scholarly journals Evaluation of the role of fundus fluorescein angiography and spectral domain-optical coherence tomography in choroidal neo-vascularization: a hospital-based study

2022 ◽  
Author(s):  
Amit Singh ◽  
Reyaz Ahmed Untoo ◽  
Ourfa Ashraf Wani ◽  
Wasim Rashid
Keyword(s):  
Optical Coherence Tomography ◽  
Confidence Interval ◽  
Diagnostic Accuracy ◽  
Fluorescein Angiography ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Predictive Values ◽  
Sd Oct

Background: The study was conducted to evaluate the role of fundus fluorescein angiography (FFA) and spectral domain-optical coherence tomography (SD-OCT) in choroidal neo-vascularisation (CNV).Methods: This was a hospital based prospective study carried out in the post-graduate department of ophthalmology, SKIMS medical college, Bemina, Srinagar, Jammu and Kashmir. All patients diagnosed with CNV fulfilling the criteria during the study period w.e.f. October 2018 to March 2020 were enrolled. Visual acuity and pinhole test using Snellen’s chart for literate and E chart for illiterate patient, slit lamp biomicroscope for anterior segment examination, ophthalmoscopy, including stereoscopic examination of the posterior pole, 90D examination of the fundus, Intra-ocular pressure measurement, FFA and SD-OCT was done in these patients.Results: Diagnostic accuracy of OCT was observed with a sensitivity 79.1% (95% confidence interval (CI): 67.3-90.7), specificity 84.3% (95% CI: 74.5-92.9), positive and negative predictive values 78.7% and 85.4%, respectively, (95% CI: 65.5-95.6) and (74.8-93.4) and diagnostic accuracy of FFA was observed with a sensitivity 81.4% (95% confidence interval (CI): 70.6-93.5), specificity 82.31% (95% CI: 71.9-89.3), positive and negative predictive values 79.9% and 83.7%, respectively, (95% CI: 68.8-92.9) and (70.3-91.2).Conclusions: FFA is the gold standard procedure for screening ARMD and detection of dry ARMD, but OCT is more specific diagnostic tool in detecting early subretinal neovascular membrane and also to assess the extent, location and activity of the neovascular membranes. This study concludes that SDOCT is highly sensitive for identifying AMD, CNV, and CNV activity and due to its non-invasive nature with no adverse effects and less time consuming can be used as 1st line of diagnostic modality and FFA be reserved for cases where SD-OCT is not helpful.

scholarly journals Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography, Fluorescein Angiography, and Autofluorescence Findings

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Tuğba Aydoğan ◽  
Esra Güney ◽  
Betül İlkay Sezgin Akçay ◽  
Tahir Kansu Bozkurt ◽  
Cihan Ünlü ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Pigment Epithelium ◽  
Outer Nuclear Layer ◽  
Fundus Autofluorescence ◽  
Retinal Pigment ◽  
Spectral Domain ◽  
Fundus Examination ◽  
Optical Coherence ◽  
Sd Oct

A 17-year-old presented with central and paracentral scotomas in his right eye for one week. There was no remarkable medical or ocular history. Blood analyses were within normal range. At presentation both eyes’ best-corrected visual acuities were 20/20. Slit-lamp examination result was normal. Fundus examination revealed yellow-white hypopigmented areas in the macula. Fluorescein angiography (FA) showed hypofluorescence surrounded by ring of hyperfluorescence. Fundus autofluorescence (FAF) was slightly increased. Spectral domain optical coherence tomography (SD-OCT) showed disruption of IS/OS junction with expansion of abnormal hyperreflectivity from retinal pigment epithelium to the outer nuclear layer (ONL). One month later fundus examination showed disappearance of the lesions. FA revealed transmission hyperfluorescence. FAF showed increased autofluorescence and pigment clumping. Hyperreflective band in SD-OCT disappeared. Loss of photoreceptor segment layers was observed in some of the macular lesions. The diagnosis of acute retinal pigment epitheliitis can be challenging after disappearance of fundus findings. FA, FAF, and SD-OCT are important tests for diagnosis after resolution of the disease.

scholarly journals Discrepancies between Spectral Domain Optical Coherence Tomography and Fluorescein Angiography in Detecting Uveitic Macular Edema

Folia Medica ◽  
2016 ◽  
Vol 57 (3-4) ◽  
pp. 207-215 ◽  
Author(s):  
Vesela T. Mitkova-Hristova ◽  
Marieta I. Konareva-Kostianeva ◽  
Arsenia M. Balian ◽  
Nina S. Stoyanova ◽  
Maria A. Semerdzhieva
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Macular Edema ◽  
Serous Retinal Detachment ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Uveitic Macular Edema ◽  
Highly Sensitive ◽  
Sd Oct ◽  
Rule Out

