ABO blood group system and occurrence of ischemic stroke

ABSTRACT Background: Ischemic stroke (IS) is a multifactorial disease that presents high rates of morbimortality in Brazil. Several studies proved that there is a link between the ABO blood group system and the occurrence of thrombotic events. Nonetheless, its association with IS is not well established. Objective: For that reason, the purpose hereof was to investigate the relation between the ABO blood groups and the occurrence of IS in a Brazilian cohort of cerebrovascular diseases. Methods: Five hundred and twenty-nine subjects were included over 12 months, from which 275 presented an IS episode and 254 composed the control group. Blood samples were drawn for direct and reverse serotyping. The control and IS groups were compared regarding the traditional risk factors and the distribution of the ABO blood groups. Results: The IS group presented a higher prevalence of systemic arterial hypertension (SAH), diabetes mellitus, smoking habits, family history, cardiopathy, and sedentary lifestyle in comparison with the control group. The AB blood type prevailed among the patients (5.1 vs. 1.6%; p<0.05) and this group had more SAH cases in comparison with the O type group (92.9 vs. 67.3%; p<0.05). Conclusions: Our results suggest that the occurrence of IS is more frequent among patients of the AB blood type.

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Relationship between ABO blood group and breast cancer at AL-Nassyria city / Iraq

10.32792/thi/sc/vol.1.is.1.04 ◽

2008 ◽

pp. 26-29

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Cancer Patients ◽

Blood Group ◽

High Frequency ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Control Samples

The current study included 200 patients with breast cancer that resemble to patient samples were collected from AL-Nassyria hospital also 279 samples as control which was collected from blood bank at ALNassiryia province . The study attempted to correlate ABO blood group with incidence to breast cancer .The results shown that type A of ABO blood group high frequency then followed by type O with in AL-Nassyria region also the results reported that A, B, O and AB blood groups frequencies of patient samples percentage were 60%, 20%, 10% and 10% respectively as well as the ABO blood groups frequencies of control samples percentage were 26%, 28%,38% and 8% respectively. The results observed there is high significant differences between ABO blood group frequencies of cancer patients and ABO blood group frequencies of control samples .The results indicated that the blood type should be considered one of risk factor as well as regarded as preclinical marker.

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Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

Frontiers in Medicine ◽

10.3389/fmed.2021.759648 ◽

2022 ◽

Vol 8 ◽

Author(s):

Herbert F. Jelinek ◽

Mira Mousa ◽

Nawal Alkaabi ◽

Eman Alefishat ◽

Gihan Daw Elbait ◽

...

Keyword(s):

Candidate Gene ◽

Blood Group ◽

Population Sample ◽

Blood Groups ◽

Blood Type ◽

Candidate Gene Approach ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Allelic Variants ◽

A Genome

Introduction: Coronavirus disease 2019 (COVID-19) disease severity differs widely due to numerous factors including ABO gene-derived susceptibility or resistance. The objective of this study was to investigate the association of the ABO blood group and genetic variations of the ABO gene with COVID-19 severity in a heterogeneous hospital population sample from the United Arab Emirates, with the use of an epidemiological and candidate gene approach from a genome-wide association study (GWAS).Methods: In this cross-sectional study, a total of 646 participants who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited from multiple hospitals and population-based (quarantine camps) recruitment sites from March 2020 to February 2021. The participants were divided into two groups based on the severity of COVID-19: noncritical (n = 453) and critical [intensive care unit (ICU) patients] (n = 193), as per the COVID-19 Reporting and Data System (CO-RADS) classification. The multivariate logistic regression analysis demonstrated the association of ABO blood type as well as circulating anti-A antibodies and anti-B antibodies as well as A and B antigens, in association with critical COVID-19 hospital presentation. A candidate gene analysis approach was conducted from a GWAS where we examined 240 single nucleotide polymorphisms (SNPs) (position in chr9: 136125788-136150617) in the ABO gene, in association with critical COVID-19 hospital presentation.Results: Patients with blood group O [odds ratio (OR): 0.51 (0.33, 0.79); p = 0.003] were less likely to develop critical COVID-19 symptoms. Eight alleles have been identified to be associated with a protective effect of blood group O in ABO 3'untranslated region (UTR): rs199969472 (p = 0.0052), rs34266669 (p = 0.0052), rs76700116 (p = 0.0052), rs7849280 (p = 0.0052), rs34039247 (p = 0.0104), rs10901251 (p = 0.0165), rs9411475 (p = 0.0377), and rs13291798 (p = 0.0377).Conclusion: Our findings suggest that there are novel allelic variants that link genetic variants of the ABO gene and ABO blood groups contributing to the reduced risk of critical COVID-19 disease. This study is the first study to combine genetic and serological evidence of the involvement of the ABO blood groups and the ABO gene allelic associations with COVID-19 severity within the Middle Eastern population.

