Comparison of imo and Humphrey field analyzer perimeters in glaucomatous eyes

AIM: To compare the imo perimeter, a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously, with the Humphrey field analyzer (HFA) perimeter to investigate correlations and their diagnostic ability in glaucomatous eyes. METHODS: The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were tested. We investigated the correlations of mean deviation, pattern standard deviation, visual field index, and the sensitivity. RESULTS: Measurements of mean deviation (r=0.886, P<0.001), pattern standard deviation (r=0.814, P<0.001), and visual field index (r=0.871, P<0.001) in both perimeters were strongly and positively correlated. The sensitivities in the imo perimeter were 80.5% for mean deviation, 81.2% for pattern standard deviation, and 80.5% in visual field index; those in the HFA were 63.3% for mean deviation, 74.5% for pattern standard deviation, and 80.5% for visual field index. Both perimeters demonstrated high diagnostic ability. CONCLUSION: The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity, specificity, and diagnostic ability. However, the difference between imo and HFA results increases with the increase in visual field disturbance.

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Comparison of Perimetric Outcomes from Melbourne Rapid Fields Tablet Perimeter Software and Humphrey Field Analyzer in Glaucoma Patients

Journal of Ophthalmology ◽

10.1155/2020/8384509 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Harsh Kumar ◽

Mithun Thulasidas

Keyword(s):

Standard Deviation ◽

Visual Field ◽

Rural Areas ◽

Visual Fields ◽

Test Time ◽

Mean Deviation ◽

Time Saving ◽

Humphrey Field Analyzer ◽

Probability Plot ◽

The Mean

Purpose. To compare visual field results obtained using Melbourne Rapid Fields (MRF) iPad-based perimeter software and Humphrey Field Analyzer (HFA) 24-2 Swedish Interactive Threshold Algorithm (SITA) standard program in glaucoma patients. Design. A cross-sectional observational study. Methods. In this single-centre study involving patients diagnosed with glaucoma, the perimetric outcomes of MRF were compared against those returned from the HFA 24-2 SITA standard. Outcomes included mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI)/visual capacity (VC), foveal threshold, test time, number of points depressed at P<5% on PSD probability plot, and glaucoma hemifield test/color coded indicator. Results. The study included 28 eyes of 28 glaucoma patients. Mean (standard deviation) test times were 342.07 (56.70) seconds for MRF and 375.11 (88.95) for HFA 24-2 SITA standard P=0.046. Mean MD was significantly lower for MRF (Δ = 3.09, P<0.001), and mean PSD was significantly higher for MRF (Δ = 1.40, P=0.005) compared with HFA. The mean foveal threshold for the MRF was significantly lower than the mean HFA foveal threshold ((Δ = 9.25, P<0.001). The number of points depressed at P<5% on the PSD probability plot was significantly less for MRF P<0.001. Other perimetric outcomes showed no significant differences between both. Bland–Altman plots showed that considerable variability existed between the programs. Conclusion. MRF is a good cost-effective, time-saving, user-friendly tool for monitoring visual fields in settings where access to traditional perimetry is limited. The lack of Internet strength in rural areas and questionable detection of early cases may be two points in MRF fields requiring an upgrade.

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Investigating the clinical usefulness of definitions of progression with 10-2 visual field

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-318188 ◽

2021 ◽

pp. bjophthalmol-2020-318188

Author(s):

Shotaro Asano ◽

Hiroshi Murata ◽

Yuri Fujino ◽

Takehiro Yamashita ◽

Atsuya Miki ◽

...

