Oral cavity status in menopausal and postmenopausal women

The purpose of this review was to analyze and summarize the available literature data on changes of oral tissues in menopausal/postmenopausal women. We searched for the relevant references in Pubmed database using appropriate key words. We had revealed about 3,500 references on these topics and analyzed the most relevant. Postmenopausal women have an increased risk of the decrease of bone mineral density due to estrogen deficiency. Estrogens induce osteoclast apoptosis and intensity of this protective mechanism decreases after the cessation of menstruation. Most cross-sectional radiographic studies have confirmed an association between age-related osteoporosis and decreased alveolar bone height. It has been established that postmenopausal women with generalized chronic periodontitis are characterized by severe destruction of the periodontium, which progresses in parallel to a decrease in bone mineral density. Sex hormones maintaining bone integrity and strength, involved in regulating the proliferation, differentiation, and growth of keratinocytes and fibroblasts of the gums. The effect of low estrogen levels on keratinization of the gum epithelium and decreased salivation can lead to menopausal gingivostomatitis. Estrogen deficiency also adversely affects the microenvironment of gingival sulcus, including the composition and circulation of crevicular fluid. Postmenopausal women have lower salivary pH and lower salivation, which is associated with deterioration of periodontal tissues. In addition, the postmenopausal period is characterized by the changes in the microbial composition of the oral cavity, IgG decreases in the crevicular fluid and prooxidant changes of saliva. Conclusions. The oral cavity status in menopausal and postmenopausal women undergoes significant changes: a decrease in bone mineral density, dryness of mucous membranes, microbiome changes, and activation of oxidative and immune processes. These changes necessitate regular examinations, timely treatment and application of all measures of preventive dentistry. There is also a need for randomized clinical trials and create standardized guidelines for the management of postmenopausal patients with periodontal disease.

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Influence of cigarette smoking on bone mineral density in postmenopausal women with estrogen deficiency in menstrual history

Journal of Health Sciences ◽

10.17532/jhsci.2014.141 ◽

2014 ◽

Vol 4 (1) ◽

pp. 26-30

Author(s):

Amila Kapetanović ◽

Dijana Avdić

Keyword(s):

Bone Mineral Density ◽

Cigarette Smoking ◽

Postmenopausal Women ◽

Bone Mineral ◽

Linear Correlation ◽

Estrogen Deficiency ◽

Control Group ◽

Mineral Density ◽

T Score ◽

Menstrual History

Introduction: Estrogen deficiency leads to bone mass loss and increased risk for osteoporosis. The aim of this study was to examine influence of cigarette smoking on bone mineral density in postmenopausal women with estrogen deficiency in menstrual history.Methods: The total of 100 postmenopausal women living in Sarajevo area, aged 50-65 years, with estrogen deficiency in menstrual history participated in this prospective study. The subjects were divided in two groups, examination and control group, based on bone mineral density values. The women in the examination group had osteoporosis while in the control group were women with osteopenia or normal bone mineral density. Bone mineral density was measured at the lumbar spine and proximal femur by Dual–Energy X–ray Absorptiometry using Hologic QDR-4000 scanner. Smoking habits were assessed for each subject.Results: The average number of cigarettes smoked per day in women with estrogen deficiency in menstrual history was 14.86 in the examination group and 4.67 in the control group. The difference in the average number of cigarettes smoked per day between the two groups was statistically significant (p <0.01). The coefficient of linear correlation between T score and the number of cigarettes smoked per day among women with estrogen deficiency in menstrual history in the examination group was statistically significant (p<0.01). The coefficient of linear correlation between T score and the number of cigarettes smoked per day among women with estrogen deficiency in menstrual history in the control group was statistically significant ( p<0.05).Conclusion: Results of this study suggest that cigarette smoking has negative impact on bone mineral density and that healthy lifestyle (no smoking) has the potential to reduce bone loss in postmenopausal women with estrogen deficiency in menstrual history.

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Influence of coffee consumption on bone mineral density in postmenopausal women with estrogen deficiency in menstrual history

Journal of Health Sciences ◽

10.17532/jhsci.2014.194 ◽

2014 ◽

Vol 4 (2) ◽

pp. 105-109 ◽

Cited By ~ 4

Author(s):

Amila Kapetanović ◽

Dijana Avdic

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Daily Intake ◽

Coffee Consumption ◽

Estrogen Deficiency ◽

Control Group ◽

Mineral Density ◽

Average Daily Intake ◽

Menstrual History

Introduction: Complex etiology of osteoporosis include genetic, hormonal, environmental and nutritional factors. The aim of this study was to examine influence of coffee consumption on bone mineral density in postmenopausal women with estrogen deficiency in menstrual history.Methods: This prospective study included 100 postmenopausal women, aged 50-65 years living in Sarajevo area, with estrogen deficiency in their menstrual history. The controlled clinical trials were conducted. Two groups were formed (based on bone mineral density values). The examination group included 50 women who had osteoporosis, while the control group included 50 women without osteoporosis (osteopenia, normal bone mineral density). The lumbar spine and proximal femur bone mineral density was measured by Dual–Energy X–ray Absorptiometry using Hologic QDR-4000 scanner. Coffee drinking habits were assessed for each subject.Results: The average daily intake of coffee in women with estrogen deficiency in menstrual history was at 267.6 ml in the examination group and in the control group 111.6 ml. The difference in the average daily intake of coffee between the two groups was statistically significant (p < 0.001). There was registered significant correlation between intake of coffee and bone mineral density in examination (p < 0.01) and in control group (p < 0.05).Conclusion: This study indicates that coffee consumption is a risk factor for osteoporosis in postmenopausal women, aged 50-65 years living in Sarajevo area, with estrogen deficiency in their menstrual history. It was shown that the effects of coffee on bone mineral density are dose-dependent.

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