The effectiveness of kinesio taping in edema-reducing treatment for fractures of the lower jaw

Aim. To assess the effect of Kinesio taping on edema reduction among the patients with fractures of the mandible (lower jaw) in the early postsurgical period of osteosynthesis. Methods. Patients with unilateral mandibular angle fractures with displacement of fragments (49 men at the age of 1850 years), divided into 2 groups: the main group 26 patients (with the inclusion of Kinesio taping in the complex of treatment) and the control group 23 patients (the traditional complex of treatment). All patients underwent splinting of the jaw and miniplate osteosynthesis. Kinesio tapes were applied the next day after surgery to the skin above and below the surgical wound. Three out of five standard landmarks were used to measure edema on the 1st and 5th days after osteosynthesis. Data were analyzed by using descriptive statistics and Student's test. In all cases, the level of statistical significance was 5% (p 0.05). Results. On the day after osteosynthesis, the patients of the main group showed a statistically significant (р 0.003) increase in the measured length for all three landmarks compared with the intact side due to pronounced postoperative edema. On the 5th day after the inclusion of Kinesio taping in the complex of treatment, there was a reduction in edema the indicators of the fractured and intact sides did not differ significantly from each other (р 0.05). In patients of the comparison group, the decrease in the parameters of postoperative edema on the 5th day of observation was negligible and insignificant in all measurements (р 0.05). Conclusion. The results indicate the effectiveness of using Kinesio taping for mandibular fractures in the early postoperative period of osteosynthesis, which makes it possible to achieve a significant reduction in postoperative edema; Kinesio taping is a promising, easy-to-perform method that can be used to reduce inflammatory edema in fractures of the mandible.

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The influence of the Kinesio Taping on selected ultrasonography measurements, and quality of life in patients with rotator cuff lesions

Scientific Reports ◽

10.1038/s41598-020-75701-6 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Aneta Bac ◽

Magdalena Wróbel ◽

Katarzyna Ogrodzka-Ciechanowicz ◽

Edyta Michalik ◽

Anna Ścisłowska-Czarnecka

Keyword(s):

Quality Of Life ◽

Rotator Cuff ◽

Statistical Significance ◽

Control Group ◽

Subacromial Space ◽

Kinesio Taping ◽

Significant Difference ◽

Rotator Cuff Lesions ◽

Significant Change

Abstract The assessment of the six-week influence of Kinesio Taping combined with a rehabilitation on selected ultrasonography measurements, the level of disability, and the quality of life in patients with rotator cuff lesions. 60 participants were randomly assigned into a taping group (KT combined with a six-week rehabilitating protocol) and a control group (only rehabilitation protocol). In all patients the following assessments were performed twice: USG, UEFI and NHP questionnaires. In the examination of the subacromial space and the subacromial bursa in the taping group, no statistical significance was observed. A statistically significant change in the thickness of the muscles was obtained only for the thickness of the infraspinatus in the taping group. A statistically significant change was obtained in the assessment of tendinopathy only for the supraspinatus muscle in both groups. Within both groups a statistically significant difference was observed in the average UEFI and NHP scores; however, the differences in the scores obtained between the groups were not statistically significant. The use of KT with a rehabilitation program did not yield statistically significantly better results in the improvement of selected shoulder region indicators, the function of the upper limb and the quality of life.

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Minimum Invasive Stabilizing and Decompressive-Stabilizing Methods of Surgical Treatment for Degenerative-Dystrophic Lesions of Spine

N.N. Priorov Journal of Traumatology and Orthopedics ◽

10.17816/vto20111843-10 ◽

2011 ◽

Vol 18 (4) ◽

pp. 3-10

Author(s):

A V Krut'ko ◽

Shamil' Al'firovich Akhmet'yanov ◽

D M Kozlov ◽

A V Peleganchuk ◽

A V Bulatov ◽

...