Keyword(s):

Visual Field ◽

False Positive ◽

False Positive Rate ◽

Clinical Validity ◽

Data Set ◽

Humphrey Field Analyzer ◽

Positive Rate ◽

Using Data ◽

Sensitivity Specificity ◽

Higher Sensitivity

Background/AimTo investigate the clinical validity of the Guided Progression Analysis definition (GPAD) and cluster-based definition (CBD) with the Humphrey Field Analyzer 10-2 test in diagnosing glaucomatous visual field (VF) progression, and to introduce a novel definition with optimised specificity by combining the ‘any-location’ and ‘cluster-based’ approaches (hybrid definition).Methods64 400 stable glaucomatous VFs were simulated from 664 pairs of 10-2 tests (10 sets × 10 VF series × 664 eyes; data set 1). Using these simulated VFs, the specificity to detect progression and the effects of changing the parameters (number of test locations or consecutive VF tests, and percentile cut-off values) were investigated. The hybrid definition was designed as the combination where the specificity was closest to 95.0%. Subsequently, another 5000 actual glaucomatous 10-2 tests from 500 eyes (10 VFs each) were collected (data set 2), and their accuracy (sensitivity, specificity and false positive rate) and the time needed to detect VF progression were evaluated.ResultsThe specificity values calculated using data set 1 with GPAD and CBD were 99.6% and 99.8%. Using data set 2, the hybrid definition had a higher sensitivity than GPAD and CBD, without detriment to the specificity or false positive rate. The hybrid definition also detected progression significantly earlier than GPAD and CBD (at 3.1 years vs 4.2 years and 4.1 years, respectively).ConclusionsGPAD and CBD had specificities of 99.6% and 99.8%, respectively. A novel hybrid definition (with a specificity of 95.5%) had higher sensitivity and enabled earlier detection of progression.

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Classification and Statistical Trend Analysis in Detecting Glaucomatous Visual Field Progression

Journal of Ophthalmology ◽

10.1155/2019/1583260 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Cristiana Valente ◽

Elisa D’Alessandro ◽

Michele Iester

Keyword(s):

Statistical Analysis ◽

Standard Deviation ◽

Visual Field ◽

Trend Analysis ◽

Open Angle Glaucoma ◽

Mean Deviation ◽

Threshold Strategy ◽

Visual Field Progression ◽

The Mean

Aim. To evaluate the agreement between different methods in detection of glaucomatous visual field progression using two classification-based methods and four statistical approaches based on trend analysis. Methods. This is a retrospective and longitudinal study. Twenty Caucasian patients (mean age 73.8 ± 13.43 years) with open-angle glaucoma were recruited in the study. Each visual field was assessed by Humphrey Field Analyzer, program SITA standard 30-2 or 24-2 (Carl Zeiss Meditec, Inc., Dublin, CA). Full threshold strategy was also accepted for baseline tests. Progression was analyzed by using Hodapp–Parrish–Anderson classification and the Advanced Glaucoma Intervention Study visual field defect score. For the statistical analysis, linear regression (r2) was calculated for mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI), and when it was significant, each series of visual field was considered progressive. We also used Progressor to look for a significant progression of each visual field series. The agreement between methods, based on statistical analysis and classification, was evaluated using a weighted kappa statistic. Results. Thirty-eight visual field series were analyzed. The mean follow-up time was 6.2 ± 1.53 years (mean ± standard deviation). At baseline, the mean MD was −7.34 ± 7.18 dB; at the end of the follow-up, the mean MD was −9.25 ± 8.65 dB; this difference was statistically significant (p<0.001). The agreement to detect progression was fair between all methods based on statistical analysis and classification except for PSD r2. A substantial agreement (κ = 0.698 ± 0.126) was found between MD r2 and VFI r2. With the use of all the statistical analysis, there was a better time-saving. Conclusions. The best agreement to detect progression was found between MD r2 and VFI r2. VFI r2 showed the best agreement with all the other methods. GPA2 can help ophthalmologists to detect glaucoma progression and to help in treatment decisions. PSD r2 was the worse method to detect progression.

