scholarly journals Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

2022 ◽  
Author(s):  
Hisham Abdullah Almottowa ◽  
Abdulmohsen Yaseer Alkhars ◽  
Maram Hussam Hassan ◽  
Hamad Adel Alhamad ◽  
Saad Munawwikh Alshammari ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Diagnostic Procedures ◽  
Intestinal Wall ◽  
Management Algorithm ◽  
Online Databases ◽  
Major Development ◽  
Histological Characteristics ◽  
Inflammatory Bowel ◽  
Based Medicine

Ulcerative colitis (UC) and Crohn’s disease (CD) are two major inflammatory disorders of the intestinal wall collectively known as inflammatory bowel disease (IBD). Colorectal carcinoma (CRC) is the most significant and grave consequence of IBD and is preceded by dysplasia in majority of the cases. In this review we aim to discuss the various types of dysplasia found in patients with CRC due to IBD. A thorough literature search was conducted in online databases such as PubMed, Google Scholar, from which all studies published in the last ten years were included in this review. The major development in diagnostic procedures and visualization modalities have aided our understanding of dysplasia, which is now known to be the strongest predictor and marker for CRC development. However, the unpredictable behavior and progression of dysplasia still warrants vigilant surveillance. Dysplasia has been classified on histological characteristics using grades of dysplasia from ‘negative for dysplasia’ to ‘high grade dysplasia’. On visibility via an endoscope from ‘visible dysplasia’ to ‘invisible dysplasia’ and macroscopic features of ‘conventional dysplasia’ and ‘non-conventional dysplasia’. No single classification can be utilized to define the stage of dysplasia and more importantly predict its progression and outcome of CRC. Using evidence-based medicine an integrated classification expanding on a management algorithm must be formulated by a panel of experts to steer management of the disease. A multidisciplinary, tailored approach with a strong emphasis on regular and timely surveillance to ensure early detection of CRC can enhance quality of life and patient outcomes.

scholarly journals Thrombotic Complications in Inflammatory Bowel Disease

2019 ◽  
Vol 29 (2) ◽  
pp. 23-26
Author(s):  
A. V. Borota ◽  
A. A. Borota ◽  
E. V. Onishchenko
Keyword(s):  
Inflammatory Bowel Disease ◽  
Chronic Inflammation ◽  
Bowel Disease ◽  
Intestinal Wall ◽  
Coagulation Cascade ◽  
Coagulation System ◽  
Primary Disease ◽  
Prevention And Treatment ◽  
Thrombotic Complications ◽  
Inflammatory Bowel

The risk of thrombotic complications is known to be 3 times higher in patients with inflammatory bowel disease (IBD) than in healthy individuals, with the relative risk being 15 times higher during the periods of relapses. Aim. To study and generalize literature data available on the prevention and treatment of IBD thrombotic complications.Key findings. In the сonditions under study, the presence of chronic inflammation and increased bleeding of the intestinal wall is shown to activate the coagulation system, impair the fibrinolysis system and reduce the activity of natural anticoagulation mechanisms. The concentration of fibrinogen — a protein of the acute inflammation phase — increases significantly. This results in an imbalance of the blood coagulation system with a tendency to hypercoagulation, which significantly increases the risk of thrombotic complications and the disseminated intravascular coagulation syndrome. In turn, the activation of the coagulation cascade may trigger the inflammatory response, which eventually leads to the formation of a vicious circle between chronic inflammation and thrombosis. The pathogenesis of thrombosis in inflammatory colon diseases is a multifactor process, which remains to be understood.Conclusion.The management of patients with IBD in combination with thromboembolic complications requires an individual multidisciplinary approach. Taking into account the pathogenetic factors, the following options are possible in the prevention and treatment of thrombotic complications in IBD: strengthening the basic therapy of the primary disease; administration of prophylactic doses of anticoagulants under dynamic continuous laboratory control in the acute period using the methods of conservative therapy of thrombotic complications (elastic compression of the lower extremities) in the period of exacerbation of the primary disease.

scholarly journals Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain

Gut ◽  
1998 ◽  
Vol 43 (1) ◽  
pp. 71-78 ◽  
Author(s):  
S Matsumoto ◽  
Y Okabe ◽  
H Setoyama ◽  
K Takayama ◽  
J Ohtsuka ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Cells ◽  
Intestinal Wall ◽  
Human Inflammatory Bowel Disease ◽  
Specific Pathogen ◽  
Inflammatory Bowel ◽  
Oxide Synthase ◽  
Senescence Accelerated Mouse ◽  
Inducible Nitric Oxide

