scholarly journals A prospective study of clinicoepidemiology, metabolic and hormonal profile of women with hirsutism in Konaseema region of Andhra Pradesh

2021 ◽  
Vol 10 (10) ◽  
pp. 3875
Author(s):  
M. Smitha
Keyword(s):  
Insulin Resistance ◽  
Cushing Syndrome ◽  
Mean Value ◽  
P Value ◽  
Hormonal Profile ◽  
Number Of Patients ◽  
Menstrual Irregularities ◽  
Before And After ◽  
The Mean ◽  
A Prospective Study

Background: Hirsutism is defined as presence of excess coarse hairs appear in male pattern in women.There is various aetiology of hirsutism like Idiopathic hirsutism, PCOS, androgen secreting ovarian tumours, menopause, CAH, Cushing’s syndrome, drugs which increases testosterone level, insulin resistance and tumour secreting androgen. We have designed present study with an aim to study the clinicoepidemiology, metabolic and hormonal profile of women with hirsutism in Konaseema region of Andhra Pradesh.Methods: All patients with hirsutism attending gynaecology outpatient department were selected for study based on inclusion and exclusion criteria. After that patient were examined clinically, BMI was calculated for each patient. Patients were clinically evaluated for signs of excess androgen secretion, Cushing syndrome, metabolic syndrome and hyperprolactinemia. Modified Ferriman-Gallwey scoring system was used for evaluating and quantifying hirsutism.Results: The mean Fasting plasma insulin12.42±2.41 (mIU/dl), the mean of HOMA-IR was 3.14±1.18. The mean value of dehydroepiandrosteronesulphate (DHEAS) 355.78±15.41 mcg/dl. There was statistically significant reduction in modified Ferriman-Gallwey scoring in before and after treatment (12.38± 1.55 vs. 9.62±1.6), the p value was 0.00001. The number of patients with menstrual irregularities were reduced from 63.3% to 20% after treatment and this difference is statistically significant (p=0.04).Conclusions: Hirsutism is associated with insulin resistance and DHEAS concentration was high. Modified Ferriman-Gallwey score was significantly reduced and there was significant weight loss and improvement in menstrual irregularities after treatment.

Evaluation of the Stability of the Subjects with Anterior Cruciate Injuries Reconstruction

2020 ◽  
Author(s):  
Hossein Akbari Aghdam ◽  
Mahsa Kavyani ◽  
Maryam Bosak ◽  
Mohammad Taghi Karimi ◽  
Mehdi Motififard
Keyword(s):  
Acl Reconstruction ◽  
Postural Stability ◽  
Center Of Pressure ◽  
Mean Value ◽  
P Value ◽  
Before And After ◽  
The Mean ◽  
The Difference ◽  
Anterior Cruciate ◽  
The Stability

AbstractAnterior cruciate ligament (ACL) is the most frequently injured ligament in the knee and is often injured during sport-related activities. ACL injuries influence the abilities of the subjects during standing and walking. Although early surgical intervention is preferred treatment for the majority of knee surgeons, the effect of this approach on postural stability of patients is not fully understood. Therefore, the aim of this study was to determine the difference between stability of ACL-reconstructed subjects before and after surgery. A group of 15 consecutive ACL injured patients participated in this study. Postural stability of the patients was evaluated 1 week before and 6 months after surgery (ACL reconstruction with hamstring autograft). A Kistler force plate was used to evaluate center of pressure (COP) sway during quiet standing. The mean values of the COP parameters were obtained in pre and postsurgery conditions. Paired sample t-test was used to evaluate the difference between the stability parameters of the two conditions. The significant point was set at 0.05. The mean value of path length of COP velocity in mediolateral (ML) direction was 1,485.57 ± 479.42 mm and 2,641.33 ± 996.26 mm before and after surgery, respectively (p-value = 0.01). Although the mean value of COP velocity in anteroposterior and ML directions increased after surgery, the difference was only significant for velocity in ML direction (p-value = 0.049). The results of this study showed that the standing stability of those with ACL reconstruction decreased significantly after ACL reconstruction, which may be due to the effects of the surgery on sensory mechanism of ACL and inability of patients to return to their previous deep sense perception and knee proprioception.

