Evaluation of hyperprolactinemia risk factors in infertile women referred to Yazd Infertility Center: A cross-sectional study

Background: Hyperprolactinemia is one of the most common causes of infertility in women. The prevalence of pituitary tumors is 25-30% among infertile participants with hyperprolactinemia. Objective: The aim of this study was to describe the causes of hyperprolactinemia in infertile women referred to Yazd Infertility Center. Materials and Methods: This cross-sectional study was conducted with 182 infertile women with hyperprolactinemia who were referred to Yazd Infertility Center from February 2018 to October 2019. Serum prolactin was assessed by the human prolactin ELISA kit according to the Padtan Gostar Isar protocol. The age, duration of infertility, causes of hyperprolactinemia, and type of infertility treatment were noted. The MRI findings were added. Results: The mean age of participants was 28.9 ± 0.36 yr and the prolactin level was 76 ± 8.97 ng/ml. The etiology of hyperprolactinemia among the study participants was 35 participants (19.2%) with pituitary adenoma, 47 participants (25.8%) with polycystic ovary syndrome, 14 participants (7.7%) with pituitary adenoma and polycystic ovary syndrome, and 86 participants (47.3%) with idiopathic hyperprolactinemia. The results of this study showed that there was no statistically significant difference between the mean prolactin levels in participants with different causes of hyperprolactinemia (p = 0.31). Conclusion: Idiopathic hyperprolactinemia and polycystic ovary syndrome are the most common reasons for hyperprolactinemia. Key words: Hyperprolactinemia, Infertility, PCOS.

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Glutathione-dependent enzymes in the follicular fluid of the first-retrieved oocyte and their impact on oocyte and embryos in polycystic ovary syndrome: A cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i6.7283 ◽

2020 ◽

Author(s):

Fatemeh Zal ◽

Pardis Ahmadi ◽

Maryam Davari ◽

Fatemeh Khademi ◽

Mojgan Akbarzadeh Jahromi ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Antioxidant System ◽

Follicular Fluid ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

The Mean

Background: Oxidative stress and GSH-dependent antioxidant system plays a key role in the pathogenesis of polycystic ovary syndrome (PCOS). Objective: We compared glutathione peroxidase (GPx) and glutathione reductase activities and reduced glutathione (GSH) levels in serum and follicular fluid (FF) of the first-retrieved follicle and their impact on quality of oocyte and embryo in PCOS women undergoing IVF. Materials and Methods: This cross-sectional study was conducted on 80 pairs of blood samples and FF of the first-retrieved follicle from PCOS women, at the Infertility center of Ghadir Mother and Child Hospital. The mean activity of GPx and GR, also GSH levels in the serum and FF were compared to the quality of the first follicle and resultant embryo. Results: Retrieved oocytes included 53 (66.25%) MII, 17 (21.25%) MI, and 10 (12.5%) germinal vesicles; after IVF 42 (52.50%) embryos with grade I and 11 (13.75%) with grade II were produced. The mean values for all three antioxidants were higher in the FF compared to serum (p < 0.001). Also all of the mean measured levels were significantly higher in the FF of the MII oocytes compared to that of oocytes with lower grades (p = 0.012, 0.006 and 0.012, respectively). The mean GPX activity and GSH levels were significantly higher in the serum (p = 0.016 and 0.012, respectively) and FF (p = 0.001 for both) of the high-quality grade I embryos. Conclusion: GSH-dependent antioxidant system functions more efficiently in the FF of oocytes and embryos with higher quality. Key words: In vitro fertilization, Glutathione, Antioxidant, Oocyte, Embryo.

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Prevalence of depression and quality of life in polycystic ovary syndrome patients at a tertiary care hospital: a cross-sectional study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20192412 ◽

2019 ◽

Vol 8 (6) ◽

pp. 2251

Author(s):

Radhika Gollapudi ◽

Venu Madhavi Lanke ◽

Manaswini Namilakoda

Keyword(s):

Quality Of Life ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

Prevalence Of Depression ◽

The Mean

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy among women of reproductive age. Physical symptoms in PCOS cause depression and decrease the Quality of Life (QoL). The objective was to study the prevalence of depression in women suffering from PCOS and to assess its correlation with QoL.Methods: This was a cross sectional study conducted among one hundred patients diagnosed with PCOS. Women 18-40 years of age diagnosed with PCOS were included in the study. Patients with known psychiatric illness were excluded. Depression severity was assessed with Hamilton depression (HAM-D) scale. The quality of life (QoL) was assessed with Polycystic ovary syndrome questionnaire (PCOSQ). The data was analyzed using SPSS 20.0 for Windows.Results: The mean age and BMI was 25.64±3.25 years and 26.78±2.72 kg/m2 respectively. The mean depression score was 12.46±6.18. QoL domains showed that the lowest score was in the menstrual problem with a mean of 12.48±4.44 and the highest was in the emotional domain with a mean of 28.07±11.17. The negative correlations were between age and Hamilton score (p < 0.05). The Hamilton score was negatively correlated with the emotional score (p <0.01) and weight score was positively correlated with infertility score (p <0.01).Conclusions: PCOS was clearly associated with depression and reduced QoL. This should warrant health professionals to consider routine screening for depression and assess the impact of symptoms on their QoL to improve patient outcomes.