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Συσχέτιση κεντρικού πάχους κερατοειδούς με πάχος οπτικών ινών και των παραμέτρων της οπτικής θηλής με HRT II στην οφθαλμική υπερτονία και στους διαφόρους τύπους γλαυκώματος

10.12681/eadd/40330 ◽

2013 ◽

Author(s):

Χρήστος Πίτσας

Keyword(s):

Standard Deviation ◽

Mean Deviation ◽

Pattern Standard Deviation

ΣΚΟΠΟΣ: Να συγκρίνουμε και να συσχετίσουμε τις παραμέτρους τηςκεφαλής του οπτικού νεύρου που λαμβάνονται με το HRT με ταελλείμματα (σκοτώματα) που εντοπίστηκαν από την short-wavelengthautomatic perimetry (SWAP) σε οφθαλμούς με οφθαλμική υπερτονία(OHT).ΜΕΘΟΟΣ: Η μελέτη περιελάμβανε με τυχαία επιλογή τον έναοφθαλμό από 146 διαδοχικούς ασθενείς με οφθαλμική υπερτονία. Όλοι οιασθενείς που περιελήφθησαν στην μελέτη είχαν αξιόπιστα οπτικά πεδία,SWAP και μετρήσεις HRT που πραγματοποιήθηκαν εντός 2 εβδομάδων.Οι οφθαλμοί κατηγοριοποιήθηκαν ως φυσιολογικοί ή παθολογικοί,σύμφωνα με τα κριτήρια του οπτικού πεδίου και του Moorfieldsregression analysis MRA για το HRT.ΑΠΟΤΕΛΕΣΜΑΤΑ: Η ανάλυση της συσχέτισης μεταξύ των δεικτώντου οπτικού πεδίου { mean deviation (MD), pattern standard deviation(PSD) και corrected pattern standard deviation (CPSD)} και τωνπαραμέτρων του HRT έγινε με τη χρήση του Spearman correlationcoefficient (r) και η συμφωνία μεταξύ των εξετάσεων, για τονχαρακτηρισμό των οφθαλμών, υπολογίστηκε με την τιμή k.Αποτελέσματα: Η μέση ηλικία των ασθενών ήταν 53 ± 10,5 χρόνια καιτο μέσο πάχους του κεντρικού κερατοειδούς (CCT) ήταν 559 ± 37 μm.Είκοσι-εννέα οφθαλμοί (19,9%) είχαν σκοτώματα στην SWAP. Είκοσιεννέα οφθαλμοί (19,9%) είχαν φυσιολογικό HRT. Έξι οφθαλμοί (4,1%)είχαν φυσιολογικό HRT και σκοτώματα στην SWAP. Άλλοι εννέαοφθαλμοί (6,2%) είχαν "οριακό" HRT και σκοτώματα στη SWAP .Το k statistic είναι 0,116 (ρ = 0,12), και έτσι υπάρχει μια πολύ χαμηλήσυμφωνία μεταξύ των δύο μεθόδων. εν ανιχνεύθηκε στατιστικάσημαντική συσχέτιση μεταξύ των παραμέτρων της HRT και τωνπαραμέτρων της SWAP.ΣΥΜΠΕΡΑΣΜΑΤΑ: Τα σκοτώματα στην SWAP μπορεί να συνυπάρχουν με βλάβες του οπτικού δίσκου που ανιχνεύει το HRT σεοφθαλμούς με οφθαλμική υπερτονία. Στους περισσότερους οφθαλμούς,ωστόσο, οι δύο μέθοδοι ανιχνεύουν διαφορετικές χαρακτηριστικά τουγλαυκώματος.

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Aqueous Humor Proteomic Alterations Associated with Visual Field Index Parameters in Glaucoma Patients: A Pilot Study

Journal of Clinical Medicine ◽

10.3390/jcm10061180 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1180

Author(s):

Sai Karthik Kodeboyina ◽

Tae Jin Lee ◽

Kathryn Bollinger ◽

Lane Ulrich ◽

David Bogorad ◽

...

Keyword(s):