scholarly journals AB0495 BIOMECHANICAL STRESS IN THE CONTEXT OF COMPETITIVE SPORTS TRAINING TRIGGERS ENTHESITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1275.1-1275
Author(s):  
D. Simon ◽  
A. Kleyer ◽  
S. Bayat ◽  
J. Knitza ◽  
L. Valor ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Mechanical Stress ◽  
Power Doppler ◽  
Mean Value ◽  
Mixed Effects ◽  
P Value ◽  
Biomechanical Stress ◽  
Score Difference ◽  
Before And After ◽  
The Mean

Background:Preclinical models have indicated that biomechanical stress can trigger entheseal inflammation (1). Furthermore, enthesitis is a hallmark of psoriatic arthritis (PsA) and spondyloarthritis (SpA), suggesting that mechanoinflammation is an important step in their pathogenesis (2). However, the relation between mechanical stress and enthesitis in humans is poorly investigated. Competitive badminton is a demanding stop-and-go sport that strains entheseal sites in particular and provides an opportunity to assess the impact of physical activity on the development of an instant inflammatory response in the entheses.Objectives:To evaluate the influence of mechanical stress on the development of immediate enthesitis.Methods:BEAT (Badminton Enthesitis Arthrosonography Study) is an interventional study that assessed entheses in competitive badminton players before and immediately after a 60-minute intensive training session by ultrasound. Power Doppler (PD) signal and Gray-Scale (GS) changes were evaluated at the insertions sites of both Achilles tendon, patellar tendons and lateral humeral epicondyles and quantified using a validated scoring system (3). Pre- and post-training scores were compared using linear mixed-effects models. We used interaction terms to assess possible differential effects on patellar, elbow and Achilles entheses.Results:Thirty-two badminton players (22 men, 10 women) with an average age of 31.1±13.0 years were included (Table 1). On average, they had been playing badminton for 16.2±10.1 years. 192 entheseal sites were examined twice. The respective empirical total scores for PD examination were 0.1 (0.3) before and 0.5 (0.9) after training (Figure 1). Mean total GS scores were 2.9 (2.5) and 3.1 (2.5) before and after training, respectively. The mean total PD score difference of 0.4 between pre- and post -training was significant with a p value of 0.0014, whereas the p value for the mean total GS score difference of 0.2 was 0.63. Overall, seven participants (22%) showed an increased empirical total PD score. A mixed-effects model showed a significant increase of PD scores after training, with a mean increase per site of 0.06 (95%CI 0.01 to 0.12, p=0.017).Table 1.Baseline characteristicsDemographic characteristicsN, total32Females, N (%)10 (31.3)Age, years (mean ± SD)36.1 ± 13.0Height, cm (mean value ± SD)178.6 ± 9.9Body weight, kg (mean value ± SD)74.7 ± 13.5Smoking, N (%)11 (34.4)Alcohol, N (%)24 (75.0)Concomitant DiseasesInflammatory bowel disease, N (%)0Psoriasis, N (%) 0Uveitis, N (%)0Diabetes mellitus, N (%)0Hypertension, N (%)2 (6.3)Sports historyYears Badminton (mean ± SD)16.2 ± 10.1Figure 1.Ultrasound scores before and after training Figure 1. A Spaghetti plots depicting inividual Gray-Scale and Power Doppler ultrasound scores before and after trainingConclusion:Mechanical stress leads to rapid inflammatory responses in the entheseal structures of humans. These data support the concept of mechanoinflammation in diseases associated with enthesitis. However, while such responses may be self-contained in healthy subjects, they may be prolonged and more pronounced in certain risk groups, such as patients with PsA or SpA.References:[1]Cambré I, et al. Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis. Nature Communications. 2018; 9:4613.[2]Schett G, et al. Enthesitis: from pathophysiology to treatment. Nat Rev Rheumatol. 2017; 13:731-741.[3]Balint PV, et al. Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative. Annals of the Rheumatic Diseases. 2018; 77:1730.Disclosure of Interests:David Simon: None declared., Arnd Kleyer: None declared., Sara Bayat: None declared., Johannes Knitza: None declared., Larissa Valor: None declared., Marina Schweiger: None declared., Georg Schett: None declared., Koray Tascilar: None declared., Axel Hueber Grant/research support from: Novartis Research Grant.