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ABO blood group and the risk of breast cancer: Multicenter, case-control, observational study.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.1572 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 1572-1572

Author(s):

Yuksel Urun ◽

Tulay Koru-Sengul ◽

Kadri Altundag ◽

Gungor Utkan ◽

Handan Onur ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Blood Group ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Blood Types ◽

Abo Blood Type

1572 Background: The role of genetic factors in the development of cancer is widely accepted. ABO blood type is an inherited characteristic and previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. Methods: All patients who had breast cancer (BC) and treated between 2000-2010 at the Departments of Medical Oncology of both Ankara and Hacettepe Universities (Ankara, Turkey) with defined ABO blood type and Rh factor were included in our retrospective reviews of tumor registry records. A group of volunteer healthy women donors of Turkish Red Crescent between 2004-2011 were identified as a control group, without any matching factors. The relationship of ABO blood types and Rh factor with various prognostic factors such as age at diagnosis, menopausal status, family history of breast cancer, and ER/PR/HER2 status were evaluated from 1740 BC patients. We compared the distributions of ABO blood types, Rh factors among 1740 patients and 204,553 healthy controls. Among BC patients, differences between each of aforementioned ABO blood groups and Rh factors with respect to various prognostic factors were explored, respectively. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (44% A, 8% AB, 16% B, 32% O, 88% Rh+) and controls (41% A, 8% AB, 16% B, 35% O, 87% Rh+). However, there were statistically significant differences between patients and controls with respect to A vs. nonA (p=0.019) and marginal significance (p=0.051) for O vs. nonO. Among patients, there were statistically significant differences between A and nonA with respect to HER2 (p=0.0421), M stage (p=0.0447), T stage (p=0.0020). Only T stage (p=0.0337) were significantly different between O vs nonO. Grade (p=0.0227) and M stage (p=0.0107) were significantly different between Rh factors. Conclusions: In our study sample, ABO blood type was statistically significantly associated with breast cancer. Additional studies are necessary to determine the mechanisms by which ABO blood type may influence the risk of breast cancer.

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Genetic Analysis of ABO and Rh Blood Groups in Backward Caste Population of Uttar Pradesh, India

Notulae Scientia Biologicae ◽

10.15835/nsb336073 ◽

2011 ◽

Vol 3 (3) ◽

pp. 07-14 ◽

Cited By ~ 2

Author(s):

Vandana RAI ◽

Pradeep KUMAR

Keyword(s):

Blood Group ◽

Uttar Pradesh ◽

Blood Groups ◽

Blood Type ◽

Allele Frequency Distribution ◽

Blood Group System ◽

Blood Group Antigens ◽

Group System ◽

Rhesus Blood Group ◽

Rhesus Blood Group System

A series of glycoproteins and glycolipids on red blood cell surface constitute blood group antigens. These are AB, A, B and O in ABO blood group system and Rh in rhesus blood group system. A total of 1065 unrelated Backward Caste (OBC) individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. Total 1065 samples analyzed, phenotype B blood type has the highest frequency 36.81% (n=392), followed by O (32.68%; n=348), A (23.66%; n=252) and AB (6.85%; n=73). The overall phenotypic frequencies of ABO blood groups were B>O>A>AB. The allelic frequencies of O, A, and B alleles were 0.5819, 0.1674 and 0.2506 respectively. Out of total 1065 samples, 1018 (95.59%) samples were Rh-positive and 47 (4.41%) were Rh-negative. Phenotypic frequency of Rh-negative in Koari, Yadav, Kurmi and Maurya samples were 0.99%, 4%, 1.4% and 7.6% respectively.

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Prevalence of ABO and Rh blood groups and their association with Transfusion-Transmissible Infections (TTIs) among Blood Donors in Islamabad, Pakistan

BioScientific Review ◽

10.32350/bsr.0304.02 ◽

2021 ◽

Vol 3 (4) ◽

Author(s):

Muhammad Yousaf Khan ◽

Farwa Sijjeel ◽

Ahmareen Khalid ◽

Rukhshan Khurshid ◽

Umm E Habiba ◽

...

