Three-dimensional (3D) facially driven workflow for anterior ridge defect evaluation: a treatment concept

The esthetic rehabilitation of anterior ridge defects and the achievement of patient satisfaction has become major clinical challenges for dentists and technicians. Poor diagnosis and treatment planning are frequently associated with multiple surgical procedures which fail to meet patient expectations. The loss of hard and soft tissues in esthetic compromised zone is commonly associated with anterior ridges and affects the rehabilitation prognosis. The presence of interdental papilla and papillary configuration play a decisive role in patient satisfaction. A treatment planning considering esthetic parameters, prosthetic needs, and morphological defects must be conducted to improve treatment outcomes. Therefore, this study aims to propose a treatment concept for anterior ridge defects focusing on digital evaluation systems and guided by an ideal facially driven smile design project. In addition, the relevance of the papilla for the esthetic outcomes and the treatment alternatives for anterior ridge defects are also addressed.

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Adult Acquired Flatfoot

Acta Balneologica ◽

10.36740/abal202001110 ◽

2020 ◽

Vol 62 (1) ◽

pp. 55-59

Author(s):

Krzysztof Mataczyński ◽

Mateusz Pelc ◽

Halina Romualda Zięba ◽

Zuzana Hudakova

Keyword(s):

Soft Tissues ◽

Three Dimensional ◽

Clinical Diagnostics ◽

Clinical Image ◽

Tibialis Posterior ◽

Dynamic Force ◽

Posterior Tibial ◽

Flat Feet ◽

Foot Arch ◽

Motion Range

Acquired adult flatfoot is a three-dimensional deformation, which consists of hindfoot valgus, collapse of the longitudinal arch of the foot and adduction of the forefoot. The aim of the work is to present problems related to etiology, biomechanics, clinical diagnostics and treatment principles of acquired flatfoot. The most common cause in adults is the dysfunction of the tibialis posterior muscle, leading to the lack of blocking of the transverse tarsal joint during heel elevation. Loading the unblocked joints consequently leads to ligament failure. The clinical image is dominated by pain in the foot and tibiotarsal joint. The physical examination of the flat feet consists of: inspection, palpation, motion range assessment and dynamic force assessment. The comparable attention should be paid to the height of the foot arch, the occurrence of “too many toes” sign, evaluate the heel- rise test and correction of the flatfoot, exclude Achilles tendon contracture. The diagnosis also uses imaging tests. In elastic deformations with symptoms of posterior tibial tendonitis, non-steroidal anti-inflammatory drugs, short-term immobilization, orthotics stabilizing the medial arch of the foot are used. In rehabilitation, active exercises of the shin muscles and the feet, especially the eccentric exercises of the posterior tibial muscle, are intentional. The physiotherapy and balneotherapy treatments, in particular hydrotherapy, electrotherapy and laser therapy, are used as a support. In advanced lesions, surgical treatment may be necessary, including plastic surgery of soft tissues, tendons, as well as osteotomy procedures.

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3D Culture Modelling: An Emerging Approach for Translational Cancer Research in Sarcomas

Current Medicinal Chemistry ◽

10.2174/0929867326666191212162102 ◽

2020 ◽

Vol 27 (29) ◽

pp. 4778-4788 ◽

Cited By ~ 1

Author(s):

Victoria Heredia-Soto ◽

Andrés Redondo ◽

José Juan Pozo Kreilinger ◽

Virginia Martínez-Marín ◽

Alberto Berjón ◽

...

Keyword(s):

High Throughput Screening ◽

Cancer Biology ◽

Soft Tissues ◽

Three Dimensional ◽

3D Culture ◽

Resistance Mechanisms ◽

In Vitro Models ◽

Tumour Spheroids ◽

Current Therapies

Sarcomas are tumours of mesenchymal origin, which can arise in bone or soft tissues. They are rare but frequently quite aggressive and with a poor outcome. New approaches are needed to characterise these tumours and their resistance mechanisms to current therapies, responsible for tumour recurrence and treatment failure. This review is focused on the potential of three-dimensional (3D) in vitro models, including multicellular tumour spheroids (MCTS) and organoids, and the latest data about their utility for the study on important properties for tumour development. The use of spheroids as a particularly valuable alternative for compound high throughput screening (HTS) in different areas of cancer biology is also discussed, which enables the identification of new therapeutic opportunities in commonly resistant tumours.