Visual Field ◽

Aqueous Humor ◽

Molecular Mechanisms ◽

Visual Fields ◽

Mean Deviation ◽

Glaucomatous Optic Neuropathy ◽

Visual Field Index ◽

Liquid Chromatography Tandem Mass ◽

Visual Field Indices ◽

Apolipoprotein D

Purpose: The purpose of this study was to discover the aqueous humor proteomic changes associated with visual field indices in glaucoma patients. Methods: Aqueous humor samples were analyzed using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). The visual fields were analyzed with the Humphrey Visual Field analyzer. Statistical analyses were performed to discover the relationship between the aqueous humor proteins and visual field parameters including Pattern Standard Deviation (PSD), Visual Field Index (VFI), Mean Deviation (MD) and Glaucoma Hemifield Test (GHT). Results: In total, 222 proteins were identified in 49 aqueous humor samples. A total of 11, 9, 7, and 6 proteins were significantly correlated with PSD, VFI, MD, and GHT respectively. These proteins include apolipoprotein D, members of complement pathway (C1S, C4A, C4B, C8B, and CD14), and immunoglobulin family (IKHV3-9, IGKV2-28). Conclusion: Several proteins involved in immune responses (immunoglobulins and complement factors) and neurodegeneration (apolipoprotein D) were identified to be associated with abnormal visual field parameters. These findings provide targets for future studies investigating precise molecular mechanisms and new therapies for glaucomatous optic neuropathy.

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Changes in Frequency-Doubling Perimetry in Patients with Type I Diabetes prior to Retinopathy

BioMed Research International ◽

10.1155/2013/341269 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Isabel Pinilla ◽

Antonio Ferreras ◽

Miriam Idoipe ◽

Ana I. Sanchez-Cano ◽

Diana Perez-Garcia ◽

...

Keyword(s):

Standard Deviation ◽

Type I Diabetes ◽

Frequency Doubling ◽

Diabetic Group ◽

Control Group ◽

Mean Deviation ◽

Diabetic Patients ◽

Type I ◽

Pattern Standard Deviation ◽

The Mean

Purpose. To evaluate the ability of frequency-doubling technology (FDT) perimetry in detecting visual field defects in young adults with type I diabetes prior to retinopathy or with minor retinovascular changes.Methods. This comparative cross-sectional study included 30 healthy subjects and 73 age-matched patients with type I diabetes mellitus. All subjects underwent a full ocular examination including an FDT with the threshold C-20-5 strategy. Only one eye per subject was randomly included in the statistical analysis. FDT results and time to perform the test were compared between the groups.Results. The mean age was 27.1 years in the control group and 26.6 years in the diabetic group (P=0.875). The mean period from the onset of diabetes was12.6±6.7years, while minimal retinovascular changes were observed in 18 eyes. Mean deviation of FDT did not differ between the groups. Although global indices of FDT were within normal limits, pattern standard deviation of FDT was higher in the diabetic group (P=0.035). The area under the receiver operating characteristic curve was 0.647 for pattern standard deviation of FDT (standard error = 0.052;P=0.017).Conclusion. FDT can detect retinal dysfunctions in diabetic patients prior to the onset of significant vascular complications.

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Evaluation of the Retinal Nerve Fiber Layer Thickness, the Mean Deviation, and the Visual Field Index in Progressive Glaucoma

Journal of Glaucoma ◽

10.1097/ijg.0000000000000280 ◽

2016 ◽

Vol 25 (3) ◽

pp. e229-e235 ◽

Cited By ~ 9

Author(s):

Sebastián A. Banegas ◽

Alfonso Antón ◽

Antonio Morilla ◽

Marco Bogado ◽

Eleonora M. Ayala ◽

...

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Mean Deviation ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Visual Field Index ◽

Nerve Fiber Layer Thickness ◽

The Mean

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Real-World Analysis of the Aging Effects on Visual Field Reliability Indices in Humans

Journal of Clinical Medicine ◽

10.3390/jcm10245775 ◽

2021 ◽

Vol 10 (24) ◽

pp. 5775

Author(s):

Tomoki Shirakami ◽

Tetsuro Omura ◽

Hiroki Fukuda ◽

Ryo Asaoka ◽

Masaki Tanito

Keyword(s):

