Evaluation of the Effectiveness of Personalized Treatment of Trace Element and Vitamin Status in Men with Initial Stages of Androgenic Alopecia Treated with Conservative Therapy

2021 ◽  
Vol 76 (6) ◽  
pp. 604-611
Author(s):  
Irina N. Kondrakhina ◽  
Alexander M. Zatevalov ◽  
Eugenia R. Gatiatulina ◽  
Alexandr A. Nikonorov ◽  
Dmitry G. Deryabin ◽  
...  
Keyword(s):  
Trace Elements ◽  
Folic Acid ◽  
Vitamin E ◽  
Conservative Therapy ◽  
Personalized Treatment ◽  
Prospective Clinical Study ◽  
Micronutrient Deficiencies ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Early Stages

Background. Androgenic alopecia (AGA) is the most common form of pathological hair loss with multiple micronutrient disorders involvedin its occurrence and development. Aimto evaluatethe effectiveness of personalized treatment of micronutrient deficiencies in patients with early stages of AGA and conservative therapy using a vasodilator drug minoxidil based on evidence-based medicine. Methods. A total 48 patients with stages IIV of AGA (according to the NorwoodHamilton scale) were recruited to experimental prospective clinical study evaluating the effectiveness of pharmaceutical forms of trace elements and vitamins. The primary diagnosis of micronutrient deficiency was carried out by comparing laboratory parameters of patients with AGA and 25 healthy volunteers. After that, conservative treatment with 5% topical minoxidilin AGA patients was enriched with 2-month personalized systemic supplementation of pharmaceutical forms of trace elements and vitamins. At the end of the study, the correspondence between changes in trace elements and vitamins content in the plasma and the trichogram parameters before and after conservative therapy was assessed. Results. The majority (96%) of the examined patients with AGA were characterized by mono- or polynutrient deficiencies. Personalized correction made it possible to restore the content of Se, Mg, Fe and vitamin E to the baseline levels and to achieve a significant increase in Zn, vitamin D and folic acid plasma content. The relationship between changes in the level of micronutrients and trichogram parameters was recorded only for Se (decrease in anagen hairs: r = 0.43; p = 0.037; decrease in hair density: r = 0.45; p = 0.028) and folic acid (an increase in anagen hairs: r = 0.41; p = 0.024); the positive effect of vitamin E on hair density was also detected. Conclusion. The results of the study allow to recommend a personalized treatment of folic acid and vitamin E deficiencies, with possible refusal to use the Se-containing drugs in conservative therapy of patients with the early stages of AGA.

scholarly journals Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 336 ◽  
Author(s):  
Irina N. Kondrakhina ◽  
Dmitry A. Verbenko ◽  
Alexander M. Zatevalov ◽  
Eugenia R. Gatiatulina ◽  
Alexandr A. Nikonorov ◽  
...  
Keyword(s):  
Plasma Level ◽  
Predictive Value ◽  
Conservative Therapy ◽  
Zinc Content ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Parietal Area ◽  
Starting Point ◽  
Topical Minoxidil ◽  
Zinc Levels

Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%).

scholarly journals Immunity, Vitamins and Nutrition

2020 ◽  
Vol 16 (34) ◽  
pp. 16-19
Author(s):  
V.M. Delyagin ◽  
Keyword(s):  
Fatty Acids ◽  
Developing Countries ◽  
Trace Elements ◽  
Vitamin E ◽  
Sharp Increase ◽  
Proliferative Activity ◽  
Secretory Iga ◽  
Micronutrient Deficiencies ◽  
Protein Energy ◽  
Pro Inflammatory Cytokines

There is a relationship between nutrition and immunity. For developing countries, the problem – the protein-energy deficits, in developed and socially oriented economy – the lack of vitamins and trace elements. In Russia, various vitamins deficiency is registered in 30–90% of schoolchildren (from 20–40% to the extent of the deep deficit). Deficiency of vitamins and minerals leads to disruption of immunity raises the index of infectious diseases, autoimmune disorders. Insufficient supply of vitamins leads to a decrease in phagocytosis, proliferative activity of lymphocytes, decreased concentrations of C3 and C5 component of complement, IgG and secretory IgA, disintegrate physiological barriers. At the same time increases the concentration of pro-inflammatory cytokines. With a lack of selenium and vitamin E is possible passage of viruses from a sharp increase in virulence. The correction of micronutrient deficiencies should be combined, which implies the appointment of vitamin-mineral complexes with the inclusion of polyunsaturated fatty acids, choline. It is recommended the use of drugs, various forms of which are adapted to the age and the physiological needs of the child.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

2021 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Bela Padhiar ◽  
Sruthy Raveendran
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Androgenic Alopecia ◽  
Open Label ◽  
Hair Density ◽  
Convenience Sample ◽  
Double Spin ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

scholarly journals Food fortification: good to have or need to have?