Keyword(s):

Surgical Treatment ◽

Lumbar Spine ◽

Surgical Techniques ◽

Pain Syndrome ◽

Early Postoperative Period ◽

Main Group ◽

Control Group ◽

Surgical Interventions ◽

Comparative Group ◽

Operative Wound

Results of randomized prospective study with participation of 94 patients aged from 20 to 70 years with monosegmental lumbar spine lesions are presented. Minimum invasive surgical interventions were performed in 55 patients from the main group. Control group consisted of 39 patients in whom decompressive-stabilizing operations via conventional posteromedian approach with skeletization of posterior segments of vertebral column were performed. Average size of operative wound in open interventions more than 10 times exceeded that size in minimum invasive interventions and made up 484 ± 56 and 36 ± 12 sq.cm, respectively. Mean blood loss was 326.6 ± 278.0 ml in the main group and 855.1 ± 512.0 ml in the comparative one. In the main group no one patient required substitution hemotransfusion, while in 13 patients from the comparative group donor erythrocytic mass and/or fresh-frozen plasma were used to eliminate the deficit of blood components. Intensity of pain syndrome in the zone of surgical intervention by visual analog scale in the main group was lower than in comparative group. In the main and comparative groups the duration of hospitalization made up 6.1 ± 2.7 and 9.7 ± 3.7 bed days, respectively. In no one patient from the main group complications in the zone of operative wound were noted. Three patients from the comparative group required secondary debridement and in 1 patient early deep operative wound suppuration was observed. Application of low invasive surgical techniques for the treatment of patients with degenerative lumbar spine lesions enabled to perform radical surgical treatment with minimal iatrogenic injury. The method possessed indubitable advantages over the conventional open operations especially intraoperatively and in early postoperative period.

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Determining the risk factors for xerostomia in dental out-patients

Kazan medical journal ◽

10.17750/kmj2015-174 ◽

2015 ◽

Vol 96 (2) ◽

pp. 174-177

Author(s):

K V Komarova ◽

N N Ratkina ◽

V K Polenichkin ◽

E P Karmanov

Keyword(s):

Risk Factors ◽

Musculoskeletal Diseases ◽

Statistical Significance ◽

Main Group ◽

Control Group ◽

Endocrine Disorders ◽

Chi Square ◽

Chi Square Test ◽

Period Duration ◽

Group 1

Aim. To determine the risk factors for xerostomia.Methods. The study included 137 patients aged 25 to 60 years (61 males, 76 females), the main group consisted of 40 patients with xerostomia (11 males, 29 females), with a median age of 44.5 years (38; 49.5). The control group included 97 patients without xerostomia (50 males, 47 females), median age - 42 years (36; 49). The questionnaire by V.V. Afanas’ev (1993) was used to collect the complaints, anamnesis and to determine the risk factors for xerostomia. Qualitative indicators are listed as absolute numbers and shares (%). In assessing the statistical significance of qualitative indicators differences, contingency tables with subsequent Pearson chi-square test were used.Results. Among the patients of the main group, 19 (47.5%) took medications decreasing the salivation, with intake period duration ranging from 1 to 4 months. When questioned, patients with xerostomia reported statistically significant increase in the rates of cardiovascular disorders (15 patients, 37.5%), gastrointestinal tract diseases (11 patients, 27.5%), endocrine diseases (10 patients, 25%), musculoskeletal diseases (9 patients, 22.5%). The combination of three or more positive answers on V.V. Afanas’ev questionnaire questions was revealed in 12 (30%) patients of the main group, which was significantly higher compared to the control group (1 patient, 1.03%).Conclusion. The most typical reasons for developing xerostomia were the following: taking medications decreasing the salivation, presence of cardiovascular, gastrointestinal, musculoskeletal and endocrine disorders. Three or more positive answers on V.V. Afanas’ev questionnaire questions increase the probability of detecting xerostomia in a respondent.