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A computational framework for modeling cell–matrix interactions in soft biological tissues

Biomechanics and Modeling in Mechanobiology ◽

10.1007/s10237-021-01480-2 ◽

2021 ◽

Author(s):

Jonas F. Eichinger ◽

Maximilian J. Grill ◽

Iman Davoodi Kermani ◽

Roland C. Aydin ◽

Wolfgang A. Wall ◽

...

Keyword(s):

Soft Tissues ◽

Three Dimensional ◽

Biological Tissues ◽

Computational Framework ◽

Cell Matrix ◽

Physiological Processes ◽

Matrix Interactions ◽

Mechanical Homeostasis ◽

Cell Matrix Interactions ◽

Short Time

AbstractLiving soft tissues appear to promote the development and maintenance of a preferred mechanical state within a defined tolerance around a so-called set point. This phenomenon is often referred to as mechanical homeostasis. In contradiction to the prominent role of mechanical homeostasis in various (patho)physiological processes, its underlying micromechanical mechanisms acting on the level of individual cells and fibers remain poorly understood, especially how these mechanisms on the microscale lead to what we macroscopically call mechanical homeostasis. Here, we present a novel computational framework based on the finite element method that is constructed bottom up, that is, it models key mechanobiological mechanisms such as actin cytoskeleton contraction and molecular clutch behavior of individual cells interacting with a reconstructed three-dimensional extracellular fiber matrix. The framework reproduces many experimental observations regarding mechanical homeostasis on short time scales (hours), in which the deposition and degradation of extracellular matrix can largely be neglected. This model can serve as a systematic tool for future in silico studies of the origin of the numerous still unexplained experimental observations about mechanical homeostasis.

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The Symmetric 3D Organization of Connective Tissue around Implant Abutment: A Key-Issue to Prevent Bone Resorption

Symmetry ◽

10.3390/sym13071126 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1126

Author(s):

Giovanna Iezzi ◽

Francesca Di Lillo ◽

Michele Furlani ◽

Marco Degidi ◽

Adriano Piattelli ◽

...

Keyword(s):

Bone Resorption ◽

Connective Tissue ◽

Inflammatory Cell ◽

Soft Tissues ◽

Three Dimensional ◽

Collagen Fibers ◽

Inflammatory Cell Infiltration ◽

Cell Infiltration ◽

Oral Epithelium ◽

Implant Abutment

Symmetric and well-organized connective tissues around the longitudinal implant axis were hypothesized to decrease early bone resorption by reducing inflammatory cell infiltration. Previous studies that referred to the connective tissue around implant and abutments were based on two-dimensional investigations; however, only advanced three-dimensional characterizations could evidence the organization of connective tissue microarchitecture in the attempt of finding new strategies to reduce inflammatory cell infiltration. We retrieved three implants with a cone morse implant–abutment connection from patients; they were investigated by high-resolution X-ray phase-contrast microtomography, cross-linking the obtained information with histologic results. We observed transverse and longitudinal orientated collagen bundles intertwining with each other. In the longitudinal planes, it was observed that the closer the fiber bundles were to the implant, the more symmetric and regular their course was. The transverse bundles of collagen fibers were observed as semicircular, intersecting in the lamina propria of the mucosa and ending in the oral epithelium. No collagen fibers were found radial to the implant surface. This intertwining three-dimensional pattern seems to favor the stabilization of the soft tissues around the implants, preventing inflammatory cell apical migration and, consequently, preventing bone resorption and implant failure. This fact, according to the authors’ best knowledge, has never been reported in the literature and might be due to the physical forces acting on fibroblasts and on the collagen produced by the fibroblasts themselves, in areas close to the implant and to the symmetric geometry of the implant itself.

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Applications of cone beam computed tomography in endodontics

Evidence-Based Endodontics ◽

10.1186/s41121-020-00020-4 ◽

2020 ◽

Vol 5 (1) ◽

Author(s):

Ateksha Bhardwaj Khanna

Keyword(s):