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Frequency of Hyperprolactinemia in PCOS and its Association with Female Infertility

Proceedings of Shaikh Zayed Medical Complex Lahore - October to December ◽

10.47489/p000s334z7301-5mc ◽

2019 ◽

Vol 33 (4) ◽

pp. 1-5

Author(s):

Anam Rehman

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Pearson Correlation ◽

Cross Sectional Study ◽

Female Infertility ◽

Health Concern ◽

Serum Prolactin ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional

Introduction: Infertility is a critical health concern partially due to intricacy in its causes and striving for its prevention, diagnosis and treatment. Various researches have documented a close linkage between polycystic ovary syndrome and hyperprolactinemia. Aims & Objectives: This study was aimed to determine the frequency of hyperprolactinemia in PCOS and its association with infertility in PCOS subjects. Place and duration of study: It was a cross sectional study, conducted during April 2017 and September 2017 at Aziz Fatimah Hospital, Faisalabad, Pakistan. Material & Methods: It was a cross sectional study which was conducted at Aziz Fatimah Hospital, Faisalabad, Pakistan from April to September 2017. This study comprised of 88 female subjects of 17-35 years old who included PCOS subjects and age matched controls. Hyperprolactinemia was assessed by the measurement of serum prolactin levels which were measured by chemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis of the data. Results: Out of total 88 female participants, 61.4% of polycystic ovary syndrome subjects had hyperprolactinemia as compared to this 36.4% of controls had hyperprolactinemia. Pearson correlation also revealed significant positive association of hyperprolactinemia with infertility. Conclusion: Hyperprolactinemia was frequently seen in polycystic ovary syndrome females as well as raised BMI was also found. Raised prolactin levels are strongly associated with female infertility. Key words: Hyperprolactinemia, Infertilty, Polycystic Ovary Syndrome.

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Comparing endometrial hysteroscopic and histological findings of infertile women with polycystic ovary syndrome and unexplained infertility: A cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v18i1.6195 ◽

2020 ◽

pp. 33-40

Author(s):

Sedigheh Amooee ◽

Mojgan Akbarzadeh-Jahromi ◽

Maedeh Motavas ◽

Fatemeh Zarei

Keyword(s):

Polycystic Ovary ◽

Endometrial Thickness ◽

Cross Sectional Study ◽

Sectional Study ◽

Histological Findings ◽

Ovary Syndrome ◽

Cross Sectional ◽

Infertile Women ◽

Proliferative Endometrium ◽

The Mean

Background: Infertility is a critical condition in women with polycystic ovary syndrome (PCOS), caused not only by anovulation but also by endometrial abnormality. Objective: This study aimed to evaluate and compare the hysteroscopic and histological findings of endometrial biopsies in infertile women with PCOS and normal endometrial thickness and women with unexplained infertility (UI). Materials and Methods: This cross-sectional study compared the initial hysteroscopy and endometrial histological findings of 70 infertile women with PCOS and normal endometrial thickness with those of 35 women with UI. The relationship between endometrial histology and clinical parameters such as including luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, testosterone, prolactin, fasting blood sugar, body mass index (BMI), and infertility duration was analyzed. Results: The mean age of women with PCOS was significantly lower than that of women with UI (27.5 ± 4.1 vs. 30 ± 4.5 years, respectively) (p < 0.001). The mean BMI was higher in women with PCOS than in women with UI (28.7 ± 4.4 vs. 25.1 ± 3 kg/m2) (p < 0.001). The hysteroscopic findings of all women with PCOS were normal, whereas 91.4% of women with UI had normal hysteroscopic findings, 2.9% had a polyp, and 5.7% had endometrial thickening. The histological findings of women with PCOS revealed proliferative endometrium in 54.3%, disordered proliferative endometrium in 17.1%, secretory endometrium in 8.6%, and endometrial polyp in 17.1%, whereas these percentages in women with UI were 28.6%, 0%, 54.3%, and 20%, respectively. Conclusion: The hysteroscopic evaluation alone of infertile women might not detect all probable endometrial pathologies in women with PCOS. Key words: Polycystic ovary, Hysteroscopy, Histology, Endometrium, Infertility.

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Comparison of Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Endometriosis: A cross-sectional Study

10.21203/rs.3.rs-27545/v1 ◽

2020 ◽

Author(s):

Zahra Daneshfar ◽

shahideh Jahanian Sadatmahalleh ◽

Nadia Jahangiri

Keyword(s):

Sexual Dysfunction ◽

Polycystic Ovary Syndrome ◽

Sexual Function ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Control Group ◽

Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

Infertile Women

Abstract Introduction: Infertility is one of the issues affecting sexual function (SF). Infertility is also one of the complications of polycystic ovary syndrome (PCOS) and endometriosis. This research seeks to assess and compare SF and the prevalence of sexual dysfunction with PCOS and endometriosis in infertile women. Methods: A cross-sectional study was carried out on 630 samples (210 infertile women with endometriosis, 210 infertile women with PCOS, and 210 healthy women of childbearing age as the control group). SF was assessed by the Female Sexual Function Index (FSFI). Descriptive statistics and inferential statistics (One Way ANOVA and logistic regression) were used to analyze the data.Results: The results showed that the mean score of total FSFI in the two groups of PCOS and endometriosis was lower than the control group (P<0.001). In addition, women with higher education (university education) had a significantly higher score of total FSFI. Conclusion: Sexual dysfunction rates are high in infertile women with endometriosis and PCOS, so infertility service providers in infertility centers need to pay attention to this issue.

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