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Diagnostics and treatment of abdominal complications after gynecological endoscopic operations

Reproductive health of woman ◽

10.30841/2708-8731.1.2021.229720 ◽

2021 ◽

Vol 1 ◽

pp. 75-79

Author(s):

Yu.P. Vdovichenko ◽

V.I. Boyko ◽

V.A. Terehov

Keyword(s):

Postoperative Complications ◽

Postoperative Period ◽

Diagnostic Laparoscopy ◽

Abdominal Cavity ◽

Early Postoperative Period ◽

Main Group ◽

Laparoscopic Technique ◽

Control Group ◽

Diffuse Peritonitis ◽

Abdominal Complications

The objective: to analyze the results of repeated laparoscopy in gynecological patients with suspected intraperitoneal postoperative complications.Materials and methods. The study involved 42 patients (mean age 46±11,3 years), in whom postoperative abdominal complications after surgical treatment of various gynecological diseases required repeated operations. Depending on the method of re-intervention, the patients were divided into 2 groups: the main group (n=20) – women who only used laparoscopy to correct postoperative complications; control (n=22) – women who were given indications for relaparotomy to correct postoperative complications during diagnostic laparoscopy. Relaparotomy was performed in 8 patients of the control group. All patients underwent a comprehensive examination using clinical, instrumental and laboratory research methods. The groups were homogeneous in terms of age and structure of operations performed on the pelvic organs, and statistically comparable.Results. During the study, the results of repeated laparoscopy of 34 gynecological patients with suspected intraperitoneal postoperative complications were analyzed. In all patients of the main group (47,6%), laparoscopy was revealed as the only and final method of treatment of postoperative complications, while in 7 women repeated relaparoscopy was used from 2 to 4 times, and in 13 women laparoscopy was performed once. In the control group (53,3%), 10 patients during diagnostic laparoscopy were exposed to indications for relaparotomy, in 4 patients the capabilities of the operating team and laparoscopic technique allowed performing some elements of the operation and completing it with a minilaparotomy approach, and 8 patients underwent relaparotomy immediately.Peritonitis and intraperitoneal bleeding prevail in the structure of early abdominal complications. The use of the video laparoscopic technique made it possible in 28,6% of patients with diffuse peritonitis to successfully eliminate the developed complication, eliminate its source and sanitize the abdominal cavity. Laparoscopic hemostasis was successfully performed in 7 patients.Compared with the standard, the use of video endoscopic technique allowed improving the indicators of diagnostic value: to increase the sensitivity level by 1,07 times, specificity by 1,39 times and diagnostic accuracy by 1,11 times.Conclusion. In general, in the early postoperative period, 47 relaparoscopies were performed for suspected complications, which is explained by programmed abdominal sanitization and the use of dynamic laparoscopy to control the course of intraperitoneal complications. Based on the analysis of the material under study, we proposed general indications and contraindications for relaparoscopy in the early postoperative period in order to diagnose and treat postoperative complications. Justifying each of the points, we were guided by the real possibilities of the method in general clinical practice, which in some cases are inferior in their effectiveness to relaparotomy.

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The Influence of Kinesio Taping on the Increase of Effort Tolerance in Patients after Laparoscopic Cholecystectomy

Reabilitacijos mokslai slauga kineziterapija ergoterapija ◽

10.33607/rmske.v1i8.852 ◽

2020 ◽

Vol 1 (8) ◽

Author(s):

Marcin Krajczy ◽

Jan Szczegielniak ◽

Katarzyna Bogacz ◽

Jacek Luniewski

Keyword(s):

