scholarly journals Comparison of psychiatric co-morbidity in patients with psychogenic non-epileptic seizures and epilepsy at a tertiary care hospital in Kashmir

Author(s):  
Saleem Yousuf ◽  
Fazle E-Roub ◽  
Athiya Fahiem Khan

Background: objective of the study was to describe and compare frequency of psychiatric disorders in two groups of patients, one with psychogenic non-epileptic seizures (PNESs) and other with epilepsy.Methods: We studied 64 patients in which 32 belonged to the group with PNESs and 32 belonged to group with Epilepsy, admitted in a video-EEG unit of tertiary care hospital in Kashmir in order to confirm epileptic diagnosis. This study was conducted from March 2019 to August 2019 in neurology department and the patients underwent neurological evaluation, inter ictal EEG, MRI, neuropsychological assessment and psychiatric diagnosis codified in DSM-5.Results: Depression was found to be the most common diagnosis in the group with epilepsy-40% versus 15.75% of those with PNES, while as personality disorder (21.88%) was the common psychiatric disorder in group with PNES. Anxiety disorder was found to be the second leading psychiatric disorder and was almost common in both the groups, 13.33% in group with epilepsy and 18.75% in the group with PNES. It was also cited that Psychotic disorder (13.33%) was found only in the group with Epilepsy, while Personality disorder and PTSD was found only in the group with PNES. Bipolar disorder was more prevalent in group with epilepsy (13.33%) than in the group with PNES (3.13%). Somatic symptom disorder, dissociation and obsessive-compulsive disorder (OCD) was also found in both the groups.Conclusions: Psychiatric disorder is more common in PNES than in epilepsy.

Author(s):  
Shruthi M. N. ◽  
Srinivas K. Jois

Background: HIV is prevalent in epidemic proportions in India. Identifying the target population and effective intervention reduces chances of vertical transmission and new infection. Authors studied the seroprevalence of HIV among women attending obstetric care in a tertiary care hospital of South India and associated maternal and perinatal outcomes among seropositive women.Methods: Retrospective descriptive study of all women who were screened for HIV at Integrated Counselling and Testing Centre, Vani Vilas hospital, from January 2014 to December 2017 in their antenatal, intranatal and postnatal period. Demographic data of seropositive women, obstetric outcomes and status of children at 18months were obtained.Results: Of the 35,455 women who were screened, 0.28% were found positive for HIV. Percentage prevalence of HIV was highest in 2014 (0.32%). Majority of the seroprevalence belonged to age group of 25-29 years (44%), 32% illiterates, 82% homemakers and 79% belonged to urban areas. Unknown partner status in 22% and majority were diagnosed in antenatal period (66%). Of them 82% had favourable CD4 count. 74 % of them delivered live baby. Three maternal deaths were observed and anaemia (65%) was the major associated co-morbidity. Vaginal route was common mode of delivery (84%). Thirteen babies required NICU admission and 6 neonates deaths were encountered. Exclusive breastfeeding was practised in 91% of live births. 62% of children were found seronegative at 18 months follow up.Conclusions: Authors observed with adequate treatment to mother and prophylaxis to the baby, the burden of vertical transmission can be significantly reduced.


Author(s):  
Ayan Roy ◽  
Nayan Kumar Patel

Background: Cardiovascular morbidity plays a villainous role globally as well as countries like India. Additionally, irrational prescription incurs greater damage to health and wellbeing. Drug utilization studies scrutinize the appropriateness of treatment and provide favorable feedbacks to strengthen clinical practices. The objective of the study was to describe treatment practices in cardiology outpatient and drug utilization pattern using core prescribing indicators by World Health Organization (WHO).Methods: A cross-sectional, observational study of 4-month duration was undertaken for cardiology Outdoor patients at a tertiary care hospital. 615 prescriptions were screened and analyzed.Results: Males (59.84%) were more in number than females (40.16%). Average number of the prescribed drugs per patient were 4.32±2.7 and (3.73±1.1 for cardiovascular drugs). Generic prescription was 60.98%. Percentage encounters with antibiotics 4.11, injectables 2.92%, fixed-dose combinations (FDCs) (11.8%) were documented. Drugs from the National List of Essential Medicines were 75.89%. The most common diagnosis was ischemic heart disease (68.29%). Hypolipidemics (78.25%) followed by antiplatelets (71.14%) were toppers in cardiovascular drug. Antiulcer drugs (PPI/Antacids) comprised 58.54% of total prescriptions.Conclusions: Less adherence to EDL, less generic prescriptions, use of FDC are major shortcomings. Areas to further rationalization like optimal use of evidence based medication like beta-blockers, newer anticoagulants/anti-platelet agents and newer anti-anginal agents are identified.


