scholarly journals Neonatal meconium ileus: a rare presentation

2019 ◽  
Vol 6 (12) ◽  
pp. 4539
Author(s):  
Sneha Hemachandran ◽  
Chaithanya J. ◽  
Anjala Kumar ◽  
Keshav Murthy ◽  
Girish M. L.

Meconium peritonitis is a non-bacterial, chemical inflammation of the peritoneum caused by antenatal or postnatal perforation of intestine by inspissated meconium. Surgery is necessary when signs of intestinal obstruction are present. The incidence of meconium peritonitis is about 1:30,000. Perinatal morbidity and mortality is about 80%. In the case of meconium peritonitis, the incidence of prematurity is 20-30 %. Author present an unusal case of meconium ileus with multiple ileal perforation leading to peritonitis.

2011 ◽  
Vol 139 (7-8) ◽  
pp. 527-530
Author(s):  
Amira Egic ◽  
Zeljko Mikovic ◽  
Vesna Mandic ◽  
Natasa Karadzov

Introduction. More recently, the regions of increased abdominal echogenicity such as echogenic bowel, meconium ileus and meconium peritonitis have been associated with an increased prevalence of a variety of unfavourable outcomes including chromosomal abnormalities, cytomegalovirus infection, intestinal obstruction, anorectal malformations and cystic fibrosis. Earlier prenatal examinations of these severe autosomal recessive diseases had been suggested only to families with history of cystic fibrosis. Recently, systemic examination has been introduced by ultrasound with bowel hyperechogenicity where the fetus is the index case for genetic disease. Risk for cystic fibrosis with this ultrasonography findings ranges from 0-33%. Outline of Cases. Two patients are presented, aged 24 and 29 years, both primigravide. The first one had ultrasonography finding of meconium peritonitis revealed at the 37th week of gestation and the other meconium ileus revealed on ultrasonography at the 29th week of gestation. Both patients had prenatal testing of foetal blood obtained by cordocenthesis, both had normal kariotype and were negative for cytomegalovirus infection. Parental DNA testing for the 2nd patient showed that parents were not carriers for the 29 most frequent mutations. Both neonates had intestinal obstruction, underwent surgery and early postoperative course was normal. Hystopathological finding suggested a possibility of cystic fibrosis for the 1st patient, but parents did not want to be tested and for the 2nd one congenital bowel stenosis as a cause of intestinal obstruction. Conclusion. Ultrasonographic echogenic bowel is an indication for invasive procedures for foetal blood testing for chromosomal abnormalities, congenital infections and parental testing for cystic fibrosis. Only if parental heterozygosity is proven foetus should be tested.


2018 ◽  
Vol 32 (19) ◽  
pp. 3278-3287 ◽  
Author(s):  
Limor Besser ◽  
Liat Sabag-Shaviv ◽  
Maayan Yitshak-Sade ◽  
Salvatore Andrea Mastrolia ◽  
Danielle Landau ◽  
...  

2021 ◽  
Vol 70 (5) ◽  
pp. 105-116
Author(s):  
Maria Yu. Abramova ◽  
Mikhail I. Churnosov

Preeclampsia is a serious complication of pregnancy and complicates its course in 2-8% of all cases. According to the literature, the disease is associated with an increase in maternal and perinatal morbidity and mortality, and is a predictor of the development of chronic diseases in the distant future, which is an important medical and social issue. Of particular interest is the study of the molecular mechanisms of etiopathogenesis and risk factors for preeclampsia, which, unfortunately, are currently poorly studied and understood, thus dictating the need for further study of this complication of pregnancy. This article discusses the current understanding of the etiology, pathogenesis and risk factors for preeclampsia.


2016 ◽  
Vol 19 (3) ◽  
pp. 167-167 ◽  
Author(s):  
Mark P. Umstad ◽  
Ricardo Palma-Dias ◽  
Asma Khalil

Monochorionic twin pregnancies are subject to unique complications that can threaten the life and well-being of both fetuses, resulting in a disproportionate increase in perinatal morbidity and mortality.


Author(s):  
Mahantappa A. Chiniwar ◽  
Joe Kaushik M. ◽  
Sharada B. Menasinkai

Background: Oligohydramnios is one of the major causes of maternal and perinatal morbidity and mortality. It is a clinical condition characterized by Amniotic Fluid Index (AFI) ≤5 cm by sonographic assessment. The aim of present study is to know the maternal and fetal outcome in oligohydramnios after 34 weeks of gestation compared with women who had normal volume of amniotic fluid.Methods: Study was done for the period of 21 months from November 2014-July 2016 at Adichunchanagiri Institute of Medical Sciences, Hospital and Research Centre Bellur. 50 antenatal cases with > 34 weeks of gestation with AFI ≤5 cm by ultrasonographic estimation were included as study group and 50 women with normal AFI were included as control group. Maternal and fetal outcome of the women with oligohydramnios were analyzed and compared with control group.Results: Results were analyzed statistically using parameters like mean, SD, Chi Sq test, P value. Amniotic fluid was clear in 32% in study and 78% in control group, thin meconium stained in 30% in study group and 14%in control group and was thick meconium stained in 38% in study group and 8% in control group (Chi square =22.31, p<0.0001). Induction of labour was done in 54% in study group and 20% in control group. Cesarean delivery was done in 58% in study group women and 28% in control group women. Regarding the birth weight of babies 62% were < 2.5 kg in study group and 18% in control group with p<0.001. 10% of babies in study group required NICU admission and perinatal mortality was 2%.Conclusions: Due to increased perinatal morbidity and mortality and increased rate of LSCS, timely decision during labour is important to reduce perinatal morbidity and mortality.


1985 ◽  
Vol 40 (1) ◽  
pp. 21-22
Author(s):  
RUTH B. KUNDSIN ◽  
SHIRLEY G. DRISCOLL ◽  
RICHARD R. MONSON ◽  
CHING YEH ◽  
STELLA A. BIANO ◽  
...  

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