Computed Tomography ◽

Treatment Planning ◽

Cone Beam Computed Tomography ◽

Oral Surgery ◽

Three Dimensional ◽

Conventional Radiography ◽

Cone Beam ◽

Oral Radiology ◽

Manual Search ◽

First Choice

Abstract Background Endodontic disease can adversely affect the quality of life and therefore early diagnosis and consequent timely treatment is of paramount importance for the Endodontist. Radiology is an essential component in treatment planning, disease monitoring and assessment of treatment outcome. Periapical radiographs and panoramic radiography are frequently utilised but they provide only two-dimensional representation of three-dimensional structures. The advent of cone beam computed tomography (CBCT) offers three-dimensional accuracy of the hard tissue images with a reasonable cost and this has revolutionised imaging of the dentomaxillofacial structures. This imaging system has been seen to overcome some limitations of conventional radiography, as brought out in this review. The improvement in the accuracy is, however, accompanied at the cost of increased radiation exposure to the patient. Nevertheless, smaller areas of exposure are normally appropriate for endodontic imaging, and adjustment in the exposure parameters can further moderate the effective dose (Loubele et al. 37(6):309-18, 2008). Aims and objectives The aim of this review is to present the pertinent literature on the various applications of cone beam computed tomography in the field of endodontics. Methods Literature was electronically searched on the following sources; Medline and Keats Library. Further, a manual search was performed on the following journals: International Endodontic Journal, Journal of Endodontics, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, Endodontology, Journal of Dental Research, European Journal of Oral Sciences & Odontology and Dentomaxillofacial Radiology. A preliminary search was performed to gain an idea of the available literature using keywords ‘Cone Beam Computed Tomography’ to view the volume of the literature evident and identify questions to be addressed in this review. The initial search showed 243 potential articles. After scrutinising the titles and abstracts of the retrieved articles, 70 relevant studies were reviewed in full text. Furthermore, ‘published guidelines on the use of CBCT’ were also searched so as to include the results as an additional source material. All the articles eligible to be included in the review were in the English language and ranged from the year 1960 to the present. Also all the studies reviewed were based on the various uses of cone beam computed tomography in the field of endodontics. The keywords used to search were ‘Cone Beam Computed Tomography (CBCT)’, ‘Conventional radiography’, ‘Applications of CBCT in endodontics’, ‘CBCT and tooth morphology’, ‘CBCT and apical periodontitis’, ‘CBCT and vertical root fractures’, ‘CBCT and resorption’, ‘CBCT and pre-surgical assessment’, ‘CBCT and dento-alveolar trauma’ and ‘CBCT and endodontic outcome’. Results Every case is unique and CBCT should be considered only after studying each case individually. CBCT imaging needs to be adopted or used where information from conventional imaging systems is either inadequate for the management of endodontic problems or inconclusive. Having said that, it is safe to state that CBCT imaging has the potential to become the first choice for endodontic treatment planning and outcome assessment, especially when new scanners with lower radiation doses and enhanced resolution would be available.

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Accuracy and Reliability of Soft Tissue Landmarks Using Three-Dimensional Imaging in Comparison With Two-Dimensional Cephalometrics: A Systematic Review

The Journal of Indian Orthodontic Society ◽

10.1177/0301574220963412 ◽

2020 ◽

Vol 54 (4) ◽

pp. 289-296

Author(s):

Adeeba Ali ◽

Anil K. Chandna ◽

Anshul Munjal

Keyword(s):

Systematic Review ◽

Soft Tissue ◽

3D Imaging ◽

Soft Tissues ◽

Three Dimensional ◽

Database Search ◽

Cochrane Library ◽

Two Dimensional ◽

Imaging Tool ◽

Electronic Database Search

Background: Concerns about the accuracy and reliability of soft tissue landmarks using two-dimensional (2D) and three-dimensional (3D) imaging. Objective: The aim of the systematic review is to estimate accuracy and reliability of soft tissue landmarks with 2D imaging and 3D imaging for orthodontic diagnosis planning and treatment planning purposes. Data Sources: Electronic database search was performed in MEDLINE via PubMed, Embase via embase.com, and the Cochrane library website. Selection Criteria: The data were extracted according to two protocols based on Centre for Evidence-Based Medicine (CEBM) critical appraisal tools. Next, levels of evidence were categorized into three groups: low, medium, and high. Data Synthesis: Fifty-five publications were found through database search strategies. A total of nine publications were included in this review. Conclusion According to the available literature, 3D imaging modalities were more accurate and reliable as compared to 2D modalities. Cone beam computed tomography (CBCT) was considered the most reliable imaging tool for soft tissues.