Author(s):  
Kanij Fatema ◽  
Md Mizanur Rahman

Background: Autoimmune encephalitis (AIE) are distinct group of encephalitis where production of autoimmune antibody causes neuroinflammation. The core clinical features are encephalopathy, psychiatric disorder, movement disorder and seizure. The investigation and treatment modalities are different from that of infectious encephalitis. There are limited studies in pediatric population in particularly in developing country like Bangladesh. Thus this study has been done to describe patients with AIE from a tertiary care hospital. Method: This is a retrospective study done in children of 1-16 year from January 2018 to December 2019. AIE was diagnosed on the basis of clinical, electrographic and neuroimaging features and was confirmed with detection of autoantibody in CSF. Treatment was given according to the published literature with immunotherapy mainly. Results: Total 15 children were studied, 14 patients were antiNMDAR encephalitis and 1 was antiMOG antibody syndrome. Mean age was 5.98 and 4.5 year respectively. Seizure was the most common clinical feature, mostly focal in nature. Other manifestations were movement disorder, psychiatric disorder, loss of consciousness etc. Most of the patients had abnormal EE, focal epileptic discharge being the commonest. Eight out of 15 had abnormal MRI of brain. Cortical  hyperintensity was important feature located mostly in temporal region. In the case of antiMOG antibody syndrome there was demyelinating lesion in multiple areas. Cornerstone of the treatment was mostly combination immunotherapy with IV methylprednisolone and IV immunoglobulin followed by oral steroid. Majority of the patients showed improvement however 3 patients had complete recovery. Complications observed were epilepsy, speech disorder, cognitive disorder, behavioural disorder, ataxia and visual impairment. Conclusion:  Timely diagnosis and prompt treatment of AIE is very important as proper treatment can cause significant improvement.  


Healthline ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 46-54
Author(s):  
Sonal Shah ◽  
Manisha Kapdi ◽  
Jyoti Vora ◽  
Kuldeep Joshi ◽  
Pratik Patel ◽  
...  

Background: The outbreak of Covid-19 has led to a health emergency and economic crisis worldwide. Mortality in productive age further worsens the crisis, so it is important to understand reasons for death in productive age group. Objective: To identify predictors of mortality and to compare the intensity of rise in inflammatory markers of amongst young Covid-19 decedents in comparison with elder Covid-19 decedents. Method: Record based study of Covid-19 infected admitted patients was conducted in tertiary care hospital. Information of all (n=3131, 209 deceased and 2922 recovered patients) Covid-19 positive patient assessed . Their clinico epidemiological markers were compared between younger (18-45 years) decedents in comparision with elder decedents (>45 years). Mann–Whitney U-test and the Chi-square test for significance were used. Bivariate Multiple logistic regression was used to identify predictors in younger and elder decedents. Results: Case Fatality Rate (CFR) in Covid-19 infected patients was 2.4% and 9.7% amongst younger and elder group respectively. (OR 8.83 : 95% CI 5.9-13.2; p < 0.001). Biomarkers were raised and similar in both groups except Neutrophil Lymphocyte Ratio (NLR) was significantly higher in elder decedent while LDH was significantly higher in younger decedents. Conclusions: Males had higher CFR than females after 45 years of age, which was due to co-morbidity. Reaching late to the health care facility and high LDH were predictors in younger decedent, while male gender, co morbidities and high NLR were more important predictors in elder group.


Author(s):  
Ravi C. Sharma ◽  
Dinesh D. Sharma ◽  
Vikesh Gupta ◽  
Rahul Gupta ◽  
Vineet Kumar ◽  
...  

Background: Suicide is the result of an act deliberately initiated and performed by a person in the full knowledge or expectation of its fatal outcome. Suicide attempts are a significant public health problem. The present study aimed to explore the variousclinical characteristics of suicideattempters in a tertiary care hospital of Shimla, Himachal Pradesh, a northern state of India.Methods: We conducted a descriptive study among patients with attempted suicide to the department of Psychiatry, Indira Gandhi Medical College (IGMC) Shimla. A structured, self-designed interview schedule and short-form revised Eyseneck personality questionnaire-Hindi (EPQRS-H) was used for data collection. Data was analyzed using Epi info software v 7.2.0.Results: There were total 77 participants in the study out of which 44 (57.1%) were females. Mean age (Standard deviation) of participants was 30.8 years (9.9 years). Relationship problems were the most common (48.1%) recent life event followed by health events (28.6%). Depression was found to be the most common diagnosis (62.3%). Pesticide consumption was the method of attempting suicide in 72.7% of females compared to 66.7% of males.Conclusions: Recent major life events especially relationship problems may lead to majority of suicide attempts. There is urgent need to focus on patients suffering from depression by health personnel as well as family members. The sale of the pesticides should be regulated to keep in check the misuse of the same.