Laparoscopic Cholecystectomy ◽

Statistical Significance ◽

Test Group ◽

Test Time ◽

Control Group ◽

Walk Test ◽

Kinesio Taping ◽

Post Operative Pain ◽

Surgery Department ◽

And Control

Physiotherapy in patients after laparoscopic cholecystectomy (CHL) is impeded by post-operative pain which causes a decline in patients’ activity, reduces respiratory muscle function and affects patients’ ability to look after themselves. The aim of this study was to assess the influence of Kinesio Taping (KT) on the increase in effort tolerance in patients after laparoscopic cholecystectomy. The task of the research was to compare results of 100-meter walk test in test group and control group before surgery, during and after physiotherapy. The research included 63 patients after CHL treated in General Surgery Department of Hospital in Nysa. Both test group (BA) and control group (KO) included randomly selected volunteers who met test qualification criteria. BA group consisted of 32 patients (26 females and 6 males), KO group consisted of 31 patients (22 females and 9 males). Both groups were subjected to complex physiotherapy and group BA had additional KT applications. The results were subjected to statistical analysis with the use of U MannWhitney test. The level of statistical significance was established at p < 0.05. The results showed that in the test conducted before surgery the level of median time recorded in the 100-meter test did not differ significantly between the two research groups. In further tests, the 100-meter walk test time was significantly shorter in the test group in comparison with the patients from the control group. Conclusion: The improvement in effort tolerance observed in the research indicates the efficiency of Kinesio Taping as a method complementing physiotherapy in patients after laparoscopic cholecystectomy.Keywords: Kinesio Taping, laparoscopic cholecystectomy, physiotherapy.

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Preoperative Preparation of Patients with Anemia before Shoulder Replacement

Messenger of Anesthesiology and Resuscitation ◽

10.21292/2078-5658-2021-18-3-53-57 ◽

2021 ◽

Vol 18 (3) ◽

pp. 53-57

Author(s):

S. V. Sokolov ◽

V. А. Gluschenko

Keyword(s):

Postoperative Period ◽

Recombinant Human Erythropoietin ◽

Early Postoperative Period ◽

Main Group ◽

Hemoglobin Level ◽

Control Group ◽

Preoperative Preparation ◽

Shoulder Replacement ◽

Preoperative Anemia ◽

Human Erythropoietin

The preoperative anemia in patients increases the risk of perioperative blood transfusion, myocardial infarction, ischemic stroke, acute kidney injury, and higher nosocomial and 30-day mortality, lengthens the duration of treatment, and increases the risk of re-hospitalization.The objective: to improve treatment results of patients after revision shoulder replacement through management of preoperative anemia.Subjects and methods. 170 medical files of patients who underwent revision shoulder replacement from 2014 to 2021 were retrospectively analyzed. On the day when they were examined by the physician, all patients had blood hemoglobin level below 130 g/l. The patients were divided into two groups that were comparable in their characteristics. Patients of the Main Group (n = 90) received preoperative preparation with iron carboxymaltate in combination with recombinant human erythropoietin 4 weeks before the expected date of surgery. Patients of the Control Group (n = 80) did not have any specific preparation.Results. The data obtained showed that the volume of intraoperative and postoperative drainage blood loss did not differ statistically between the groups; hemoglobin blood level in patients from the Main Group was statistically significantly higher both before the surgery and on the first day after it, and no hemotransfusion was indicated. In the Control Group, a statistically significantly greater decrease in hemoglobin level was observed in the postoperative period; 3 (3.8%) patients in the Control Group required RBC-transfusion. Complications in the early postoperative period (myocardial infarction, pulmonary embolism, and cardiac arrhythmia) were significantly less frequent in the Main Group versus the Control one (4.5% of cases vs. 8.8%; p < 0.05).Conclusion. The use of iron carboxymaltate at the dose of 1,000 mg once and, if necessary, repeatedly in 14 days in combination with recombinant human erythropoietin at the dose of 150 IU/kg allows preparing patients for revision shoulder replacement within the period from two weeks to one month. Preoperative management of anemia until the hemoglobin concentration reaches 130 g/l using the proposed regimen can significantly reduce the need for blood transfusion and frequency of somatic complications in the early postoperative period.

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Associations of SNP rs_7927894 of FLG gene and TARC/CCL17 with atopic dermatitis in children

Modern pediatrics. Ukraine ◽

10.15574/sp.2021.118.12 ◽

2021 ◽

pp. 12-18

Author(s):

V.O. Dityatkovsky ◽

◽

O.E. Abaturov ◽

N.V. Naumenko ◽

O.O. Alifirenko ◽

...

