scholarly journals Serum Zinc Levels and the Effect of Oral Zinc in Acne Vulgaris

2020 ◽  
Vol 7 (47) ◽  
pp. 2777-2782
Author(s):  
Mohan Rao Munnaluri ◽  
Sravan Chittla ◽  
Nihal Perumalla
Keyword(s):  
Zinc Sulphate ◽  
Social Issues ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Normal Serum ◽  
Female Ratio ◽  
Chronic Inflammatory Condition ◽  
Different Types ◽  
Zinc Levels ◽  
Serum Zinc Levels

BACKGROUND Acne vulgaris is a chronic inflammatory condition of the pilosebaceous unit which occurs in adolescent age groups. Physical and psychological scars can create social issues in the family, school and workplace. The disorder is multifactorial. There are plenty of recovery choices but are not satisfactory. We wanted to investigate the serum zinc levels and the therapeutic utility of oral zinc supplementation in acne vulgaris patients. METHODS This is a prospective study conducted over a period of one and a half years among one hundred acne patients who reported to the outpatient clinic of the Department of Dermatology, Venereology and Leprology with untreated patients of acne vulgaris. RESULTS Males were 65 % and females were 35 % with male : female ratio of 6.5 : 3.5. Most of the patients were students occupying 71 % of the study. Family history was observed in 46 % of patients, either in the siblings or in the parents. Premenstrual flare-up of acne lesions was noted in 71.42 % of female patients indicating a pivotal role of hormones in the pathogenesis of acne. Aggravation of lesions in summer was noted in 45 % of patients. Aggravation of acne lesions with different types of diet like non-vegetarian food, oily food and chocolates was noticed in 69 % of the study. History of usage of different types of cosmetics available in the market was noted in 76 % of the patients. In the present study, 62 % had lower than normal serum zinc levels and 38 % had normal serum zinc levels. Thus, serum zinc levels were found to be lower in both male and female acne patients in the majority (62 %) of the study patients and also normal healthy controls. The fasting serum zinc levels in the 62 patients before and after oral zinc sulphate were estimated after completion of 3 months treatment. Normal serum zinc levels were observed in all 62 patients treated. CONCLUSIONS Oral zinc sulphate is an effective, safe and economic remedy in the treatment of acne vulgaris. The extra advantage with oral zinc sulphate is that it is devoid of many adverse reactions commonly seen after prolonged use of systemic antibiotics. KEYWORDS Oral Zinc Sulphate, Acne Vulgaris

scholarly journals Dysgeusia Due to Zinc Deficiency After Pancreaticoduodenectomy Requiring Continuous Intravenous Zinc Supplementation: a Case Report and Literature Review

2021 ◽  
Author(s):  
Hironobu Hata ◽  
Yojiro Ota ◽  
Katsuhiko Uesaka ◽  
Yutaka Yamazaki ◽  
Tsubasa Murata ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Oral Surgery ◽  
Oral Care ◽  
Serum Zinc ◽  
Zinc Level ◽  
Normal Serum ◽  
Acrodermatitis Enteropathica ◽  
Proximal Jejunum ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies regarding the development of zinc deficiency after PD and presented the case of a patient with zinc deficiency after PD, who required home intravenous zinc replacement.Case presentation: A 73-year-old woman with glossitis, taste disorder, and acrodermatitis enteropathica-like eruption on her fingers presented to the Division of Dentistry and Oral Surgery 69 days after PD. Her serum zinc level markedly decreased to 30 μg/dL. Oral zinc administration was inadequate to treat hypozincemia after PD; therefore, multi-trace elements were injected intravenously under readmission. Her serum zinc levels recovered, and the lesions gradually improved. Furthermore, a central venous port was implanted to maintain normal serum zinc levels, and she continued self-injecting zinc at home.Conclusion: Zinc deficiency after PD rarely occurs. The clinical oncologist community, including dentists responsible for the oral care of cancer patients, should be aware of dysgeusia associated with zinc deficiency after cancer surgery, as well as that induced by chemotherapy or head and neck radiation therapy.

scholarly journals Association between serum zinc level and simple febrile seizures in children: a hospital-based study

2018 ◽  
Vol 6 (9) ◽  
pp. 3116
Author(s):  
Najmus Saqib ◽  
Mahvish Qazi
Keyword(s):  
Hospital Admissions ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Chi Square ◽  
Febrile Convulsions ◽  
Female Ratio ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Brittany E. Yee ◽  
Phillip Richards ◽  
Jennifer Y. Sui ◽  
Amanda Fleming Marsch
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Treatment ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Majid Rostami Mogaddam ◽  
Nastaran Safavi Ardabili ◽  
Nasrollah Maleki ◽  
Maedeh Soflaee
Keyword(s):  
Acne Vulgaris ◽  
Serum Zinc ◽  
Atomic Absorption Spectrophotometry ◽  
Zinc Level ◽  
Healthy Controls ◽  
Serum Zinc Level ◽  
Absorption Spectrophotometry ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P=0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

scholarly journals Supplementation of Zinc Sulphate Decrease for Cytokine Levels TNF-Α, IL-1β and IL-6 in Multibacillary Leprosy Patients

