scholarly journals Toxicological Effects of Artificial Fine Particulate Matter in Rats through Induction of Oxidative Stress and Inflammation

2021 ◽  
Vol 255 (1) ◽  
pp. 19-25
Author(s):  
Zhicong Hong ◽  
Peiji Zeng ◽  
Guoshun Zhuang ◽  
Qiaoling Guo ◽  
Chengfu Cai
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Toxicological Effects ◽  
Fine Particulate

scholarly journals Effects of ambient PM2.5and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in the lungs of rats

2017 ◽  
Vol 6 (5) ◽  
pp. 654-663 ◽  
Author(s):  
Ruijin Li ◽  
Lifang Zhao ◽  
Li Zhang ◽  
Minghui Chen ◽  
Jing Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Dna Damage ◽  
Particulate Matter ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Fine Particulate Matter ◽  
Complex Mixture ◽  
Dna Damage And Repair ◽  
Fine Particulate

Ambient fine particulate matter (PM2.5) is a complex mixture associated with lung cancer risk.

scholarly journals Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in C. elegans

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Yunli Zhao ◽  
Ling Jin ◽  
Yuxin Chi ◽  
Jing Yang ◽  
Quan Zhen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Metabolic Enzyme ◽  
C Elegans ◽  
Unfolded Protein ◽  
Fine Particulate ◽  
Underlying Mechanisms ◽  
Protein Response ◽  
Phenylbutyric Acid

Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM2.5-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM2.5-induced toxic effects, the current study explored the effects of oxidative stress induced by PM2.5 on UPR and lifespan in C. elegans. The results implicated that PM2.5 exposure induced oxidative stress response, enhanced metabolic enzyme activity, activated UPR, and shortened the lifespan of C. elegans. Antioxidant N-acetylcysteine (NAC) could suppress the UPR through reducing the oxidative stress; both the antioxidant NAC and UPR inhibitor 4-phenylbutyric acid (4-PBA) could rescue the lifespan attenuation caused by PM2.5, indicating that the antioxidant and moderate proteostasis contribute to the homeostasis and adaptation to oxidative stress induced by PM2.5.

Exposure to fine particulate matter induces self-recovery and susceptibility of oxidative stress and inflammation in rat lungs

2020 ◽  
Vol 27 (32) ◽  
pp. 40262-40276 ◽  
Author(s):  
Huiqing Ren ◽  
Jianjiang Lu ◽  
Jianying Ning ◽  
Xianghui Su ◽  
Yanbin Tong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Rat Lungs
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