Keyword(s):

Atopic Dermatitis ◽

Statistical Significance ◽

Venous Blood ◽

Clinical Signs ◽

Main Group ◽

Control Group ◽

Serum Concentrations ◽

Control Groups ◽

And Control ◽

Severity Degree

One of the main genetic factors of the development of atopic dermatitis (AD) in children are single nucleotide polymorphisms (SNP) of the filagrin gene (FLG), particularly rs_7927894 FLG. One of the mostly studied and promising AD marker chemokines (CK) is the thymusE and activation regulated chemokine (TARC/CCL17). Purpose – to detect the associations and role of different variants of SNP rs_7927894 FLG gene and TARC/CCL17 in children suffering different AD clinical proE files (CP) – isolated or combined with comorbid atopic disorders (AtD). Materials and methods. The main group comprised 39 patients aged 3 to 18 years, suffering the isolated AD or combined with comorbid AtD. The control group comprised 47 patients aged 3 to 18 years, suffering the pathology of gastrointestinal tract without clinical signs of atopy. All the patients of the main and control groups had undergone detection of the genotype variants of SNP rs_7927894 FLG gene by real-time polymerase chain reaction and detection of TARC/CCL17 serum concentrations in venous blood. The cutEoff value of statistical significance was set as p<0.05. Results. The incidence and association of genotype variants C/C, C/T and T/T SNP rs_7927894 FLG gene in patients of cohorts of the studied groups were detected as follows: C/T rs_7927894 FLG was significantly the most common in the general main group (56.4%, p<0.05), within the cohort of CP AD isolated (61.1%, p<0.05) and CP of AD combined with comorbid AtD (52.4%, p<0.05). There were detected the associations of studied SNP with AD: C/T rs_7927894 FLG is significantly directly associated with AD (r=0.291, p<0.05), C/C rs_7927894 FLG has a reverse association with a trend to significance (r=-0.194, p=0.07). Mean serum concentrations of TARC/CCL17 did not differ significantly among patients cohorts of the main and control groups, respectively: general main group — 615.8 pg/ml, main with a CP AD isolated — 651.3 pg/ml, main with a CP of AD combined with comorbid AtD — 585.4 pg/ml, control — 608.4 pg/ml (p>0.05). Associations of serum TARC/CCL17 concentrations were determined as follows: elevation trending to significance within increasing AD severity degree (r=0.290, p=0.07) and significant elevation within the AD exhacerbation period (r=0.426, p<0.05). No significant association of TARC/CCL17 as to AD patients compared to the control group was detected in our study (r=-0.027, p>0.05). Conclusions. The genotype heterozygote variant C/T rs_7927894 FLG is significantly the most common and associated with all AD CP in children — isolated and combined with comorbid AtD. Variant C/C rs_7927894 of FLG gene is significantly reversely associated with AD in children. Serum concentrations of TARC/CCL17 did not reveal any significant differences between the AD patients and nonEatopic ones. However, they significantly elevate within AD exacerbation phase and trending to significance within AD severity degree increase in children. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: atopic dermatitis, children, associations, polymorphism, filaggrin, thymus- and activation regulated chemokine.

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Diagnostic capabilities of the biochemical composition of amniotic fluid in assessing fetal conditions

Kazan medical journal ◽

10.17816/kmj2021-773 ◽

2021 ◽

Vol 102 (5) ◽

pp. 773-777

Author(s):

I B Fatkullina ◽

A Yu Lazareva ◽

Yu N Fatkullina ◽

L A Faizullina ◽

N A Stecenko ◽

...

Keyword(s):