Comparative Study of Organizational Measures on Helmet Use Rate in Trang Hospital Personnel

2021 ◽  
Vol 104 (2) ◽  
pp. 247-251
Keyword(s):  
Video Camera ◽  
P Value ◽  
Policy Measure ◽  
Chi Square ◽  
Helmet Use ◽  
Before And After ◽  
Chi Square Test ◽  
Policy Measures ◽  
The Mean ◽  
A Prospective Study

Objective: To compare the efficacy of organizational measures on helmet use rate of the motorcycle driver and rider in Trang Hospital. Materials and Methods: The present study was a prospective study comparing the helmet use rate before and after the measures including helmet policy, supportive and incentive organizational measure, and penalizing organizational measure. The personnel of Trang Hospital included 1,441 people. There were 637 drive-only personnel, 143 ride-only personnel and 443 drive-ride personnel. The helmet use rate was collected at the front gate of the hospital by closed circuit video camera monitoring during 07:00 am to 08:30 am every day for one week before and after the various measures. The mean helmet use rates were compared by the chi-square test was considered significant at the p value of less than 0.05. Results: The increased rate of helmet use in driver after the supportive and incentive organizational measure and the penalizing organizational measure compared to the helmet use rate before the policy measures were statistically significant (p<0.001). Unlike the increased rate of helmet use in driver and rider after the policy measure compared to the helmet use rate before the policy measure were not statistically significant (p=0.220, 0.470, consecutively). The increased helmet use of the rider after the penalizing organizational measure was statistically significant when compared to the helmet use rate before the policy (p<0.001), and the supportive and incentive measure (p=0.019). However, the increased rate of helmet use in driver after the penalizing organizational measure compared to the helmet use rate after the supportive and incentive organizational measure were not statistically significant (p=0.990). Conclusion: Only the policy measure has not significantly increased the rate of helmet use in both drivers and riders. The supportive and incentive organizational measure have significantly increased the helmet use rate in the drivers, but not significantly increased the rate of helmet use in the riders. However, the penalizing organizational measure has significantly increased the rate of helmet use in the riders, but not significantly increased the rate of helmet use in the drivers. Keywords: Helmet implementation, Organizational measure, Head injury prevention, Motorcycle accident, Helmet use rate

scholarly journals Effectiveness of Integrated Teaching Module among Final Year Medical students

2016 ◽  
Vol 06 (02) ◽  
pp. 024-026
Author(s):  
Akshatha Rao Aroor ◽  
Dileep K. S. ◽  
Rama Prakasha Saya ◽  
Sudheendra Rao
Keyword(s):  
Medical Students ◽  
Medical Curriculum ◽  
Teaching Method ◽  
Tertiary Care ◽  
General Medicine ◽  
P Value ◽  
College Hospital ◽  
Before And After ◽  
The Mean ◽  
A Prospective Study

AbstractBackground: Didactic lectures and the current practice of teaching in Medical colleges has many limitations. Correlation and integration of knowledge into practice becomes difficult in the absence of integrated teaching at appropriate levels in medical curriculum.Aim: To assess the effectiveness of the vertical integrated teaching method among the final year MBBS students and to study the attitude towards integrated teaching. Materials and Methods: This is a prospective study conducted among 102 final year MBBS students at a tertiary care medical college hospital in South India. The teaching was implemented by the active participation of faculty from the departments of Physiology, Pathology and General Medicine on a single topic. Students' knowledge about the subject before and after the session was evaluated by a questionnaire of 20 questions (Pre-test and Post-test). The mean score before and after the session was compared using the paired't' test. The students were also asked to give their feedback about the usefulness of this method in improving their knowledge.Results: The mean scores before and after the session were 8.8± 2.87 and 16.88±1.23 (p value < 0.001). Majority of the students (97.1%) opined the need for integrated teaching to be a part of medical curriculum. Most of them (54.9%) felt the need for integrated teaching to be conducted monthly. On self-grading the knowledge on a scale of 1 to 10 before and after the session, the mean scores were 4.73±1.84 and 7.83±1.86 respectively (p value < 0.001). Conclusion: The integrated teaching was found to be an effective method of teaching. Medical students had a positive attitude towards integrated teaching.