2014 ◽  
Vol 3 (8) ◽  
pp. 309-312 ◽  
Author(s):  
Muhammad Zahid Iqbal ◽  
Muhammad Shahid Iqbal ◽  
Dayana Nicholas ◽  
Jamaluddin Awang ◽  
Amer Hayat Khan ◽  
...  

To assess the adherence of physicians involved in the management of diabetes mellitus with or without co-morbidities with reference to Clinical Practice Guideline 2009 given by Ministry of Health Malaysia in the tertiary care hospital, Pinang General Hospital Malaysia. Cross-sectional study was done at tertiary care hospital, Penang, Malaysia. The total 51 physicians and 1020 patient’s prescriptions written by same physicians were taken from the record of the Penang General Hospital (20 prescriptions for each enrolled physician). All 1020 patients were suffering from diabetes mellitus with or without co-morbidities. These patients were recruited from the different wards of the Penang General Hospital. Depending on the recommendations of CPG 2009 the prescriptions of patients were divided into adherent and non-adherent prescriptions. The overall good level of physician adherence was seen with respect to the recommendations of CPG 2009 in all prescriptions. A statistically significant negative association (?= 0.094, p-value=0.003) was observed between diabetes mellitus control and co-morbidities. CPG adherent had statistically weak negative association (?= -0.081, p-value=0.010) with patients having co-morbidities. No statistically significant association was observed between CPG adherence and any other co-morbidity. The study explored the several features of prescription pattern of physicians involved in the management of diabetes mellitus with or without co-morbidities and recognized the need for improvement in their prescription pattern for treating the diabetes mellitus.DOI: http://dx.doi.org/10.3329/icpj.v3i8.19405 International Current Pharmaceutical Journal, July 2014, 3(8): 309-312


2019 ◽  
Vol 18 (4) ◽  
pp. 773-778
Author(s):  
Fahmida Ahmed ◽  
Anwar Husain ◽  
Meherunnessa Begum ◽  
Mohd Nurul Alam ◽  
Muhammad Ayaaz Ibrahim

Background: Acne vulgaris is a chronic inflammatory skin disorder which has a high prevalence among adolescence and young adults. Although acne does not cause direct physical impairment, it can produce a significant psychosocial burden. As the face is almost always the site of involvement of acne, its presence can alter one’s perception of body image. Increased levels of anxiety, anger, depression, and frustration are also observed in patients with acne. Acne affects social, vocational, and academic performance of teenagers & young adult. Objective: To identify socio-demographic profile and to evaluate the psychiatric morbidity in patients with acne vulgaris in a tertiary care hospital. Materials and Methods: This cross sectional study was conducted from June 2017 to December 2017 among the patients of acne vulgaris attending outpatient department of Dermatology in Ibn Sina Medical College Hospital, Dhaka. Purposive sampling technique was used. The sample size of the study was 181. Data were collected by using semi structured socio-demographic questionnaire and the SRQ to screen psychiatric symptoms. The Self Reporting Questionnaire (SRQ), is a psychiatric case finding instrument, was developed by World Health Organization (WHO) to screen for psychiatric disturbance especially among developing countries. The data obtained was collected, tabulated and subjected to statistical analysis using the Statistical Package for Social Sciences (SPSS), for windows version 20. Results: Study was conducted on 181patients comprising 135(74.6%) were female & 46(25.4%) were male. Age group between 16 to 22 years carried maximum incidence 100(55.2%). Among the patients Psychiatric morbidity was found in86(48%) of the study population. Psychiatric morbidity was found more in young and females patients. Among the types of psychiatric morbidity Anxiety disorders were 57(66.3%) & Major Depressive Disorder(MDD) was 29(33.7%).Anxiety disorders were included social phobia (26.7%), generalized anxiety disorder (GAD) (18.6%), panic disorder (14%) and obsessive compulsive disorder (OCD)(7%). Conclusion: Patients with acne vulgaris in whom psychiatric morbidity is present, should be routinely evaluated and their psychiatric morbidity need to be treated adequately for maximize their health. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.773-778


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