Amniotic Fluid ◽

Biochemical Composition ◽

Statistical Significance ◽

Fetal Distress ◽

Main Group ◽

Control Group ◽

Gamma Glutamyl Transpeptidase ◽

Exact Test ◽

Nitrogenous Substances ◽

Diagnostic Capabilities

Aim. To analyze the nature of changes in the biochemical parameters of amniotic fluid during fetal hypoxia. Methods. The study was carried out in the maternity ward of the Republican Clinical Hospital named after Kuvatov (Ufa) between January 2016 and September 2018. The main group 72 women in labor with symptoms of fetal distress, the control group 70 women in labor without it. The biochemical composition of the amniotic fluid was measured using an analyzer. Statistical analysis was performed by using the Statistica 10.0 software. Comparison of qualitative characteristics was carried out by using Fisher's exact test when comparing quantitative data, the MannWhitney test. The statistical significance of the differences was set at p 0.05. Results. It was found that in fetal distress, there is a decrease in such biochemical indicators of the composition of amniotic fluid as the level of triglycerides (0.20.1 and 0.30.1 mmol/L, p=0.0036) and cholesterol (0.10.16 and 0.30.2 mmol/L, p=0.0275), gamma-glutamyl transpeptidase activity (34.511 and 48.76.8 U/L, p=0.0261), while the level the lactate (in the main group 3.51.2 and 3.10.9 mmol/L in the control group, p=0.0035), glucose (1.20.6 and 0.60.3 mmol/L, p=0.0002) and nitrogenous substances such as urea (4.51.1 and 3.01.3 mmol/L, p=0.0018) increases. Conclusion. The biochemical composition of amniotic fluid reflects the state of the fetus at birth, and therefore the study of the amniotic fluid is a relevant and accessible method.

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Percutaneous antegrade ureterolithotripsy for proximal ureteral stones: overview own experience use

Herald Urology ◽

10.21886/2308-6424-2021-9-2-92-99 ◽

2021 ◽

Vol 9 (2) ◽

pp. 92-99

Author(s):

S. V. Popov ◽

R. G. Guseinov ◽

N. K. Gadjiev ◽

A. V. Davydov ◽

V. M. Obidnyak ◽

...

Keyword(s):

Surgical Intervention ◽

Urine Analysis ◽

Complete Blood Count ◽

Statistical Significance ◽

Main Group ◽

Ureteral Stones ◽

Control Group ◽

Renal Ultrasound ◽

Biochemical Tests ◽

Extracorporeal Shock Wave

Introduction. Currently, a large number of techniques are used in the treatment of patients with ureteral stones: extracorporeal shock-wave lithotripsy (ESWL), retrograde ureterolithotripsy (RULT), laparoscopic and retro-peritoneoscopic ureterolithotomy.Purpose of the study. To evaluate the possibilities and effectiveness of percutaneous antegrade ureterolithotripsy in the treatment of patients with proximal ureteral stones in comparison with transurethral contact ureterolithotripsy.Materials and methods. Twenty-eight patients with urolithiasis were treated, who underwent percutaneous antegrade ureterolithotripsy (PAULT) and 27 patients of the control group, who underwent RULT. All patients included in the study underwent a standard preoperative examination: complete blood count and urine analysis, bacteriological urine culture, biochemical tests, and X-ray research methods. Plain urography, renal ultrasound, computed tomography were used as imaging methods. The OLYMPUS URF-V3 8.4 Ch (Olympus Europa SE & Co. KG., Germany) video uretero-renoscope was used for PAULT in patients of the main group; lithotripsy was performed using thulium laser. The results of the study were subjected to statistical processing in order to determine the statistical significance of the differences between the data obtained. Quantitative variables were described using the arithmetic mean (M) and standard deviation (5). Qualitative variables were estimated by absolute and relative frequencies (percentages). The data were considered reliable at p values < 0.05.Results. The average time of surgical intervention in patients of the main group from the moment of placement of the ureteral catheter was 47 ± 12 min, with access without preliminary renal catheterization: 28 ± 4 min. Average time of surgical intervention in patients of the control group: 42.0 ± 10.7 minutes. The presented data indicate a significant (p < 0.05) greater cases' number of complete stone removal among patients of the main group compared with patients in the control group (74.0%).Conclusion. PAULT is preferred among choice treatment methods for patients with proximal ureteral large stones, for whom RULT and ESWL cannot be performed with a high level of “stone-free” rate and a minimum number of complications.

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Госпитальные результаты коронарного шунтирования и течение раннего послеоперационного периода у больных с низкой фракцией выброса левого желудочка: аргументы в пользу предоперационной подготовки левосименданом

Kardiologicheskii vestnik ◽

10.36396/ms.2019.15.4.007 ◽

2019 ◽

Author(s):

V.P. Gazizova ◽

E.E. Vlasova ◽

E.V. Dzybinskaya ◽

V.V. Gramovich ◽

V.P. Vasiliev ◽

...