Standard Deviation ◽

Visual Field ◽

Real World ◽

University Hospital ◽

Mean Deviation ◽

Aging Effects ◽

Macular Function ◽

Mixed Effect ◽

Reliability Indices ◽

Age Related

Relationships between age and visual field (VF) reliability indices were investigated using a large real-world dataset (42,421 VF data points from 11,525 eyes of 5930 subjects). All VFs tested and stored at Shimane University Hospital between 1988 and 2019 were exported. Correlations between age, mean deviation (MD), pattern standard deviation (PSD), and reliability indices including fixation losses (FLs), false negatives (FNs), and false positives (FPs) were analyzed. The mean ± standard deviation age was 65.0 ± 15.1 years; MD—−6.9 ± 8.1 decibels (dB); PSD—6.3 ± 4.6 dB; FL—8.6 ± 11.7%; FN—5.3 ± 8.3%; and FP—2.6 ± 5.0%. Univariate analyses showed strong associations between age and FNs (correlation coefficient, ρ = 0.20, p < 0.0001) and MD (ρ = −0.21, p < 0.0001). All FLs, FNs, and FPs were lowest during the third decade (20–29 years) of life. FLs were elevated consistently after that decade, and FNs were elevated sharply after the seventh decade. FPs were relatively stable after the fourth decade (30–39 years). Mixed-effect regression analyses in subjects 40 years and older showed that older age was associated with worse FLs (p < 0.0001) and FNs (p < 0.0001) but not FPs (p = 0.4126). Aging affects FLs and FNs with different modes but had minimal effects on FPs. Decreased VF sensitivity, deteriorated macular function, and technical difficulties with testing may be mechanisms of age-related changes in FLs and FNs.

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Progression detection in different stages of glaucoma: mean deviation versus visual field index

Japanese Journal of Ophthalmology ◽

10.1007/s10384-011-0110-7 ◽

2011 ◽

Vol 56 (2) ◽

pp. 128-133 ◽

Cited By ~ 11

Author(s):

Jung Woo Cho ◽

Kyung Rim Sung ◽

Sung-Cheol Yun ◽

Jung Hwa Na ◽

Youngrok Lee ◽

...

Keyword(s):

Visual Field ◽

Mean Deviation ◽

Visual Field Index

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New visual field indices of disharmony for early diagnosis of glaucoma, alone or associated with conventional parameters

European Journal of Ophthalmology ◽

10.1177/1120672118762668 ◽

2018 ◽

Vol 28 (5) ◽

pp. 590-597

Author(s):

Rodrigo Abreu-Gonzalez ◽

Marta Gonzalez-Hernandez ◽

Cristina Pena-Betancor ◽

Paloma Rodriguez-Esteve ◽

Manuel Gonzalez De La Rosa

Keyword(s):

Optical Coherence Tomography ◽

Standard Deviation ◽

Visual Field ◽

Early Diagnosis ◽

Structural Data ◽

Cross Sectional Study ◽

University Hospital ◽

Mean Deviation ◽

Optical Coherence ◽

Cross Sectional

Purpose: To evaluate the specificity of new perimetric indices based on harmony, alone and in combination with structural data, for glaucoma detection. Methods: In this prospective observational cross-sectional study, one eye of 105 healthy subjects and 97 early and suspect glaucomas were sequentially included and examined with Cirrus optical coherence tomography, twice with OCULUS Smartfield perimeter (SPARK strategy) and twice with Humphrey Analyzer (24-2 SITA-Fast) at the Ophthalmology Department from the University Hospital La Candelaria. Disharmony in the visual field was evaluated including vertical threshold symmetry, threshold rank), and homogeneity (threshold standard deviation from its maximum) using the patient himself/herself as a reference. We also evaluated disharmony in combination with the mean deviation and the pattern standard deviation in a single index (mismatch) and various combinations of morphological and functional indices. Combinations used a new score based on values above certain critical cut-off levels of each index. Results: For 95% specificity, the highest sensitivities were as follows: vertical cup/disc ratio: 28.9%; SPARK threshold rank: 29.9%; and SITA-Fast threshold standard deviation: 28.9%. For the combined indices and 100% specificity, they were 5 SPARK indices mismatch: 10.3%; 5 SITA-Fast indices mismatch: 11.3%; 8 optical coherence tomography indices: 21.9%; 13 SPARK and optical coherence tomography indices: 27.8%; and 13 SITA-Fast and optical coherence tomography indices: 32.0%. Conclusion: Disharmony combined with normative value-based indices and/or optical coherence tomography indices is useful for very specific early diagnosis of glaucoma.

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