scholarly journals Evaluation the influence of core stability exercise on standing stability of hemiplegic cerebral palsy

2020 ◽  
Author(s):  
mohammad Karimi
Keyword(s):  
Cerebral Palsy ◽  
Approximate Entropy ◽  
Normal Subjects ◽  
Mean Value ◽  
Core Stability ◽  
Quiet Standing ◽  
P Value ◽  
Before And After ◽  
The Mean ◽  
The Stability

Abstract Background: Cerebral palsy (CP) is one of the most common neurological disorders influences the abilities of the subjects to stand and walk. Various kinds of exercise are recommended to improve the stability of CP subjects during quiet standing. However, there is no evidence regarding the effects of core stability exercise on stability of CP subjects. Therefore, the aim of this research was to determine the efficiency of this exercise on stability of CP subjects.Method: Two group of normal and CP children were recruited in this study (10 subjects). The stability of the subjects was determined by use of a Kistler forceplate. The stability of the subjects was measured by Approximate entropy (ApEn) based on COP sways. The dynamic stability was evaluated by Berge balance scale. Ashworth scale was used to determine the spasticity of lower limb muscles groups. Results: The mean value of ApEn of CP patients in the anteroposterior and mediolateral directions were 0.465±0.11 and 0.426±0.99, respectively compared to 1.02±0.11 and 0.426±0.099 for normal subjects. There was a significant increase in ApEn of CP subjects before and after exercise (p-value<0.05). The mean value of Berge scale was 46.2±5.77 and 51.87±3.9 before and after exercise, respectively.Conclusion: As lower value of ApEn associated with decrease in complexity, higher rigidity and unstability, it can be concluded that CP subjects were unstable than normal subjects. Use of core stability exercise improves complexity of the system and improves the stability of the subjects due to its effect on muscular spasm.

scholarly journals A prospective study of insulin resistance among infertile women with polycystic ovarian syndrome

2018 ◽  
Vol 7 (9) ◽  
pp. 3786
Author(s):  
M. Smitha ◽  
S. Jyothi ◽  
Anand Acharya
Keyword(s):  
Insulin Resistance ◽  
Mean Value ◽  
The Body ◽  
P Value ◽  
Infertile Women ◽  
Androgen Synthesis ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Infertile Patients

Background: Insulin plays a key role in producing hyperandronism and suppression of insulin secretion in women with PCOS is associated with decreased cytochrome P450c17α. cytochrome P450c17α is a bifunctional enzyme present in ovary is a key enzyme for androgen synthesis. Various studies have been conducted regarding association of insulin resistance with PCOS in infertile patients but there is no study is available about this in our area. So we have designed this study to evaluate insulin resistance in infertile patients with PCOS in rural Andhra Pradesh.Methods: The study population include 180 untreated patients who attended the infertility clinic in outpatient department of obstetrics with infertility due to different cause that include polycystic ovarian disorder also. They have been selected for this study randomly based on inclusion and exclusion criteria.Results: The mean value of glucose insulin ratio was 5.146+2.611 in group A and 8.62 + 5.55 in group B the P value was 0.004909. The mean of LH/FSH ratio was 1.78+0.423 in group A and 1.02 +0.042 in group B. The P value was <0.00001. The mean of HOMA IR was 8.375+ 2.68 in group A and 3.03+ 1.09 in group B, with P value <0.00001. The mean value of QUICKI was 0.2815+ 0.0002875 in group A and 0.347+0.10 in group B with P value <0.00001. Mean serum DHEAS level was 275.59 + 53.48 in infertile patient with PCOS and 208.48 + 36.11 in infertile patients without PCOS. The p value was 0.00012.Conclusions: Based on present study we would like to conclude that the body mass index was high among infertile women with PCOS and a greater number of women presented with acanthosis. There was decrease insulin sensitivity and increase insulin resistance among infertile women with poly cystic ovarian disease, in rural area of Andhra Pradesh and that is not different from the study of other part of world.