Keyword(s):

Viral Infection ◽

Blood Group ◽

Blood Donors ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Syphilis Infection ◽

Group System ◽

Group A ◽

Group B

Certain Rh positive blood groups showed a link between the ABO blood grouping and susceptibility to some infectious ailments. Study was carried out to find the association of ABO Blood Group System / Rh type with different viral infection. A retrospective observational study was carried in 7631 blood donors to find the association of ABO Blood Group System / Rh type with viral infection due to hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Syphilis. Data of the study indicateF that the highest incidence of blood group in blood donor was B followed by O, A and AB. The incidence of HBsAg +ve, HCV Ab +ve and infection of Syphilis was also highest in donor with blood group B followed by O, A and AB. Blood group A were more susceptible to HIV Ab +ve followed by blood group B, O and AB. The group B donors had the greatest risk of viral infection with HBV, HCV, HIV, and Syphilis; followed by the groups O, A, and AB. Donors in group AB had the lowest incidence rate of all viral infection. The study revealed that blood group B is most prevalent among donors, followed by blood groups O, A, and AB. On the other side, the rate of HBV, HCV, HIV, and Syphilis infection was greatest among group B donors, followed by group O, group A, and group AB. Copyright(c) The Authors

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ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis

Iberoamerican Journal of Medicine ◽

10.53986/ibjm.2021.0012 ◽

2020 ◽

Vol 3 (1) ◽

pp. 71-84

Author(s):

Richard Chinaza Ikeagwulonu ◽

◽

Chinonyelum Thecla Ezeonu ◽

Mark Uchejeso Obeta ◽

Ngozi Immaculata Ugwu ◽

...

Keyword(s):

Blood Group ◽

Meta Analysis ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Blood Group A ◽

Search Terms ◽

Group A

Introduction: Conflicting evidences exist that ABO blood groups correlate with the susceptibility to COVID-19 and its clinical outcomes. This study aimed to pool available articles that assessed a possible relationship between COVID-19 and ABO blood groups. Materials and methods: A search was conducted in four databases comprising Pubmed/Medline, Google scholar, Journal storage (JSTOR) and African Journals Online (AJOL) for relevant studies available before 25th August 2020 and contained extractable data on ABO blood type distribution and COVID-19 disease. Search terms included a combination of “ABO blood group, and COVID-19, coronavirus, and SARS-COV-2”. Results: Fourteen articles that met study inclusion criteria were selected from a total of five hundred and eighty-five articles identified through database search. The fourteen articles reviewed comprised of a total of 73934 subjects (13189 SARS-COV-2 positive cases and 60745 controls). Overall, the risk of SARS-COV-2 infection was found to be significantly increased in patients with blood group A with ORs: 1.24 (95%Cl: 1.09-1.41, P = 0.001). Additionally, blood group O subjects were seen to have decreased odds of contracting COVID-19 infection (OR: 0.78, 95%Cl: 0.68 – 0.89, P=0.0003). No significant association was found between ABO blood groups and COVID -19 severity and mortality. Conclusions: Blood group A was associated with a higher risk of SARS-COV-2 infection whereas risk of infection was lower in blood group O subjects. No statistical significant association was found between ABO blood groups and COVID-19 severity and mortality. The precise role of ABO blood group in COVID-19 susceptibility, severity and mortality requires further research for clarification.

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COVID-19 and blood groups: A six-months observational study in Ferrara, Italy

Hematology Reports ◽

10.4081/hr.2021.9177 ◽

2021 ◽

Vol 13 (3) ◽

Author(s):

Salvatore Greco ◽

Nicolò Fabbri ◽

Alessandro Bella ◽

Beatrice Bonsi ◽

Alessandra Violi ◽

...

Keyword(s):

Blood Group ◽

Cox Regression ◽

Laboratory Data ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Survival Functions ◽

Group System ◽

Hospital Stays ◽

A Minor

The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care - IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (p=0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (p=0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative.

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RGB Image Cluster Evaluation for Human Blood Group Identification by MLP Classification

International Journal of Recent Technology and Engineering - 2 ◽

10.35940/ijrte.c6005.098319 ◽

2019 ◽

Vol 8 (3) ◽

pp. 4197-4202

Keyword(s):

