scholarly journals The first experience of transperineal prostate biopsy without antibiotic prophylaxis

2021 ◽  
Vol 17 (2) ◽  
pp. 46-52
Author(s):  
D. Yu. Chernysheva ◽  
S. V. Popov ◽  
I. N. Orlov ◽  
A. V. Tsoy ◽  
V. A. Neradovskiy
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Soft Tissues ◽  
Urine Culture ◽  
Randomized Study ◽  
Control Group ◽  
Antibacterial Prophylaxis ◽  
Safe Alternative ◽  
Transperineal Prostate Biopsy ◽  
Complications Rate

Objective: to study the safety of omitting the antibiotic prophylaxis before transperineal prostate biopsy.Materials and methods. The prospective randomized study included data, obtained during the diagnostical process of 85 patients, who underwent transperineal prostate biopsy in 2020. In the control group (n = 50) patients received 1 g Ceftriaxone IV 1 h before the biopsy. In the study group (n = 35) biopsy was performed without previous antibacterial prophylaxis. Age median was 63.2 (52-75) years.Results. No significant differences in the infection complications rate (UTI, soft tissues infections, prostatitis, fever, sepsis) were obtained between the groups. No patient developed UTI, prostatitis or sepsis, confirmed with urine culture.Conclusion. Performing transperineal prostate biopsy without antibiotic prophylaxis seems to be a safe alternative to common prophylaxis regiments, dedicated to infection complications prevention after prostate biopsy.

scholarly journals Options for antibacterial prophylaxis of infectious complications of prostate biopsy

2021 ◽  
Vol 14 (3) ◽  
pp. 150-155
Author(s):  
S.V. Popov ◽  
◽  
I.N. Orlov ◽  
D.Yu. Chernysheva ◽  
T.M. Topuzov ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Clinical Guidelines ◽  
Urine Culture ◽  
Infectious Complications ◽  
Antibacterial Prophylaxis ◽  
Scientific Databases ◽  
Transrectal Prostate Biopsy ◽  
Long Time ◽  
Transperineal Biopsy

Introduction. Amount of prostate biopsy procedures rises every year and up to 95% of cases of prostate biopsy is performed via transrectal approach. The incidence of infectious complications of transrectal prostate biopsy reaches up to 17%, while incidence of such complications of transperineal biopsy is about 1%. The majority of international clinical guidelines recommends for obligatory antibiotic prophylaxis prior to prostate biopsy of any approach, but the choice of antibiotic is still debatable. The aim of this review is to sum up the approaches of international urological guidelines to the antibiotic prophylaxis prior to prostate biopsy. Materials and methods. We analyzed the search results in the scientific databases PubMed, Google Scolar, elibrary.ru for the queries «prostate biopsy», «antibacterial prophylaxis» and «guidelines». Results. According to the recommendations of most professional communities, antibacterial prophylaxis of infectious complications of prostate biopsy can be carried out in various ways - once or for a long time, one- or two-component, empirically or on the basis of urine culture on microflora. Conclusion. Despite the differences in the levels of sensitivity and resistance of coliform flora around the world, the clinical guidelines in most countries are uniform in terms of the choice of drugs to reduce the risk of developing infectious complications after prostate biopsy. Approaches to antibacterial prophylaxis after prostate biopsy differ only depending on the type of biopsy access.

scholarly journals ANTIBIOTIC PROPHYLAXIS WITH DIFFERENT ANTIBIOTIC REGIMEN IN PROSTATE BIOPSY PATIENTS

2013 ◽  
Vol 20 (1) ◽  
Author(s):  
Dimas Sindhu Wibisono ◽  
Doddy M. Soebadi ◽  
Soetojo Soetojo ◽  
Budiono Budiono
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Urine Culture ◽  
Blood Levels ◽  
Positive Urine Culture ◽  
Blood Leukocytes ◽  
Biopsy Material ◽  
Reactive Protein ◽  
Significant Difference ◽  
Blood Leukocyte