AbstractAIM: To compare spectral-domain optical coherence tomography (SD-OCT) with fluorescein angiography (FA) in detecting macular edema in patients with uveitis and analyse discrepancies in the findings obtained by the two methods. METHODS: The study included 133 eyes from 117 patients with uveitis that had SD-OCT (RTVue-100/ Optovue) and FA (Topcon TRC 50DX) scans performed to detect or rule out macular edema. RESULTS: Macular edema was found in 57 (42.9%) of the 133 surveyed eyes. In 37 eyes (27.8%) macular edema was confirmed by both imaging methods. In 17 eyes (12.8%) macular edema was detected on SD-OCT but not on FA;in 15 eyes of these the edema was diffuse, and in 2 eyes - serous retinal detachment was verified in the macular area. Focal macular edema was detected on FA in three eyes (2.3%) in which SD-OCT showed normal finding. In 76 eyes (57.1%) no pathological changes in the macula were observed on both SD-OCT and FA. Kappa coefficient was 0.675 at p < 0.001. The agreement rate between the two methods calculated using Kendall’s tau-b was 0.693 at p < 0.001. CONCLUSION: Fluorescein angiography and spectral domain optical coherence tomography are highly sensitive methods used in detecting macular edema in patients with uveitis, but they might fail to be efficient in this if used independently. Optical coherence tomography is a more informative method, especially in diagnosing diffuse macular edema.

scholarly journals Multimodal Imaging of Acquired Vitelliform Lesion Diagnosed at Pseudohypopyon Stage

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Nuno Moreira Gonçalves ◽  
Ângela M. Carneiro ◽  
Elisete Brandão ◽  
Fernando M. Falcão-Reis
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Fluorescein Angiography ◽  
Fundus Autofluorescence ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Macular Lesion ◽  
Multiple Round ◽  
One Year ◽  
Sd Oct

Purpose. To present a case study of a monocular acquired vitelliform lesion, studied with multimodal fundus imaging (spectral-domain-optical coherence tomography, fundus autofluorescence, and fluorescein angiography) with a followup of three years.Case Report. An asymptomatic macular lesion was detected on a 64-year-old man. Fundus exam revealed a macular lesion with an apparent horizontal level associated with multiple round small whitish lesions, suggestive of cuticular drusen. He was studied with autofluorescence of the fundus (FAF), fluorescein angiography (FA), spectral domain-optical coherence tomography (SD-OCT), and electrooculogram. The findings were compatible with the diagnosis of acquired vitelliform lesion, associated with cuticular drusen. After one year, the visual acuity decreased to 20/50, without identifiable alterations of the FAF, FA, or SD-OCT. Three years later, fundoscopy and imaging showed an evolution to a state similar to vitelli disruptive phase of Best disease with an improvement of visual acuity to 20/25. We report the results of FAF, FA, and SD-OCT at this stage.Conclusion. Acquired vitelliform lesions associated with cuticular drusen can present as a pseudohypopyon lesion, and the evolution to the atrophic phase can be associated with an improvement of visual acuity.

Correlation of Spectral-Domain Optical Coherence Tomography with Fundus Fluorescein Angiography in an Infant with Retinal Hamartomas

2015 ◽  
Vol 25 (6) ◽  
pp. e106-e108 ◽  
Author(s):  
Lavanya Chidambara ◽  
Chaitra Jayadev ◽  
Shwetha Mangalesh ◽  
Munusamy Sivakumar ◽  
Bhujang Shetty ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography

scholarly journals Case Series of Pediatric Sickle Retinopathy By Sensitive Clinical Imaging Technologies Suggests Frequent Early Pathology

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 3672-3672
Author(s):  
Pahl A. Daniel ◽  
Nancy S. Green ◽  
Monica Bhatia ◽  
Maureen Licursi ◽  
Courtney Briamonte ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Sickle Cell Disease ◽  
Fluorescein Angiography ◽  
Sickle Cell ◽  
Optical Coherence Tomography Angiography ◽  
Case Series ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Cell Disease ◽  
Sd Oct