scholarly journals PENGARUH PENYULUHAN TERHADAP PERUBAHAN PENGETAHUAN BAGI IBU-IBU PKK KELURAHAN PENGGARON LOR TENTANG PEMANFAATAN TANAMAN PISANG SEBAGAI MEDIA MENJAGA KESEHATAN GIGI DAN MULUT

2014 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Yayun Siti Rochmah ◽  
Minidian Fasitasari
Keyword(s):  
Mean Value ◽  
Primary Data ◽  
P Value ◽  
Banana Plant ◽  
Optimal Method ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
The Village

Background: Banana counted as nearly perfect food since it contains six nutrients : water , sugar , proteins , fats , vitamins , and minerals . Because of that , bananas are often used as a staple food for most people because of its nutritional value. However, sometimes people do not realize the benefits of bananas as a whole , from leaves , fruits , flowers and stems of the bananas . Penggaron Lor society , still minimal in using the banana plant . Usually the community will sell fruit and leaves to the market , so that the results obtained from the banana plant community less than optimal. Method : This study is an observational analytic study . The research was done in the Village of Penggaron Lor Semarang , and was conducted in March-June 2014. The instrument in this research was primary data obtained directly from respondents through interviews using questionnaires distributed before and after counseling . To determine whether there are differences in knowledge before and after counseling on the benefits of banana plants as a medium for maintaining oral hygiene, statistical test Wilcoxon Sign Ranks test was conducted, and processed with SPSS. Result: The results of SPSS calculation because the data is not normal ( p value < 0.05), then the data was processed using the non-parametric test for two sample pairs , ie Wilcoxon Sign Ranks test , and obtained p value of 0.008 . This means that there was a significant difference between the mean value of the pre-test and post-test. Conclusion : there are differences in knowledge before and after counseling , counseling means that a significant impact on respondents' knowledge of the benefits of banana plants for maintain oral health.

scholarly journals Serum lactate as a prognostic marker in patients with sepsis: a prospective study

2020 ◽  
Vol 7 (5) ◽  
pp. 1530
Author(s):  
Suhas T. Shetty ◽  
Dayanand S. Biradar ◽  
Ramakant Balookar ◽  
Shreedevi Kori
Keyword(s):  
Prospective Study ◽  
Prognostic Marker ◽  
Mean Value ◽  
Serum Lactate ◽  
Research Centre ◽  
P Value ◽  
College Hospital ◽  
The Mean ◽  
Lactate Levels ◽  
A Prospective Study

Background: A prospective study to estimate the serum lactate levels and as a prognostic marker in patients with sepsis.Methods: 170 patients admitted with sepsis in B.L.D.E. (Deemed to be University) Shri. B. M. Patil Medical College, Hospital and Research Centre, Vijayapur from October 2014 to June 2016.Results: In this study the mean serum lactate value of first sample in survivors (146 patients) is 3.8±1.2 and non-survivors (24 patients) is 6.2±1.9 with p value<0.001 which is significant. The serum lactate value of the second sample in survivors (146) is 2.7±1.0 and in non survivors (24) is 6.3±1.8 with p value<0.001 which is significant. The mean value of serum lactate 1st sample collected at the time of admission is 4.1±1.6 and the mean value of serum lactate second sample collected at 24 - 48 hours after admission is 3.1±1.6.Conclusions: Lactate level more than 4 mmol/l, patients are at highest risk of mortality and an aggressive resuscitation strategy shall be warranted. Hence serum lactate is considered as an independent and significant prognostic marker in patients with sepsis and evaluates the treatment outcome.

