scholarly journals Seasonal effect of Brazilian propolis on seric biochemical variables

2002 ◽  
Vol 8 (2) ◽  
pp. 244-254 ◽  
Author(s):  
J. M. SFORCIN ◽  
E. L. B. NOVELLI ◽  
S. R. C. FUNARI
2001 ◽  
Vol 7 (1) ◽  
pp. 139-144 ◽  
Author(s):  
J. M. SFORCIN ◽  
A. FERNANDES JÚNIOR ◽  
C. A. M. LOPES ◽  
S. R. C. FUNARI ◽  
V. BANKOVA

2000 ◽  
Vol 73 (1-2) ◽  
pp. 243-249 ◽  
Author(s):  
J.M Sforcin ◽  
A Fernandes ◽  
C.A.M Lopes ◽  
V Bankova ◽  
S.R.C Funari

Author(s):  
Fabio Galeotti ◽  
Federica Capitani ◽  
Francesca Maccari ◽  
Veronica Mantovani ◽  
Nicola Volpi

Abstract Propolis is important in complementary and alternative medicine having well-known therapeutic applications. Artepillin C, a main component of Brazilian (green) propolis, has attracted great attention for its anticancer action. Consequently, the synthesis of artepillin C has been reported but, due to the limited yield and elevated costs, this biomolecule is largely produced from Brazilian propolis. We report the capillary electrophoresis (CE) separation of artepillin C in Brazilian propolis also comparing the results with those of HPLC-UV-MS. Optimal separation was obtained with a simple buffer constituted of sodium tetraborate 30 mM pH 9.2 and detection at 210 nm. Artepillin C and the polyphenols of propolis were fully separated with a voltage gradient of 30 to 8 kV and a current of 300 μA for a total run of 50 min. The sensitivity of CE-UV was 22 times greater than HPLC-UV and 100 times more than HPLC-MS with also a stronger reduction in the run time and a greater robustness and reproducibility. The development of CE as an effective and reliable method for the analysis of artepillin C is desired as the standardized quality controls are essential before propolis or its biomolecules can be adopted routinely in nutraceuticals, food ingredients and therapeutic applications.


2008 ◽  
Vol 5 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Fabiane Missima ◽  
José Maurício Sforcin

Stress is a generic term that summarizes how psychosocial and environmental factors influence physical and mental well-being. The interaction between stress and immunity has been widely investigated, involving the neuroendocrine system and several organs. Assays using natural products in stress models deserve further investigation. Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory. The aim of this study was to evaluate if and how propolis activated macrophages in BALB/c mice submitted to immobilization stress, as well as the histopathological analysis of the thymus, bone marrow, spleen and adrenal glands. Stressed mice showed a higher hydrogen peroxide (H2O2) generation by peritoneal macrophages, and propolis treatment potentiated H2O2generation and inhibited nitric oxide (NO) production by these cells. Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen. Propolis treatment counteracted the alterations found in the spleen of stressed mice. New research is being carried out in order to elucidate propolis immunomodulatory action during stress.


2011 ◽  
Vol 184 (5) ◽  
pp. 2677-2689 ◽  
Author(s):  
Christabelle E. G. Fernandes ◽  
Anindita Das ◽  
B. N. Nath ◽  
Daphne G. Faria ◽  
P. A. Loka Bharathi

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