Abstract Introduction: Sickle cell retinopathy (SCR) reflects disease-related vascular injury. Previous studies of pediatric SCR using standard imaging approaches reported retinopathy in <15% of children (Estepp JH, Br J Haematol 161:402;2013). Sensitive clinical retinal imaging modalities of ultra-widefield fluorescein angiography (UWFA), spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCT-A) may better characterize early retinal changes in pediatric SCR. Fluorescein angiography detects retinopathy through dynamic visualization of retinal blood flow. UWFA captures up to twice as much retinal area as conventional fluorescein angiography and is more sensitive in identifying peripheral vascular changes in SCR (Friberg TR, Ophthalmic Surg Lasers Imaging 39:304;2008). SD- OCT and OCT-A utilize reflected light to produce detailed cross-sectional images of the retina and allow visualization of blood flow in retinal layers. To our knowledge, this is the first case series using these technologies in pediatric SCR. Methods: A consecutive series of children with sickle cell disease (SCD) of any phenotype, ages 10-19 years, accepting enrollment are described. Examinations including acuity, standard slit-lamp examination (biomicroscopy), UWFA, SD- OCT and OCT-A were performed according to standard acquisition protocols. Testing is non-invasive except fluorescein angiography, which requires a small volume of intravenous dye. Results: Eight children (mean age 16.3 years; 5 HbSS, 2 HbSC,1 HbS-Beta thalassemia0) were evaluated. Three were on hydroxyurea therapy, 1 on chronic transfusion, 1 on both and 3 on no therapy. No patient had vision disturbance at the time of examination. Biomicroscopic examination revealed sunburst lesions in the mid-peripheral retina in 3 patients and subtle vascular changes in the far periphery of all patients. In contrast, UWFA detected extensive capillary non- perfusion of the peripheral retina with abnormal vascular loops (Goldberg Stage I) in all 8 patients; 3 patients had peripheral arteriovenous anastomoses (Goldberg Stage II) that were undetectable by biomicroscopy. No patient had Goldberg Stages III-V. SD-OCT demonstrated thinning of the temporal macula in 2 patients, and OCT-A of both patients revealed flow voids in both the superficial and deep retinal capillary plexus in the area of thinned retina. Both the SD- OCT and OCT-A abnormalities were undetectable with standard biomicroscopy. Conclusions: All 8 children with SCD in this case series demonstrated evidence of SCR using the combination of standard biomicroscopy, UWFA, SD-OCT, and OCT-A imaging. Findings from these sensitive imaging modalities suggest that pediatric SCR is more prevalent than previously suspected. Additional patients and age-equivalent controls will be included in this report to validate the specificity of findings to SCD. Larger cross-sectional and prospective analyses using sensitive retina imaging are needed to confirm our findings and identify their significance for detecting pathology. If confirmed, these approaches may enhance early screening for patients at risk of vision-threatening consequences of SCR. Supported by the Irving Institute CTSA at CUMC and by 2T35HL007616 (DP). Retinal findings in pediatric sickle cell disease patients SD-OCT: Spectral-domain optical coherence tomography; OCT-A: Optical coherence tomography angiography; UWFA: Ultra-widefield fluorescein angiography. Retinal findings in pediatric sickle cell disease patients. / SD-OCT: Spectral-domain optical coherence tomography; OCT-A: Optical coherence tomography angiography; UWFA: Ultra-widefield fluorescein angiography. Disclosures No relevant conflicts of interest to declare.

scholarly journals Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ying-Yi Chen ◽  
Yi-Chen Sun ◽  
Chia-Ying Tsai ◽  
Hsiao-Sang Chu ◽  
Jo-Hsuan Wu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ocular Surface ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Slit Lamp ◽  
Ocular Rosacea ◽  
Unilateral Disease ◽  
Healthy Eyes ◽  
Slit Lamp Biomicroscopy ◽  
Sd Oct

AbstractSpectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Eighteen eyes of 10 patients with advancing wavelike epitheliopathy (AWE) and 15 eyes of 9 patients with phlyctenular keratitis/ocular rosacea were recruited. SD-OCT could detect abnormal changes in the POV in 100% of the lesion sites. In presumed-healthy areas of the diseased eyes diagnosed by slit-lamp biomicroscopy, SD-OCT detected abnormal changes in the POV in 100% of the eyes in both groups. In patients with unilateral disease, abnormal changes in the POV were detected by SD-OCT in 50% and 100% of presumed-healthy eyes diagnosed by slit-lamp biomicroscopy in the AWE group and phlyctenular keratitis/ocular rosacea group, respectively. SD-OCT is powerful in detecting POV changes in ocular surface disorders and can provide useful information that cannot be provided by slit-lamp biomicroscopy.

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