chromatographic Methods ◽  
Ich Guidelines ◽  
Sensitivity And Selectivity ◽  
Keratin Fibers

Abstract Background Aminexil, a new compound patented by L’Oreal, has a stimulating effect on human keratin fibers. Pyridoxine HCl and niacinamide are added to boost the hair tonic effect of aminexil. Objective Two novel chromatographic methods were developed for the determination of aminexil (AX), niacinamide (NA) and pyridoxine HCl (PD) in the novel hair tonic preparation. Methods The developed methods were high-performance liquid chromatography (HPLC) and thin layer chromatography (TLC) with densitometric determination. Different experimental parameters were investigated and optimized to achieve complete baseline separation and well resolved peaks. The RP-HPLC separation was achieved using a Thermoscientific BDS hypersil C18 (250 × 4.6 mm, 5 µm) column using 0.005 M hexane sulfonic acid: methanol (80: 20, v/v) as a mobile phase. For the TLC method, the three analytes were partitioned between propanol: toluene: ammonia solution (40:60:2, v/v/v) and fluorescent silica plates. The two methods were validated in compliance with International Conference on Harmonization (ICH) guidelines. The obtained data were statistically analyzed to confirm the existing results. The developed methods were successfully applied for determination of the studied drugs in pure forms and in the cosmetic preparation. Results For the HPLC method, the RSDs of AX, NA and PD were 0.70, 0.88 and 1.17 respectively. For the TLC method, the RSDs of AX, NA and PD were 1.06, 1.37 and 0.73 respectively. Conclusions The proposed chromatographic methods showed high sensitivity and selectivity for the three compounds under analysis in the laboratory prepared mixture and in the hair tonic preparation. Highlights Aminexil, Pyridoxine, Niacinamide, HPLC. The present work offers two reproducible, accurate, validated, time and cost saving alternatives for the quantitative and qualitative determination of medicated hair preparation.

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