A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases

2015 ◽  
Vol 14 (3) ◽  
pp. 391-403 ◽  
Author(s):  
Ida Gregersen ◽  
Sverre Holm ◽  
Tuva B Dahl ◽  
Bente Halvorsen ◽  
Pål Aukrust
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Atherosclerotic Cardiovascular Diseases

scholarly journals Which One to Endorse Among the Multitude of Lipid Guidelines?

2015 ◽  
Vol 11 (1) ◽  
pp. 32
Author(s):  
Alper Sonmez ◽  
Keyword(s):  
Risk Assessment ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Treatment Target ◽  
Advantages And Disadvantages ◽  
Lipid Guidelines ◽  
Atherosclerotic Cardiovascular Diseases

Dyslipidemia is the major risk factor for atherosclerotic cardiovascular diseases. A multitude of lipid guidelines exist, with several controversies, and the best approach in dyslipidemia management is not clear. The tools and lipoproteins used for risk assessment, whether to use a treatment target and implementing drugs other than statins are all controversial points. Until the time for the publication of an agreeable lipid guideline, physicians should choose their way by considering the advantages and disadvantages of the existing guidelines.

Which One to Endorse Among the Multitude of Lipid Guidelines?

2015 ◽  
Vol 11 (01) ◽  
pp. 53
Author(s):  
Alper Sonmez ◽  
Keyword(s):  
Risk Assessment ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Treatment Target ◽  
Advantages And Disadvantages ◽  
Lipid Guidelines ◽  
Atherosclerotic Cardiovascular Diseases

Dyslipidemia is the major risk factor for atherosclerotic cardiovascular diseases. A multitude of lipid guidelines exist, with several controversies, and the best approach in dyslipidemia management is not clear. The tools and lipoproteins used for risk assessment, whether to use a treatment target and implementing drugs other than statins are all controversial points. Until the time for the publication of an agreeable lipid guideline, physicians should choose their way by considering the advantages and disadvantages of the existing guidelines.

scholarly journals A CASE STUDY ON ESSENTIAL HYPERTENSION MANAGING THROUGH AYURVEDA W.S.R. RAKTAGATA VYAN VAISHAMYA

2021 ◽  
Vol p5 (4) ◽  
pp. 2965-2968
Author(s):  
Ruhi Zahir ◽  
Iqbal Khan
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Risk Factor ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
High Blood Pressure ◽  
Direct Reference ◽  
Major Risk Factor ◽  
End Stage

Essential hypertension is high blood pressure that doesn't have any known etiopathology. Most of sufferers (85%) are asymptomatic and as per available reports, in more than 95% cases of hypertension under lying cause is not found. It is estimated that 600 million people are affected worldwide. Hypertension is a major risk factor for the development of cardiovascular diseases (CVD). Its impact is greatest on stroke, MI and end stage is renal failure as it’s known as a Silent Killer. Hence there is no direct reference of hypertension in Ayurvedic classics by name as well as by its path physiological views. Many works have been carried out on hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Different nomenclatures also have been adopted by Ayurveda experts like Raktagata Vata, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Raktavrita Vata, Siragata Vata etc. Keywords: Essential hypertension, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Cardiovascular diseases, Silent Killer.

scholarly journals Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

2020 ◽  
Vol 245 (15) ◽  
pp. 1326-1334
Author(s):  
Mohamed M Elseweidy ◽  
Sousou I Aly ◽  
Sally K Hammad ◽  
Noura I Shershir
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Rat Model ◽  
Myocardial Injury ◽  
Major Risk Factor ◽  
Albino Rats ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Hypercholesterolemic Diet

Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury. The present study aimed to illustrate the myocardial injury induced in a diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-DHGD intake either individually or in combination form. Male albino rats were selected for the study, received alloxan, hypercholesterolemic diet, and categorized into four groups. The first one (DHC), received hypercholesterolemic diet only and referred to as control. The remaining groups (2, 3, 4) received vitamin D3, 10-DHGD, and combination of both, respectively. Certain biomarkers that were selected for MI evaluation included blood glucose, lipogram pattern, Copeptin, C-reactive protein, myeloperoxidase, heart fatty acid-binding protein, and histopathological changes in myocardium and aorta. Vitamin D3 and 10-DHGD intake induced significant hypoglycemic, hypolipidemic effects, decreased inflammation, and MI biomarkers. Decreased myocardial vacuoles, foam cells, and intimal lesions were also observed compared to DHC. Their combination intake induced more marked reduction in all biomarkers and showed a histopathological pattern similar to normal features of myocardium and aorta. Our findings suggest the therapeutic roles of vitamin D3, 10-DHGD, and their combination against myocardial injury in diabetic hyperlipidemic rats. Impact statement Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

scholarly journals Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Hao Qian ◽  
Na Luo ◽  
Yuling Chi
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Molecular Mechanism ◽  
Major Risk Factor ◽  
Cardiovascular Disorders ◽  
Endothelium Dysfunction ◽  
Age Related ◽  
Endothelium Function ◽  
Available Information ◽  
Age Related Changes

Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.

Cholesterol-lowering effect of bile salt hydrolase from a Lactobacillus johnsonii strain mediated by FXR pathway regulation

2021 ◽  
Author(s):  
Huanjing Zhu ◽  
Fang Zhao ◽  
Wenjun Zhang ◽  
Wenxu Xia ◽  
Yin Chen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Bile Salt ◽  
Major Risk Factor ◽  
Bile Salt Hydrolase ◽  
Cholesterol Reduction ◽  
High Cholesterol ◽  
Lactobacillus Johnsonii ◽  
Pathway Regulation ◽  
Cholesterol Lowering Effect

Hypercholesterolemia is a major risk factor for cardiovascular diseases worldwide. In this study, recombinant bile salt hydrolase (BSH) from the strain L. johnsonii 334 with high cholesterol reduction ability was...

scholarly journals EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON THE CARDIOVASCULAR SYSTEM AND CARDIAC ANTI-AGING

2021 ◽  
Vol 9 (2) ◽  
pp. 109
Author(s):  
Olivia Dharmasanti
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
High Intensity ◽  
Interval Training ◽  
Major Risk Factor ◽  
High Intensity Interval Training ◽  
High Intensity Interval

Abstract   There are several risk factors leading to the development and progression of CVD, but one of the most prominent is a sedentary lifestyle. A healthy lifestyle can be characterized by both obesity and consistently low levels of physical activity. Lifestyle interventions that aim to increase physical activity and decrease obesity are attractive therapeutic methods to combat most non-congenital types of CVD. Aging is the another major risk factor for cardiovascular diseases (CVD), which are the leading cause of death in the United States. Epidemiological studies clearly show that aging itself is the major risk factor for cardiovascular and cerebrovascular diseases. Most of the research efforts on prevention of these diseases have ignored the mechanisms underlying cardiac and vascular effects of aging, and have focused, instead, on the development of interventions that target conventional cardiovascular risk factors. High-intensity interval training (HIIT) is frequently used in sports training. The effects on cardiorespiratory and muscle systems have led scientists to consider its application in the field of cardiovascular diseases. HIIT is defined as high intensity exercise for a defined period of time interspersed with rest periods (moderate light intensity or complete rest). This literature review was conducted to determine the correlation between high intensity interval training with the cardiovascular system and cardiac anti-aging.   Keywords: Cardiac anti-aging, cardiovascular system, cardiovascular disease, high intensity interval training.

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