scholarly journals Evaluation esthetic and functional outcomes after rhinoplasty

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Falah Abdulla Hussein Hawrami ◽  
Zanyar M. Amin ◽  
Muhammad Mahmood ◽  
Rebwar A. Hama
Keyword(s):  
Outcome Evaluation ◽  
P Value ◽  
Open Rhinoplasty ◽  
Public And Private ◽  
Validated Questionnaire ◽  
Before And After ◽  
Post Operation ◽  
The Mean ◽  
A Prospective Study ◽  
And Function

Objective: The aim of this study was to determine patient satisfaction in regard to nose appearance and function with the use of a validated questionnaire, before and after rhinoplasty surgery. Methods: A prospective study was conducted of all adult patients that underwent open rhinoplasty including other nasal procedures like septoplasty or turbinoplasty between September 2018 and August 2019 in both public and private hospital (Sulaimani Surgical Teaching Hospital and Faruk Medical City).The Rhinoplasty Outcome Evaluation (ROE) questionnaire was used to study the patients' view. Results: 100 patients participated in this study by completing the questionnaires and the follow-up period. The main reasons for rhinoplasty in our patients were: aesthetic 54% (n=54), functional 2 %( n=2), and a combination of both in 44% (n=44) patients The mean ROE score of all patients pre operation was 51.8 (males: 49.04, females 54.74.) and the mean score post operation was 75.22(males 75.64, females 74.81) at six months with no statistically significant gender differences p value=0.79 However, both genders showed a statistically significant improvement between the preoperative and postoperative scores (mean difference = 23.42, P<0.017).In the pre-operative stage, patients recorded worse score for anxious and insecure (p < 0.05). There were no difference for gender, age, cause or literacy level in the mean post-operative scores (p > 0.05). Conclusions: We found that patients who consider themselves anxious before surgery were less satisfied with the result of the procedure. Additionally Rhinoplasty surgery significantly improved patient quality of life regarding nose shape and function.

scholarly journals Influence before and after Early Mobilization of Changes in Pain Levels in Post Orthopedic Surgery Patients at Royal Prima Medan Hospital in 2021

2021 ◽  
Vol 4 (1) ◽  
pp. 24-30
Author(s):  
Zhan Chengwu ◽  
Florenly ◽  
Johannes Bastira Ginting ◽  
Fioni
Keyword(s):  
Orthopedic Surgery ◽  
Structural Equation ◽  
Univariate Analysis ◽  
Early Mobilization ◽  
Mean Value ◽  
Wilcoxon Test ◽  
P Value ◽  
Post Surgery ◽  
Before And After ◽  
The Mean

Orthopedic surgery is a surgical action associated with the correction of musculoskeletal system deformities and orthopedic problems that aim to improve function by restoring movement and stability and reducing pain and disabilities. Early mobilization is a prominent factor in speeding up postoperative recovery and may prevent postoperative complications. This study aims to find out the influence before and after early mobilization of changes in pain levels in orthopedic postoperative clients at RSU Royal Prima. This type of research uses a correlational descriptive research design, using the One Group Pretest-Postest approach. The location of this study was conducted at RSU Royal Prima Medan in March 2021. The population of all patients’ post-surgery orthopedic hospitalization amounted to 176 patients. The size of the sample uses the formula Structural Equation Modelling (SEM), then the number of samples is determined to be 100 people. Univariate analysis, bivariate with t-dependent test (paired t-test) with a meaningful limit of 0.05. The results of the study that there was a change in the level of pain Wilcoxon test results at the time of the pre-test the result of the mean value of 3.82, at the time of the post-test test the mean value was 2.34. So the result of Z = -5,358 then p-value as much as 0.004 < 0.05 so that Ho is rejected and Ha accepts. The conclusion of the level of pain before early mobilization in the client post orthopedic surgery the majority feels even more pain and the minority experience severe pain. The level of pain after early mobilization in the majority of orthopedic postoperative clients was slightly more painful and the minority felt even more pain. There is an early mobilization effect on pain changes in orthopedic postoperative clients in patients in the hospital room of RSU Royal Prima in 2021.

Sign in / Sign up

Export Citation Format

Share Document