2004 ◽  
Vol 10 (6) ◽  
pp. 771-777
Author(s):  
A. Verster
Keyword(s):  
Developing Countries ◽  
Folic Acid ◽  
Food Fortification ◽  
Micronutrient Deficiencies ◽  
Vicious Cycle ◽  
Child Bearing ◽  
Large Populations ◽  
Life Threatening ◽  
Iron And Folic Acid ◽  
Staple Foods

Only very small quantities of vitamins and minerals are needed for human health but deficiencies can have disproportionately large, often life-threatening, effects. Micronutrient deficiencies lead to a vicious cycle of malnutrition and infection in poorly nourished populations. Fortification of staple foods is the cheapest, most efficient and most effective way to supply large populations with essential micronutrients. This paper reviews the case for fortification of flour supplies with iron and folic acid and concludes that it is the best way to provide daily doses of these nutrients to populations in developing countries, especially for women of child-bearing age

scholarly journals Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 337 ◽  
Author(s):  
Rondanelli ◽  
Faliva ◽  
Gasparri ◽  
Peroni ◽  
Naso ◽  
...  
Keyword(s):  
Vitamin D ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Dietary Supplementation ◽  
Research Strategy ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Micronutrient Deficiencies ◽  
Good Compliance

Background and objective: Often micronutrient deficiencies cannot be detected when patient is already following a long-term gluten-free diet with good compliance (LTGFDWGC). The aim of this narrative review is to evaluate the most recent literature that considers blood micronutrient deficiencies in LTGFDWGC subjects, in order to prepare dietary supplementation advice (DSA). Materials and methods: A research strategy was planned on PubMed by defining the following keywords: celiac disease, vitamin B12, iron, folic acid, and vitamin D. Results: This review included 73 studies. The few studies on micronutrient circulating levels in long-term gluten-free diet (LTGFD) patients over 2 years with good compliance demonstrated that deficiency was detected in up to: 30% of subjects for vitamin B12 (DSA: 1000 mcg/day until level is normal, then 500 mcg), 40% for iron (325 mg/day), 20% for folic acid (1 mg/day for 3 months, followed by 400–800 mcg/day), 25% for vitamin D (1000 UI/day or more-based serum level or 50,000 UI/week if level is <20 ng/mL), 40% for zinc (25–40 mg/day), 3.6% of children for calcium (1000–1500 mg/day), 20% for magnesium (200–300 mg/day); no data is available in adults for magnesium. Conclusions: If integration with diet is not enough, starting with supplements may be the correct way, after evaluating the initial blood level to determine the right dosage of supplementation.

scholarly journals Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1864 ◽  
Author(s):  
Pallavi Dubey ◽  
Vikram Thakur ◽  
Munmun Chattopadhyay
Keyword(s):  
Insulin Resistance ◽  
Trace Elements ◽  
Relevant Information ◽  
Micronutrient Deficiencies ◽  
Essential Trace Elements ◽  
Cobalt Iron ◽  
Different Populations ◽  
Minerals And Trace Elements ◽  
Iron Chromium

Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in these micronutrients are related to widespread human health problems. This review article is focused on some of these minerals and trace element deficiencies and their consequences in diabetes and insulin resistance. The levels of trace elements vary considerably among different populations, contingent on the composition of the diet. In several Asian countries, large proportions of the population are affected by a number of micronutrient deficiencies. Local differences in selenium, zinc, copper, iron, chromium and iodine in the diet occur in both developed and developing countries, largely due to malnutrition and dependence on indigenous nutrition. These overall deficiencies and, in a few cases, excess of essential trace elements may lead to imbalances in glucose homeostasis and insulin resistance. The most extensive problems affecting one billion people or more worldwide are associated with inadequate supply of a number of minerals and trace elements including iodine, selenium, zinc, calcium, chromium, cobalt, iron, boron and magnesium. This review comprises various randomized controlled trials, cohort and case-controlled studies, and observational and laboratory-based studies with substantial outcomes of micronutrient deficiencies on diabetes and insulin resistance in diverse racial inhabitants from parts of Asia, Africa, and North America. Changes in these micronutrient levels in the serum and urine of subjects may indicate the trajectory toward metabolic changes, oxidative stress and provide disease-relevant information.

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