ScamElite Power CBD Gummies ! review and side effects! v1

2022 ◽  
Author(s):  
hostingwebx not provided
Keyword(s):  
Side Effects ◽  
Full Range

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scholarly journals AVATAR Therapy for Distressing Voices: A Comprehensive Account of Therapeutic Targets

2020 ◽  
Vol 46 (5) ◽  
pp. 1038-1044 ◽  
Author(s):  
Thomas Ward ◽  
Mar Rus-Calafell ◽  
Zeyana Ramadhan ◽  
Olga Soumelidou ◽  
Miriam Fornells-Ambrojo ◽  
...  
Keyword(s):  
Side Effects ◽  
Future Development ◽  
Full Range ◽  
Therapeutic Targets ◽  
Digital Representation ◽  
Face To Face ◽  
Comprehensive Account ◽  
First Time ◽  
Therapy Delivery ◽  
Complete Account

Abstract AVATAR therapy represents an effective new way of working with distressing voices based on face-to-face dialogue between the person and a digital representation (avatar) of their persecutory voice. To date, there has been no complete account of AVATAR therapy delivery. This article presents, for the first time, the full range of therapeutic targets along with information on acceptability and potential side effects. Interest in the approach is growing rapidly and this report acts as a necessary touchstone for future development.

scholarly journals Heterogeneous side-effects of cortical inactivation in behaving animals

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Ariana R Andrei ◽  
Samantha Debes ◽  
Mircea Chelaru ◽  
Xiaoqin Liu ◽  
Elsa Rodarte ◽  
...  
Keyword(s):  
Side Effects ◽  
Full Range ◽  
Network Connectivity ◽  
Careful Consideration ◽  
Network Activity ◽  
Cortical Region ◽  
Target Area ◽  
Response Modulation ◽  
Cortical Column ◽  
Local Circuits

Cortical inactivation represents a key causal manipulation that allows the study of cortical circuits and their impact on behavior. A key assumption in these studies is that the neurons in the target area become silent while the surrounding cortical tissue is only negligibly impacted. However, individual neurons are embedded in complex local circuits comprised of excitatory and inhibitory cells with connections extending hundreds of microns. This raises the possibility that silencing one part of the network could induce complex, unpredictable activity changes in neurons outside the targeted inactivation zone. These off-target side effects can potentially complicate interpretations of inactivation manipulations, especially when they are related to changes in behavior. Here, we demonstrate that optogenetic inactivation of glutamatergic neurons in the superficial layers of monkey V1 induces robust suppression at the light-targeted site, but destabilizes stimulus responses in the neighboring, untargeted network. We identified 4 types of stimulus-evoked neuronal responses within a cortical column, ranging from full suppression to facilitation, and a mixture of both. Mixed responses were most prominent in middle and deep cortical layers. Importantly, these results demonstrate that response modulation driven by lateral network connectivity is diversely implemented throughout a cortical column. Furthermore, consistent behavioral changes induced by optogenetic inactivation were only achieved when cumulative network activity was homogeneously suppressed. Therefore, careful consideration of the full range of network changes outside the inactivated cortical region is required, as heterogeneous side-effects can confound interpretation of inactivation experiments.

Expanding patient-reported outcomes to oral health complications from systemic cancer therapy.

2012 ◽  
Vol 30 (34_suppl) ◽  
pp. 60-60
Author(s):  
Rebecca A. Miksad ◽  
Rohit Goyal ◽  
G. Scott Gazelle ◽  
J. Shannon Swan
Keyword(s):  
Oral Health ◽  
Side Effects ◽  
Cancer Therapy ◽  
Performance Measurement ◽  
Cancer Patients ◽  
Patient Reported Outcomes ◽  
Full Range ◽  
Cross Sectional ◽  
Patient Reported ◽  
Health Complications

60 Background: Cross-disciplinary patient reported outcomes (PROs) assess the full range of side effects from systemic cancer therapy. For oral health complications, however, the validity of oral-health specific and generic health-related quality-of-life (QoL) instruments is unknown for cancer patients. This study evaluates the performance, measurement, and prediction characteristics of the Oral Health Impact Profile (OHIP–14) and EQ–5D in cancer patients with bisphosphonate-associated Osteonecrosis of the Jaw (ONJ). Methods: 34 cancer patients assessed the QoL of their own ONJ with the OHIP–14 and evaluated the QoL of 4 standardized ONJ Health States with the EQ–5D, as previously published. For each instrument, the standard response mean (SRM), effect size (ES), and ability to distinguish minimally important differences (MID) were evaluated for ONJ compared to baseline (longitudinal responsiveness). Instrument MIDs (cross-sectional responsiveness) were also calculated. Performance of a published general dentistry algorithm to predict EQ–5D values from OHIP–14 results was tested. Results: The OHIP–14 and EQ-5D instruments demonstrated moderate to large longitudinal and cross-sectional responsiveness. Pain was one of the most responsive domains for both instruments. Ceiling/floor effects were most prominent for OHIP–14. A general dentistry algorithm did not adequately predict EQ–5D values for cancer patients. Conclusions: This study provides the first empirical evidence for the performance, measurement, and prediction characteristics of oral-health specific and generic QoL instruments for the oral health side effects of systemic cancer treatment. Instrument validity is supported for oral health complications in cancer patients. These results provide benchmarks for PROs at the intersection of oral medicine and surgery, dentistry, and oncology. [Table: see text]

scholarly journals A modern approach to pain relief in labour

Pain medicine ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 36-42
Author(s):  
Ye V Grizhymalskyi ◽  
A I Harha ◽  
Ye V Sulimenko
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
General Condition ◽  
Local Anaesthetic ◽  
Full Range ◽  
Modern Approach ◽  
Safe Method ◽  
Neuraxial Analgesia ◽  
Low Concentrations ◽  
Points Of View