Keyword(s):

Standard Therapy ◽

Statistical Significance ◽

Artery Bypass ◽

Left Ventricular ◽

Early Postoperative Period ◽

Left Ventricular Ejection ◽

Control Group ◽

Oxygen Balance ◽

Low Cardiac Output Syndrome ◽

Ventricular Ejection Fraction

Введение. Синдром низкого сердечного выброса основное и наиболее опасное осложнение коронарного шунтирования (КШ) у больных с низкой фракцией выброса левого желудочка (ФВЛЖ), повышающее госпитальную летальность. Снизить риск его развития главная задача предоперационной медикаментозной подготовки. Помимо стандартных препаратов для лечения сердечной недостаточности (СН) с этой целью используется левосимендан, способный сохранять кислородный баланс ишемизированного миокарда на фоне положительного инотропного действия. Получены обнадеживающие результаты сохраняется потребность в накоплении данных. Материал и методы. Обследованы 59 пациентов с многососудистой коронарной болезнью и ФВЛЖ35, которым выполнено КШ. Из них 19 пациентов, оперированных в 20162017 гг., за 23 сут до операции в дополнение к стандартной терапии хронической СН получили предоперационную подготовку левосименданом (12,5 мг в течение 2410,5 ч, без болюса) и составили группу Л. Группу ретроспективного контроля К сформировали 40 пациентов, оперированных ранее, которые получали только стандартную терапию ХСН. Проведено сравнение госпитальных результатов КШ у больных обеих групп. Результаты. При сходной длительности искусственного кровообращения проблемы при его отключении развивались в группе Л реже (5 против 20), однако статистическая достоверность не достигнута по причине различной численности групп. Также отмечена тенденция к меньшей продолжительности послеоперационной инотропной поддержки (24 ч против 72 ч) у больных, получивших левосимендан использовались более низкие дозы препаратов. Заключение. При включении левосимендана в предоперационную подготовку больных с ишемической болезнью сердца с низкой ФВЛЖ определенно прослеживается позитивный эффект на течение постперфузионного и раннего послеоперационного периодов. Исследование рассматривается как пилотное. На основании полученных данных принято решение о продолжении изучения эффективности препарата в аналогичной селективной группе больных с целью формировании весомой доказательной базы.Objective. Low cardiac output syndrome is the main complication of coronary artery bypass surgery (CABG) in patients with low left ventricular ejection fraction (LVEF), wich increases in-hospital mortality. To reduce the risk of this syndrome is the main goal of preoperative medical preparation. Levosimendan (L) in addition to standard therapy for chronic heart failure (CHF) is expected to be useful for this purpose due to its ability to maintain oxygen balance in ischemic myocardium and at the same time showing a positive inotropic action. Promising results have already received there is still a need to accumulate more data. Methods. 59 patients with multivessel coronary disease and LVEF 35 who underwent CABG were included. 19 patients received L, administered by a cardiologist, as infusion of 12.5mg for 24 10,5h, without a bolus, 2 days before surgery (group L). 40 patients, operated earlier, made up the retrospective control group (group C). We compared in-hospital results of CABG in patients with LVEF35 who was preoperatively treated only with standard therapy for CHF (group C) and who additionally received levosimendan (group L). Results. While the duration of cardiopulmonary bypass was similar, the problems after weaning developed significantly less frequently in group L (5 vs 20), however, statistical significance was not achieved due to the different size of the groups. We also noted a tendency for a shorter duration of postoperative inotropic support (24h vs 72h) in patients who received L as well as significantly lower doses of sympathomimetics used. Conclusion. The inclusion of levosimendan in the preoperative preparation of CAD patients with low LVEF definitely has a positive effect on the CABG results and the course of the early postoperative period. The study is considered as a pilot. It is necessary to continue to form a significant evidence base and to confirm the cardioprotective effect of levosimendan in a similar selective group of patients.

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