Objective: To know the incidence of urinary tract infection (UTI) with different antibiotic prophylaxis for transrectal ultrasonography (TRUS) prostate biopsy. Material & Method: The study included 34 patients at Soetomo Hospital Surabaya, who were divided into 2 groups, each group consisting of 17 patients. In the first group patients received 1000 mg of ciprofloxacin orally, in the second group cefotaxime 1000 mg iv was given prior to biopsy. The two groups were compared in terms of UTI incidence as observed from the blood levels of leukocytes, C-reactive protein (CRP) and urine culture 3 days after the procedure. Results: Based on blood leukocyte levels, there was no statistically significant difference between the two groups (p = 0,74 and p = 0,42). So was the comparison of CRP levels. There was no other significant difference found (p = 0,53 and p = 0,27). From the results of urine culture, the ciprofloxacin group had positive urine culture results lower than the cefotaxime group (29,4% : 35,3%), although it was not statistically significant (p = 1,0). Conclusion: Based on the parameters of blood leukocytes levels, CRP and urine culture, there were no differences in the incidence of UTI after biopsy in the two groups.Keywords: TRUS prostate biopsy, UTI, ciprofloxacin, cefotaxime.

Safety and side effects of transperineal prostate biopsy without antibiotic prophylaxis

2021 ◽  
Author(s):  
August Sigle ◽  
Rodrigo Suarez-Ibarrola ◽  
Marian Pudimat ◽  
Jakob Michaelis ◽  
Cordula A. Jilg ◽  
...  
Keyword(s):  
Side Effects ◽  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Transperineal Prostate Biopsy

scholarly journals Comprehensive analysis of complications after transperineal prostate biopsy without antibiotic prophylaxis: results of a multicenter trial with 30 days’ follow-up

2021 ◽  
Author(s):  
Tobias Kohl ◽  
August Sigle ◽  
Timur Kuru ◽  
Johannes Salem ◽  
Hanjo Rolfs ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Median Number ◽  
Multicenter Trial ◽  
Infectious Complications ◽  
Bleeding Complications ◽  
Transperineal Prostate Biopsy ◽  
Multicenter Cohort

Abstract Background To investigate infectious and non-infectious complications after transperineal prostate biopsy (TPB) without antibiotic prophylaxis in a multicenter cohort. Secondly, to identify whether increasing the number of cores was predictive for the occurrence of complications. Thirdly, to examine the relation between TPB and erectile dysfunction. Methods We analyzed a retrospective multicenter cohort of 550 patients from three different urological centers undergoing TPB without antibiotic prophylaxis. The median number of cores was 26. Demographic and clinical data were extracted by reviewing patients’ electronic medical records and follow-up data such as postoperative complications obtained by structured phone interviews. To investigate the influence of the number of cores taken on the occurrence of complications, we performed univariate and multivariate mixed effects logistic regression models. Results There was no case of sepsis reported. Overall, 6.0% of patients (33/550) presented with any complication besides mild macrohematuria. In all, 46/47 (98%) complications were ≤Grade 2 according to Clavien–Dindo. In multivariate regression analyses, an increased number of cores was associated with overall complications (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.02–1.14, P = 0.01) and specifically bleeding complications (OR 1.28, 95% CI 1.11–1.50, P = 0.01) but not with infectious complications (OR 1.03, 95% CI 0.97–1.10, P = 0.67). A total of 14.4% of patients referred impairment of erectile function after TPB. Of note, 98% of these men were diagnosed with prostate cancer. Conclusions This is the first multicenter trial to investigate complications after TPB without antibiotic prophylaxis. In our study, we found no case of sepsis. This underlines the safety advantage of TPB even without antibiotic prophylaxis and supports the ongoing initiative to abandon TRB of the prostate. A higher number of cores were associated with an increase in overall complications specifically bleeding complications, but not with infectious complications. Post-biopsy erectile dysfunction was mainly present in patients diagnosed with PCa.

scholarly journals MP35-12 IS ANTIBIOTIC PROPHYLAXIS INDICATED FOR TRANSPERINEAL PROSTATE BIOPSY? LOCAL ANTIBIOGRAM FINDINGS TO INFORM ANTIBIOTIC SELECTION

2021 ◽  
Vol 206 (Supplement 3) ◽  
Author(s):  
Ashley Davis ◽  
Mariela Martinez Rivera ◽  
Michael Silver ◽  
David Daniel ◽  
David Silver ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Antibiotic Selection ◽  
Transperineal Prostate Biopsy
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