Background—A new subline of the senescence accelerated mouse (SAM) P1/Yit strain has been established which shows spontaneous enteric inflammation under specific pathogen free (SPF) conditions.Aims—To elucidate the pathogenesis of enteric inflammation in this new subline.Methods—The SPF and germ free (GF) SAMP1/Yit strains were used. Histological, immunological, and microbiological characterisation of the mice with enteric inflammation was performed.Results—Histologically, enteritic inflammation developed as a discontinuous lesion in the terminal ileum and caecum with the infiltration of many inflammatory cells after 10 weeks of age. The activity of myeloperoxidase, and both immunolocalisation and mRNA expression of inducible nitric oxide synthase increased in the lesion. CD3-ε positive T cells, neutrophils, and macrophages were more numerous in the inflamed mucosa of the SAMP1/Yit strain. The GF SAMP1/Yit strain did not show any inflammation in the intestinal wall, by the age of 30 weeks, and the enteritis and caecitis developed 10 weeks after the conventionalisation of the GF SAMP1/Yit strain.Conclusion—Enteric inflammation in the ileum and caecum developed in the SAMP1/Yit strain. The pathophysiological characteristics of the disease in this mouse have some similarities to those of human inflammatory bowel disease (IBD). This mouse strain should be a useful model system for elucidating the interaction between the pathogenesis of IBD and the gut microflora.

Ultrasonographic evaluation of the thickness of the small intestinal wall in dogs with inflammatory bowel disease

2005 ◽  
Vol 46 (7) ◽  
pp. 322-326 ◽  
Author(s):  
H. Rudorf ◽  
G. van Schaik ◽  
R. T. O'Brien ◽  
P. J. Brown ◽  
F. J. Barr ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Intestinal Wall ◽  
Inflammatory Bowel ◽  
Small Intestinal

scholarly journals Feline inflammatory bowel disease

2019 ◽  
Vol 75 (10) ◽  
pp. 6293-2019
Author(s):  
DIANA STĘGIERSKA ◽  
ANDRZEJ PUCHALSKI ◽  
MARTA STANIEC ◽  
RENATA URBAN-CHMIEL ◽  
ANNA ŁOJSZCZYK ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Signs ◽  
Immunosuppressive Drugs ◽  
Intestinal Wall ◽  
Response To Treatment ◽  
Inflammatory Infiltration ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Antiparasitic Drugs

Inflammatory bowel disease (IBD) is one of the most common causes of chronic clinical signs from the gastrointestinal tract, associated with histological evidence of inflammation in the lamina propria of the small and/or large intestine in cats. The underlying etiopathogenesis of this inflammation remains unclear. IBD is probably caused by a combination of environmental and immune factors in genetically susceptible individuals. The process of diagnosing IBD involves several steps and is based on the exclusion of other causes of gastrointestinal signs and on the confirmation of the presence of inflammatory infiltration in the intestinal wall by histopathological assessment of biopsies. The treatment is based on anti-inflammatory and immunosuppressive drugs. In addition, dietotherapy, antibiotics, antiparasitic drugs, prebiotics, probiotics and supplementation of vitamin b12 are also used. For most patients, the response to treatment is satisfactory, but the maintenance of clinical remission in most of them may require anti-inflammatory drugs for the rest of their lives.

scholarly journals Synchronous pyoderma gangrenosum and inflammatory bowel disease, healing after total proctocolectomy

2012 ◽  
Vol 87 (4) ◽  
pp. 637-639 ◽  
Author(s):  
Pedro Andrade ◽  
Maria Manuel Brites ◽  
Américo Figueiredo
Keyword(s):  
Inflammatory Bowel Disease ◽  
Pyoderma Gangrenosum ◽  
Ulcer Healing ◽  
Bowel Disease ◽  
Clinical Presentation ◽  
Diagnostic Procedures ◽  
Colonic Perforation ◽  
Lower Limbs ◽  
Total Proctocolectomy ◽  
Inflammatory Bowel

We present a female patient observed with painful violaceous plaques with central bullae and pustules on the lower limbs, rapidly transformed into ulcers, associated with bloody diarrhea, recurrent oral erosions and hyperthermia in the previous 3 months. Cutaneous biopsy was consistent with pyoderma gangrenosum, and intestinal diagnostic procedures revealed a non-classifiable inflammatory bowel disease with high x-ANCA titers. Soon after admission the patient was submitted to total proctocolectomy following colonic perforation. Complete ulcer healing occurred three months after surgery, without recurrence. Pyoderma gangrenosum is a rare dermatosis frequently associated with inflammatory bowel disease. This case is particularly interesting for the synchronic clinical presentation of cutaneous and intestinal diseases, but also for the prompt regression of the former after total proctocolectomy.

Mo1680 EUS Assessment of Intestinal Wall for Diagnosis and Differentiation of Inflammatory Bowel Disease

2016 ◽  
Vol 83 (5) ◽  
pp. AB476-AB477
Author(s):  
Liangru Zhu ◽  
Mely Huang ◽  
Jinfang Zhao ◽  
Ruifeng Zhao ◽  
Ling Cheng
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Intestinal Wall ◽  
Inflammatory Bowel
Sign in / Sign up

Export Citation Format

Share Document