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Polymeric Bioinks for 3D Hepatic Printing

Chemistry ◽

10.3390/chemistry3010014 ◽

2021 ◽

Vol 3 (1) ◽

pp. 164-181

Author(s):

Joyita Sarkar ◽

Swapnil C. Kamble ◽

Nilambari C. Kashikar

Keyword(s):

Tissue Engineering ◽

3D Printing ◽

Soft Tissues ◽

Three Dimensional ◽

Stem Cell Differentiation ◽

Synthetic Polymers ◽

Bioactive Molecules ◽

Complex Geometries ◽

Printing Techniques ◽

Natural And Synthetic

Three-dimensional (3D) printing techniques have revolutionized the field of tissue engineering. This is especially favorable to construct intricate tissues such as liver, as 3D printing allows for the precise delivery of biomaterials, cells and bioactive molecules in complex geometries. Bioinks made of polymers, of both natural and synthetic origin, have been very beneficial to printing soft tissues such as liver. Using polymeric bioinks, 3D hepatic structures are printed with or without cells and biomolecules, and have been used for different tissue engineering applications. In this review, with the introduction to basic 3D printing techniques, we discuss different natural and synthetic polymers including decellularized matrices that have been employed for the 3D bioprinting of hepatic structures. Finally, we focus on recent advances in polymeric bioinks for 3D hepatic printing and their applications. The studies indicate that much work has been devoted to improvising the design, stability and longevity of the printed structures. Others focus on the printing of tissue engineered hepatic structures for applications in drug screening, regenerative medicine and disease models. More attention must now be diverted to developing personalized structures and stem cell differentiation to hepatic lineage.

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The Effect of Closed Septorhinoplasty on Nasal Functions and on External and Internal Nasal Valves: A Prospective Study

American Journal of Rhinology and Allergy ◽

10.2500/ajra.2017.31.4459 ◽

2017 ◽

Vol 31 (5) ◽

pp. 323-327 ◽

Cited By ~ 2

Author(s):

Giancarlo Pecorari ◽

Giuseppe Riva ◽

Francesca Antonella Bianchi ◽

Giovanni Cavallo ◽

Francesca Revello ◽

...

Keyword(s):

Prospective Study ◽

Nasal Obstruction ◽

Laser Scanning ◽

Soft Tissues ◽

Statistical Significance ◽

Three Dimensional ◽

Subjective Assessment ◽

Nasal Airflow ◽

Nasal Valve ◽

Objective Reduction

Background Because nasal function and shape are so closely intertwined, quantitative assessments can better define their relationship and how they are affected by septorhinoplasty. Objective The aim of this prospective study was to perform an analysis of the nasal airflow resistances and a three-dimensional (3D) evaluation of the soft-tissue changes after closed septorhinoplasty. Methods Before surgery (TO) and 6 months after closed septorhinoplasty (Tl), 30 patients underwent symptoms evaluation by means of the Italian version of the Nasal Obstruction Symptom Evaluation scale, endoscopic fiberoptic nasal examination, and visual analog scale for subjective assessment of nasal obstruction. Nasal airflow resistances were investigated with active anterior active rhinomanometry. A 3D laser scanner was used to evaluate facial soft-tissues, with specific nasal points and angles. Results Subjective nasal obstruction decreased. Anterior active rhinomanometry demonstrated a reduction in total inspiratory and expiratory resistances between T0 and T1 but without statistical significance. The significance was still absent after decongestion, excluding turbinate hypertrophy as a cause of failed objective amelioration of nasal resistance. Facial laser scanning showed statistically significant reduction of the superior nasal width and superior alar angle, and a weak negative correlation between the superior alar angle and nasal resistances. Conclusion The absence of objective reduction of nasal airflow resistances could be the result of concurrent surgery on nasal septum and nasal valve. In particular, the ameliorating effect on nasal airflow resistances is counterbalanced by the worsening effect of the narrowing of nasal valve.

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Fetal Occipital Encephalocele: A Case Report

Journal of Diagnostic Medical Sonography ◽

10.1177/87564793211066884 ◽

2021 ◽

pp. 875647932110668

Author(s):

Amanda Hogan ◽

Natalie Ullmer

Keyword(s):

Case Report ◽

Patient Care ◽

Treatment Planning ◽

Neural Tube ◽

Neural Tube Defects ◽

Three Dimensional ◽

Improve Patient Care ◽

Two Dimensional ◽

Occipital Encephalocele ◽

Improve Patient

Encephaloceles are considered neural tube defects, but their exact cause is unknown. The outcome is dismal, and essential management and counseling are needed for patients. Two-dimensional and three-dimensional sonography can be used to detect encephaloceles as early as 11 weeks, assist in treatment planning, and improve patient care. This case report presents an occipital encephalocele diagnosed by sonography and followed until delivery.

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