scholarly journals Diabetes and hypertension in patients with psoriasis: a cross sectional and case control study in a tertiary care hospital of Bangladesh

2021 ◽  
Vol 9 (8) ◽  
pp. 2217
Author(s):  
Samira Jamal ◽  
Sheikh Anwarul Karim ◽  
Sheikh Mahee Ridwan Raihan ◽  
Rajat Biswas ◽  
Mansurul Alam
Keyword(s):  
Case Control Study ◽  
Skin Diseases ◽  
Tertiary Care ◽  
Case Control ◽  
Control Group ◽  
Care Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Increased Risk ◽  
Control Study

Background: In this study our main goal was to evaluate the association of psoriasis as a risk predictor for the occurrence of diabetes mellitus (DM) and hypertension (HTN).Methods: This case control study was carried out in the department of dermatology and venereology, Chittagong medical college hospital (CMCH), Chittagong, Bangladesh from 15 June 2011 to 14 May 2012. Where 60 patients with psoriasis and 60 patients with skin diseases other than psoriasis were included according to availability within the study period.Results: During study, among the psoriatic patients, most of the patients with DM and HTN had body mass index (BMI) within normal limit. During analysis of different clinical findings in psoriatic patients scaling was present in all the cases followed by Auspitz sign, koebnerization, itching, scalp involvement and nail changes. Patients with psoriasis were found to have higher incidence of DM and HTN in comparison to their non-psoriatic control group. It was also observed that psoriatic patients having DM and HTN had longer duration of diseases (p<0.05).Conclusions: In conclusion, our study indicates that patients with psoriasis have an increased risk of DM and HTN, confirming the findings from previous several case control and cross sectional studies. These data illustrate the importance of considering psoriasis as a systemic disorder rather than simply a skin disease. Awareness of concurrent diseases will provide the clinician an opportunity of screening .for others systemic diseases.

scholarly journals Possible association between -954G/C iNOS polymorphism in nasal polyposis. A case-control study in a population group of Northern Romania

2016 ◽  
Vol 6 (24) ◽  
pp. 197-201
Author(s):  
Andreea Catana ◽  
Alma Maniu ◽  
Doinel Radeanu ◽  
Radu A. Popp ◽  
Roxana F. Ilies ◽  
...  
Keyword(s):  
Nasal Polyposis ◽  
Case Control Study ◽  
Pcr Amplification ◽  
Case Control ◽  
Control Group ◽  
Restriction Enzyme Digestion ◽  
Significant Finding ◽  
Cross Sectional ◽  
Increased Risk ◽  
Control Study

Abstract BACKGROUND. Polymorphisms for genes encoding chemosensitive signalling proteins like NOS2 might contribute to the variability in individual susceptibility to nasal polyposis. NO produced by the inducible NO synthase enzyme NOS2A is generated at high levels in certain types of inflammation, so that the role of NOS2 might also be important in nasal polyposis etiopathogeny. MATERIAL AND METHODS. This is a cross-sectional, randomized, case-control study for the evaluation of the frequency of -954G/C NOS2A2 alleles among patients with nasal polyposis. The study included 91 cases of nasal polyposis diagnosed patients (nasal endoscopy and CT scan examination), and 117 healthy unrelated controls. NOS2 genotyping was carried out using PCR amplification of relevant gene fragment and it was followed by restriction enzyme digestion. Detection of the variant alleles was determined through analysis of resulting restriction fragment length polymorphism (RFLP) followed by gel electrophoresis. RESULTS. Molecular analysis revealed an increased frequency of NOS2 variant allele in the study group compared to the control group (p=0.019, OR=1.991, CI=1.08-3.67). A statistically significant finding was highlighted among allergic and nonallergic patients with nasal polyposis (p=0.046, OR=0.449. CI=0.208-0.969) and a relationship between nasal polyposis patients with asthma and non-asthmatic patients (p=0.119, OR=1.825, CI=0.875-3.80). CONCLUSION. The main finding of our study is that -954G/C polymorphism of NOS gene seems to be associated with an increased risk for nasal polyposis.

Mastalgia and associated factors: A case control study

2021 ◽  
Vol 19 (2) ◽  
pp. 45-47
Author(s):  
Y Satish Reddy ◽  
Keyword(s):  
Pain Score ◽  
Case Control Study ◽  
Tertiary Care ◽  
Case Control ◽  
Control Group ◽  
Care Hospital ◽  
Breast Pain ◽  
The Mean ◽  
Cyclical Mastalgia ◽  
Control Study

Background: patients with breast pain are often referred to surgery department. The present study was conducted to determine the factors associated with Mastalgia among women attending a tertiary care hospital Methods: This case control study was conducted on 120 women between the age 18 to 65 in the department of General surgery. The study included case subjects (n = 50) with Mastalgia and the control subjects (n = 50) without Mastalgia. The severity of breast pain was calculated with visual analog scale. questionnaire was given to all the participants and data is collected. Data was analysed by SPSS version 16 and P value of < 0.05 was considered statistically significant value. Results: Among those who had experienced mastalgia, 76% (46) had cyclical mastalgia and 24% (14) had non-cyclical mastalgia. The mean of pain score was 4.72 ± 2.28 and most of the women(18%) had pain score of “6” which is moderate pain The mean age and Body mass index were higher in the case group than control group (p<0.005). Stressful lifestyle, caffeine consumption, smoking, higher BMI and higher breast-fed infants were significantly associated with mastalgia (p < 0.001). postmenopausal women have decreased frequency of mastalgia which is significantly associated with mastalgia (p < 0.001). Conclusion: age, BMI, Stress, caffeine, smoking, lactation frequency, menopause state were found to be related with mastalgia.