Blood Sample ◽

Blood Group ◽

Median Filter ◽

Group Identification ◽

Optimal Solution ◽

Blood Groups ◽

Blood Type ◽

Blood Group System ◽

Group System ◽

Blood Exchange

Image processing is helping researchers to reach their goals in many ways, especially in medical fields. Blood organization is very important when it comes to receiving a blood exchange. The most important blood group identification method is ABO blood group system and the RhD blood group system. Blood groups are defined by the occupancy or preoccupied of a specific agglutinate on the get around of a red blood cell. Identifying the blood group is very important for medical treatment in pathological tests, at some point it gives us an inaccurate and also expensive result, therefore, to overcome these problems an efficient and optimal solution is required. The need for accurate detection is high in a disaster situation where there are no laboratory people or experts available to detect the type of it. In the proposed method, we have collected 50 blood sample images for each of 8 blood groups, total 400 blood sample images are considered for experimentation. In preprocessing, the median filter is used to eliminate noise from the blood images. Then these images are converted from RGB to grayscale conversion and also resizing of the images is carried out. Region based segmentation by using two methods Markov Random Field and Region Adjacency Graph are used for segmentation, texture, color, and shape features are extracted from segmented images. Hence this paper proposes a pixel cluster based analysis of the blood type based on the pixel analysis features. The overall accuracy of blood group determination is 93.85%.

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The ABO Blood Group System and Plasmodium Infection in Iran: A Comprehensive Study

Iranian Journal Of Health Sciences ◽

10.18502/jhs.v7i3.1533 ◽

2019 ◽

Author(s):

Farshid Karami ◽

Mozhdeh Mohammadian ◽

Seif Ali Mahdavi ◽

Mohammad Taghi Rahimi

Keyword(s):

Blood Group ◽

Geographical Distribution ◽

Significant Relationship ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Plasmodium Infection ◽

Group System ◽

Group Distribution ◽

Comprehensive Study

Background: Geographical distribution of ABO blood groups affects by race, ethnicity, migration and some infectious agents, such as Plasmodium species. P. falciparum is the major causative agent of death in malaria that can affect ABO blood group distribution in different populations. Therefore, the objective of the current study was to determine the effect of p. falciparum on ABO blood group distribution in Iran. Materials & Methods The present study was conducted on the database of Iranian Blood Transfusion Organization (IBTO) in 30 provinces of the country about ABO and Rh blood groups of the people who referred to health centers from June 2011 to August 2012. Results: A total number of 2124560 individuals were referred to IBTO in 30 provinces. The highest and lowest rates of O blood group were observed in Sistan & Baluchestan (64.6%) and Lorestan (37.7%), respectively. P. falciparum was the most common species of malaria in Sistan & Baluchestan (53215) and the rarest infection agent in Semnan province (20). The results showed statistically significant relationship (p < 0.05) between prevalence of P. falciparum with O blood group, while this relationship for a blood group was not significant (p > 0.05). Conclusion: Our results revealed a significant relationship between prevalence of P. falciparum and geographical distribution of ABO blood. There was also found more susceptibility and risk to malaria infection and cerebral malaria in a blood group compared to other groups. In addition, this was the first comprehensive study on the ABO blood group system and Plasmodium infection in Iran.

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Evaluation of blood groups in patients with anti TPO positive

Asian Journal of Medical Sciences ◽

10.3126/ajms.v10i6.25878 ◽

2019 ◽

Vol 10 (6) ◽

pp. 67-70 ◽

Cited By ~ 1

Author(s):

Eşref Araç ◽

İhsan Solmaz

Keyword(s):

Diabetes Mellitus ◽

Blood Group ◽

Blood Groups ◽

Abo Blood Group ◽

Blood Group System ◽

Negative Group ◽

Positive Group ◽

Group System ◽

The Relationship ◽

B Blood Group

Background: In studies, ABO blood group system has been shown to be associated with type 2 diabetes mellitus, chronic renal failure, gestational diabetes mellitus, postpartum depression, coronary artery disease, Crohn’s disease as well as various cancer types such as stomach, breast, skin cancers and rheumatologic diseases. Aims and Objective: The relationship between anti TPO positivity and ABO blood group system is aimed to be investigated by using blood groups which are the product of genetic structure and easy to identify by considering the relationship between anti TPO positivity and blood group. Materials and Methods: 4312 patients with determined blood groups were included among the patients, who were admitted to the internal medicine outpatient clinics of our hospital between January 2, 2017 and May 28, 2019 and were screeened for thyroid antibodies with thyroiditis susceptibility. Results: The most common blood group was A in both anti TPO positive and anti TPO negative patient groups.The rate of those with O blood group was 2.65% higher in anti TPO positive group than anti TPO negative group. B blood group was found to be 4.87% higher in anti TPO negative group than anti TPO positive group (p:0.148). Conclusion: In conclusion, it was found that O blood group may be a risk factor for anti TPO positivity and B blood group is much lower in anti TPO positive ones. However, it is obvious that more comprehensive prospective multicentered clinical and experimental studies are needed to establish the relationship between blood groups and autoimmune diseases, especially autoimmune thyroiditis.

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