Until now, there are opposite points of view on the problem of pain in labour. The side effects of pain during labour can significantly affect the general condition of the woman and the fetus, the course of labour, and the prognosis. Pain relief in labour is based on the use of various pharmacological and non-pharmacological methods that reduce the level of psychological anxiety, relieve tension, and also block the conduction of pain impulse. For pain relief in labour, the full range of currently available pharmacological and non-pharmacological methods cannot be used, since many of them, simultaneously with pain relief, negatively affect the fetus and the process of childbirth. The use of neuraxial analgesia with local anaesthetic solutions at low concentrations is a safe method of pain relief during labour.

scholarly journals The use of botanical raw materials in hair dyeing

2021 ◽  
Vol 10 (6) ◽  
pp. 263-269
Author(s):  
Natalia Schäfer ◽  
◽  
Radosław Balwierz ◽  
Anna Krzeszewska-Zaręba ◽  
Zbigniew Skotnicki ◽  
...  
Keyword(s):  
Side Effects ◽  
Raw Materials ◽  
Full Range ◽  
Target Color ◽  
Short Term ◽  
Plant Materials ◽  
Natural Hair ◽  
Materials Used

The cosmetic market is rich in products that allow changing the color of hair. There are three options for chemical coloring, depending on the duration of the target color. Among them, there are short-term, semi-permanent, and long-term dyeing. Using synthetic ingredients, it is possible to obtain a full range of colors. Reports of undesirable side effects of chemical dyes on both the scalp and hair structure support a return to natural hair coloration and a development in this direction. The aim of the work was to draw attention to apply botanical raw materials in hair dyeing. The work presents the characteristics of the following plant materials used in hair dyeing: defenseless lawsonia, oxalic hibiscus, rhubarb, elderberry and chamomile.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Effects of cisplatin treatment on the rat neurohypophysis

1986 ◽  
Vol 44 ◽  
pp. 122-123
Author(s):  
J.M. Fadool ◽  
P.J. Boyer ◽  
S.K. Aggarwal
Keyword(s):  
Side Effects ◽  
Urine Output ◽  
Morphological Changes ◽  
Limiting Factor ◽  
Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

Time Block After Time Block

ASHA Leader ◽  
2013 ◽  
Vol 18 (8) ◽  
pp. 40-45 ◽  
Author(s):  
Judy Rudebusch ◽  
JoAnn Wiechmann
Keyword(s):  
Full Range ◽  
Time Block ◽  
School Based ◽  
Schedule Activity

To offer a full range of RTI and IEP services, school-based SLPs can schedule activity blocks rather than go student by student—here's how.

The Use of Neuroplastic Principles Affects the Swallow Motor Plan of a Patient in Severe Cognitive Decline: A Case Study

2016 ◽  
Vol 1 (15) ◽  
pp. 79-83
Author(s):  
Ed Bice ◽  
Kristine E. Galek
Keyword(s):  
Central Nervous System ◽  
Cognitive Decline ◽  
Full Range ◽  
Movement Speed ◽  
Positive Outcomes ◽  
Verbal Cues ◽  
Motor Plan ◽  
Bolus Size ◽  
The Central Nervous System

Dysphagia is common in patients with dementia. Dysphagia occurs as a result of changes in the sensory and motor function of the swallow (Easterling, 2007). It is known that the central nervous system can undergo experience-dependent plasticity, even in those individuals with dementia (Park & Bischof, 2013). The purpose of this study was to explore whether or not the use of neuroplastic principles would improve the swallow motor plan and produce positive outcomes of a patient in severe cognitive decline. The disordered swallow motor plan was manipulated by focusing on a neuroplastic principles of frequency (repetition), velocity of movement (speed of presentation), reversibility (Use it or Lose it), specificity and adaptation, intensity (bolus size), and salience (Crary & Carnaby-Mann, 2008). After five therapeutic sessions, the patient progressed from holding solids in her mouth with decreased swallow initiation to independently consuming a regular diet with full range of liquids with no oral retention and no verbal cues.

Severe Drooling and Treatment With Botulinum Toxin

2012 ◽  
Vol 21 (1) ◽  
pp. 15-21
Author(s):  
Merete Bakke ◽  
Allan Bardow ◽  
Eigild Møller
Keyword(s):  
Botulinum Toxin ◽  
Side Effects ◽  
Health Risk ◽  
Flow Rate ◽  
Clinical Evidence ◽  
Acetylcholine Release ◽  
Psychosocial Problems ◽  
Rate Reduction ◽  
Local Inhibition ◽  
Surgical Treatments

Severe drooling is associated with discomfort and psychosocial problems and may constitute a health risk. A variety of different surgical and non-surgical treatments have been used to diminish drooling, some of them with little or uncertain effect and others more effective but irreversible or with side effects. Based on clinical evidence, injection with botulinum toxin (BTX) into the parotid and submandibular glands is a useful treatment option, because it is local, reversible, and with few side effects, although it has to be repeated. The mechanism of BTX is a local inhibition of acetylcholine release, which diminishes receptor-coupled secretion and results in a flow rate reduction of 25–50% for 2–7 months.

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