scholarly journals DERMATOGLYPHIC STUDY OF BETA THALASSEMIA IN A TERTIARY CARE HOSPITAL – A CASE CONTROL STUDY

2020 ◽  
pp. 58-61
Author(s):  
Oindrila Chhatui ◽  
Pranab Mukherjee ◽  
Premananda Bharati ◽  
Debarshi Jana
Keyword(s):  
Case Control Study ◽  
Genetic Disorder ◽  
Tertiary Care ◽  
Case Control ◽  
Beta Thalassemia ◽  
Control Group ◽  
Care Hospital ◽  
Control Groups ◽  
Control Male ◽  
Control Study

BACKGROUND: The term “thalassemia” was coined by Whipple and Bradford in 1932, in their classical paper of pathology of the condition. Thalassemia is a heterogenous group of genetic disorder affecting haemoglobin synthesis which results from a reduced rate of production of one or more globin chains of haemoglobin. AIM: The current study will try to find out the dermatoglyphic correlation between thalassemic children and children not having thalassemia in respect of gender as well as bilateral asymmetry. METHODS: The sample for the present case control study was collected from Thalassemia unit, under Paediatric department at R.G. Kar Medical College and Hospital, Kolkata. Among 204 individuals- 102 are cases, who are diagnosed Beta Thalassemia patients up to 12 yrs of age and 102 are normal children upto 12yrs of age taken as control groups. Among 102 in each case and control groups, 51 are male and 51 are female individuals. RESULT: Association of control male and Beta thalassemic male vs. Triradial count right was statistically significant (p<0.0001). Association of control male and Beta thalassemic male vs. Triradial count left was statistically significant (p<0.0001). CONCLUSION: In female thalassemia patients, there was complete absence of radial loops. But, significant lower incidence of radial loops of left hand was observed in male Beta thalassemics than the control group.

scholarly journals Quantitative Assessment of Serum Magnesium Levels in Head and Neck Cancer: A Tertiary Hospital Based Case Control Study

2021 ◽  
pp. 249-257
Author(s):  
Surender Kumar ◽  
Neha Salaria ◽  
Deepak Verma ◽  
Uma Garg ◽  
Monika Verma
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Case Control Study ◽  
Serum Magnesium ◽  
Tertiary Care ◽  
Case Control ◽  
Control Group ◽  
Control Study

Background- Head and neck squamous cell carcinomas(HNSCC) are one of the most widespread malignancies worldwide. Trace elements such as magnesium are essential at cellular level, and it has been suggested that magnesium plays a role in carcinogenesis. Methods- A hospital based case control study was conducted in a tertiary care medical college with an aim to determine the levels of serum magnesium in patients with head and neck cancer and to  compare  the  levels  of  serum  magnesium  of head and neck cancer patients   with healthy matched control  group  and  derive significance if any. Results- HNSCC was mainly found in males of age group 46 to 55 years. The mean serum Mg value of head and neck cancer patients was 0.71± 0.18 mmol/l while that seen in controls was 0.85± 0.09 mmol/l which was significantly lower(p<0.001). Average serum magnesium levels in stages I, II, III and IV were 0.85, 0.849, 0.682 and 0.554 mmol/l respectively, and a statistically significant association was determined between the two. Conclusion- As the stage of cancer progressed, average magnesium levels decreased congruently, hence establishing that magnesium levels were undeniably correlated to onset as well as progression of HNC. These evidences could be utilized to identify role of magnesium asa potential prognostic biomarker to assess progression of disease or clinical response to various modes of therapy in head and neck cancer patients.

Adrenal insufficiency in kidney transplant patients during low-dose prednisolone therapy: a cross-sectional case–control study

2019 ◽  
Vol 35 (12) ◽  
pp. 2191-2197 ◽  
Author(s):  
Amalie Valentin ◽  
Stina Willemoes Borresen ◽  
Marianne Rix ◽  
Thomas Elung-Jensen ◽  
Søren Schwartz Sørensen ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Low Dose ◽  
Case Control Study ◽  
Case Control ◽  
Adrenal Crisis ◽  
Control Group ◽  
Cross Sectional ◽  
Prednisolone Treatment ◽  
Synacthen Test ◽  
Control Study