2020 ◽  
Vol 3 (4) ◽  
pp. 191-197
Author(s):  
Joko Kurnianto ◽  
Hertanto W S ◽  
Prasetyowati Prasetyowati ◽  
Suharyo H. S.
Keyword(s):  
Proinflammatory Cytokines ◽  
Zinc Sulfate ◽  
Zinc Sulphate ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Control Group ◽  
Tnf Α ◽  
Leprosy Patients ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: The role of zinc as an anti-oxidant and anti-inflammatory has been widely proven, this substance is relatively inexpensive and easily available to the public. Serum zinc levels of leprosy patients and patients with leprosy reactions are lower compared to healthy people, and proinflammatory cytokines including TNF-α, IL-1β and IL-6 play a role in the mechanism of leprosy reactions. Research on the effect of zinc supplementation on leprosy sufferers who have not experienced a reaction has not been done. Objective: To analyze the effect of 40 mg / day dose of zinc sulphate supplementation for 12 weeks on the levels of proinflammatory cytokines levels TNF-α, IL-1β and IL-6 in type MB leprosy patients. Method: This is an experimental study using a randomized control group pretest and posttest design. The study participants were MB patients with 121 patients who did not experience a leprosy reaction, the sample was taken randomly as many as 31 patients as a supplementation group (treatment), and 31 patients as Control group. BMI measurements, food intake by re-call method, Hb level using Hematology Analyzer, serum zinc levels using Atomic Absorption Spectrophotometry (AAS) method, TNF-α, IFN-γ, and IL-1β levels used the ELISA method. Data were analysed using chi-square and t-tests. Results: Zinc sulfate supplementation dose of 40 mg / day for 12 weeks in type MB leprosy patients was able to maintain a decrease in zinc levels of 1.22 pg / dL higher than leprosy patients who did not receive zinc supplementation, reduce levels of IL-1β (p=0.032). However, statistically there is insufficient evidence to reduce levels of TNF-α (p=0.063) and IL-6 (p=0.389) and risk factors. Conclusion: The study confirmed that 40 mg / day supplementation of zinc sulfate for 12 weeks in type MB leprosy patients able to maintain a decrease in serum zinc levels, reduce IL-1β levels. Keywords: Supplementation, Cytokines, Type MB leprosy

scholarly journals EVALUATION OF SERUM ZINC LEVEL

2018 ◽  
Vol 25 (02) ◽  
pp. 307-312
Author(s):  
Thiga Mohammed Mohammed Osman Alhassan ◽  
Abdelmula Mohamed Abdalla ◽  
Eshtiag Mohammed Mohammed Osman Alhassan ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Reference Group ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Level ◽  
Chronic Inflammatory Disease ◽  
Acrodermatitis Enteropathica ◽  
Serum Zinc Level ◽  
Severe Acne ◽  
Zinc Levels ◽  
Serum Zinc Levels

Back ground: Acne vulgaris is a common chronic inflammatory disease ofthe skin. Zinc is a trace element, exists in high amounts within the skin and especially theepidermis. Its importance for human metabolism has been noted by the dramatic improvementof acrodermatitis enteropathica following zinc supplementation. Objectives: To evaluate theserum zinc level among patients with acne vulgaris, and to correlate age, grade and durationof acne vulgaris with serum zinc level. Study Design: Case- control hospital base study.Setting: Khartoum state at Khartoum Dermatology & Venerology Hospital. Period: February toSeptember 2017. Materials Methods: 100 samples were collected from patients attending toKhartoum Dermatology & Venerology hospital suffering from acne vulgaris. Acne severity wasclassified according to Global Acne Grading System (GAGS). In addition to other 100 samplescollected from healthy individuals (students and nurse) sex and age matched as control. Thelevels of serum zinc was measured in each group by atomic absorption spectroscopy. Results:The study showed significant decrease in the zinc concentrations in acne vulgaris patientswhen compared with the reference group (0.207±0.04 mg/l versus 0.788 ± 0.14 mg/l) (p=0.000). The study observed decreased serum zinc level with advancedgrade of acne; mild47 patients (47%) (0.247 ± 0.05), moderate 33 (33%) (0.1925 ± 0.04) and severe in 20 (20%)(0.180 ± 0.03), based on the anova test analysis mean serum zinc levels were significantlylower in patients with mild to moderate and to severe acne vulgaris when compared betweenacne vulgairs grades and with reference group(p ≤ 0.001, p ≤ 0.01, p ≤ 0.05 respectively).The present study showed no correlation between zinc level (mg/l) and age in patient with acnevulgaris (years) (r=0.032, P =0.827). On the other hand significant correlation was recordedbetween serum zinc level (mg/l) and duration of the acne vulgaris in the study group (r=-0.311,p = 0.028). Conclusion: Study revealed that serum zinc levels is significantly decreased inpatients with acne vulgaris, and prescribing zinc supplement treatments help increasing thesuccess rate of acne treatment.

Role of serum zinc levels in simple febrile convulsions in children

2019 ◽  
Vol 9 (1) ◽  
pp. 36-38
Author(s):  
S W Srikanth ◽  
◽  
Sharanagouda Patil ◽  
Rachapudi Venkata Anusha ◽  
◽  
...  
Keyword(s):  
Serum Zinc ◽  
Febrile Convulsions ◽  
Zinc Levels ◽  
Serum Zinc Levels
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