Abstract Background Maintenance immunosuppressive regimens after renal transplantation (RTx) most often include prednisolone, which may induce secondary adrenal insufficiency, a potentially life-threatening side effect to glucocorticoid (GC) treatment due to the risk of acute adrenal crisis. We investigated the prevalence of prednisolone-induced adrenal insufficiency in RTx patients receiving long-term low-dose prednisolone treatment. Methods We performed a case–control study of patients on renal replacement therapy differing in terms of GC exposure. The study included 30 RTx patients transplanted &gt;11 months before enrolment in the study and treated with prednisolone (5 or 7.5 mg prednisolone/day for ≥6 months) and 30 dialysis patients not treated with prednisolone. Patients underwent testing for adrenal insufficiency by a 250-µg Synacthen test performed fasting in the morning after a 48-h prednisolone pause. Normal adrenal function was defined as P-cortisol ≥420 nmol/L 30 min after Synacthen injection. This cut-off is used routinely for the new Roche Elecsys Cortisol II assay and is validated locally based on the Synacthen test responses in 100 healthy individuals. Results Thirteen RTx patients {43% [95% confidence interval (CI) 27–61]} had an insufficient response to the Synacthen test compared with one patient in the control group [3% (95% CI 0.6–17)] (P = 0.0004). Insufficient responses were seen in 9/25 and 4/5 RTx patients treated with 5 and 7.5 mg prednisolone/day, respectively. Conclusions We found a high prevalence of adrenal insufficiency among RTx patients receiving low-dose prednisolone treatment. We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.

scholarly journals Comparison of maternal and perinatal outcome in pregnancy with altered thyroid profile and euthyroid patients: a prospective, observational and case control study in a tertiary care centre

2019 ◽  
Vol 8 (4) ◽  
pp. 1594
Author(s):  
Vandna Singh ◽  
Neeta Natu ◽  
Artika Sudhir Gupta
Keyword(s):  
Thyroid Dysfunction ◽  
Case Control Study ◽  
Tertiary Care ◽  
Case Control ◽  
Normal Vaginal Delivery ◽  
Care Hospital ◽  
Altered Thyroid ◽  
Thyroid Profile ◽  
Control Study ◽  
In Pregnancy

Background: Thyroid disease is one of the commonest endocrine disorder affecting women of reproductive age, and when untreated during pregnancy is associated with an increased risk of complications. The objective of this review was to increase awareness and to provide a review on adverse effect of thyroid dysfunction on maternal and perinatal outcome.Methods: This prospective, observational hospital-based case-control study carried on women coming for antenatal check-up in a Tertiary Care Hospital in INDORE from May 2018-December 2018. 50 known booked antenatal (case) patient with established thyroid disorder, more than 32 week of gestation, and 50-matched euthyroid patients (control) were taken.Results: Women suffering from overt and subclinical hypothyroidism and hyperthyroidism are nulliparous in 72% cases as compared to 32% in euthyroid patient. Increased maternal age was associated with higher incidence of thyroid dysfunction. Normal vaginal delivery by spontaneous labour seen in 56% of euthyroid, while it is reduced with thyroid dysfunction. 38% of altered thyroid profile patient undergo induction of labour and 24% cases undergo caesarean section as compared to control (17%). Adverse fetal outcome like intrauterine growth retardation, preterm birth and ICU admission seen increased with thyroid dysfunction  as compared to euthyroid patients.Conclusions: Thyroid dysfunction in pregnancy, although has a low incidence, but is associated with adverse maternal and fetal implications. Thus, thyroid screening should be done in antenatal period to improve fetomaternal outcome.

Evaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with preserved ejection fraction via VEGF and sVEGFR-1

2018 ◽  
Vol 44 (1) ◽  
pp. 25-31
Author(s):  
Ismail Erturk ◽  
Erdim Sertoglu ◽  
Cumhur Bilgi ◽  
Kenan Saglam ◽  
Fatih Yesildal ◽  
...  
Keyword(s):  
Case Control Study ◽  
Beta Blockers ◽  
Case Control ◽  
Treatment Modalities ◽  
Control Group ◽  
Preserved Ejection Fraction ◽  
Cross Sectional ◽  
Positive Effects ◽  
Vegf Level ◽  
Control Study

Abstract Objective In this study, our aim was to investigate the clinical significance of VEGF, sVEGFR-1 in HFpEF patients. Materials and methods Seventy-two participants enrolled in this cross-sectional case-control study including HFpEF patients (n=41) and healthy (n=31) subjects. Blood samples were collected and serum VEGF, sVEGFR-1 analysis, and transthoracic echocardiography were performed. Results and discussion The average sVEGFR-1 level of HFpEF patient group was significantly higher than the control group (respectively 0.136 ng/L (0.04–0.34), 0.06 ng/L (0.01–0.25); p<0.001). The average VEGF level of HFpEF patients using beta blocker was significantly higher than the HFpEF patients not using it (respectively 0.585±0.194 ng/L; 0.349±0.269 ng/L; p=0.025). The average VEGF level of HFpEF patients using statins was significantly higher than the HFpEF patients without a medication (respectively 0.607±0.099 ng/L; 0.359±0.273 ng/L; p=0.038). Conclusion Our study is the first study demonstrating the relations among HFpEF, accompanying morbidities, VEGF and sVEGFR-1 levels. Statins and beta blockers may have positive effects on angiogenesis in HFrEF patients via increasing VEGF levels.

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